Gene

KWMTBOMO01089  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007425

Annotation

PREDICTED:_phosphoglucomutase_[Amyelois_transitella]

Location

Bomo_Chr3(+):1863638-1874930      View in EpiBrowser

Full name

Phosphoglucomutase      

Alternative Name

Glucose phosphomutase

Location in the cell

Cytoplasmic   Reliability : 2.147

CDS

ATGTCTAACAGTGTAACGGTTGACACTAAACCGTATGAGGGCCAAAAGCCGGGCACAAGTGGATTGCGTAAAAAAGTTAAAGTTTTCGTTCAAGAAAACTACACGGAGAATTTTATTCAATGCATTTTGGACGTGAATAAAACCTCTTTGATAGGATCGACGCTGGTTGTCGGAGGAGACGGAAGGTATCTCGTGAAAGAGGTTGTTGATAAAATTATTAAGATCAGTGCAGCGAATGGGGTTTCGAAATTGATAGTAGGACAAAATGGAATACTATCAACTCCTGCTGTGTCTTATATTATTAGAAAATATAAAACTCTCGGTGGTATAGTTCTCACGGCGTCCCACAATCCGGGCGGTGTGGACGAAGACTTTGGCATAAAGTTCAACTGCAGTAACGGAGGCCCAGCTTCCGATGCTACCACCGATGCCATCTACAAACTCACCACCTCGATAAAGCAGTACAAGATTGTTCCAGATTTAAACTGCGCCATTGACAAAATCGACGTACATACTTTTCAGGTAGATCAGCGGCAGTTTACAGTCGAAGTCATAGATGCAGTGGAAGATTATGTTTCGTACATGAAGGAGATCTTCGATTTCCCGAAGATCAAGGCTTTGATCCAGGGAACGGAGCAGAGGAAGCCCTTCAACGTGCTCATTGATGCTATGAACGGAGTAACCGGACCCTACGTGAAGCGGATATTCTTAGAGGAGCTAGGTTGTTCCGAGAAGAACGTGCGACGTATCGTGCCCCTGGAAGACTTCGGCGGGGCTCATCCGGATCCGAACTTGACGTACGCCGCGGATTTGGTCGAGGCTGTCAAAGAAGGGGACTATGATTTCGGGGCCGCTTTCGACGGAGACGGGGACCGCAACATGATACTAGGGCGGGACGCGTTCTTCGTGACGCCGTCGGACTCCCTGGCGGTGCTGGCCGACAATCTGGAGTGCATACCGTACTTCGCGCGAGGGGGCGTGCGGGGGCTGGCGCGCAGCATGCCCACCGCCGCCGCCGTGGATCGGGTGGCGGCCGCGCGCGCCCTGCCCCTCTTCGAGGTGCCCACCGGTTGGAAATACTTTGGCAACCTGATGGACGCGGGCCAGCTGTCGCTGTGCGGAGAGGAGAGCTTCGGTACCGGGTCCGACCACGTGCGGGAGAAGGACGGGCTGTGGGCGGCGCTGGCCTGGCTCTCCCTCCTGGCGCACTCCGGCCGGTCCGTGCAGGAGATGCTGCAGGCGCACTGGAAACAGTTCGGGAGGAACTACTTCACGAGGTACGACTACGAGAACTGTTCCTCGGAGTCCTGCGAGGAGATGATGAGCGTCCTTGAGCGCACCATGACCTCGCCCGGGTTCGTGGGCTCGGCGCACTCCGCCGGCGGTAAGGAGTACGTCGTCAAGCTAGCCGACAACTTCTCCTACGTGGACCCCATCGATCAGAGCGTGGCCAAGAGACAGGGCCTGCGGATAATATTCGAGGACGGATCCCGCATAGTGTTCCGTCTCAGCGGCACGGGCAGTTCCGGCGCTACCGTCAGAGTCTACGTGGACTCGTACGAGGCGGTGAGCGTGGGGGGCGCCGCTGCTGACGCGCTGGGGCCGCTCGTCAGCATCGCCCTGGACATATCCCGCTTGAAGCAATACACGGGTCGGGACGAGCCCACAGTCATCACTTAA

