Gene

KWMTBOMO00999

Annotation

PREDICTED:_LYR_motif-containing_protein_4_[Amyelois_transitella]

Location

Bomo_Chr2(-):8207791-8210181      View in EpiBrowser

Full name

LYR motif-containing protein 4       + More
LYR motif-containing protein 4B      
Protein bcn92      

Location in the cell

Mitochondrial   Reliability : 2.142

CDS

ATGTCTGGCGCGATACCTAAAATACAAATATTATCTCTCTATAAATTGCTTCTCAGAGAATCCCAGAAGTTCCCTAACTATAATTTCAGAGCATACGCACTAAGAAGAATTCGAGATGCTTTTAAAGATAATAAAAATGTGTCTGATGTTAAGATTGTGAAGAAAGAGTTTGAATTTGGAAAAGAAAATTTAAATGTTATCAGGAGACAGGCAGCCATTGGAAATATGTATAAAACAGAAAAACTTGTTATCGAAAATCTGCGGTAG

Protein

MSGAIPKIQILSLYKLLLRESQKFPNYNFRAYALRRIRDAFKDNKNVSDVKIVKKEFEFGKENLNVIRRQAAIGNMYKTEKLVIENLR

Description

Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.

Subunit

Interacts with FXN. Interaction is increased by nickel. Interaction is inhibited by calcium, magnesium, manganese, copper, cobalt, zinc, and iron. Forms a complex with the cytosolic/nuclear form of NFS1. The complex increased the stability of NFS1.

Miscellaneous

Reduction of LYRM4 levels by siRNA increases the total iron content, and reduces cytosolic and mitochondrial aconitase activities and NFS1 protein levels.

Similarity

Belongs to the complex I LYR family.

Keywords

Mitochondrion   Nucleus   Complete proteome   Reference proteome   Coiled coil   3D-structure   Direct protein sequencing   Disease mutation   Polymorphism   Primary mitochondrial disease  

Feature

chain  LYR motif-containing protein 4
sequence variant  In dbSNP:rs2224391.

Uniprot

S4NPZ7   A0A2A4J4W8   A0A1E1WJM5   A0A2H1V2F1   A0A212EPI9   A0A194R4S4   + More
A0A194PSP1   A0A023EBS4   A0A1B0D317   Q178E3   C1BY44   W5N120   A0A1L8FXV4   Q6DCS1   A0A1Q3FCT5   B0W311   A0A182P6Q7   A0A3B4AAZ9   U5ESJ4   A0A1L8DAM0   U3KFD8   A0A0K8TS46   A0A1S3NCR0   B5XD90   A0A1W5B7P0   A0A139WG63   E3TD00   A0A023EE00   A0A3P8QEA8   A0A3P9CXS0   A0A1D2MU10   B5FZA8   E9FZ49   A0A182ILR3   A0A3P9M4E5   R4GGF7   A0A218UX08   A0A1U7S454   A0A151NFI0   A0A2M3ZCC2   A0A3B3IJ86   A0A2I4CYP2   A0A2M4C4U6   A0A182VC15   E3TDP8   A0A2M3ZCD8   A0A1V4JWI7   A0A3B3CWU1   A0A3P8RWE4   A0A3B3SED9   A0NDE4   A0A2R8Q8D7   A0A3B4UVV0   A0A2K5JM35   A0A1I8MBU7   A0A287AUJ0   Q9HD34   M4AUT3   A0A340Y1T5   P82116   A0A067RAW7   A0A0S7HTE1   B3MSG3   A0A2M4CZC2   A0A2U4C5N2   T1DHP7   A0A2K6DQ88   A0A2K6MNX1   A0A2K5TXT0   A0A0D9R4P3   A0A2I3MAL7   A0A2K5MDQ8   H9FMX8   A0A182RYR1   A0A2Y9SKG8   A0A0E9X8C4   L8ITK0   Q0VCG0   A0A2I2Z0B2   A0A2R9A3H3   A0A2I3SE95   A0A2R7WVE7   N6TU46   A0A1A7YW81   A0A2R8MCW8   A0A384C8D0   A0A2I3H651   A0A2K6UTV4   A0A0L0C3T1   K9IGF1   A0A2Y9PAL3   A0A2K5CXV1   A0A3B3XFT7   A0A0P5XQH2   A0A286XEV2   A0A3B0JY32   A0A2Y9KHY1   M3XN76   A0A1W4Z0F0   W5JBU6  

