Gene

KWMTBOMO00979  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001364

Annotation

PREDICTED:_vacuolar_protein_sorting-associated_protein_53_homolog_[Papilio_xuthus]

Location

Bomo_Chr2(+):7799738-7811273      View in EpiBrowser

Full name

Vacuolar protein sorting-associated protein 53 homolog      

Location in the cell

Nuclear   Reliability : 2.894

CDS

ATGGATTCGAATGATGCTACGGATGATAAAGACAGCGGGCCAGAAGTTCAAATTAACTTTCCGAGTTCCGTAATGAGCCGCATAGAGGAATTAATGGGAGGAACGGAACAGTTCGATAGCGATGACTTTGATGCAGTGGCGTACATCAACAGAGTGTTCCCAACTGAGCAATCTCTTTCTGGAGTGGAAAGTGCTGTGGCTCGCTGTGAATTTAGACTCTCAGGAGTGGAGCAAGATATTAGAAGACTGGTCCGAGCACAGGCTGAACAGAGGGAAGCTGGACAGGAGGCACTAACGGAAGCTCAGAGATGTATAGCAGAGTTAGCTTTGCAGGTCGCGGATATAAACAAGAAAGCTGAAAGAAGCGAAAGCATGGTCAGGGAGATAACTTGCGAGATAAAGCAGTTGGACTGCGCTAAGTGTAATCTGACCGCTGCTATTACCGCCCTCAACCATCTGCACATGCTGGCTGGCGGTGTGGACACCCTCACAACAATGACGAAGAACCGCCAGTACAAGGAAATAGCGTTGCCCATGCAGGCTATTATGGAGGTCTTACAGCACTTTGAATGTTACCGAGACATCCGCGAACTCAGCGTCTTAAGGGATCAAGTGCACTCGATAAGGCACGATTTGGGCAATCAAATATTAGCTGATTTTAAACAAGCCTTTACAGGCGGCAGTAAAAGCAACATAACTCATAGGACGTTATCGGAGGCTTGCGGCGTCGTCGACATCTTAGACCCGAAGGTCAAACAGGATCTGTTAAAGTGGTTCATCAGCATGCAACTACAGGAATACCAGCACCTGTACTCGTCGGAGCAGGAGTGCGCCTGGCTCACTCACATCGAGCGACGGTACGCGTGGCTCAAGAAGCATCTCCTCACGTTCGAAGACACCCTCGGAAATATATTCCCTTACCAGTGGGCTCTGAGCGAGAACATAGCCAGGCAGTTCTGTAAGATCACCTCAACGGAATTAAGCAATCTAATGGCGGCGCGGAGAAACGAATTAGACGTGAAACTGCTGCTGTACGCGATACAGAACACTTATAACTTCGAATTACTGCTGCACAAGAGGTTCACAGGTACAGACCTGAAGCCTGACAATGTAGACACGAACTCTAAACAGCCGTTCGATAATGAAACGAAAGATAACACCGCAGACTCGGACGGCCAGCAGGCGGAAGGCTCGTCCAGCAGTTGGGTCGGGCTGATAGGGTCCTGCTTCGAGCCCTATCTCTCATTGTACATCAACAGTCTGGACTCGAACCTGAGCTCGCTCATCGAGAGATTCGTGCAGGATGCAAAGACGTCGCCCTCTGAAGCCAACATGACCGCCAGTGGTGAAGGGGCCGTCATATCCAGCTGCGCGGATTTGTTCCTCTTCTACAAGAAATGCTTGGTGCAATGCGCCAGGCTCACCACAGGGGAACCGATGCTGGAACTAGCGGGAGTATTCCAGAAGTATCTACGCGAGTACGCCAGCTCTGTGCTGCAAGCTGCCCTGCCCAGGACCAACCCGACGTCCCTCCTCTCGCTGTCGCTAAGTGGCAACACCGTGCCGAGCATAGTCACGAACTTACACACGCTACTCAGAGATGAAGCCGGTAACGTTTCCAGATACACAAAACAGGAAATCTCAAAGATAACAAGCGTGATCACGACCTCGGAGTACTGCCTCGAGACCACGATACATCTGGAGCAGAAACTCAAGGAGAAGGTCAGTCCGAAGCTGTCCGACAAAATCGATTTGACACCGGAACAGGATTTGTTCCACAAGATCATCAGCAACTGCATCCAGATGCTGGTCCAGGACCTGGAGACGGCCTGCGAGCCGGCCCTCCAGAGCATGACCAAGATATCCTGGCTGAGCTTCGACAACGTAGGCGACCAGAGTTCTTACGTGACTCAGATAATAATGCACTTGAAGAACACCGTGCCGAACCTGAGGGACAACTTATCGTCGTCCAGGAAGTACTTCACGCAGTTCTGCATACGATTCGCTAATTCTTTCATACCGAAGTTCATTCAGAACGTGTACAAGTGCAAGCCCATCTCCACGGTCGGCTCTGAGCAGCTGTTGCTTGACACGCACATGCTGAAGACGGCGCTGTTAGAACTACCCTCAATCGGGTCGGAGGTCAAAAGGGCCGCACCCGCAACCTACACGAAAGTCGTCCTCAAGCTGATGACGAAAGCGGAAATGGTTCTCAAATTGGTGATGGCCCCCCTCGAGGGGAATCTGGAGGGGTTCGTCACGCAGTTCGTCAAATTGCTACCGGATTGCTCCTTGGCTGAGTTCCACAAGGTTTTAGACATGAAAGGCGCTAAGCTATCTAAAACTCAGATGAGCAACTTGGATGCTGTCTTCAAGAATGCCTGCAAGTCTGCCGATGTTAAATAG

