Gene

KWMTBOMO01090

Pre Gene Modal

BGIBMGA007344

Annotation

PREDICTED:_sodium-coupled_neutral_amino_acid_transporter_9-like_[Bombyx_mori]

Location

Bomo_Chr3(-):1879096-1904497      View in EpiBrowser

Full name

Sodium-coupled neutral amino acid transporter 9 homolog      

Location in the cell

PlasmaMembrane   Reliability : 4.981

CDS

ATGCGGTTTCTTAAGAGTTCACCTAGAAAAAGCGAAGATGATCTGTCAACACAGAGCTCTTTGAGGTCAATGGATAGTTGTGAATTATTCGGGAGTGCCTGCTCTGACTATTCTGACTGTGAGTACTGTGATGAGAGAAGACGACAGATTAAAAAAAAGTATTCACCAAGTGACAGCTACTGTAGTGCAATGAGTCGTTTGGAAACGACCCCTTTGCTTGGAGTACTGGCAACAAGACCGGCCTACAAATCCTTGGGAGACAGCACGGATACACTGGGTCCCGGAGAGGTTTCCTCAGATGCCGTATTATCTACTTACAAGAAAAATTTCGAAAAAACTGTCAAAAATGAAAATAAGAAGCAAAGCTCTTTAGTTACAATTTTTTCAATATGGAACACGATAATGGGGTCGTCGCTACTGACCATGGCGTGGGGCGTCGAGCGGGCTGGTCTCCCGGCCGCTCTGGTCCTGGTCGCAGTAATGGCGGCCTTGTGTCTTTACACCGCCTACATATTGATCTCAGTAAACGCTTATCACGGTAGCGACACGTGCTCGGTGCAGGCGCTGTGCCGGCTGCTGCTGGGCGGCTGGGCGGAGGCGCTGGCGCACGTGTTCAGCGTGCTGGTACTCCTCGGAGCGAACATCGTATACTGGATACTCATCACCAACTTCTTTTACTTCACCGTTAATTATTTTATAGATCTAAGTGTGTCGAACGCAACCGAATACAACACGACCCTGCTATGTCCGAATCAAATAGTTAACGAGTCGTTAATGATTCCGAGCCCCGCGGAGGAGTCTCGGTACTGGGGGCTCCACACGACGGCGCCTCTATACACGGCCCTCATTGTCTTCCCGCTCTTAAACTTCAGAAACGTTTCGTTCTTCACTAAATTCAATTCTTTAGGAACCCTATCGGTGTTCTACCTCTTGATCTTCGTAACGGTCAAAGGCTACGCGTGGGGCATCAACATGGGCGCGCTGTGGTCAGAGACCCACGCCGCCAGGAACGCGGCCGTTCTGAGCGGCATGCTGGCCCTATCTTTCTACATCCACAACATCATTATAGAGATCATGAGTAATAACGCAAGGCAAGACAAAAATGGCAGGGATCTAACCATAGCCTTCGTGCTGGTCACGATCACGTACACGATGGTTGGCGCCGTCTTCTACGTCTGCTTCCCGCTCGCCAAGTCCTGCATTGAAGACAACATTCTGAACAACTTCGAGCGTCACGACGTAATGACCGCCGTGGCCAGAGTTCTGTTGCTCTTCCAGGTCGTGACGGTGTACCCGCTGGTGGCGTACATGCTGCGTACGGAGGCGGCCATCTTGTTGTCGTTGCGAGACACGCCCGCCCTTATGTTGCTCGTCAACGTGTGCATAGTTGTCATGTGCATATTGTTCGCGTGCTTCTGCCCTAATATAGGGACAATTATAAGGTACACGGGCGCGCTGAGCGGGCTGGTGCACGTGTTCGCGCTGCCGGCCGCGCTGCACGTGCGCTCGCTGCACCTGCGCGGGGAGCTCGCGCACTGGATGACGTTACTCTACTGTCTCCTCGTGCTCGCCGGGGCCGCCAACCTGCTAATGCAATTCTTCATTACCGAGTGA

