Gene

KWMTBOMO01076  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007418

Annotation

adenosine_kinase_[Bombyx_mori]

Location

Bomo_Chr3(+):1670046-1674262      View in EpiBrowser

Full name

Receptor protein serine/threonine kinase      

Location in the cell

Cytoplasmic   Reliability : 1.413 Extracellular   Reliability : 1.841

CDS

ATGGACGTTTCTGATTCCATATGTGACCAAGAAGGATTATTAGTGGGCATAGGGAATCCTTTGTTGGACATATCCGCCAGTGTTGACGAGGACTTGCTGAAGAAGTATGACCTGCACCCCGACGATGCCATTATGGCTGAAGAAAAACACATGCCACTCTACTCGGAACTCGTTGACAAGTATAATGCAGAGTATATTGCTGGTGGAAGCGTTCAGAATTCATTAAGAGTAGCACAATGGATTCTAAAGAAACCAAATATTTGTACTTACTTTGGCTGTGTGGGAAATGATGAATATGCTAAATTATTAAAGGAGAGAGCAATTGCAGATGGAGTCCACGTTCAATATCAAGTATCAAATGAGGTAGCAACTGGTACATGTGCAGTGCTAGTAACTGGTACACACCGCTCACTGTGCGCCAATCTCGGTGCTGCACAACACTTCACACCAGATCATTTACAGAAAGAAGAATGCAAGAAAAGCATTGAAGCAGCGAAGTTCTTTTATGCTTCTGGTTTCTTTGTGGCAGTTTCTCCAGAGTCGATATTGTTATTGGCCCAGCATGCGCACGATAATGGACATACGTTTGTTATGAACTTGAGTGCGCCCTTTGTCTCACAGTTCTATAAGGAACCGCTCGAGAAACTTCTCCCATATGTCGACGTGCTCTTCGGGAATGAATCGGAGGCAGACGCTTTCGCGAAGGCATTCAACATAAATTCGAGCGATGTGCAGGAGATCGCTTTACGGATCGCCAGCATGCCCAAATTGAACGCGAACCGTCAGCGCGTCGTGGTCATCACGCAGGGCTGCCAACCCGTCGTGCTGGTACAGAGCGGACGAGTCACCCTGATACCGGTCGAGGCTTTGCCGAGGGAACGTATCATTGACACAAACGGTGCCGGAGATGCCTTTACTGGTGGGTACTTGGCGCAGCTCGTGCTGAACCGCGAGCCAGCCGCCTGCGTGCGGTGCGCTGTCTACTGTGCCACGCATGTCATCCAGCACCCGGGCTGCACATTCAGCGGACCCAGCGAATACAATGACTGA

Protein

MDVSDSICDQEGLLVGIGNPLLDISASVDEDLLKKYDLHPDDAIMAEEKHMPLYSELVDKYNAEYIAGGSVQNSLRVAQWILKKPNICTYFGCVGNDEYAKLLKERAIADGVHVQYQVSNEVATGTCAVLVTGTHRSLCANLGAAQHFTPDHLQKEECKKSIEAAKFFYASGFFVAVSPESILLLAQHAHDNGHTFVMNLSAPFVSQFYKEPLEKLLPYVDVLFGNESEADAFAKAFNINSSDVQEIALRIASMPKLNANRQRVVVITQGCQPVVLVQSGRVTLIPVEALPRERIIDTNGAGDAFTGGYLAQLVLNREPAACVRCAVYCATHVIQHPGCTFSGPSEYND

Catalytic Activity

[receptor-protein]-L-serine + ATP = [receptor-protein]-O-phospho-L-serine + ADP + H(+)
[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-phospho-L-threonine + ADP + H(+)

