SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO01004  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA001380
Annotation
PREDICTED:_CLIP-associating_protein_[Bombyx_mori]
Full name
CLIP-associating protein      
Alternative Name
Misexpression suppressor of ras 7
Protein Multiple asters
Protein Orbit
Protein chromosome bows
Location in the cell
Nuclear   Reliability : 2.847
 

Sequence

CDS
ATGATTGCGGCGCCGCCCCTCGCCGTGTATGGAGTGCGCGGGCTGGACGACACCGTGCGCCTCGCCGCCGCGCTGCTGGGCGACCGCGCCGCCGACTGGGAGAAGCGCGTCGACGCGTTAAAGAAGATCCGCGCTCTGCTCACCGCCAACGTCCACCAGCAGTACCCCGTGGAGTTCGCTGCACATCTCAAGGATCTGTCCATTCCATTTCTTGTTGTCATCAAGGACTTGAGGAGTCAGGTGGTGCGCGAAGCCTGCATCACGATAGCCCACATGGCGAAAGTGCTCAAGAATAAAATGGAACAGTTCAGTTTGTACATACTCCAGGAGCTGATCAACCTCATACAGAACGCCGCTAAGGTGGTGTCGTCGGCGGGCACCGTGTGCGTGCAGTACATAGTATCGTTTGTACACTCACCGAGGCTCATCCCGGTCTTGCTCACCAATTTAACTTCAAATAAATCCAAGGAAATACGTTCTACACTCAGTGAAGTACTAGTCATGATACTGGAGAAGTGGCCGGCTCAGACCATAGAGAAGCAGCAGCAAAATATCCGAGACGCCATCCGCGTCGCCTGCGTGGACGCCGACAGCACCGCCAGGAACCACGGACGAAGAGCGTACTGGTCCTACCAGCGACTGTTCCCTGCGGAGGCCGAGCTGCTGTTCGAGCGGCTGGATGCTGCGGCCCAGAAGCAACTCGAGCGGGAGAGGAACGTCGGCAACGTCGGCAGCCTCGACGGACTACAGCGACTCGGCACGGAGAGGAGAGCCGCCGCCTGCAGCCCGCGCAGCCCGTCGGCCAGCGTGTCAGCTTCCACTGAGAATTTAGTGTCAAGTTTGAACAGGAGTCACTCCCTGAGGAGACGACGAGCCTCCCAGGACAGAGTCGCGGTCACACAGATCCCCGTCGCCCTGCGAGCTCGAGCGAAGAGATCTCCGGTGGGCGCAGCGGCCGCCGTCCCGCCCAGCCCCGAGCGCGGCGCCGGCCGGTCGCGCTCCCGGCCCGGCGTGTCGCAGTCGCAGCCCACGTCGCGCTCGGCGTCCCCGTCCGGCCGCGCGCCCGGCCCCGCCTCGCTGCACGCCGCGCGCCGCCGACCCTCCGGCATCCCGCGCTCGCTCGCCGGCTCCAGGGAGACCAGCCCCACCAGGAGCGGCAGGTCGAGCAGCGGGGTGAGACGGCGGGAGTCGATGGAGAGGACGGCGCCCAGCCGCGCCCCGGCACACACGCTGCGCCTGCTGCAGCAGACCAGGGACGCCGAGGCCGCGCTCAGGAGTCCAGAGGACAGTTCGGCATGCGAGGGCGGGAGAGGAAGGGACGACGATTCCGAAGCCTCCAGCGTTTGTTCCGAGAGGAGTCTAGACTCGTACAGGAGACACGATAGCATGTCGTGGTCGGGCTCCGGGGCGCGCCTCGGCTGGGAGGGCTCCCCCCCTCCTCCTCCGCCGGCCGATGACATCATCGTGCTGTGCTCTTCCACGCACTGGACCGAACGGAAGGATGGACTCACGCATCTTGCGAACTACCTCAACAGCGGGCGCCTGCTGACGGACGAGCAGCTGCGGCGCCTCACGGAGCTGTTGAACAAAATGTTCGTGGACGCTCACACCAAGGTGTTCTCCCTGCTGCTGGACGCCGTCTGCGAGCTGCTCCTCGTGCACTGGCAGCAGCTCAAGGACTGGCTGTACCAGCTCATGTTCAGACTACTGATGAAACTCGGCACTGACATCCTCGGCTCGGTGCAGAGCAAGATAATGAAGACACTAGACGTCATACACGAGTGCTTCCCCGCTGAGCTGCAGCTACACAACATATTCAGGTTCCTGTCGGACGGCGCCGCGGCTCCCCCCGCGCGTACCCGCGCCGCCGCGCTGCGATTCCTGGCCGAGCTGGCGCTGCACTACTGCACGCCCGGCGCGCTGGCGCTCGCGCTTCAGGGCGGCGGCGGCGGCGTGGCGGGGCGCGGCGTGGCCAAGGTGTGCGCGTTGGCGGCCGACCCCCGCGCGGGCGACGTGCGGACCGCCGCGCGCCGCGCGCTCGCCGCACTGTACGACTGCAGCCCGGCGCACTTCACAGCCTTGATGAGCGAGCTACCAGCGGAAACGCAGACATTCGTCAACGGTATAGTGCAGCAACACGTCAGAAGAACATCTAGCACCGGCAGCGACAGTCCGCTGCGCACGGCAAGCTCCGCGTCCAACAACGAGGACGTCCTCTCCCGCATCAGGAAAACGACGTCGGAGATACACTCCTACACCGCGCACCATTCTAACGCGGAGTGCGGCAACTACACATCGAGTAAAGACTCCGGTATCAGTCAGATGTCGGACCTCACGCTGGGGAACAAGGGGCACAACGGAGTGCCTAATGGTCATGCAGAGGCAATAGGACGTGCCGCTTCAGCAGACAGTTCCGAAGAGGCGAACAGCACTAAAGAATCGTCGCCCATCCCGGGACACAACCGGCTCGACTACCAACTGCAACACGGGGACTACACCGGCAGTCAGCTGGGACGCGACAAGGCCAGGCCCTACGAGGTGGACGAGCACGGATACATCATCACTAAATGTGGATTGGGCGAGGAGGCGGTGCTGGAGGCTCTGTGTGCGCTGGACGCCGTGACGTCACCGCCCGAGCGCTGGGAGCAGCTGCTGCTGGCCGCGCACGAGCTGCTCAAGTACGGGGACTGCTCCAAGCCCAAGGAATACTTCAAGAACATAGTTCGTGTAGCGCTGGCGGCGCTCTCCATCGAGGACAACTCCGGGGACAAGGAGAACACTGAAAACGCGACCAACGCGCACCAGACATCCGGCTGGGGGACGGCGAACGAGCGAGCAGCCGCCGAAGCCGTAAAGGTTCTGATCTGGTTGTGCCGCAGGCCAGAGACCAGACCCCAGTGGCAAGAGTACTTCGATCTCATCCTACTGAAGCTCATCCAGGCCTACGAGTCTCTGAACAAGGAGGTGATGCGGGCGGTGGAGGCCGGCATGCCGCACATCGCTAGGGCGCTGCCCGCGCTGCAGGTGCTCGCCCTGCTGAAGCCAGTGATCCGCACGCGTGGCTACCCGACCTCCCTGTGCGCCCTCAAGCTCGCCGGAGAGGTCGCCAAGGCGCGCCCCCACGAGCTCACCGACGACATCGTGCAGCAACTCATGGAGGGGGTCAGCCAGCTGGCGGACCACCAGAACTCCGCGGTGCGCAAGGCGGCCGTGTTCTGCATGGTGGCCTTCACGTTCGCGCTGGGCGAGGCGCGCATGCAGCCGCACCTCACGCACCTCTCCGTCAGCAAGTACCGCCTCTTGCAGGTGTACATCAGCAAGCAGCGCGAGGAGTCCACCCGACAACAACACGCCAACAGCGCGACAACGACGTAG
Protein
MIAAPPLAVYGVRGLDDTVRLAAALLGDRAADWEKRVDALKKIRALLTANVHQQYPVEFAAHLKDLSIPFLVVIKDLRSQVVREACITIAHMAKVLKNKMEQFSLYILQELINLIQNAAKVVSSAGTVCVQYIVSFVHSPRLIPVLLTNLTSNKSKEIRSTLSEVLVMILEKWPAQTIEKQQQNIRDAIRVACVDADSTARNHGRRAYWSYQRLFPAEAELLFERLDAAAQKQLERERNVGNVGSLDGLQRLGTERRAAACSPRSPSASVSASTENLVSSLNRSHSLRRRRASQDRVAVTQIPVALRARAKRSPVGAAAAVPPSPERGAGRSRSRPGVSQSQPTSRSASPSGRAPGPASLHAARRRPSGIPRSLAGSRETSPTRSGRSSSGVRRRESMERTAPSRAPAHTLRLLQQTRDAEAALRSPEDSSACEGGRGRDDDSEASSVCSERSLDSYRRHDSMSWSGSGARLGWEGSPPPPPPADDIIVLCSSTHWTERKDGLTHLANYLNSGRLLTDEQLRRLTELLNKMFVDAHTKVFSLLLDAVCELLLVHWQQLKDWLYQLMFRLLMKLGTDILGSVQSKIMKTLDVIHECFPAELQLHNIFRFLSDGAAAPPARTRAAALRFLAELALHYCTPGALALALQGGGGGVAGRGVAKVCALAADPRAGDVRTAARRALAALYDCSPAHFTALMSELPAETQTFVNGIVQQHVRRTSSTGSDSPLRTASSASNNEDVLSRIRKTTSEIHSYTAHHSNAECGNYTSSKDSGISQMSDLTLGNKGHNGVPNGHAEAIGRAASADSSEEANSTKESSPIPGHNRLDYQLQHGDYTGSQLGRDKARPYEVDEHGYIITKCGLGEEAVLEALCALDAVTSPPERWEQLLLAAHELLKYGDCSKPKEYFKNIVRVALAALSIEDNSGDKENTENATNAHQTSGWGTANERAAAEAVKVLIWLCRRPETRPQWQEYFDLILLKLIQAYESLNKEVMRAVEAGMPHIARALPALQVLALLKPVIRTRGYPTSLCALKLAGEVAKARPHELTDDIVQQLMEGVSQLADHQNSAVRKAAVFCMVAFTFALGEARMQPHLTHLSVSKYRLLQVYISKQREESTRQQHANSATTT

