Gene

KWMTBOMO00982  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001353

Annotation

PREDICTED:_protein_ERGIC-53_[Bombyx_mori]

Location

Bomo_Chr2(-):7854993-7878027      View in EpiBrowser

Full name

Eukaryotic translation initiation factor 6      

Location in the cell

Cytoplasmic   Reliability : 1.774

CDS

ATGGAGTTTTTAAATTTTAAATTAATTGTGTGTGCGTTTTTATTGTGCCTATTTGTTAGTGTAAACACGCAATCGGTGCACAGACGTTTTGAATACAAATATTCATTCAAACCACCTTATTTAGCGCAAAAAGATGGATCGGTGCCGTTTTGGGAGTATGGTGGAAACGCAATAGCATCAGGGGAGAGCGTCCGTCTCGCGCCGTCGCTTCGAAGCCAGAAGGGGGCTATATGGACCAAACAGCCCATTAACTTTGACTGGTGGGAGGTCGATATCATGTTCAAGATTACCGGCAGAGGCAGAATAGGTGCTGACGGCTTGGCGTTCTGGTATACAACACAGCGAGGCGACTACACCGGCGAAGTGTTCGGCTCGTCAGACAAATGGAACGGTCTCGGAGTCATATTCGATTCTTTCGACAATGACAATAAGCACAACAATCCCTACATCATGGCCGTTGTCAATGACGGCACTAAGGTCTTCGATCACAAGAGTGACGGCACCACTCAGCTCCTGTCCGGATGTCTGCGCGACTTCAGGAACAAGCCGTTCCCGACCCGGGCCAAGATAGAATACTACATGAACACGTTAACTGTCTACTTCCACAACGGAATGACGAACAACGAGCAGGACTACGAGCTGTGCTTCCGCGCCGAGAACGTGGTGCTGCCCCGGGGCGGACACTTCGGTCTGTCGGCCGCCACCGGGGGGCTGGCCGACGACCACGACGTCATCCACTTCCTCACCACCGCTCTCTACTCCACGCAGCAACCAGGCACCCAGCAGATCAGCTCTGATGAACAGCAGAAACTGTCTCAAGAATATCAGGAGTACCAGAAGAAACTGGAACAGCAGAAGGAGGAATACAGGAAGGAACATCCCGATGAGGTGCGCGACAAGGACGGCGAGTTCGACGACTGGTTCGAGTCGGACGGGCAGCGCGAGCTGAGGCAGATCTTCCAAGGACAGGCGCAGATACACGACGTGCTGAGGGACTTGAACAAGAAAGTTGACGAGGTGATTGGCAAACAGATGAACTCCATGTCAATGCTCACGGCAGTGTACAGCCAGGCCCAGGGACAGCCCCAACAGGTCGCCCCGGGACAGATCCCTCAACAGATGCCGAGTATGCCGATCGGCCGCCACGACTGGGACGCGCTGGTGGCCAACAATCAGCTCATGATCAACACCATAGCCGAGCTCAAGGGCTTCGTGATCGAGGTGGCTCGCAAGTCTGACTCGCTGCTGGCGGCCAGCGGCGGTACTGCTGCGGGGGGCGGCATCAACCCTCAGTTCCTGACAGAGTTGAGGGACTCCATCACCAACATCAAGCAGACTGTCGGCGGCGTCTCGCAAAGGTTAATGGCCCAGGCGCAGGTAGCCCCGCCTCCGTGCCCTGCCGCGACCTGCGCTAGTTTCACCGCCATCCTGCTGGTGGCAGCGATGCAATTAGCGCTCATGTTCATATATGCTCTGTACAAAGAGAGGAAAGAGGCCCAAGCAAAGAAATTCTTCTAA