Similarity

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Uniprot

Q2F635   A0A194QBY3   A0A1I8PKS1   A0A1I8PKZ2   A0A0L0CEB8   A0A182PBL9   + More
A0A182V6Y9   A0A182WZC4   A0A182HPX9   A0A182KSU8   A0A1I8MVS8   A0A1I8MVS6   A0A182U6C2   A0A2W1BIT6   A0A182Y1X9   A0A182JWJ2   A0A182SV27   A0A158P348   A0A0J7KXH2   A0A182PZK2   A0A182W9A9   A0A182RGK6   D6WX36   A0A182J1V8   A0A182NPF1   A0A3L8E2Y0   A0A1A9WSS3   A0A1B0A694   A0A1S4EXT2   A0A1Q3FEE8   A0A1B0FA86   D3TS39   A0A182M5Y4   Q1HQJ8   A0A1Q3FDY0   A0A1L8E206   B0WEK9   E9IIK6   A0A1A9VKW1   F4W4H8   A0A1B0AWD3   A0A182GS07   A0A1B0CRL5   A0A1L8E2F0   A0A1A9Y2T2   A0A1L8E1V5   W8C768   A0A084WB55   A0A087ZS94   A0A0A1XI02   A0A1W4VIX3   V9IHF0   A0A0A1XNF6   A0A1W4V6S3   A0A2R7WNX4   A0A232EIL7   A0A067RTD0   A0A336M4V2   B4HGN5   B4L0J3   A0A0K8V7Z8   A0A0K8V3D4   A0A034W2N7   A0A0Q9XD88   A0A034W125   E2A1C3   A0A1W4XE72   A0A2J7R4D5   A0A0K8VX64   B4MM65   A0A0K8W0U2   A0A3B0J432   A0A1Y1LM30   A0A0A9YAB8   N6TS29   A0A1B6J821   B4LBH2   A0A0Q9WTX8   A0A0V0G398   B4GRU4   A0A0L7RD75   A0A023F891   B5DPJ4   A0A161TIT7   A0A1B6DN45   A0A0P8XT85   B4PHB3   B3MAT9   R4G8F0   A0A0P4W088   B4K005   A0A1A9UKT6   A0A1B0FM18   A0A154PIR7   Q86NZ5   A0A0R1DXF0   Q9VU39   Q9VU38   B3NCY4   B4QIY5  

EC Number

2.7.11.30

Pubmed

19121390    26354079    26108605    20966253    25315136    28756777    + More
25244985    21347285    18362917    19820115    30249741    20353571    17204158    17510324    21282665    21719571    26483478    24495485    24438588    25830018    28648823    24845553    17994087    25348373    20798317    28004739    25401762    26823975    23537049    25474469    15632085    17550304    27129103    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249   

EMBL

BABH01027708    DQ311237    ABD36182.1    KQ459232    KPJ02500.1    JRES01000502    + More
KNC30591.1    APCN01003283    KZ150062    PZC74201.1    ADTU01007749    LBMM01002325    KMQ94979.1    AXCN02001826    KQ971361    EFA08050.1    QOIP01000001    RLU26348.1    GFDL01009157    JAV25888.1    CCAG010005457    EZ424241    ADD20517.1    AXCM01002231    DQ440446    CH477208    ABF18479.1    EAT47810.1    GFDL01009265    JAV25780.1    GFDF01001398    JAV12686.1    DS231910    EDS45725.1    GL763494    EFZ19582.1    GL887532    EGI70873.1    JXJN01004651    JXUM01083613    KQ563387    KXJ73934.1    AJWK01024924    GFDF01001399    JAV12685.1    GFDF01001397    JAV12687.1    GAMC01003809    JAC02747.1    ATLV01022314    KE525331    KFB47449.1    GBXI01003747    JAD10545.1    JR047701    AEY60485.1    GBXI01001463    JAD12829.1    KK855177    PTY21294.1    NNAY01004209    OXU18196.1    KK852475    KDR23079.1    UFQT01000391    SSX23889.1    CH480815    EDW41343.1    CH933809    EDW19162.1    GDHF01028455    GDHF01018702    GDHF01017250    JAI23859.1    JAI33612.1    JAI35064.1    GDHF01018900    JAI33414.1    GAKP01010909    JAC48043.1    KRG06523.1    GAKP01010910    JAC48042.1    GL435760    EFN72749.1    NEVH01007425    PNF35701.1    GDHF01008843    JAI43471.1    CH963847    EDW73074.2    GDHF01014834    GDHF01007561    JAI37480.1    JAI44753.1    OUUW01000002    SPP76165.1    GEZM01051782    JAV74702.1    GBHO01015043    GBRD01010871    GBRD01010870    GDHC01001973    JAG28561.1    JAG54953.1    JAQ16656.1    APGK01056679    KB741277    KI209362    KI210050    ENN71091.1    ERL96023.1    ERL96146.1    GECU01012443    JAS95263.1    CH940647    EDW70782.1    KRF85105.1    GECL01003558    JAP02566.1    CH479188    EDW40479.1    KQ414615    KOC68769.1    GBBI01001225    JAC17487.1    CH379069    EDY73542.2    GEMB01000307    JAS02812.1    GEDC01010194    JAS27104.1    CH902618    KPU77928.1    CM000159    EDW94374.1    EDV39173.2    ACPB03002940    GAHY01001087    JAA76423.1    GDKW01001441    JAI55154.1    CH916383    EDV98687.1    CCAG010006681    KQ434931    KZC11776.1    BT003559    AAO39563.1    KRK01798.1    AE014296    AY060709    AAF49852.1    AAL28257.1    AHN58079.1    AAF49853.1    CH954178    EDV51640.1    CM000363    CM002912    EDX10316.1    KMY99350.1   