Protein

MDSNDATDDKDSGPEVQINFPSSVMSRIEELMGGTEQFDSDDFDAVAYINRVFPTEQSLSGVESAVARCEFRLSGVEQDIRRLVRAQAEQREAGQEALTEAQRCIAELALQVADINKKAERSESMVREITCEIKQLDCAKCNLTAAITALNHLHMLAGGVDTLTTMTKNRQYKEIALPMQAIMEVLQHFECYRDIRELSVLRDQVHSIRHDLGNQILADFKQAFTGGSKSNITHRTLSEACGVVDILDPKVKQDLLKWFISMQLQEYQHLYSSEQECAWLTHIERRYAWLKKHLLTFEDTLGNIFPYQWALSENIARQFCKITSTELSNLMAARRNELDVKLLLYAIQNTYNFELLLHKRFTGTDLKPDNVDTNSKQPFDNETKDNTADSDGQQAEGSSSSWVGLIGSCFEPYLSLYINSLDSNLSSLIERFVQDAKTSPSEANMTASGEGAVISSCADLFLFYKKCLVQCARLTTGEPMLELAGVFQKYLREYASSVLQAALPRTNPTSLLSLSLSGNTVPSIVTNLHTLLRDEAGNVSRYTKQEISKITSVITTSEYCLETTIHLEQKLKEKVSPKLSDKIDLTPEQDLFHKIISNCIQMLVQDLETACEPALQSMTKISWLSFDNVGDQSSYVTQIIMHLKNTVPNLRDNLSSSRKYFTQFCIRFANSFIPKFIQNVYKCKPISTVGSEQLLLDTHMLKTALLELPSIGSEVKRAAPATYTKVVLKLMTKAEMVLKLVMAPLEGNLEGFVTQFVKLLPDCSLAEFHKVLDMKGAKLSKTQMSNLDAVFKNACKSADVK

Description

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Acts as component of the EARP complex that is involved in endocytic recycling.

Cofactor

Mn(2+)

Subunit

Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.

Similarity

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Belongs to the VPS53 family.

Keywords

Coiled coil   Complete proteome   Endosome   Golgi apparatus   Membrane   Protein transport   Reference proteome   Transport  

Feature

chain  Vacuolar protein sorting-associated protein 53 homolog

Uniprot

H9IVT3   A0A194PTR3   A0A194RHQ9   A0A212FDA0   A0A2W1BFT3   D2A3P8   + More
A0A067RBC2   A0A2J7PF47   A0A1W4XMU3   A0A1Y1L9F9   T1IEK0   N6URT6   A0A0N0U3P0   A0A0L7RFC1   A0A088A2I1   A0A0A9XAK6   A0A224XIW5   A0A310S573   A0A026X1V8   A0A069DWG6   A0A2R7VYU7   A0A0V0G9Z7   C3Y0K3   A0A154PBP9   A0A232FGE0   K7J7Y8   E2BNX9   A0A1B6E0N4   T1J5E2   A0A195E2P9   F4WYI8   A0A151I2P3   A0A158P1G8   A0A087T6F5   A0A195F4G9   A0A195CSI7   A0A1S3DUQ1   A0A2R5LJE5   A0A293MHW9   K1Q8K0   A0A2T7PHL6   V5HWX5   A0A1B6IVP8   A0A210Q0M7   A0A1L8DW08   V4AJT6   W5KN75   A0A224YSH5   A0A0K8TM60   A0A1L8HG35   A0A3B4DJP8   A0A2R2MS88   A0A218UUP7   F6P6T6   Q5ZLD7   A0A226NXN2   E7FAG0   A0A0P5PA70   A0A1L8H870   A0A164QN31   A0A1V4K267   A0A2G8LEP1   A0A0P5XBY7   A0A2S2QG09   W5MAP0   A0A3P9IQV4   V9KCP0   A0A0L0CG23   A0A087R014   A0A087VBJ9   A0A091UMF0   A0A091T6J2   A0A093N8A2   A0A336KA85   A0A093FJA0   A0A091HX73   A0A3P9LFR0   A0A1B0DEF8   E9G261   A0A091UDH5   A0A091M7V2   G3P0E5   A0A1W4YID7   A0A091P9A8   A0A091L0K2   A0A151NAC3   A0A2D0SUY7   A0A091EJD6   F6WN34   R0K9M1   A0A093JN66   A0A093JHW5   M7CAR2   H3APE0   A0A2K5D0V0   U3JT97   A0A091KGI8   A0A1A7XDJ7   L5LLT4   A0A091H6I2  