Pubmed

23622113    22118469    26354079    24945155    26483478    17510324    + More
20433749    25069045    27762356    25463417    26369729    18362917    19820115    20634964    25186727    27289101    17018643    21292972    17554307    22293439    29451363    29240929    12364791    14747013    17210077    23594743    25315136    11342225    14702039    14574404    15489334    17331979    18650437    19454487    21269460    25944712    23814038    23542700    7705632    24845553    17994087    25319552    25613341    22751099    22398555    22722832    16136131    23537049    24813606    26108605    21993624    20920257    23761445   

EMBL

GAIX01013386    JAA79174.1    NWSH01003363    PCG66470.1    GDQN01003947    JAT87107.1    + More
ODYU01000154    ODYU01010951    SOQ34444.1    SOQ56381.1    AGBW02013452    OWR43403.1    KQ460890    KPJ10861.1    KQ459593    KPI96451.1    JXUM01109088    GAPW01006666    GAPW01006665    KQ565289    JAC06933.1    KXJ71126.1    AJVK01023187    CH477365    EAT42558.1    EJY57609.1    EJY57610.1    BT079523    ACO13947.1    AHAT01031817    AHAT01031818    CM004476    OCT76404.1    BC077926    GFDL01009651    JAV25394.1    DS231830    EDS30719.1    GANO01003219    JAB56652.1    GFDF01010576    JAV03508.1    AGTO01000234    GDAI01000853    JAI16750.1    BT049009    KQ971351    KYB26845.1    GU588230    ADO28186.1    GAPW01006754    JAC06844.1    LJIJ01000555    ODM96294.1    DQ214409    GL732527    EFX87649.1    MUZQ01000101    OWK58364.1    AKHW03003201    KYO35510.1    GGFM01005456    MBW26207.1    GGFJ01011212    MBW60353.1    GU588478    ADO28434.1    GGFM01005418    MBW26169.1    LSYS01005643    OPJ76586.1    AAAB01008880    EAU76964.2    BX784022    CABZ01061196    CABZ01074958    CU104764    FQ790217    AEMK02000051    AF285118    AF170070    AK291158    AL035653    AL121978    AL162381    BC009552    Z46522    KK852816    KDR15786.1    GBYX01437054    GBYX01437053    GBYX01437052    JAO44289.1    CH902622    EDV34718.1    GGFL01006030    MBW70208.1    GAMD01002236    JAA99354.1    AQIA01052906    AQIA01052907    AQIA01052908    AQIB01159265    AQIB01159266    AHZZ02024070    AHZZ02024071    JU332232    JU473752    JV044062    AFE75987.1    AFH30556.1    AFI34133.1    GBXM01009861    JAH98716.1    JH880690    ELR59686.1    BC120188    CABD030043064    CABD030043065    CABD030043066    CABD030043067    CABD030043068    AJFE02018850    AJFE02018851    AJFE02018852    AACZ04065956    NBAG03000244    PNI62945.1    KK855635    PTY23371.1    APGK01052243    KB741211    KB632263    ENN72790.1    ERL90924.1    HADX01011973    SBP34205.1    ADFV01069846    ADFV01069847    ADFV01069848    ADFV01069849    ADFV01069850    ADFV01069851    JRES01000940    KNC26998.1    GABZ01008683    JAA44842.1    GDIP01068723    JAM34992.1    AAKN02036990    AAKN02036991    OUUW01000003    SPP77631.1    AEYP01034674    AEYP01034675    AEYP01034676    AEYP01034677    AEYP01034678    AEYP01034679    ADMH02001952    ETN60340.1   