Proteomes

UP000005204    UP000053268    UP000095300    UP000037069    UP000075885    UP000075903    + More
UP000076407    UP000075840    UP000075882    UP000095301    UP000075902    UP000076408    UP000075881    UP000075901    UP000005205    UP000036403    UP000075886    UP000075920    UP000075900    UP000007266    UP000075880    UP000075884    UP000279307    UP000091820    UP000092445    UP000092444    UP000075883    UP000008820    UP000002320    UP000078200    UP000007755    UP000092460    UP000069940    UP000249989    UP000092461    UP000092443    UP000030765    UP000005203    UP000192221    UP000215335    UP000027135    UP000001292    UP000009192    UP000000311    UP000192223    UP000235965    UP000007798    UP000268350    UP000019118    UP000030742    UP000008792    UP000008744    UP000053825    UP000001819    UP000007801    UP000002282    UP000015103    UP000001070    UP000076502    UP000000803    UP000008711    UP000000304   

PRIDE

Q2F635    Q86NZ5    Q9VU39    Q9VU38   

Pfam

PF00294   PfkB        + More
PF00076   RRM_1
PF00098   zf-CCHC
PF00069   Pkinase
PF01064   Activin_recp
PF08515   TGF_beta_GS

Interpro

IPR002173   Carboh/pur_kinase_PfkB_CS        + More
IPR011611   PfkB_dom       
IPR001805   Adenokinase       
IPR029056   Ribokinase-like       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR000504   RRM_dom       
IPR035979   RBD_domain_sf       
IPR001878   Znf_CCHC       
IPR003605   GS_dom       
IPR000472   Activin_recp       
IPR000719   Prot_kinase_dom       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR000333   TGFB_receptor       
IPR017441   Protein_kinase_ATP_BS       

SUPFAM

SSF53613   SSF53613        + More
SSF54928   SSF54928       
SSF56112   SSF56112       

Gene 3D

3.40.1190.20     3.30.70.330    

ProteinModelPortal

Q2F635   A0A194QBY3   A0A1I8PKS1   A0A1I8PKZ2   A0A0L0CEB8   A0A182PBL9   + More
A0A182V6Y9   A0A182WZC4   A0A182HPX9   A0A182KSU8   A0A1I8MVS8   A0A1I8MVS6   A0A182U6C2   A0A2W1BIT6   A0A182Y1X9   A0A182JWJ2   A0A182SV27   A0A158P348   A0A0J7KXH2   A0A182PZK2   A0A182W9A9   A0A182RGK6   D6WX36   A0A182J1V8   A0A182NPF1   A0A3L8E2Y0   A0A1A9WSS3   A0A1B0A694   A0A1S4EXT2   A0A1Q3FEE8   A0A1B0FA86   D3TS39   A0A182M5Y4   Q1HQJ8   A0A1Q3FDY0   A0A1L8E206   B0WEK9   E9IIK6   A0A1A9VKW1   F4W4H8   A0A1B0AWD3   A0A182GS07   A0A1B0CRL5   A0A1L8E2F0   A0A1A9Y2T2   A0A1L8E1V5   W8C768   A0A084WB55   A0A087ZS94   A0A0A1XI02   A0A1W4VIX3   V9IHF0   A0A0A1XNF6   A0A1W4V6S3   A0A2R7WNX4   A0A232EIL7   A0A067RTD0   A0A336M4V2   B4HGN5   B4L0J3   A0A0K8V7Z8   A0A0K8V3D4   A0A034W2N7   A0A0Q9XD88   A0A034W125   E2A1C3   A0A1W4XE72   A0A2J7R4D5   A0A0K8VX64   B4MM65   A0A0K8W0U2   A0A3B0J432   A0A1Y1LM30   A0A0A9YAB8   N6TS29   A0A1B6J821   B4LBH2   A0A0Q9WTX8   A0A0V0G398   B4GRU4   A0A0L7RD75   A0A023F891   B5DPJ4   A0A161TIT7   A0A1B6DN45   A0A0P8XT85   B4PHB3   B3MAT9   R4G8F0   A0A0P4W088   B4K005   A0A1A9UKT6   A0A1B0FM18   A0A154PIR7   Q86NZ5   A0A0R1DXF0   Q9VU39   Q9VU38   B3NCY4   B4QIY5  

PDB

3LOO     E-value=2.7049e-121,     Score=1113

KEGG

692855    K00856 adenosine kinase [EC:2.7.1.20] | (RefSeq) adenosine kinase

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004001   GO:0006166   GO:0016021   GO:0005634   GO:0005829   GO:0008270   GO:0003723   GO:0005524   GO:0004675   GO:0006167   GO:0005654   GO:0016773   GO:0042026   GO:0048280   GO:0008565   GO:0016020   GO:0051015   GO:0003779  

PANTHER

PTHR23255  

Length:

349

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.51761

Exp number, first 60 AAs:

0.00559

Total prob of N-in:

0.08664

outside

1  -  349

 

 

Pi

77.64217

Theta

143.476104

Tajima's D

-1.089263

CLR

0.63531

CSRT

0.122293885305735

Interpretation

Uncertain