Protein

MRFLKSSPRKSEDDLSTQSSLRSMDSCELFGSACSDYSDCEYCDERRRQIKKKYSPSDSYCSAMSRLETTPLLGVLATRPAYKSLGDSTDTLGPGEVSSDAVLSTYKKNFEKTVKNENKKQSSLVTIFSIWNTIMGSSLLTMAWGVERAGLPAALVLVAVMAALCLYTAYILISVNAYHGSDTCSVQALCRLLLGGWAEALAHVFSVLVLLGANIVYWILITNFFYFTVNYFIDLSVSNATEYNTTLLCPNQIVNESLMIPSPAEESRYWGLHTTAPLYTALIVFPLLNFRNVSFFTKFNSLGTLSVFYLLIFVTVKGYAWGINMGALWSETHAARNAAVLSGMLALSFYIHNIIIEIMSNNARQDKNGRDLTIAFVLVTITYTMVGAVFYVCFPLAKSCIEDNILNNFERHDVMTAVARVLLLFQVVTVYPLVAYMLRTEAAILLSLRDTPALMLLVNVCIVVMCILFACFCPNIGTIIRYTGALSGLVHVFALPAALHVRSLHLRGELAHWMTLLYCLLVLAGAANLLMQFFITE

Description

Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.

Similarity

Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.

Keywords

Amino-acid transport   Complete proteome   Disulfide bond   Endosome   Glycoprotein   Lysosome   Membrane   Metal-binding   Reference proteome   Sodium   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium-coupled neutral amino acid transporter 9 homolog

Uniprot

A0A2A4ISI3   H9JCU7   A0A2W1BC50   A0A2H1W9C5   A0A0L7KSP1   A0A194RAH9   + More
A0A212FKR0   A0A1Y1MNC3   J9JJJ9   F4WL87   A0A151I6H5   A0A158NZH8   A0A151WV43   A0A195BPC1   A0A0M9AAM9   A0A2H8TWV6   D2A624   A0A1W4WSP1   A0A026WE26   A0A0A9YEE3   A0A0A9Y6S4   A0A195FCC5   A0A146M953   A0A146L796   A0A146KWI5   A0A2S2PXV9   A0A023F2V8   A0A232FCL7   K7J4T8   E2AB04   A0A2S2PM27   A0A2P8YL72   A0A088ASL6   A0A2J7PXT2   A0A067R137   A0A1B6EGR0   A0A1B6DYX7   A0A1B6IQ56   A0A2J7PXT1   A0A1B6GP34   A0A1B6KXM9   A0A0P5PN38   A0A0N8D107   A0A0P6I656   A0A0P5V4M4   A0A0P5DUB3   A0A0N8DIP9   A0A0N8CRQ7   A0A1I7ZIQ5   A0A0P5MJL0   A0A0P6JCD5   A0A154PH15   A0A2A2L8C9   A0A2A2JQF6   A0A0K0FHV4   A0A0P5Y260   A0A1D2NCA3   A0A0N5BL15   E9GGK7   A0A131YAQ8   A0A087UI50   A0A131YK51   W4XMD1   V5HQ84   A0A224YTD6   A0A1S3KA10   A0A1S3KAJ6   A0A131XPI0   A0A1E1XML5   A0A2G8KUM6   L7M139   A0A1I7S498   A0A131XIN2   A0A0N4ZHU8   A0A090KSG6   A0A0P6EC80   A0A1W2WAC7   A0A0K0EB88   A0A1E1X2Q2   A0A0P4XVN9   F1L1V1   W2TQD0   A0A0P5SCG9   A7SP81   A0A016WK41   A0A016WJY7   A0A0P6CV59   A0A016TGY6   A0A2B4RZW0   A0A293LUP0   A0A061ADY8   Q0G831   A0A016TGV2   Q19425   Q8T3E2   A0A226EN74   A0A1I7UCP6   A0A0N8AIL8   A0A0P5S9L1  

Pubmed

19121390    28756777    26227816    26354079    22118469    28004739    + More
21719571    21347285    18362917    19820115    24508170    30249741    25401762    26823975    25474469    28648823    20075255    20798317    29403074    24845553    26392177    27289101    21292972    26830274    25765539    28797301    29209593    29023486    25576852    21909270    28049606    28503490    21685128    17615350    25730766    9851916    25567906   

