Gene

KWMTBOMO01065

Pre Gene Modal

BGIBMGA007355

Annotation

PREDICTED:_bone_morphogenetic_protein_receptor_type-1B_isoform_X2_[Papilio_machaon]

Location

Bomo_Chr3(-):1487420-1494845      View in EpiBrowser

Full name

Serine/threonine-protein kinase receptor       + More
Receptor protein serine/threonine kinase      

Location in the cell

Nuclear   Reliability : 1.321 PlasmaMembrane   Reliability : 1.168

CDS

ATGAGGCTGAGTCGGGGCCTGCGGTGCGAGTGCGCCGGCGCGCGAGCGTGCCCCGACGGCTCGTCCAACGGCACGTGCGTCACGCAGGTCGGGGGCTACTGCTTCGTCGCCGTCGAGGAGGTGCTCGACGAGAGCGGCAGCGTGGTGCTGGACCGGACCGCCGGGTGTCTCTCCGCTGACGAGTCGGGCTTGATGCAATGCAAAAGTTCACAAGTGCCACATCAGCACCCGAAAGTAATCGAGTGCTGTTACGACGACGACCTGTGCAACCTTCGGCTCCATCCTCAGCTATCTGAACCGTCACCGGACGTGACGGAGTCCCCGGGGGTGCGGCCCCCGATCACGAGCAGTCCCACCTTATTGGTCGCCATCGCTCTCTGCGTGGCTCTCATCGCTTTCCTGGCAGCTTTTTTGTTGTTATTCAGACGACGGAGGCGCGGCTGCAAGAGGCCGCCGTCTCCACCAGCGCCGCCGATATGTTCCGAAATATCTTCAGGGTCGGGCTCTGGCTTGCCGCTACTCGTCCAAAGGACTGTTGCCAAACAAATACAGATGGTGGAGTCCATCGGGAAAGGGCGTTACGGGGAGGTGTGGCTCGCAAGATGGCGCGGTGAGAAAGTAGCCGTCAAAGTATTCTTCACGACCGAGGAAGCGTCCTGGTTCAGAGAAACCGAGATTTACCAGACGGTGTTGATGCGACACGATAACATTCTTGGATTCATCGCTGCCGACATCAAGGGCACGGGCTCCTGGACCCAGATGCTCCTTATTACGGATTACCACGAGAACGGCTCGCTGCACGACTACCTTCAGACCGTCGTCCTCGACTCTAACTCCCTCATGACGATGACGTATTCGATAGTGAGCGGCCTCGCGCATCTGCACATGGACATATACGGCACGAAGGGCAAGCCGGCGATCGCGCACCGCGACATCAAGAGCAAGAACATCCTCGTGAAGCGCAACGGGCAGTGCGCCATCGCAGACTTCGGTCTGGCCGTGCGGTACGTCGCCGAGCGGAACGAGGTGGACATCGCGCCCAACACGCGCGTGGGCACCCGCCGGTACATGGCGCCCGAGGTGCTCGACGAGACGCTCGACGTCACAGACTTCGAGGCCTTCAAGATGGCCGACATGTACTCGCTCGGGCTCGTGCTGTGGGAGGTGTGTCGGCGCTGCGCCAGTGGGGACAAGGCGCAGCTCGTGGAGCCCTACGCGCTGCCGTACCAGGACGCGGTGCCGCCTGACCCTTCCTTCGAGGACATGCACGCTGTGGTGGTGCGCGCCAACCTGCGGCCCGCCCTGCCGCCGCGCTGGAGACACTGCGACCGACTGGCGGCGCTGGGGGCGCTCATGTCGGAGTGCTGGTCGGCCAGCCCCAGGGCGAGACTCTCCGCATTACGCGTCAAAAAGACGCTCGCCAAATATCGCGCGGACACAGCGCTGAAGCTCGTGTGA

Protein

MRLSRGLRCECAGARACPDGSSNGTCVTQVGGYCFVAVEEVLDESGSVVLDRTAGCLSADESGLMQCKSSQVPHQHPKVIECCYDDDLCNLRLHPQLSEPSPDVTESPGVRPPITSSPTLLVAIALCVALIAFLAAFLLLFRRRRRGCKRPPSPPAPPICSEISSGSGSGLPLLVQRTVAKQIQMVESIGKGRYGEVWLARWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGTGSWTQMLLITDYHENGSLHDYLQTVVLDSNSLMTMTYSIVSGLAHLHMDIYGTKGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVRYVAERNEVDIAPNTRVGTRRYMAPEVLDETLDVTDFEAFKMADMYSLGLVLWEVCRRCASGDKAQLVEPYALPYQDAVPPDPSFEDMHAVVVRANLRPALPPRWRHCDRLAALGALMSECWSASPRARLSALRVKKTLAKYRADTALKLV

Catalytic Activity

[receptor-protein]-L-serine + ATP = [receptor-protein]-O-phospho-L-serine + ADP + H(+)
[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-phospho-L-threonine + ADP + H(+)

Similarity

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Belongs to the protein kinase superfamily.