Summary

Description
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for several aspects of mitotic spindle formation including the formation of the overlapping central spindle microtubules and kinetochore attachment. Required for the incorporation of tubulin subunits at the plus ends of kinetochore microtubules during poleward microtubule flux. Acts antagonistically to Klp10A and Klp67A to maintain metaphase spindle length. Also required for guidance of CNS axons downstream of Abl. May function to identify a subset of microtubules that probe the peripheral growth cone domain, where guidance signals exert their influence on cytoskeletal organization. Also required during oogenesis for the organization of the polarized microtubule network inside the 16-cell cyst that ensures oocyte differentiation.
Subunit
Interacts with CLIP-190 and microtubules.
Similarity
Belongs to the CLASP family.
Keywords
3D-structure   Cell cycle   Cell division   Cell projection   Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   Differentiation   Microtubule   Mitosis   Nucleus   Oogenesis   Phosphoprotein   Reference proteome   Repeat  
Feature
chain  CLIP-associating protein
EMBL
NWSH01000296    PCG77657.1    PCG77658.1    PCG77656.1    AGBW02013452    OWR43410.1    + More
KQ459593    KPI96676.1    GFDL01002844    JAV32201.1    GANO01000599    JAB59272.1    GFDL01002840    JAV32205.1    GGFJ01000440    MBW49581.1    GGFL01003103    MBW67281.1    GGFK01002890    MBW36211.1    GGFK01002925    MBW36246.1    UFQS01000388    UFQT01000388    SSX03475.1    SSX23840.1    JXUM01128212    JXUM01128213    KQ567288    KXJ69489.1    GGFK01003557    MBW36878.1    GFDL01016170    JAV18875.1    GFDL01002839    JAV32206.1    GFDL01001007    JAV34038.1    CH477330    EAT43389.1    GALA01001780    JAA93072.1    JXUM01099860    JXUM01099861    JXUM01099862    JXUM01099863    JXUM01099864    JXUM01099865    JXUM01099866    JXUM01099867    JXUM01099868    KQ564524    KXJ72138.1    GALA01001789    JAA93063.1    KA646215    AFP60844.1    GFDF01000056    JAV14028.1    CCAG010020666    GFDF01000010    JAV14074.1    JXJN01018482    ADMH02001692    ETN61406.1    GGFM01001160    MBW21911.1    ATLV01017805    ATLV01017806    KE525192    KFB42467.1    AXCM01000215    APCN01000215    GGFM01006634    MBW27385.1    AAAB01008807    EAA03965.4    AXCN02000593    JRES01000364    KNC31925.1    GDHF01024514    GDHF01017957    GDHF01015910    JAI27800.1    JAI34357.1    JAI36404.1    GAKP01009050    GAKP01009048    GAKP01009047    JAC49902.1    GBXI01015923    GBXI01005413    GBXI01005045    GBXI01001373    JAC98368.1    JAD08879.1    JAD09247.1    JAD12919.1    UFQS01000676    UFQT01000676    SSX06095.1    SSX26451.1    SSX06094.1    SSX26450.1    SSX06096.1    SSX26452.1    SSX03473.1    SSX23838.1    SSX03474.1    SSX23839.1    GAMC01020201    JAB86354.1    CH902618    EDV39774.1    AF250842    AF195498    AB031048    AE014296    AY069579    OUUW01000009    SPP85354.1    CH479246    EDW37782.1    KQ971354    EFA05834.1    CH379068    EAL31231.1    KRT07473.1    GEZM01043701    JAV78897.1    GEZM01043700    JAV78898.1    GDRN01092355    JAI60127.1   
Pfam
PF12348   CLASP_N        + More
PF02985   HEAT
Interpro
IPR011989   ARM-like        + More
IPR024395   CLASP_N_dom       
IPR021133   HEAT_type_2       
IPR016024   ARM-type_fold       
IPR034085   TOG       
IPR028399   CLASP_1       
IPR000357   HEAT       
SUPFAM
SSF48371   SSF48371       
Gene 3D
PDB
4K92     E-value=1.0343e-38,     Score=406

Ontologies

Topology

Subcellular location
Cytoplasm  
Cytoskeleton  
Nucleus  
Microtubule organizing center  
Centrosome  
Spindle  
Cell projection  
Growth cone  
Cleavage furrow  
Length:
1124
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.06182
Exp number, first 60 AAs:
0.00026
Total prob of N-in:
0.00111
outside
1  -  1124
 
 

Population Genetic Test Statistics

Pi
292.148149
Theta
184.322265
Tajima's D
1.971227
CLR
0.334767
CSRT
0.878106094695265
Interpretation
Uncertain
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