Gene

KWMTBOMO01091  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007343

Annotation

Cytochrome_c_oxidase_copper_chaperone_[Papilio_machaon]

Location

Bomo_Chr3(-):1906399-1906977      View in EpiBrowser

Full name

Cytochrome c oxidase copper chaperone      

Alternative Name

Dopuin

Location in the cell

Mitochondrial   Reliability : 1.172

CDS

ATGGGAAACGCTAGTGCTAAAGCGGTTGAAGTTAAAGTTTTAGAAGGTCCTGCACCTGAAAACGTCGAGAAACCTAAACTAAAGCCTTGCTGTGCTTGCCCTGAAACAAAAAGAGCACGCGATGCATGCATTATAGAAAATGGAGAAGAGAACTGTGGACCACTTATTGAAGAACACAAGGCCTGTATGAGAAAAATGGGATTCAATATTTAA

Protein

MGNASAKAVEVKVLEGPAPENVEKPKLKPCCACPETKRARDACIIENGEENCGPLIEEHKACMRKMGFNI

Description

Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).

Subunit

Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure.

Similarity

Belongs to the COX17 family.

Keywords

Chaperone   Complete proteome   Copper   Cytoplasm   Direct protein sequencing   Disulfide bond   Metal-binding   Mitochondrion   Phosphoprotein   Reference proteome  

Feature

chain  Cytochrome c oxidase copper chaperone

Uniprot

H9JCU6   A0A2H1WXW4   A0A2A4J4U0   A0A194R5B3   I4DL33   A0A0L7L8C6   + More
S4NU29   A0A212FKQ4   A0A0K8TN45   A0A182FMI1   E1ZYM8   A0A026WVB5   A0A2M4AX27   F4W4N1   A0A3B3DQW0   A0A1W4XS15   A0A067RGF6   A0A195F015   A0A2P8XDS8   A0A0L8G5R0   B3NUV4   A0A1Q3FI52   B0X3C6   B4PWA3   A0A2U3V6X8   B4R4Y5   A0A0B6ZG75   H2LXH0   A0A3P9ILZ3   A0A195CEY7   A0A182JJ64   B4IJ95   A0A084WPQ5   D6WXE2   A0A340WQF7   A0A2Y9MI12   A0A341D545   A0A182HHD9   A0A182VEF7   A0A182XGS2   A8XMM4   Q5TMP2   A0A0K0EYN3   W5JPX4   A0A3P9LKG9   F6QD94   A0A2F0B568   A0A0Q3X223   A0A384A3K3   R4WD65   A0A1Y1NG65   A0A240SWD0   Q5U537   A0A0N5BFQ7   U3EK92   A0A2M3ZD40   G3SYL6   I3MNW8   P81045   A0A182W614   A0A218VEH9   A0A3B4XZ33   A0A0M5J8F5   A0A2K6GDL3   A0A182RIK9   D2XUP7   A0A1U7T8V4   A0A2J8M3G8   A0A2J8W284   M4AKG4   H7C4E5   A0A2Y9ENZ5   W5P542   Q3ZBE2   A0A212CJG3   G1PAP2   A0A2Y9DGI4   A0A2I2ZM97   G1QYQ3  

Pubmed

19121390    26354079    22651552    26227816    23622113    22118469    + More
26369729    20798317    24508170    30249741    21719571    29451363    24845553    29403074    17994087    18057021    17550304    17554307    24438588    18362917    19820115    14624247    12364791    14747013    17210077    20920257    23761445    19393038    23691247    28004739    27762356    25243066    9370362    17182746    23542700    16641997    21269460    20809919    21993624   

