Gene

KWMTBOMO01070  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007413

Annotation

PREDICTED:_serine/threonine-protein_kinase_RIO3_[Papilio_machaon]

Location

Bomo_Chr3(+):1631226-1634235      View in EpiBrowser

Full name

Serine/threonine-protein kinase RIO3       + More
Inhibitor of growth protein      

Location in the cell

Nuclear   Reliability : 4.228

CDS

ATGTCGAATCCTTGGAAAAAAGTGACAGCACCAGTAGAGGCGCAGAAGCTGTCGGATATCATGTCTGAAGAATTTGCAAGAGACCTTCAGGTTAGAGAAGAGATAAAATTTGCAGAACATCTCTCTGAGCACCATGTCGGCACCTCTAATGAAGTTCCAGTTGAGTTGTTACAAGAAATAGAAAGCTGCAACGCAAAGGAATATTGTGACTCTGACGCGATTATTGCAAAAGTTTTGCAATGTCAGTTCGACAGAGAACACGATGACGAAATCAAACGCGTAGAGAAAAAACGTAATGGAGATGCTAAAGTATCCGTTTCCTATGATAATTACCGCAACGTACCATCGCATTTGATTTACGACTCTGAAGACGACGATGACTTTGAGGGCGATAAGAAAGACTGGGATCGCTTCGAAACAAACGAAAAGGAATTCGCAAGCCTTCCGAAACGCGGATTTATCATAAAAGATGGAGCAATGGTCACCAAACACGACAGTGTTATCACTGGAAGGCGGAATGCTTGTAAAGTTATGGCATTCCCTCCGGAAGTATGCACTGGAGATGGCGCTGGCTTCGATATGAAACTCTCCAATTCTGTATTTAATCATTTGAAAGAACAGACGAGATATCACAATACACGTAAACATAAAATGTTGGACAGAAAGGAGAGTCAAGCTACAGCCGAAATGGGCCTGGATGAGCCTACTAGATTGATACTATTCAAACTTATTAACAATGGGGTATTAGAGGATATCAATGGTGTCATCTCAACAGGAAAGGAGTCTGTTGTTCTACATGCTAATGGTGACACAACTTATCCTGACTTAGATGTACCTAGAGAATGTGCTATTAAAGTCTTCAAAACAACTCTTAACGAGTTCAAAACTCGAGACAAATACATAGAAGCCGATTATAGATTCAAAGATCGCTTCTCGAAACAAAATCCAAGAAAAATTGTACACATGTGGGCTGAGAAGGAGATGCACAACATGATGCGCTTGCAGAAGATAGGATTGAACTGTCCGGATATGATCTGCTTGAAGAAACATATACTTTTAATGTCATTTATTGGGAAGGATAACAAGCCAGCCCCCAAGCTAAGAGACATAATCTTAAGGTCAGATAAATGGCACAGTGTTTACAATGAGGTTGTGGAGAGTATGCATAAAATGTACAATGTTGGTCATCTGATTCATGCTGATCTATCAGAGTATAACATTCTCTGGTGGGATAATAAATGCTGGTTTATTGATGTTTCTCAGTCTGTGCAACCTGACCACCCTAACGGGTTGGAGTTTTTACTTCGAGATTGTCGTAATATTGTCAATTTCTTTGAAAAAAAGGGGGTCTCACATGTGCAAACTGCAGAAGAACTTTTTAAATCAATAACCGGCTTTAATGAAGTTGATGTGAACTTATTGGAAGGAGTTCATACCACATACAATTCTCTGGCATGCCGATTTGAAATCGCCCCCGATGATAATCGAAACGTTAGCTATCCATTTGAATATTGTTGGCAGAAAACCAATGAAGAGAAAGCTAAAAGTGATAAAAGTGATGATAATGAAGAAGATGAATTTGAGGAAATGTGGAATCATGCTGCCAAAAGTAAAACTGTTGATAGTGCTGCCAATTTTGGTAATGAAGTCAAGATTGACAATGAAATAACTTCAACAGCTTCTAAAACCTCTGATTGTAGAGATATTATCGATGATGAATCATGTTTTGGTAATGAATTTAAGGGTACTATACCCACAAATTCAGACGGAGACACCTCTAGTAGTAGAGTAGAGAAAAAGTCTTAA

