Gene

KWMTBOMO01016

Pre Gene Modal

BGIBMGA007384

Annotation

PREDICTED:_frizzled-10-like_[Amyelois_transitella]

Location

Bomo_Chr3(+):38656-55716      View in EpiBrowser

Full name

Frizzled-10      

Location in the cell

PlasmaMembrane   Reliability : 1.906

CDS

ATGGCTCGGATCGTTTGCGTGCTGCTGCTGGCGTGGCTCGCGGCCGCCGAGCAGGAGGAAGCAGAGGGCGGCAAGTGCGAGAGGATCACCCTGCCGCTCTGTCAGGAGCTAGGCTACAACTGGACCTCCATGCCCAACCTCATGGGTCACAAGGACCAAAAGGAAGCCGAACAAGCGATGTCACCGTTCAGCGACATCTTGGGCAGTGGGTGCTCGCTCCACGCTCGCTTCTTGTTGTGCTCGGCCTTCGCCCCACTGTGCTCGGAGGAGGTGTCGGGTTCCGTGAGCGCCTGCCGGGCGCTTTGCGAGACTGTCGCTGATGACTGCAAGGAACAGATAAAGATACTGTCGCCGACGGTGATGCTGGACTGCTCTGCTTTCCCGCTCCGAGCCAACCGAAAGCTGTGCATGCGGCCCCCCAACGCCAGCGAAGCCGAGCCCGAGCCGGCGCCCCCTTCCCGATGGCCCTTCCGCGAGCACGAGCCGCGCGCTGGGGGCTGTGCGCCGGGCCGGGCCCGCGCGCCCGCCGGCCAGTGCTGGCCCGCCTGCGGCCAGGATGCCGACTACACGCGCGAGGATAAGCGGACCGTGGACATCTGGATGAGTGCGCTCGCGTGGGCTTCGCTGCTGTCGACGTCGTTCGGTCTACTGACGTTCTGCGCGGAGCCCGGGCGGTACCGCTACCCGGAGCGGCCGGCCGTGTGGACGGCGGCGTGCCACGGCGCGGTGGCGCTGGCGCACGTGGCGCGCGGCTGGCTGGGCGCGGAGGCCGTGTCGTGCGCCGGCGCCACGCTGGCCGTGGACGGGCTGGGGGCGCCGGCGTGCGTCGCCTTCTTCGTACTCACGTACTACTTCACGCTGGCGGCGGACGCATGGTTCGCAAACGCGGCCGTCGCGTGGTATCTGACAGCCGCCAGCGAGTGGTCGACGGAGGCGCTGGAGCGGGCCGCCGCCTACCTGCACGCGGGCGCGTGGGGCTGGGCGGGCGCGTGGACGGCGGCGACGCTGGCCCTGCGGCGAGTGTCGGCGGACGAGCTGTCGGGCACGTGCGGCGTGGCGGAGGGTGCGACGGCGGCGCTGGTGGGCGTGCCACGGTGTGCCCTGCTGGTGACGGCGGCTGCGCTGGCGGCGGGGGCGGCGCCGGGCCTGGCGCGGGTGCGGCGGGCGCTGGACGCGGCCGGCTCGAGGCGCGTGGGTCGGCTGGCGGCGCGCGCTGGAGCGGCGGGTCTGGGGTACCTGGTGCTGGCGGCGGCGGGCACTGCGGCGCGCGTGTGGGGCGCGGGCGCGGCGTGGCGCGGCGTGTGGCTGTGCTGCGGCGTGGCGGCGGGGTCGTGGGCGTGGTCGCGCAAGTCTGCGGCGGTGTGGCGGCGCGCGCTGTGCCCGCCCCGCAAGGCGCCGTGCTGTGCGCCGCCGCTGCTGCGGGCGCCCCCGGGCTGCAAGCGGCCGCCCGTGTCCCGGGTGTGA

Protein

MARIVCVLLLAWLAAAEQEEAEGGKCERITLPLCQELGYNWTSMPNLMGHKDQKEAEQAMSPFSDILGSGCSLHARFLLCSAFAPLCSEEVSGSVSACRALCETVADDCKEQIKILSPTVMLDCSAFPLRANRKLCMRPPNASEAEPEPAPPSRWPFREHEPRAGGCAPGRARAPAGQCWPACGQDADYTREDKRTVDIWMSALAWASLLSTSFGLLTFCAEPGRYRYPERPAVWTAACHGAVALAHVARGWLGAEAVSCAGATLAVDGLGAPACVAFFVLTYYFTLAADAWFANAAVAWYLTAASEWSTEALERAAAYLHAGAWGWAGAWTAATLALRRVSADELSGTCGVAEGATAALVGVPRCALLVTAAALAAGAAPGLARVRRALDAAGSRRVGRLAARAGAAGLGYLVLAAAGTAARVWGAGAAWRGVWLCCGVAAGSWAWSRKSAAVWRRALCPPRKAPCCAPPLLRAPPGCKRPPVSRV

Description

Receptor for Wnt proteins (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

Subunit

Interacts with MYOC (By similarity). Interacts with WNT7B (PubMed:15923619).