Protein

MSNSVTVDTKPYEGQKPGTSGLRKKVKVFVQENYTENFIQCILDVNKTSLIGSTLVVGGDGRYLVKEVVDKIIKISAANGVSKLIVGQNGILSTPAVSYIIRKYKTLGGIVLTASHNPGGVDEDFGIKFNCSNGGPASDATTDAIYKLTTSIKQYKIVPDLNCAIDKIDVHTFQVDQRQFTVEVIDAVEDYVSYMKEIFDFPKIKALIQGTEQRKPFNVLIDAMNGVTGPYVKRIFLEELGCSEKNVRRIVPLEDFGGAHPDPNLTYAADLVEAVKEGDYDFGAAFDGDGDRNMILGRDAFFVTPSDSLAVLADNLECIPYFARGGVRGLARSMPTAAAVDRVAAARALPLFEVPTGWKYFGNLMDAGQLSLCGEESFGTGSDHVREKDGLWAALAWLSLLAHSGRSVQEMLQAHWKQFGRNYFTRYDYENCSSESCEEMMSVLERTMTSPGFVGSAHSAGGKEYVVKLADNFSYVDPIDQSVAKRQGLRIIFEDGSRIVFRLSGTGSSGATVRVYVDSYEAVSVGGAAADALGPLVSIALDISRLKQYTGRDEPTVIT

Description

This enzyme participates in both the breakdown and synthesis of glucose.

Catalytic Activity

alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate

Cofactor

Mg(2+)

Biophysicochemical Properties

140 uM for glucose-1-phosphate (for Pgm-A at pH 6.0)
158 uM for glucose-1-phosphate (for Pgm-A at pH 7.4)
4.4 uM for glucose-1,6-diphosphate (for Pgm-A at pH 6.0)
4.4 uM for glucose-1,6-diphosphate (for Pgm-A at pH 7.4)
142.2 uM for glucose-1-phosphate (for Pgm-B at pH 6.0)
112.4 uM for glucose-1-phosphate (for Pgm-B at pH 7.4)
21.7 uM for glucose-1,6-diphosphate (for Pgm-B at pH 6.0)
4.2 uM for glucose-1,6-diphosphate (for Pgm-B at pH 7.4)

Similarity

Belongs to the phosphohexose mutase family.
Belongs to the adaptor complexes medium subunit family.

Keywords

Carbohydrate metabolism   Glucose metabolism   Isomerase   Magnesium   Metal-binding   Phosphoprotein   Polymorphism   Complete proteome   Reference proteome  

Feature

chain  Phosphoglucomutase

Uniprot

H9JD28   A0A2W1BH83   S4NNG7   A0A2H1W8N8   E1U7I4   A0A194R6J8   + More
A0A0N1I3K6   A0A1B6JU52   A0A0K8UNQ3   A0A1B6C217   W8BDR3   A0A131Y3J0   B4MM44   A0A147BV33   A0A034VEB3   A0A1Y1LPW3   B0WEU6   A0A154PH97   A0A0J9RWA8   A0A1Q3FKJ2   Q7KHA1   A0A3B0KME6   A0A1W4UGN4   U5ELU3   Q9GQ67   B4PI34   B3NI51   A0A2A4ITA8   Q9VUY9   A0A1I8NQ07   A0A1I8NQ09   Q29EN2   A0A336MMP4   A0A1S4FP29   A0A3B0JY52   Q16U43   A0A1W4WSY5   B4H296   B4LDE2   T1PCB7   A0A182G2L5   A0A182Q403   E9J743   J9JMZ9   A0A1I8M689   V5I8J8   A0A2M4A6T3   A0A026WBF7   A0A1A9W7M1   A0A182YEF1   Q58I84   B3M958   A0A182JRR5   A0A0M9A9D5   A0A088ASJ9   A0A182KPX6   A0A182XMC2   A0A2M3YZ53   A0A182U8R6   A0A182V3C5   A0A0P5XC22   A0A182I257   A0A182PTN1   A0A0P5FDA1   A0A164ZBS7   A0A2M4BJ32   Q7Q6G4   A0A084WEB1   B4L9P4   A0A182MMX7   A0A3L8DQF8   E9GBC4   A0A182NJD6   A0A182FH19   N6TII1   W5J6Z3   A0A0P5T336   A0A182R4I5   A0A346A6M0   D3TM66   J3JVE4   A0A182ITM5   A0A182WLC1   A0A0P4VPJ3   A0A0M4EYD5   A0A2J7PXV5   A0A1L8E1W5   T1E9Z7   B4IZY5   A0A1A9ZF25   A0A1L8E216   A0A1S3KAE3   A0A2A3EEZ1   A0A232FCN4   K7IN84   A0A023EWH2   A0A1J1I236   A0A2P6L0L9   A0A151I722   C0KJJ8  