Proteomes

UP000218220    UP000007151    UP000053240    UP000053268    UP000069940    UP000249989    + More
UP000092462    UP000008820    UP000265140    UP000018468    UP000186698    UP000002320    UP000075885    UP000261520    UP000016665    UP000087266    UP000192224    UP000007266    UP000265100    UP000265160    UP000094527    UP000007754    UP000000305    UP000075880    UP000265180    UP000265200    UP000197619    UP000189705    UP000050525    UP000001038    UP000192220    UP000075903    UP000221080    UP000190648    UP000261560    UP000265080    UP000261540    UP000007062    UP000000437    UP000261420    UP000233080    UP000095301    UP000008227    UP000005640    UP000002852    UP000265300    UP000027135    UP000007801    UP000245320    UP000233120    UP000233180    UP000233100    UP000029965    UP000028761    UP000233060    UP000075900    UP000248484    UP000009136    UP000001519    UP000240080    UP000002277    UP000019118    UP000030742    UP000008225    UP000261680    UP000291021    UP000001073    UP000233220    UP000037069    UP000248483    UP000233020    UP000261480    UP000005447    UP000268350    UP000248482    UP000000715    UP000000673   

PRIDE

Q9HD34    Q0VCG0   

Pfam

PF05347   Complex1_LYR

Interpro

IPR008011   Complex1_LYR       

ProteinModelPortal

S4NPZ7   A0A2A4J4W8   A0A1E1WJM5   A0A2H1V2F1   A0A212EPI9   A0A194R4S4   + More
A0A194PSP1   A0A023EBS4   A0A1B0D317   Q178E3   C1BY44   W5N120   A0A1L8FXV4   Q6DCS1   A0A1Q3FCT5   B0W311   A0A182P6Q7   A0A3B4AAZ9   U5ESJ4   A0A1L8DAM0   U3KFD8   A0A0K8TS46   A0A1S3NCR0   B5XD90   A0A1W5B7P0   A0A139WG63   E3TD00   A0A023EE00   A0A3P8QEA8   A0A3P9CXS0   A0A1D2MU10   B5FZA8   E9FZ49   A0A182ILR3   A0A3P9M4E5   R4GGF7   A0A218UX08   A0A1U7S454   A0A151NFI0   A0A2M3ZCC2   A0A3B3IJ86   A0A2I4CYP2   A0A2M4C4U6   A0A182VC15   E3TDP8   A0A2M3ZCD8   A0A1V4JWI7   A0A3B3CWU1   A0A3P8RWE4   A0A3B3SED9   A0NDE4   A0A2R8Q8D7   A0A3B4UVV0   A0A2K5JM35   A0A1I8MBU7   A0A287AUJ0   Q9HD34   M4AUT3   A0A340Y1T5   P82116   A0A067RAW7   A0A0S7HTE1   B3MSG3   A0A2M4CZC2   A0A2U4C5N2   T1DHP7   A0A2K6DQ88   A0A2K6MNX1   A0A2K5TXT0   A0A0D9R4P3   A0A2I3MAL7   A0A2K5MDQ8   H9FMX8   A0A182RYR1   A0A2Y9SKG8   A0A0E9X8C4   L8ITK0   Q0VCG0   A0A2I2Z0B2   A0A2R9A3H3   A0A2I3SE95   A0A2R7WVE7   N6TU46   A0A1A7YW81   A0A2R8MCW8   A0A384C8D0   A0A2I3H651   A0A2K6UTV4   A0A0L0C3T1   K9IGF1   A0A2Y9PAL3   A0A2K5CXV1   A0A3B3XFT7   A0A0P5XQH2   A0A286XEV2   A0A3B0JY32   A0A2Y9KHY1   M3XN76   A0A1W4Z0F0   W5JBU6  

PDB

6NZU     E-value=8.28291e-16,     Score=197

KEGG

101736228    K22069 LYR motif-containing protein 4 | (RefSeq) LYR motif-containing protein 4

GO

GO:0005634   GO:0005739   GO:0016604   GO:0005759   GO:0044281  

Subcellular location

Mitochondrion  
Nucleus  

Length:

88

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00054

Exp number, first 60 AAs:

0.00054

Total prob of N-in:

0.21900

outside

1  -  88

 

 

Pi

430.105169

Theta

210.902502

Tajima's D

3.408876

CLR

0.067463

CSRT

0.993000349982501

Interpretation

Uncertain