Similarity

Belongs to the G-protein coupled receptor Fz/Smo family.

Keywords

Cell membrane   Complete proteome   Developmental protein   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Reference proteome   Signal   Transducer   Transmembrane   Transmembrane helix   Ubl conjugation   Wnt signaling pathway  

Feature

chain  Frizzled-10

Uniprot

A0A194R4X6   A0A1S3CWX8   A0A1B6CWR1   A0A146KW08   E0V9Z7   A0A1U7QTM7   + More
A0A3P8WZS6   E2ABY3   A0A1S3PI41   A0A3L7HPE8   A0A3B4XI18   A0A3B4VGH9   Q149J3   Q8BKG4   I3KZY1   A0A1A6FVP4   A0A3P8NZV6   Q71S95   A0A3B4G314   G3NXM0   A0A3B4A7U5   A0A0F8AI70   A0A3B5A224   A0A3P9BLI2   A0A3P8TML8   A0A341CID8   M3XZ91   A0A1A7ZFC3   A0A1A7X691   A0A1A8P2K2   A0A1A8Q7T4   A0A1A8JPR3   A0A2U9B5Y8   A0A1A8F988   A0A1A8E7V3   A0A2Y9KHA5   A0A1A8PDS1   H9GKW6   A0A3P8YWY7   A0A3B5K442   A0A2I2UJS3   W5U8Z5   F6VL64   A0A3B3CZU8   H3BHV4   A0A3P9JTT8   A0A3B3T315   A0A3P8YT27   H2MEU7   A0A3B3DKY6   A0A0F8APT6   A0A0P7XVP1   A0A3P9KY33   H2M7Q8   A0A3P9LN57   A0A2I4B4D4   A0A2U9BRN7   A0A147AIA7   A0A3P8PWE1   A0A315VMD1   A0A3B3U6W2   A0A087YS63   A0A3B4EPS4   A0A3P9BNK2   A0A3B3XTY6   A0A315V8F3   A0A3B5MBW3   A0A3B4GT35   I3KXG0   A0A3P9PZ05   A0A3B5MHH7   M4ARN6   A0A3P9I588   A0A2D0WJ24   A0A3B4XM11   A0A3B4VKJ4   A0A0S7I4V4   M4B090   A0A3P8WEA8   A0A146WQX1   A0A3P9MZY9   X1WCT3   A0A3B4C9B0   A0A3P8SLM5   Q4SXY4   A3QK10   A0A0G2KQU3  

Pubmed

26354079    26823975    20566863    24487278    20798317    29704459    + More
12040188    15489334    14758554    16141072    15923619    25186727    25463417    25835551    21881562    25069045    21551351    17975172    23127152    19892987    29451363    9215903    17554307    29240929    29703783    23542700    23594743    15496914   

EMBL

KQ460685    KPJ12858.1    GEDC01030850    GEDC01019411    GEDC01010436    JAS06448.1    + More
JAS17887.1    JAS26862.1    GDHC01019352    JAP99276.1    DS235002    EEB10203.1    GL438386    EFN69078.1    RAZU01000164    RLQ67817.1    BC117759    CH466529    AAI17760.1    EDL19534.1    AY509002    AK052950    AERX01007254    LZPO01116977    OBS58021.1    AF310970    AAQ14553.1    KQ041854    KKF21628.1    AEYP01093574    AEYP01093575    HADY01002698    HAEJ01017816    SBP41183.1    HADW01011934    HADX01004944    SBP13334.1    HAEI01001285    SBR75506.1    HAEH01010289    SBR89332.1    HAED01011541    HAEE01002036    SBR22056.1    CP026245    AWO99168.1    HAEB01008167    HAEC01013142    SBQ54694.1    HADZ01004648    HAEA01013777    SBQ42257.1    HAEF01007327    HAEG01007396    SBR79162.1    AANG04002765    JT408201    AHH38270.1    AFYH01006738    KQ041208    KKF29252.1    JARO02000222    KPP79391.1    CP026251    AWP06711.1    GCES01008408    JAR77915.1    NHOQ01001971    PWA20363.1    AYCK01010028    NHOQ01002094    PWA19663.1    AERX01013692    KY053804    AQY15976.1    GBYX01434044    JAO47282.1    GCES01054821    JAR31502.1    CR753838    CAAE01012285    CAF94498.1    BX322606   