EMBL

NWSH01008264    PCG62629.1    BABH01027731    BABH01027732    KZ150177    PZC72558.1    + More
ODYU01007041    SOQ49442.1    JTDY01006103    KOB66283.1    KQ460685    KPJ12866.1    AGBW02008002    OWR54322.1    GEZM01026177    JAV87173.1    ABLF02023704    GL888207    EGI65050.1    KQ978473    KYM93691.1    ADTU01004623    ADTU01004624    KQ982717    KYQ51724.1    KQ976433    KYM87302.1    KQ435710    KOX79916.1    GFXV01005853    MBW17658.1    KQ971346    EFA05454.2    KK107293    QOIP01000005    EZA53284.1    RLU22491.1    GBHO01015724    JAG27880.1    GBHO01015725    GBRD01015111    JAG27879.1    JAG50715.1    KQ981685    KYN38046.1    GDHC01003322    JAQ15307.1    GDHC01015572    JAQ03057.1    GDHC01019217    JAP99411.1    GGMS01001001    MBY70204.1    GBBI01003338    JAC15374.1    NNAY01000460    OXU28233.1    AAZX01009238    GL438234    EFN69280.1    GGMR01017825    MBY30444.1    PYGN01000517    PSN44983.1    NEVH01020852    PNF21141.1    KK852819    KDR15632.1    GEDC01000181    JAS37117.1    GEDC01006424    JAS30874.1    GECU01018661    JAS89045.1    PNF21142.1    GECZ01005656    JAS64113.1    GEBQ01023764    JAT16213.1    GDIQ01126080    JAL25646.1    GDIP01079391    LRGB01000725    JAM24324.1    KZS16380.1    GDIQ01034946    JAN59791.1    GDIP01105392    JAL98322.1    GDIP01168435    JAJ54967.1    GDIP01029855    JAM73860.1    GDIP01105391    JAL98323.1    GDIQ01155712    JAK96013.1    GDIQ01019477    JAN75260.1    KQ434902    KZC11176.1    LIAE01007070    PAV82297.1    LIAE01010291    PAV63900.1    GDIP01065058    JAM38657.1    LJIJ01000093    ODN02861.1    GL732543    EFX81470.1    GEDV01012580    JAP75977.1    KK119903    KFM77039.1    GEDV01010266    JAP78291.1    AAGJ04062965    AAGJ04062966    GANP01008380    JAB76088.1    GFPF01005956    MAA17102.1    GEFM01006673    JAP69123.1    GFAA01003125    JAU00310.1    MRZV01000359    PIK51716.1    GACK01007477    JAA57557.1    GEFH01003180    JAP65401.1    LN609399    CEF60460.1    GDIQ01070701    JAN24036.1    GFAC01005655    JAT93533.1    GDIP01237144    JAI86257.1    JI169778    ADY44105.1    KI658235    ETN83316.1    GDIP01141553    JAL62161.1    DS469729    EDO34495.1    JARK01000235    EYC39961.1    EYC39960.1    GDIQ01086903    JAN07834.1    JARK01001439    EYC01927.1    LSMT01000190    PFX23994.1    GFWV01006919    MAA31649.1    BX284604    CDR32714.1    CAL36498.1    EYC01926.1    Z68748    CAD27622.1    LNIX01000003    OXA58658.1    GDIP01143793    JAJ79609.1    GDIP01142652    JAL61062.1   

Proteomes

UP000218220    UP000005204    UP000037510    UP000053240    UP000007151    UP000007819    + More
UP000007755    UP000078542    UP000005205    UP000075809    UP000078540    UP000053105    UP000007266    UP000192223    UP000053097    UP000279307    UP000078541    UP000215335    UP000002358    UP000000311    UP000245037    UP000005203    UP000235965    UP000027135    UP000076858    UP000095287    UP000076502    UP000218231    UP000035680    UP000094527    UP000046392    UP000000305    UP000054359    UP000007110    UP000085678    UP000230750    UP000095284    UP000038045    UP000035681    UP000001593    UP000024635    UP000225706    UP000001940    UP000198287    UP000095282   