Protein

MEFLNFKLIVCAFLLCLFVSVNTQSVHRRFEYKYSFKPPYLAQKDGSVPFWEYGGNAIASGESVRLAPSLRSQKGAIWTKQPINFDWWEVDIMFKITGRGRIGADGLAFWYTTQRGDYTGEVFGSSDKWNGLGVIFDSFDNDNKHNNPYIMAVVNDGTKVFDHKSDGTTQLLSGCLRDFRNKPFPTRAKIEYYMNTLTVYFHNGMTNNEQDYELCFRAENVVLPRGGHFGLSAATGGLADDHDVIHFLTTALYSTQQPGTQQISSDEQQKLSQEYQEYQKKLEQQKEEYRKEHPDEVRDKDGEFDDWFESDGQRELRQIFQGQAQIHDVLRDLNKKVDEVIGKQMNSMSMLTAVYSQAQGQPQQVAPGQIPQQMPSMPIGRHDWDALVANNQLMINTIAELKGFVIEVARKSDSLLAASGGTAAGGGINPQFLTELRDSITNIKQTVGGVSQRLMAQAQVAPPPCPAATCASFTAILLVAAMQLALMFIYALYKERKEAQAKKFF

Description

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.

Subunit

Monomer. Associates with the 60S ribosomal subunit.

Similarity

Belongs to the eIF-6 family.

Uniprot

A0A194PYY8   A0A2A4JAB8   S4PGA2   A0A212FE18   A0A1E1W8Q4   A0A194RMY0   + More
D6WSC8   A0A1Y1MQ12   W8BG62   A0A2J7RK09   A0A224XLY2   V5GWJ2   A0A0A1XMH2   A0A023EUV5   A0A034VSZ0   A0A182GC94   A0A067RIW2   B4N3T5   A0A1L8E340   A0A1L8E363   A0A1L8E2V6   A0A1L8E2X7   A0A1L8E3K2   A0A0M4ED49   A0A0N8ES37   A0A3L8DWJ3   A0A1Q3G2X8   A0A1Q3G2V0   A0A1Q3G2V9   A0A1Q3G2W2   A0A1Q3G2S8   A0A1Q3G2T4   A0A026WKQ3   R4WCT3   B4K039   A0A232FCH8   A0A2R7W032   A0A0T6BEK3   A0A0M9A0P6   R4FQE8   A0A1W4UFC7   A0A3B0KI44   A0A182NH17   B4LEJ7   A0A1A9YN27   A0A1A9UJE7   A0A084VPY6   A0A1A9WKW6   A0A1A9Z2Q6   E0VAE4   B3M693   A0A182R9V8   B4KZ52   B4PG08   A0A2M4BKX4   D3TL23   A0A1W4X6J4   Q9V3A8   A0A182M0A5   A0A1B6KP40   A0A146M0Q9   A0A2M3YZI6   A0A0L7QN57   A0A1L8EDM7   E2B8X5   A0A1L8EDC7   A0A182XCY2   Q7Q7B2   A0A182TTC0   A0A154PRI4   A0A182LJV7   B4QM42   B3NBR9   A0A1B6GZ86   A0A195CS42   A0A1B6I0V0   A0A1J1ISL9   A0A182ISM2   U5EV65   A0A1B0FLH0   A0A2H8TDE4   K7IPC0   A0A182K100   A0A1I8MB50   J9JJE7   T1PCS7   A0A158NZ29   F4WFN8   E9JDA8   A0A151J0Q9   A0A182QG86   A0A182PJW0   T1E2K7   A0A2M4A293   A0A182HMA9   A0A195BL29   A0A182YQQ1   A0A0J9RRD1   E2AHH9   A0A336LLH2  

Pubmed

26354079    23622113    22118469    18362917    19820115    28004739    + More
24495485    25830018    24945155    25348373    26483478    24845553    17994087    26999592    30249741    24508170    23691247    28648823    24438588    20566863    17550304    20353571    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26823975    20798317    12364791    14747013    17210077    20966253    20075255    25315136    21347285    21719571    21282665    24330624    25244985    22936249   