EC Number

5.4.2.2

Pubmed

19121390    28756777    23622113    26354079    24495485    17994087    + More
29652888    25348373    28004739    22936249    11102370    17550304    12049662    10731132    12537572    44190    18327897    11290720    11560897    15632085    17510324    26483478    21282665    25315136    24508170    25244985    20966253    12364791    14747013    17210077    24438588    30249741    21292972    23537049    20920257    23761445    29187976    20353571    22516182    28648823    20075255    24945155   

EMBL

BABH01027730    KZ150177    PZC72557.1    GAIX01013936    JAA78624.1    ODYU01007041    + More
SOQ49441.1    FJ793041    ACY69180.1    KQ460685    KPJ12865.1    KQ459072    KPJ03853.1    GECU01005000    JAT02707.1    GDHF01024005    JAI28309.1    GEDC01029894    JAS07404.1    GAMC01011429    GAMC01011427    JAB95128.1    GEFM01002718    JAP73078.1    CH963847    EDW73053.1    GEGO01000824    JAR94580.1    GAKP01018507    GAKP01018505    JAC40447.1    GEZM01050186    JAV75683.1    DS231911    EDS45859.1    KQ434902    KZC11177.1    CM002912    KMY99951.1    GFDL01007021    JAV28024.1    AF290357    AF290358    AF290359    AF290360    AF290361    AF290362    AF290363    AF290364    AF290365    AF290366    AF290367    AF290368    AF290369    AAG42290.1    AAG42291.1    AAG42292.1    AAG42293.1    AAG42294.1    AAG42295.1    AAG42296.1    AAG42297.1    AAG42298.1    AAG42299.1    AAG42300.1    AAG42301.1    AAG42302.1    OUUW01000012    SPP86996.1    GANO01001270    JAB58601.1    AF290370    AAG42303.1    CM000159    EDW95482.1    CH954178    EDV52207.1    NWSH01008264    PCG62628.1    AF290313    AF290314    AF290315    AF290316    AF290317    AF290318    AF290319    AF290320    AF290321    AF290322    AF290323    AF290324    AF290325    AF290326    AF290327    AF290328    AF290329    AF290330    AF290331    AF290332    AF290333    AF290334    AF290335    AF290336    AF290337    AF290338    AF290339    AF290340    AF290341    AF290342    AF290343    AF290344    AF290345    AF290346    AF290347    AF290348    AF290349    AF290350    AF290351    AF290352    AF290353    AF290354    AF290355    AF290356    AF416981    AF416982    AF416983    AF416984    AE014296    BT010043    AAF49533.1    AAG44900.1    AAG44901.1    AAG44902.1    AAG44903.1    AAG44904.1    AAG44905.1    AAG44906.1    AAG44907.1    AAG44908.1    AAG44909.1    AAG44910.1    AAG44911.1    AAG44912.1    AAG44913.1    AAG44914.1    AAG44915.1    AAG44916.1    AAG44917.1    AAG44918.1    AAG44919.1    AAG44920.1    AAG44921.1    AAG44922.1    AAG44923.1    AAG44924.1    AAG44925.1    AAG44926.1    AAG44927.1    AAG44928.1    AAG44929.1    AAG44930.1    AAG44931.1    AAG44932.1    AAG44933.1    AAG44934.1    