PRIDE

H9JCU7    Q19425   

Pfam

PF01490   Aa_trans        + More
PF01044   Vinculin
PF00293   NUDIX

Interpro

IPR013057   AA_transpt_TM        + More
IPR017997   Vinculin       
IPR000633   Vinculin_CS       
IPR006077   Vinculin/catenin       
IPR036723   Alpha-catenin/vinculin-like_sf       
IPR020084   NUDIX_hydrolase_CS       
IPR000086   NUDIX_hydrolase_dom       
IPR015797   NUDIX_hydrolase-like_dom_sf       

SUPFAM

SSF47220   SSF47220        + More
SSF55811   SSF55811       

ProteinModelPortal

A0A2A4ISI3   H9JCU7   A0A2W1BC50   A0A2H1W9C5   A0A0L7KSP1   A0A194RAH9   + More
A0A212FKR0   A0A1Y1MNC3   J9JJJ9   F4WL87   A0A151I6H5   A0A158NZH8   A0A151WV43   A0A195BPC1   A0A0M9AAM9   A0A2H8TWV6   D2A624   A0A1W4WSP1   A0A026WE26   A0A0A9YEE3   A0A0A9Y6S4   A0A195FCC5   A0A146M953   A0A146L796   A0A146KWI5   A0A2S2PXV9   A0A023F2V8   A0A232FCL7   K7J4T8   E2AB04   A0A2S2PM27   A0A2P8YL72   A0A088ASL6   A0A2J7PXT2   A0A067R137   A0A1B6EGR0   A0A1B6DYX7   A0A1B6IQ56   A0A2J7PXT1   A0A1B6GP34   A0A1B6KXM9   A0A0P5PN38   A0A0N8D107   A0A0P6I656   A0A0P5V4M4   A0A0P5DUB3   A0A0N8DIP9   A0A0N8CRQ7   A0A1I7ZIQ5   A0A0P5MJL0   A0A0P6JCD5   A0A154PH15   A0A2A2L8C9   A0A2A2JQF6   A0A0K0FHV4   A0A0P5Y260   A0A1D2NCA3   A0A0N5BL15   E9GGK7   A0A131YAQ8   A0A087UI50   A0A131YK51   W4XMD1   V5HQ84   A0A224YTD6   A0A1S3KA10   A0A1S3KAJ6   A0A131XPI0   A0A1E1XML5   A0A2G8KUM6   L7M139   A0A1I7S498   A0A131XIN2   A0A0N4ZHU8   A0A090KSG6   A0A0P6EC80   A0A1W2WAC7   A0A0K0EB88   A0A1E1X2Q2   A0A0P4XVN9   F1L1V1   W2TQD0   A0A0P5SCG9   A7SP81   A0A016WK41   A0A016WJY7   A0A0P6CV59   A0A016TGY6   A0A2B4RZW0   A0A293LUP0   A0A061ADY8   Q0G831   A0A016TGV2   Q19425   Q8T3E2   A0A226EN74   A0A1I7UCP6   A0A0N8AIL8   A0A0P5S9L1  

PDB

6C08     E-value=1.77467e-72,     Score=694

KEGG

101736087    K14995 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9 | (RefSeq)

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0015171   GO:0003333   GO:0007155   GO:0005198   GO:0051015   GO:0015629   GO:0016787   GO:0046872   GO:0005765   GO:0031902  

PANTHER

PTHR46180  

Subcellular location

Lysosome membrane  
Late endosome membrane  

Length:

537

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

247.29173

Exp number, first 60 AAs:

0.00083

Total prob of N-in:

0.93669

inside

1  -  121

TMhelix

122  -  144

outside

145  -  153

TMhelix

154  -  176

inside

177  -  188

TMhelix

189  -  211

outside

212  -  214

TMhelix

215  -  237

inside

238  -  268

TMhelix

269  -  288

outside

289  -  307

TMhelix

308  -  330

inside

331  -  336

TMhelix

337  -  359

outside

360  -  373

TMhelix

374  -  396

inside

397  -  415

TMhelix

416  -  438

outside

439  -  452

TMhelix

453  -  472

inside

473  -  478

TMhelix

479  -  498

outside

499  -  512

TMhelix

513  -  535

inside

536  -  537

 

 

Pi

242.474109

Theta

156.41281

Tajima's D

2.025118

CLR

0.356349

CSRT

0.887605619719014

Interpretation

Uncertain