EMBL

KQ459593    KPI96370.1    NWSH01002278    PCG68706.1    GAIX01003737    JAA88823.1    + More
AGBW02008983    OWR51981.1    GDQN01007813    JAT83241.1    KQ460152    KPJ17356.1    KQ971352    EFA06622.1    GEZM01029617    JAV86046.1    GAMC01008823    JAB97732.1    NEVH01002981    PNF41173.1    GFTR01006824    JAW09602.1    GALX01003853    JAB64613.1    GBXI01002534    JAD11758.1    GAPW01000837    JAC12761.1    GAKP01013378    JAC45574.1    JXUM01053946    JXUM01053947    JXUM01053948    JXUM01053949    KQ561798    KXJ77501.1    KK852657    KDR19213.1    CH964095    EDW79290.1    GFDF01001008    JAV13076.1    GFDF01001010    JAV13074.1    GFDF01001011    JAV13073.1    GFDF01001007    JAV13077.1    GFDF01001009    JAV13075.1    CP012525    ALC43458.1    GDUN01000554    JAN95365.1    QOIP01000003    RLU24870.1    GFDL01000929    JAV34116.1    GFDL01000913    JAV34132.1    GFDL01000911    JAV34134.1    GFDL01000924    JAV34121.1    GFDL01000917    JAV34128.1    GFDL01000918    JAV34127.1    KK107161    EZA56617.1    AK417153    BAN20368.1    CH916386    EDV94287.1    NNAY01000447    OXU28322.1    KK854113    PTY11515.1    LJIG01001168    KRT85772.1    KQ435782    KOX74767.1    ACPB03025435    GAHY01000434    JAA77076.1    OUUW01000009    SPP85426.1    CH940647    EDW69082.2    ATLV01015081    KE525001    KFB40030.1    DS235005    EEB10350.1    CH902618    EDV39713.1    CH933809    EDW17849.1    CM000159    EDW93152.1    GGFJ01004307    MBW53448.1    EZ422117    ADD18318.1    AF223385    AE014296    AY051971    AAF34704.1    AAF50400.1    AAK93395.1    AAO41269.1    AXCM01001750    GEBQ01027003    JAT12974.1    GDHC01005235    JAQ13394.1    GGFM01000926    MBW21677.1    KQ414864    KOC59999.1    GFDG01002126    JAV16673.1    GL446390    EFN87874.1    GFDG01002143    JAV16656.1    AAAB01008960    EAA11908.3    KQ435087    KZC14535.1    CM000363    EDX09725.1    CH954178    EDV50665.1    GECZ01012229    GECZ01002047    JAS57540.1    JAS67722.1    KQ977329    KYN03516.1    GECU01027158    JAS80548.1    CVRI01000059    CRL03199.1    GANO01002017    JAB57854.1    CCAG010009358    CCAG010009359    GFXV01000290    MBW12095.1    ABLF02024368    KA646556    AFP61185.1    ADTU01004533    GL888120    EGI67015.1    GL771866    EFZ09327.1    KQ980591    KYN15207.1    AXCN02000347    GALA01001175    JAA93677.1    GGFK01001447    MBW34768.1    APCN01004387    KQ976444    KYM86232.1    CM002912    KMY98406.1    GL439543    EFN67107.1    UFQT01000007    SSX17483.1   

Proteomes

UP000053268    UP000218220    UP000007151    UP000053240    UP000007266    UP000235965    + More
UP000069940    UP000249989    UP000027135    UP000007798    UP000092553    UP000279307    UP000053097    UP000001070    UP000215335    UP000053105    UP000015103    UP000192221    UP000268350    UP000075884    UP000008792    UP000092443    UP000078200    UP000030765    UP000091820    UP000092445    UP000009046    UP000007801    UP000075900    UP000009192    UP000002282    UP000192223    UP000000803    UP000075883    UP000053825    UP000008237    UP000076407    UP000007062    UP000075902    UP000076502    UP000075882    UP000000304    UP000008711    UP000078542    UP000183832    UP000075880    UP000092444    UP000002358    UP000075881    UP000095301    UP000007819    UP000005205    UP000007755    UP000078492    UP000075886    UP000075885    UP000075840    UP000078540    UP000076408    UP000000311   