Protein

MSNPWKKVTAPVEAQKLSDIMSEEFARDLQVREEIKFAEHLSEHHVGTSNEVPVELLQEIESCNAKEYCDSDAIIAKVLQCQFDREHDDEIKRVEKKRNGDAKVSVSYDNYRNVPSHLIYDSEDDDDFEGDKKDWDRFETNEKEFASLPKRGFIIKDGAMVTKHDSVITGRRNACKVMAFPPEVCTGDGAGFDMKLSNSVFNHLKEQTRYHNTRKHKMLDRKESQATAEMGLDEPTRLILFKLINNGVLEDINGVISTGKESVVLHANGDTTYPDLDVPRECAIKVFKTTLNEFKTRDKYIEADYRFKDRFSKQNPRKIVHMWAEKEMHNMMRLQKIGLNCPDMICLKKHILLMSFIGKDNKPAPKLRDIILRSDKWHSVYNEVVESMHKMYNVGHLIHADLSEYNILWWDNKCWFIDVSQSVQPDHPNGLEFLLRDCRNIVNFFEKKGVSHVQTAEELFKSITGFNEVDVNLLEGVHTTYNSLACRFEIAPDDNRNVSYPFEYCWQKTNEEKAKSDKSDDNEEDEFEEMWNHAAKSKTVDSAANFGNEVKIDNEITSTASKTSDCRDIIDDESCFGNEFKGTIPTNSDGDTSSSRVEKKS

Catalytic Activity

ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Subunit

Interacts with H3K4me3 and to a lesser extent with H3K4me2.

Similarity

Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
Belongs to the ING family.

Uniprot

H9JD16   A0A194R4W0   A0A2W1BLP5   A0A194QAN4   A0A2A4J0W2   A0A2H1WAA3   + More
A0A1E1WK44   A0A0L7LQ88   S4PMA0   A0A212FK40   A0A0K8TM27   A0A1L8DLT7   A0A034V663   A0A067QUR6   A0A0K8UMG9   A0A2P8XG71   Q7Q135   A0A2J7Q9X8   A0A182P7Z4   A0A182K953   W8C3V4   A0A182UV86   Q16VU9   A0A182W8R1   A0A1Q3G358   A0A1S4FMF7   A0A182TT67   A0A182KZ44   A0A182GLE5   A0A182XGY5   A0A182Y699   A0A182G6J3   A0A0A1X499   A0A182RWQ7   A0A182LXC9   B4N0J4   A0A1B0D5R0   A0A1S4J7U9   A0A182F554   A0A1Y1LDC5   A0A084VSR4   A0A182HR90   T1PAS4   W5J4J9   A0A2M4AHY0   A0A1I8ML05   A0A2M4BHW8   A0A2M4BI49   A0A2M4AIH5   A0A182Q2S1   A0A2M4AJF5   T1E355   Q29M98   B4G9J4   A0A182NP21   B3MVJ5   A0A0L0CQJ0   A0A0J9QVS9   A0A1W4UIE4   B4NZ24   B4I178   B4MDQ5   A0A0M4E7S5   Q9VR42   A0A1A9UR86   A0A2M4BJ61   B3N4B2   A0A1B0CT99   A0A182IVQ1   A0A1A9YPR6   A0A1I8P092   A0A1B0BFF2   A0A1A9WUJ8   A0A3B0K0K4   B0W708   A0A1A9Z542   D6WVA9   A0A0T6AT21   B4KGQ8   B4JQA5   A0A1B0FN97   E9GFI5   U5EX34   A0A0P5YUC9   A0A1W4X9G6   A0A0P6ESE4   A0A1D2MN83   A0A336JWB3   A0A0P6BNV1   A0A0P5VJF9   A0A218V1A6   A0A3M0KS59   A0A091KSY3   A0A093FYQ7   U3JUF5   A0A2I0MX49   A0A091JRL0   A0A1V4KFX1   K7FFS5   A0A2I0MX50  

EC Number

2.7.11.1

Pubmed

19121390    26354079    28756777    26227816    23622113    22118469    + More
26369729    25348373    24845553    29403074    12364791    24495485    17510324    20966253    26483478    25244985    25830018    17994087    28004739    24438588    20920257    23761445    25315136    24330624    15632085    18057021    26108605    22936249    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18362917    19820115    21292972    27289101    23371554    17381049   