AAG44935.1    AAG44936.1    AAG44937.1    AAG44938.1    AAG44939.1    AAG44940.1    AAG44941.1    AAG44942.1    AAG44943.1    AAL08565.1    AAL08568.1    AAQ22512.1    CH379070    EAL30028.1    UFQS01001397    UFQT01001397    SSX10687.1    SSX30369.1    SPP86997.1    CH477632    EAT38042.1    CH479203    EDW30448.1    CH940647    EDW68880.1    KA645583    AFP60212.1    JXUM01006654    KQ560219    KXJ83762.1    AXCN02000448    GL768421    EFZ11363.1    ABLF02017858    ABLF02023700    ABLF02023704    GALX01004560    JAB63906.1    GGFK01003131    MBW36452.1    KK107293    EZA53283.1    AY944755    AAX47078.1    CH902618    EDV40042.1    KQ435710    KOX79915.1    GGFM01000799    MBW21550.1    GDIP01074252    JAM29463.1    APCN01000123    GDIQ01257217    GDIQ01054612    JAJ94507.1    LRGB01000745    KZS16178.1    GGFJ01003901    MBW53042.1    AAAB01008960    EAA11635.2    ATLV01023198    KE525341    KFB48555.1    CH933816    EDW17092.1    AXCM01002346    QOIP01000005    RLU22492.1    GL732538    EFX83182.1    APGK01036673    KB740941    KB632225    ENN77623.1    ERL90249.1    ADMH02002052    ETN59746.1    GDIQ01097040    JAL54686.1    MF908520    AXK92642.1    EZ422518    ADD18794.1    BT127212    AEE62174.1    GDRN01108558    JAI57209.1    CP012525    ALC43182.1    NEVH01020852    PNF21144.1    GFDF01001387    JAV12697.1    GAMD01001468    JAB00123.1    CH916366    EDV96757.1    GFDF01001388    JAV12696.1    KZ288271    PBC29769.1    NNAY01000480    OXU28087.1    GAPW01000774    JAC12824.1    CVRI01000035    CRK92902.1    MWRG01002894    PRD32122.1    KQ978473    KYM93692.1    FJ609649    ACM78949.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007798    UP000002320    UP000076502    + More
UP000268350    UP000192221    UP000002282    UP000008711    UP000218220    UP000000803    UP000095300    UP000001819    UP000008820    UP000192223    UP000008744    UP000008792    UP000069940    UP000249989    UP000075886    UP000007819    UP000095301    UP000053097    UP000091820    UP000076408    UP000007801    UP000075881    UP000053105    UP000005203    UP000075882    UP000076407    UP000075902    UP000075903    UP000075840    UP000075885    UP000076858    UP000007062    UP000030765    UP000009192    UP000075883    UP000279307    UP000000305    UP000075884    UP000069272    UP000019118    UP000030742    UP000000673    UP000075900    UP000075880    UP000075920    UP000092553    UP000235965    UP000001070    UP000092445    UP000085678    UP000242457    UP000215335    UP000002358    UP000183832    UP000078542   

PRIDE

H9JD28    Q9VUY9    A0A088ASJ9   

Pfam

PF02880   PGM_PMM_III        + More
PF00408   PGM_PMM_IV
PF02878   PGM_PMM_I
PF02879   PGM_PMM_II
PF00928   Adap_comp_sub
PF01217   Clat_adaptor_s