Pfam

PF03388   Lectin_leg-like        + More
PF01912   eIF-6

Interpro

IPR013320   ConA-like_dom_sf        + More
IPR033085   LMAN1       
IPR005052   Lectin_leg       
IPR002769   eIF6       

SUPFAM

SSF49899   SSF49899       

CDD

cd00527  IF6

ProteinModelPortal

A0A194PYY8   A0A2A4JAB8   S4PGA2   A0A212FE18   A0A1E1W8Q4   A0A194RMY0   + More
D6WSC8   A0A1Y1MQ12   W8BG62   A0A2J7RK09   A0A224XLY2   V5GWJ2   A0A0A1XMH2   A0A023EUV5   A0A034VSZ0   A0A182GC94   A0A067RIW2   B4N3T5   A0A1L8E340   A0A1L8E363   A0A1L8E2V6   A0A1L8E2X7   A0A1L8E3K2   A0A0M4ED49   A0A0N8ES37   A0A3L8DWJ3   A0A1Q3G2X8   A0A1Q3G2V0   A0A1Q3G2V9   A0A1Q3G2W2   A0A1Q3G2S8   A0A1Q3G2T4   A0A026WKQ3   R4WCT3   B4K039   A0A232FCH8   A0A2R7W032   A0A0T6BEK3   A0A0M9A0P6   R4FQE8   A0A1W4UFC7   A0A3B0KI44   A0A182NH17   B4LEJ7   A0A1A9YN27   A0A1A9UJE7   A0A084VPY6   A0A1A9WKW6   A0A1A9Z2Q6   E0VAE4   B3M693   A0A182R9V8   B4KZ52   B4PG08   A0A2M4BKX4   D3TL23   A0A1W4X6J4   Q9V3A8   A0A182M0A5   A0A1B6KP40   A0A146M0Q9   A0A2M3YZI6   A0A0L7QN57   A0A1L8EDM7   E2B8X5   A0A1L8EDC7   A0A182XCY2   Q7Q7B2   A0A182TTC0   A0A154PRI4   A0A182LJV7   B4QM42   B3NBR9   A0A1B6GZ86   A0A195CS42   A0A1B6I0V0   A0A1J1ISL9   A0A182ISM2   U5EV65   A0A1B0FLH0   A0A2H8TDE4   K7IPC0   A0A182K100   A0A1I8MB50   J9JJE7   T1PCS7   A0A158NZ29   F4WFN8   E9JDA8   A0A151J0Q9   A0A182QG86   A0A182PJW0   T1E2K7   A0A2M4A293   A0A182HMA9   A0A195BL29   A0A182YQQ1   A0A0J9RRD1   E2AHH9   A0A336LLH2  

PDB

1R1Z     E-value=3.08087e-86,     Score=813

KEGG

101737155    K10080 lectin, mannose-binding 1 | (RefSeq) protein ERGIC-53

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0005537   GO:0016021   GO:0006888   GO:0016020   GO:0005793   GO:0007029   GO:0030134   GO:0007030   GO:0005789   GO:0000139   GO:0003743   GO:0042256   GO:0043022   GO:0005730   GO:0043023   GO:0042273   GO:0012505   GO:0005622   GO:0005840   GO:0006412   GO:0007275   GO:0004812   GO:0006418   GO:0004887   GO:0003707  

PANTHER

PTHR12223:SF32  

Subcellular location

Cytoplasm   Shuttles between cytoplasm and nucleus/nucleolus.   With evidence from 1 publications.
Nucleus   Shuttles between cytoplasm and nucleus/nucleolus.   With evidence from 1 publications.
Nucleolus   Shuttles between cytoplasm and nucleus/nucleolus.   With evidence from 1 publications.

SignalP

Position:   1 - 23,         Likelihood:  0.975967

 

 

Length:

505

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

30.96463

Exp number, first 60 AAs:

8.55952000000001

Total prob of N-in:

0.40072

outside

1  -  470

TMhelix

471  -  493

inside

494  -  505

 

 

Pi

284.572934

Theta

167.392865

Tajima's D

2.534592

CLR

0.098165

CSRT

0.946152692365382

Interpretation

Uncertain