Feature

chain  Receptor protein serine/threonine kinase

Uniprot

H9JCV8   A0A2A4ITA9   A0A2Z4EM27   A0A2H1VW44   S4NNS3   A0A0L7LLR4   + More
A0A194RAF3   A0A194QAJ1   A0A0N1INT0   A0A0L7RD95   A0A087ZS89   A0A0N0BJM1   A0A232ES11   A0A2A3E0I9   A0A310SFX3   F4W4I2   A0A026W3X9   E9IIK9   A0A158P346   A0A151WYW8   A0A195F071   A0A1B6I265   A0A1W4WCQ4   A0A1W4WMS1   A0A1W4WCQ6   A0A1W4WNS4   A0A1B6GZE1   B4MF93   E2C3J2   W5J8Z6   A0A2M4BM12   A0A2M4BM56   A0A182F663   A0A2M4AIR5   A0A0R3NT01   A0A0R3NT51   K7IPQ4   A0A3B3U2Z5   A0A195BHA7   A0A0P8Y439   A0A336LVE2  

EC Number

2.7.11.30

Pubmed

19121390    29902488    23622113    26227816    26354079    28648823    + More
21719571    24508170    30249741    21282665    21347285    17994087    20798317    20920257    23761445    15632085    20075255   

EMBL

BABH01027686    NWSH01007327    PCG63005.1    MG581416    AWV63129.1    ODYU01004797    + More
SOQ45050.1    GAIX01012164    JAA80396.1    JTDY01000601    KOB76498.1    KQ460685    KPJ12841.1    KQ459232    KPJ02492.1    KQ461000    KPJ10049.1    KQ414615    KOC68770.1    KQ435714    KOX79222.1    NNAY01002529    OXU21131.1    KZ288486    PBC25237.1    KQ760382    OAD60690.1    GL887532    EGI70877.1    KK107447    QOIP01000001    EZA50708.1    RLU26846.1    GL763494    EFZ19567.1    ADTU01007746    KQ982649    KYQ53073.1    KQ981905    KYN33557.1    GECU01026685    JAS81021.1    GECZ01001995    JAS67774.1    CH940667    EDW57262.1    GL452320    EFN77530.1    ADMH02001847    ETN60912.1    GGFJ01004893    MBW54034.1    GGFJ01004892    MBW54033.1    GGFK01007177    MBW40498.1    CH379060    KRT04296.1    KRT04295.1    KQ976467    KYM84154.1    CH902620    KPU73615.1    UFQT01000134    SSX20633.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000053268    UP000053825    + More
UP000005203    UP000053105    UP000215335    UP000242457    UP000007755    UP000053097    UP000279307    UP000005205    UP000075809    UP000078541    UP000192223    UP000008792    UP000008237    UP000000673    UP000069272    UP000001819    UP000002358    UP000261500    UP000078540    UP000007801   

PRIDE

H9JCV8   

Pfam

PF00069   Pkinase        + More
PF01064   Activin_recp
PF08515   TGF_beta_GS
PF07714   Pkinase_Tyr

Interpro

IPR000719   Prot_kinase_dom        + More
IPR003605   GS_dom       
IPR011009   Kinase-like_dom_sf       
IPR000472   Activin_recp       
IPR017441   Protein_kinase_ATP_BS       
IPR000333   TGFB_receptor       
IPR008271   Ser/Thr_kinase_AS       
IPR017194   Transform_growth_fac-b_typ-2       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

H9JCV8   A0A2A4ITA9   A0A2Z4EM27   A0A2H1VW44   S4NNS3   A0A0L7LLR4   + More
A0A194RAF3   A0A194QAJ1   A0A0N1INT0   A0A0L7RD95   A0A087ZS89   A0A0N0BJM1   A0A232ES11   A0A2A3E0I9   A0A310SFX3   F4W4I2   A0A026W3X9   E9IIK9   A0A158P346   A0A151WYW8   A0A195F071   A0A1B6I265   A0A1W4WCQ4   A0A1W4WMS1   A0A1W4WCQ6   A0A1W4WNS4   A0A1B6GZE1   B4MF93   E2C3J2   W5J8Z6   A0A2M4BM12   A0A2M4BM56   A0A182F663   A0A2M4AIR5   A0A0R3NT01   A0A0R3NT51   K7IPQ4   A0A3B3U2Z5   A0A195BHA7   A0A0P8Y439   A0A336LVE2  

PDB

3MDY     E-value=2.34542e-132,     Score=1210

KEGG

101741200    K13578 bone morphogenetic protein receptor type-1B [EC:2.7.11.30] | (RefSeq) bone morphogenetic prot

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0004675   GO:0016021   GO:0005524   GO:0043235   GO:0007179   GO:0004672   GO:0006468   GO:0016020   GO:0004702   GO:0007178   GO:0051015   GO:0003779  

PANTHER

PTHR23255  

Subcellular location

Membrane  

Length:

485

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

28.2274999999999

Exp number, first 60 AAs:

0.10492

Total prob of N-in:

0.20106

outside

1  -  118

TMhelix

119  -  141

inside

142  -  485

 

 

Pi

23.815356

Theta

20.462997

Tajima's D

0.412793

CLR

1042.924359

CSRT

0.495325233738313

Interpretation

Uncertain