Proteomes

UP000053240    UP000079169    UP000009046    UP000189706    UP000265120    UP000000311    + More
UP000087266    UP000273346    UP000261360    UP000261420    UP000000589    UP000005207    UP000092124    UP000265100    UP000261460    UP000007635    UP000261520    UP000261400    UP000265160    UP000265080    UP000252040    UP000000715    UP000246464    UP000248482    UP000001646    UP000265140    UP000005226    UP000011712    UP000221080    UP000002281    UP000261560    UP000008672    UP000265200    UP000261540    UP000001038    UP000034805    UP000265180    UP000192220    UP000261500    UP000028760    UP000261440    UP000261480    UP000261380    UP000242638    UP000002852    UP000000437    UP000007303   

PRIDE

Q8BKG4   

Pfam

PF01392   Fz        + More
PF01534   Frizzled
PF00018   SH3_1
PF03114   BAR

Interpro

IPR015526   Frizzled/SFRP        + More
IPR036790   Frizzled_dom_sf       
IPR017981   GPCR_2-like       
IPR020067   Frizzled_dom       
IPR000539   Frizzled/Smoothened_TM       
IPR026549   FZD10       
IPR041777   FZ9_CRD       
IPR036028   SH3-like_dom_sf       
IPR035824   Endophilin_A_SH3       
IPR027267   AH/BAR_dom_sf       
IPR032469   Endophilin-A3_BAR       
IPR001452   SH3_domain       
IPR004148   BAR_dom       

SUPFAM

SSF63501   SSF63501        + More
SSF103657   SSF103657       
SSF50044   SSF50044       

Gene 3D

1.10.2000.10     1.20.1270.60    

CDD

cd07463  CRD_FZ9
cd11803  SH3_Endophilin_A
cd07615  BAR_Endophilin_A3

ProteinModelPortal

A0A194R4X6   A0A1S3CWX8   A0A1B6CWR1   A0A146KW08   E0V9Z7   A0A1U7QTM7   + More
A0A3P8WZS6   E2ABY3   A0A1S3PI41   A0A3L7HPE8   A0A3B4XI18   A0A3B4VGH9   Q149J3   Q8BKG4   I3KZY1   A0A1A6FVP4   A0A3P8NZV6   Q71S95   A0A3B4G314   G3NXM0   A0A3B4A7U5   A0A0F8AI70   A0A3B5A224   A0A3P9BLI2   A0A3P8TML8   A0A341CID8   M3XZ91   A0A1A7ZFC3   A0A1A7X691   A0A1A8P2K2   A0A1A8Q7T4   A0A1A8JPR3   A0A2U9B5Y8   A0A1A8F988   A0A1A8E7V3   A0A2Y9KHA5   A0A1A8PDS1   H9GKW6   A0A3P8YWY7   A0A3B5K442   A0A2I2UJS3   W5U8Z5   F6VL64   A0A3B3CZU8   H3BHV4   A0A3P9JTT8   A0A3B3T315   A0A3P8YT27   H2MEU7   A0A3B3DKY6   A0A0F8APT6   A0A0P7XVP1   A0A3P9KY33   H2M7Q8   A0A3P9LN57   A0A2I4B4D4   A0A2U9BRN7   A0A147AIA7   A0A3P8PWE1   A0A315VMD1   A0A3B3U6W2   A0A087YS63   A0A3B4EPS4   A0A3P9BNK2   A0A3B3XTY6   A0A315V8F3   A0A3B5MBW3   A0A3B4GT35   I3KXG0   A0A3P9PZ05   A0A3B5MHH7   M4ARN6   A0A3P9I588   A0A2D0WJ24   A0A3B4XM11   A0A3B4VKJ4   A0A0S7I4V4   M4B090   A0A3P8WEA8   A0A146WQX1   A0A3P9MZY9   X1WCT3   A0A3B4C9B0   A0A3P8SLM5   Q4SXY4   A3QK10   A0A0G2KQU3  

PDB

5BQE     E-value=7.0933e-17,     Score=214

KEGG

101745658    K18443 golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 | (RefSeq) golgi-s

GO

GO:0007275   GO:0004888   GO:0016021   GO:0016055   GO:0007166   GO:0038031   GO:0034260   GO:0042813   GO:0043547   GO:0017147   GO:0009986   GO:0060070   GO:0005737   GO:0005654   GO:0032956   GO:0043507   GO:0004930   GO:0035567   GO:0005886   GO:0090504   GO:0006897   GO:0005515   GO:0016020   GO:0007016   GO:0005856   GO:0007155   GO:0051015   GO:0003779  

PANTHER

PTHR11309   PTHR11309:SF86  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 16,         Likelihood:  0.997724

 

 

Length:

487

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

135.10699

Exp number, first 60 AAs:

0.0015

Total prob of N-in:

0.31965

outside

1  -  198

TMhelix

199  -  221

inside

222  -  232

TMhelix

233  -  255

outside

256  -  264

TMhelix

265  -  287

inside

288  -  404

TMhelix

405  -  427

outside

428  -  430

TMhelix

431  -  448

inside

449  -  487

 

 

Pi

224.228163

Theta

200.631311

Tajima's D

0.032285

CLR

1.102042

CSRT

0.376181190940453

Interpretation

Uncertain