Interpro

IPR005846   A-D-PHexomutase_a/b/a-III        + More
IPR016066   A-D-PHexomutase_CS       
IPR036900   A-D-PHexomutase_C_sf       
IPR005845   A-D-PHexomutase_a/b/a-II       
IPR005844   A-D-PHexomutase_a/b/a-I       
IPR005841   Alpha-D-phosphohexomutase_SF       
IPR005843   A-D-PHexomutase_C       
IPR016055   A-D-PHexomutase_a/b/a-I/II/III       
IPR011012   Longin-like_dom_sf       
IPR028565   MHD       
IPR022775   AP_mu_sigma_su       
IPR036168   AP2_Mu_C_sf       

SUPFAM

SSF53738   SSF53738        + More
SSF55957   SSF55957       
SSF64356   SSF64356       
SSF49447   SSF49447       

ProteinModelPortal

H9JD28   A0A2W1BH83   S4NNG7   A0A2H1W8N8   E1U7I4   A0A194R6J8   + More
A0A0N1I3K6   A0A1B6JU52   A0A0K8UNQ3   A0A1B6C217   W8BDR3   A0A131Y3J0   B4MM44   A0A147BV33   A0A034VEB3   A0A1Y1LPW3   B0WEU6   A0A154PH97   A0A0J9RWA8   A0A1Q3FKJ2   Q7KHA1   A0A3B0KME6   A0A1W4UGN4   U5ELU3   Q9GQ67   B4PI34   B3NI51   A0A2A4ITA8   Q9VUY9   A0A1I8NQ07   A0A1I8NQ09   Q29EN2   A0A336MMP4   A0A1S4FP29   A0A3B0JY52   Q16U43   A0A1W4WSY5   B4H296   B4LDE2   T1PCB7   A0A182G2L5   A0A182Q403   E9J743   J9JMZ9   A0A1I8M689   V5I8J8   A0A2M4A6T3   A0A026WBF7   A0A1A9W7M1   A0A182YEF1   Q58I84   B3M958   A0A182JRR5   A0A0M9A9D5   A0A088ASJ9   A0A182KPX6   A0A182XMC2   A0A2M3YZ53   A0A182U8R6   A0A182V3C5   A0A0P5XC22   A0A182I257   A0A182PTN1   A0A0P5FDA1   A0A164ZBS7   A0A2M4BJ32   Q7Q6G4   A0A084WEB1   B4L9P4   A0A182MMX7   A0A3L8DQF8   E9GBC4   A0A182NJD6   A0A182FH19   N6TII1   W5J6Z3   A0A0P5T336   A0A182R4I5   A0A346A6M0   D3TM66   J3JVE4   A0A182ITM5   A0A182WLC1   A0A0P4VPJ3   A0A0M4EYD5   A0A2J7PXV5   A0A1L8E1W5   T1E9Z7   B4IZY5   A0A1A9ZF25   A0A1L8E216   A0A1S3KAE3   A0A2A3EEZ1   A0A232FCN4   K7IN84   A0A023EWH2   A0A1J1I236   A0A2P6L0L9   A0A151I722   C0KJJ8  

PDB

3PMG     E-value=5.98662e-168,     Score=1518

KEGG

101743212    K01835 phosphoglucomutase [EC:5.4.2.2] | (RefSeq) phosphoglucomutase

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00030    Pentose phosphate pathway - Bombyx mori (domestic silkworm)
00052    Galactose metabolism - Bombyx mori (domestic silkworm)
00230    Purine metabolism - Bombyx mori (domestic silkworm)
00500    Starch and sucrose metabolism - Bombyx mori (domestic silkworm)
00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005975   GO:0016868   GO:0000287   GO:0005978   GO:0004614   GO:0006006   GO:0005829   GO:0019388   GO:0015031   GO:0016020   GO:0000786   GO:0003677   GO:0005634   GO:0006334   GO:0003779   GO:0016021   GO:0071704  

Length:

559

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.32987

Exp number, first 60 AAs:

0.00735

Total prob of N-in:

0.01642

outside

1  -  559

 

 

Pi

263.10696

Theta

161.461531

Tajima's D

2.063753

CLR

0.399103

CSRT

0.893105344732763

Interpretation

Uncertain