EMBL

BABH01027703    KQ460685    KPJ12843.1    KZ150062    PZC74207.1    KQ459232    + More
KPJ02494.1    NWSH01004393    PCG65164.1    ODYU01007262    SOQ49886.1    GDQN01003823    JAT87231.1    JTDY01000344    KOB77610.1    GAIX01003680    JAA88880.1    AGBW02008144    OWR54101.1    GDAI01002422    JAI15181.1    GFDF01006672    JAV07412.1    GAKP01021899    JAC37053.1    KK852910    KDR13927.1    GDHF01024749    JAI27565.1    PYGN01002247    PSN31013.1    AAAB01008980    EAA13880.4    NEVH01016341    PNF25400.1    GAMC01005885    GAMC01005884    GAMC01005881    GAMC01005879    JAC00672.1    CH477580    EAT38710.1    GFDL01000803    JAV34242.1    JXUM01071880    KQ562689    KXJ75327.1    JXUM01007600    KQ560243    KXJ83629.1    GBXI01012959    GBXI01008707    JAD01333.1    JAD05585.1    AXCM01000709    CH963920    EDW77607.1    AJVK01025533    GEZM01058838    JAV71652.1    ATLV01016137    KE525057    KFB41008.1    APCN01001659    KA645018    AFP59647.1    ADMH02002089    ETN59392.1    GGFK01007075    MBW40396.1    GGFJ01003491    MBW52632.1    GGFJ01003490    MBW52631.1    GGFK01007087    MBW40408.1    AXCN02001964    GGFK01007599    MBW40920.1    GALA01000134    JAA94718.1    CH379060    EAL33796.2    CH479180    EDW29024.1    CH902624    EDV33260.1    KPU74376.1    JRES01000044    KNC34640.1    CM002910    KMY88157.1    CM000157    EDW87688.1    CH480820    EDW54285.1    CH940661    EDW71316.1    CP012523    ALC37938.1    ALC38425.1    AE014134    AY071312    AAF50965.1    AAL48934.1    GGFJ01003903    MBW53044.1    CH954177    EDV57782.1    AJWK01027315    JXJN01013398    OUUW01000004    SPP79146.1    DS231851    EDS37282.1    KQ971363    EFA07752.1    LJIG01022899    KRT78166.1    CH933807    EDW13258.1    CH916372    EDV99085.1    CCAG010010817    GL732542    EFX81645.1    GANO01000262    JAB59609.1    GDIP01054565    LRGB01001161    JAM49150.1    KZS13409.1    GDIQ01059064    JAN35673.1    LJIJ01000809    ODM94398.1    UFQS01000003    UFQT01000003    SSW96759.1    SSX17146.1    GDIP01012440    JAM91275.1    GDIP01099149    JAM04566.1    MUZQ01000072    OWK59716.1    QRBI01000104    RMC15511.1    KK755440    KFP43112.1    KL214831    KFV61958.1    AGTO01010370    AKCR02000001    PKK34258.1    KK502398    KFP23242.1    LSYS01003169    OPJ83370.1    AGCU01046922    AGCU01046923    AGCU01046924    AGCU01046925    PKK34257.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000037510    UP000007151    + More
UP000027135    UP000245037    UP000007062    UP000235965    UP000075885    UP000075881    UP000075903    UP000008820    UP000075920    UP000075902    UP000075882    UP000069940    UP000249989    UP000076407    UP000076408    UP000075900    UP000075883    UP000007798    UP000092462    UP000069272    UP000030765    UP000075840    UP000000673    UP000095301    UP000075886    UP000001819    UP000008744    UP000075884    UP000007801    UP000037069    UP000192221    UP000002282    UP000001292    UP000008792    UP000092553    UP000000803    UP000078200    UP000008711    UP000092461    UP000075880    UP000092443    UP000095300    UP000092460    UP000091820    UP000268350    UP000002320    UP000092445    UP000007266    UP000009192    UP000001070    UP000092444    UP000000305    UP000076858    UP000192223    UP000094527    UP000197619    UP000269221    UP000053875    UP000016665    UP000053872    UP000053119    UP000190648    UP000007267   