EMBL

BABH01027736    ODYU01011858    SOQ57842.1    NWSH01003336    PCG66524.1    KQ460685    + More
KPJ12867.1    AK402001    AK402002    KQ459072    BAM18623.1    KPJ03850.1    JTDY01002354    KOB71600.1    GAIX01011976    JAA80584.1    AGBW02008002    OWR54323.1    GDAI01001811    JAI15792.1    GL435237    EFN73692.1    KK107087    QOIP01000001    EZA59962.1    RLU27275.1    GGFK01012035    MBW45356.1    GL887532    EGI70926.1    KK852699    KDR18189.1    KQ981905    KYN33502.1    PYGN01002638    PSN30155.1    KQ423801    KOF72164.1    CH954180    EDV47052.1    KQS30321.1    GFDL01007808    JAV27237.1    DS232312    EDS39818.1    CM000162    EDX01734.1    KRK06327.1    CM000366    EDX17942.1    HACG01019986    HACG01019987    CEK66851.1    CEK66852.1    KQ977935    KYM98623.1    CH480847    EDW51074.1    ATLV01025119    KE525369    KFB52199.1    KQ971361    EFA08829.1    APCN01002407    HE600979    CAP33900.1    AAAB01008986    EAL38853.2    ADMH02000836    ETN64915.1    NTJE010074963    MBV98146.1    LMAW01000083    KQL60847.1    AK417259    BAN20474.1    GEZM01003093    GEZM01003092    JAV96924.1    BC084847    BC133789    CM004468    AAH84847.1    AAI33790.1    OCT93570.1    GAMR01003289    GAMP01010051    JAB30643.1    JAB42704.1    GGFM01005664    MBW26415.1    AGTP01049885    AGTP01049886    MUZQ01000007    OWK63992.1    CP012528    ALC49756.1    AEMK02000089    GU255509    ADB22522.1    NBAG03000270    PNI54072.1    NDHI03003402    PNJ63882.1    AC023494    AMGL01025927    BC103398    AAI03399.1    MKHE01000019    OWK06183.1    AAPE02022505    CABD030023620    ADFV01006450   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000037510    UP000007151    + More
UP000069272    UP000000311    UP000053097    UP000279307    UP000007755    UP000261560    UP000192223    UP000027135    UP000078541    UP000245037    UP000053454    UP000008711    UP000002320    UP000002282    UP000245320    UP000000304    UP000001038    UP000265200    UP000078542    UP000075880    UP000001292    UP000030765    UP000007266    UP000265300    UP000248483    UP000252040    UP000075840    UP000075903    UP000076407    UP000008549    UP000007062    UP000035680    UP000000673    UP000265180    UP000009136    UP000051836    UP000261681    UP000091820    UP000186698    UP000046392    UP000007646    UP000005215    UP000008227    UP000075920    UP000197619    UP000261360    UP000092553    UP000233160    UP000075900    UP000189704    UP000002852    UP000005640    UP000248484    UP000002356    UP000001074    UP000248480    UP000001519    UP000001073   

PRIDE

H9JCU6    P81045    D2XUP7    H7C4E5   

Pfam

PF05051   COX17

Interpro

IPR007745   Cyt_c_oxidase_Cu-chaperone        + More
IPR009069   Cys_alpha_HP_mot_SF       

SUPFAM

SSF47072   SSF47072       

ProteinModelPortal

H9JCU6   A0A2H1WXW4   A0A2A4J4U0   A0A194R5B3   I4DL33   A0A0L7L8C6   + More
S4NU29   A0A212FKQ4   A0A0K8TN45   A0A182FMI1   E1ZYM8   A0A026WVB5   A0A2M4AX27   F4W4N1   A0A3B3DQW0   A0A1W4XS15   A0A067RGF6   A0A195F015   A0A2P8XDS8   A0A0L8G5R0   B3NUV4   A0A1Q3FI52   B0X3C6   B4PWA3   A0A2U3V6X8   B4R4Y5   A0A0B6ZG75   H2LXH0   A0A3P9ILZ3   A0A195CEY7   A0A182JJ64   B4IJ95   A0A084WPQ5   D6WXE2   A0A340WQF7   A0A2Y9MI12   A0A341D545   A0A182HHD9   A0A182VEF7   A0A182XGS2   A8XMM4   Q5TMP2   A0A0K0EYN3   W5JPX4   A0A3P9LKG9   F6QD94   A0A2F0B568   A0A0Q3X223   A0A384A3K3   R4WD65   A0A1Y1NG65   A0A240SWD0   Q5U537   A0A0N5BFQ7   U3EK92   A0A2M3ZD40   G3SYL6   I3MNW8   P81045   A0A182W614   A0A218VEH9   A0A3B4XZ33   A0A0M5J8F5   A0A2K6GDL3   A0A182RIK9   D2XUP7   A0A1U7T8V4   A0A2J8M3G8   A0A2J8W284   M4AKG4   H7C4E5   A0A2Y9ENZ5   W5P542   Q3ZBE2   A0A212CJG3   G1PAP2   A0A2Y9DGI4   A0A2I2ZM97   G1QYQ3  

PDB

2RNB     E-value=1.49547e-12,     Score=169

KEGG

101743531    K02260 cytochrome c oxidase assembly protein subunit 17 | (RefSeq) cytochrome c oxidase copper chape

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005758   GO:0016531   GO:0006825   GO:0046688   GO:0033617   GO:1903136   GO:1904960   GO:0008284   GO:0005507   GO:0000786   GO:0003677   GO:0005634   GO:0006334   GO:0003779   GO:0016021  

PANTHER

PTHR16719  

Subcellular location

Mitochondrion intermembrane space  
Cytoplasm  

Length:

70

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.52688

inside

1  -  70

 

 

Pi

227.712819

Theta

193.210996

Tajima's D

0.43477

CLR

0

CSRT

0.494575271236438

Interpretation

Uncertain