Pubmed

19121390    26354079    22118469    28756777    18362917    19820115    + More
24845553    28004739    23537049    25401762    26823975    24508170    26334808    18563158    28648823    20075255    20798317    21719571    21347285    22992520    25765539    28812685    23254933    25329095    28797301    26369729    27762356    23594743    15642098    24621616    29023486    17554307    24402279    26108605    21292972    22293439    17495919    23624526    9215903   

EMBL

BABH01038060    KQ459593    KPI96363.1    KQ460152    KPJ17363.1    AGBW02009096    + More
OWR51697.1    KZ150094    PZC73648.1    KQ971348    EFA04902.1    KK852571    KDR21126.1    NEVH01026085    PNF14951.1    GEZM01061827    JAV70302.1    ACPB03014069    APGK01019131    KB740092    ENN81447.1    KQ435881    KOX69808.1    KQ414601    KOC69677.1    GBHO01026943    GBRD01003331    GDHC01018923    JAG16661.1    JAG62490.1    JAP99705.1    GFTR01008036    JAW08390.1    KQ771508    OAD52537.1    KK107024    EZA62262.1    GBGD01000521    JAC88368.1    KK854169    PTY12509.1    GECL01001249    JAP04875.1    GG666478    EEN66276.1    KQ434869    KZC09263.1    NNAY01000231    OXU29836.1    GL449511    EFN82571.1    GEDC01014517    GEDC01005827    JAS22781.1    JAS31471.1    JH431859    KQ979709    KYN19440.1    GL888450    EGI60720.1    KQ976538    KYM81313.1    ADTU01006541    KK113646    KFM60694.1    KQ981852    KYN34979.1    KQ977305    KYN03673.1    GGLE01005544    MBY09670.1    GFWV01020569    MAA45297.1    JH818600    EKC30298.1    PZQS01000004    PVD32916.1    GANP01005495    JAB78973.1    GECU01016692    JAS91014.1    NEDP02005302    OWF42265.1    GFDF01003464    JAV10620.1    KB201305    ESO97342.1    GFPF01009411    MAA20557.1    GDAI01002159    JAI15444.1    CM004468    OCT95053.1    MUZQ01000126    OWK57356.1    BX908796    AJ719797    AWGT02000338    OXB71889.1    GDIQ01131476    JAL20250.1    CM004469    OCT92293.1    LRGB01002384    KZS07903.1    LSYS01005108    OPJ78526.1    MRZV01000103    PIK58739.1    GDIP01074339    JAM29376.1    GGMS01007418    MBY76621.1    AHAT01005740    JW863462    AFO95979.1    JRES01000438    KNC31196.1    KL226004    KFM06818.1    KL487157    KFO09991.1    KL409726    KFQ91547.1    KK440511    KFQ70049.1    KL224565    KFW61233.1    UFQS01000107    UFQT01000107    SSW99683.1    SSX20063.1    KK628337    KFV54369.1    KL217847    KFO99742.1    AJVK01032716    AJVK01032717    AJVK01032718    GL732530    EFX86362.1    KK426351    KFQ87860.1    KK524251    KFP67556.1    KK654874    KFQ04190.1    KK549994    KFP33494.1    AKHW03003672    KYO33760.1    KK718508    KFO57181.1    KB742569    EOB06971.1    KL206227    KFV80179.1    KK609846    KFW11467.1    KB521250    EMP37747.1    AFYH01008281    AFYH01008282    AFYH01008283    AFYH01008284    AFYH01008285    AFYH01008286    AFYH01008287    AFYH01008288    AFYH01008289    AFYH01008290    AGTO01000875    KK744034    KFP39669.1    HADW01014530    HADX01007053    SBP15930.1    KB110620    ELK26971.1    KL526823    KFO91451.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000007266    UP000027135    + More
UP000235965    UP000192223    UP000015103    UP000019118    UP000053105    UP000053825    UP000005203    UP000053097    UP000001554    UP000076502    UP000215335    UP000002358    UP000008237    UP000078492    UP000007755    UP000078540    UP000005205    UP000054359    UP000078541    UP000078542    UP000079169    UP000005408    UP000245119    UP000242188    UP000030746    UP000018467    UP000186698    UP000261440    UP000085678    UP000197619    UP000000437    UP000000539    UP000198419    UP000076858    UP000190648    UP000230750    UP000018468    UP000265200    UP000037069    UP000053286    UP000053283    UP000054081    UP000054308    UP000265180    UP000092462    UP000000305    UP000007635    UP000192224    UP000050525    UP000221080    UP000052976    UP000002280    UP000053584    UP000031443    UP000008672    UP000233020    UP000016665   