PRIDE

H9JD16    Q9VR42   

Pfam

PF08676   MutL_C        + More
PF12998   ING
PF05669   Med31

Interpro

IPR017406   Ser/Thr_kinase_Rio3        + More
IPR000687   RIO_kinase       
IPR018935   RIO_kinase_CS       
IPR011009   Kinase-like_dom_sf       
IPR008266   Tyr_kinase_AS       
IPR042121   MutL_C_regsub       
IPR014790   MutL_C       
IPR042120   MutL_C_dimsub       
IPR037198   MutL_C_sf       
IPR013083   Znf_RING/FYVE/PHD       
IPR024610   ING_N_histone_binding       
IPR011011   Znf_FYVE_PHD       
IPR019786   Zinc_finger_PHD-type_CS       
IPR019787   Znf_PHD-finger       
IPR001965   Znf_PHD       
IPR008831   Mediator_Med31       
IPR038089   Med31_sf       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF56112   SSF56112        + More
SSF118116   SSF118116       
SSF57903   SSF57903       

Gene 3D

2.30.42.20     3.30.1370.100     3.30.40.10     1.10.10.1340    

ProteinModelPortal

H9JD16   A0A194R4W0   A0A2W1BLP5   A0A194QAN4   A0A2A4J0W2   A0A2H1WAA3   + More
A0A1E1WK44   A0A0L7LQ88   S4PMA0   A0A212FK40   A0A0K8TM27   A0A1L8DLT7   A0A034V663   A0A067QUR6   A0A0K8UMG9   A0A2P8XG71   Q7Q135   A0A2J7Q9X8   A0A182P7Z4   A0A182K953   W8C3V4   A0A182UV86   Q16VU9   A0A182W8R1   A0A1Q3G358   A0A1S4FMF7   A0A182TT67   A0A182KZ44   A0A182GLE5   A0A182XGY5   A0A182Y699   A0A182G6J3   A0A0A1X499   A0A182RWQ7   A0A182LXC9   B4N0J4   A0A1B0D5R0   A0A1S4J7U9   A0A182F554   A0A1Y1LDC5   A0A084VSR4   A0A182HR90   T1PAS4   W5J4J9   A0A2M4AHY0   A0A1I8ML05   A0A2M4BHW8   A0A2M4BI49   A0A2M4AIH5   A0A182Q2S1   A0A2M4AJF5   T1E355   Q29M98   B4G9J4   A0A182NP21   B3MVJ5   A0A0L0CQJ0   A0A0J9QVS9   A0A1W4UIE4   B4NZ24   B4I178   B4MDQ5   A0A0M4E7S5   Q9VR42   A0A1A9UR86   A0A2M4BJ61   B3N4B2   A0A1B0CT99   A0A182IVQ1   A0A1A9YPR6   A0A1I8P092   A0A1B0BFF2   A0A1A9WUJ8   A0A3B0K0K4   B0W708   A0A1A9Z542   D6WVA9   A0A0T6AT21   B4KGQ8   B4JQA5   A0A1B0FN97   E9GFI5   U5EX34   A0A0P5YUC9   A0A1W4X9G6   A0A0P6ESE4   A0A1D2MN83   A0A336JWB3   A0A0P6BNV1   A0A0P5VJF9   A0A218V1A6   A0A3M0KS59   A0A091KSY3   A0A093FYQ7   U3JUF5   A0A2I0MX49   A0A091JRL0   A0A1V4KFX1   K7FFS5   A0A2I0MX50  

PDB

6G5I     E-value=4.34152e-58,     Score=571

KEGG

101741422    K08872 RIO kinase 3 [EC:2.7.11.1] | (RefSeq) serine/threonine-protein kinase RIO3

GO

GO:0046872   GO:0004674   GO:0005524   GO:0005829   GO:0030490   GO:0030688   GO:0006298   GO:0004672   GO:0005634   GO:0005737   GO:0006468   GO:0006325   GO:0003712   GO:0006355   GO:0016592   GO:1990786   GO:0089720   GO:0071359   GO:0045089   GO:0032728   GO:0039534   GO:0098586   GO:0043124   GO:0032463   GO:0006412   GO:0016020   GO:0004702   GO:0007178   GO:0051015   GO:0003779   GO:0016021  

Subcellular location

Nucleus  

Length:

601

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00108

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00220

outside

1  -  601

 

 

Pi

243.136268

Theta

189.890615

Tajima's D

0.453847

CLR

0.003402

CSRT

0.503774811259437

Interpretation

Uncertain