PRIDE

H9IVT3    V5HWX5    Q5ZLD7   

Pfam

PF04100   Vps53_N        + More
PF00652   Ricin_B_lectin
PF00535   Glycos_transf_2
PF16854   VPS53_C

Interpro

IPR039766   Vps53        + More
IPR007234   Vps53_N       
IPR001173   Glyco_trans_2-like       
IPR029044   Nucleotide-diphossugar_trans       
IPR000772   Ricin_B_lectin       
IPR035992   Ricin_B-like_lectins       
IPR031745   Vps53_C       
IPR038260   Vps53_C_sf       

SUPFAM

SSF50370   SSF50370        + More
SSF53448   SSF53448       

Gene 3D

3.90.550.10     1.10.357.110    

CDD

cd00161  RICIN

ProteinModelPortal

H9IVT3   A0A194PTR3   A0A194RHQ9   A0A212FDA0   A0A2W1BFT3   D2A3P8   + More
A0A067RBC2   A0A2J7PF47   A0A1W4XMU3   A0A1Y1L9F9   T1IEK0   N6URT6   A0A0N0U3P0   A0A0L7RFC1   A0A088A2I1   A0A0A9XAK6   A0A224XIW5   A0A310S573   A0A026X1V8   A0A069DWG6   A0A2R7VYU7   A0A0V0G9Z7   C3Y0K3   A0A154PBP9   A0A232FGE0   K7J7Y8   E2BNX9   A0A1B6E0N4   T1J5E2   A0A195E2P9   F4WYI8   A0A151I2P3   A0A158P1G8   A0A087T6F5   A0A195F4G9   A0A195CSI7   A0A1S3DUQ1   A0A2R5LJE5   A0A293MHW9   K1Q8K0   A0A2T7PHL6   V5HWX5   A0A1B6IVP8   A0A210Q0M7   A0A1L8DW08   V4AJT6   W5KN75   A0A224YSH5   A0A0K8TM60   A0A1L8HG35   A0A3B4DJP8   A0A2R2MS88   A0A218UUP7   F6P6T6   Q5ZLD7   A0A226NXN2   E7FAG0   A0A0P5PA70   A0A1L8H870   A0A164QN31   A0A1V4K267   A0A2G8LEP1   A0A0P5XBY7   A0A2S2QG09   W5MAP0   A0A3P9IQV4   V9KCP0   A0A0L0CG23   A0A087R014   A0A087VBJ9   A0A091UMF0   A0A091T6J2   A0A093N8A2   A0A336KA85   A0A093FJA0   A0A091HX73   A0A3P9LFR0   A0A1B0DEF8   E9G261   A0A091UDH5   A0A091M7V2   G3P0E5   A0A1W4YID7   A0A091P9A8   A0A091L0K2   A0A151NAC3   A0A2D0SUY7   A0A091EJD6   F6WN34   R0K9M1   A0A093JN66   A0A093JHW5   M7CAR2   H3APE0   A0A2K5D0V0   U3JT97   A0A091KGI8   A0A1A7XDJ7   L5LLT4   A0A091H6I2  

KEGG

101746290    K20299 vacuolar protein sorting-associated protein 53 | (RefSeq) vacuolar protein sorting-associated

GO

GO:0005829   GO:0042147   GO:0000938   GO:0016757   GO:0030246   GO:0006486   GO:0016021   GO:0032456   GO:0007041   GO:0010008   GO:1990745   GO:0015031   GO:0055037   GO:0005802   GO:0048471   GO:0016020  

PANTHER

PTHR12820  

Subcellular location

Golgi apparatus   Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.   With evidence from 1 publications.
trans-Golgi network membrane   Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.   With evidence from 1 publications.
Endosome membrane   Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.   With evidence from 1 publications.
Recycling endosome   Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.   With evidence from 1 publications.

Length:

801

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0835800000000004

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00407

outside

1  -  801

 

 

Pi

197.56881

Theta

166.418846

Tajima's D

1.222821

CLR

0.024094

CSRT

0.71776411179441

Interpretation

Uncertain