Gene

KWMTBOMO00954  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009808

Annotation

PREDICTED:_putative_adenosylhomocysteinase_3_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr2(+):7122316-7142730      View in EpiBrowser

Full name

Adenosylhomocysteinase       + More
Adenosylhomocysteinase-like 1      

Alternative Name

Inactive S-adenosyl-L-homocysteine hydrolase
S-adenosylhomocysteine hydrolase-like protein 1

Location in the cell

Cytoplasmic   Reliability : 2.488

CDS

ATGTCGAAAGGCGGTATCTTAAAAGGCGAAACAAAACAAAGCGTGAAGAAGCGGCATTCTCTGATTTCGACAAAGAGCGAATGGTCATCTTCAGATGAAGACGAAGGAGCACAGCCCCACGAGAAAGCCATAGCGGCCGGTCAGCCCAACCCACCTTATTGTGTGAGGAATATAGAGCAAAACGCCTTCGGTCGGCGGGAGATTGAGATCGCAGAGCAAGAGATGCCAGGGATCATGGCACTGCGTGCCAGAGCCAAGGACGATAAACCTTTGAAAGATGCCAAGATCGTTGGTTGTACGCACATCAACGCTCAGACAGCGGTTCTGATTGAAACCCTGGCCGCGTTGGGAGCCACCGTGCGCTGGGCCGCCTGCAACATTTACAGCACCCAGAACGAAGTGGCCGCCGCCTTAGCGCACGCGGGTTACGCGATATTCGCGTGGCGCGGCGAAAGCGAGGAGGCTTTCTGGTGGTGCATCGACCAGTGCTGCACCCCGACGGCGACGTGGCAGCCCAACATGATCCTAGACGACGGAGGTGATGCCACGCACCTCATGCTCAAGAAACACGGAGCCGCCTTCAAGAATATCAAAGGTATAGTAGAGGAGAGCGTGACGGGAGTCCATCGGCTCTATCAGCTCAGTAAAGCGGGCAAGCTCTGCGTGCCGGCGATGAACGTGAATGACTCTGTGACGAAAACGAAATTTGATAATTTATATTCATGTCGAGAAAGCATAATAGACGCGTTAAAACGTAGCACGGACTTGATGTTTGGCGGCAAACAGTCTGTGGTGTGCGGTTACGGGGAGGTAGGAAAGGGATGCTGTCAGGCCCTCAAGGCCCTCGGGTGCGTGGTGTACGTCACGGAAATCGATCCGATATGCGCCCTGCAGGCTGCCATGGACGGCTTCCGGGTCGTCAAACTCAACGAGGTCATAAGGCAGGTGGATATCGTGATCACGGCGACGGGAAATAAAGGCGTGGTGACGCGGGAGCACATGGAGAGGATGAAGAATGGCTGCGTGGTGTGCAACATGGGCCACAGCAACACCGAGATCGACGTGTACGCCCTGAAGACCCCAGATTTACTGTGGGAGAGGGTCCGCAGCCAGGTGGACCACATAATATGGCCGAACGGCAAACGCATCGTGCTGCTGGCCGAAGGGAGACTAGCGAACCTCTGCTGCTCCTCCTTACCCTCGTTCGTGGTGTCCGTGACCGCGGCCACCCAGGCCCTGGCCCTCATCGAGCTGTACAACGCGCCCAACCAGAGGTACAAGGCCGATGTTTATTTACTACCGAAGAAAATGGACGAATACGTCGCCAGCCTCCACCTGCCGACCTTCGACGCTCATCTCACCGAGTTAACGGACGAGCAAGCGAAATACCTCGGTCTCAACAAAGTCGGCCCGTTCAAACCTAATTACTATAGATACTAA

Protein

MSKGGILKGETKQSVKKRHSLISTKSEWSSSDEDEGAQPHEKAIAAGQPNPPYCVRNIEQNAFGRREIEIAEQEMPGIMALRARAKDDKPLKDAKIVGCTHINAQTAVLIETLAALGATVRWAACNIYSTQNEVAAALAHAGYAIFAWRGESEEAFWWCIDQCCTPTATWQPNMILDDGGDATHLMLKKHGAAFKNIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKTKFDNLYSCRESIIDALKRSTDLMFGGKQSVVCGYGEVGKGCCQALKALGCVVYVTEIDPICALQAAMDGFRVVKLNEVIRQVDIVITATGNKGVVTREHMERMKNGCVVCNMGHSNTEIDVYALKTPDLLWERVRSQVDHIIWPNGKRIVLLAEGRLANLCCSSLPSFVVSVTAATQALALIELYNAPNQRYKADVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKVGPFKPNYYRY

Description

Might play a role in the regulation of methionine metabolism possibly by binding and inactivating Ahcy.

Catalytic Activity

H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine

Cofactor

NAD(+)

Subunit

Interacts with Ahcy; the interaction may negatively regulate Ahcy catalytic activity.

Similarity

Belongs to the adenosylhomocysteinase family.

Keywords

Complete proteome   NAD   One-carbon metabolism   Reference proteome  

Feature

chain  Adenosylhomocysteinase-like 1

Uniprot

H9JJV7   A0A194PV76   A0A2A4J7Z0   A0A0N1IPS8   E9IY47   E2A9N0   + More
A0A0J7L0H2   A0A3L8DGY3   A0A154PN64   A0A195BQ05   A0A087ZTP9   A0A2A3ECJ8   A0A026WCS3   A0A195CZQ0   K7IY01   A0A232F080   A0A1B6KUW3   A0A0L7RBS6   A0A0C9PP62   A0A195EF15   F4WQS6   A0A195ESL2   A0A0C9RFQ2   E2C5J6   A0A1W4X3X7   A0A1B6MML8   A0A1B6EU97   A0A336LTI0   A0A1W4X2R5   A0A1B6LC53   A0A1B6LEW7   A0A151X3G4   A0A1B6BY01   A0A1B6DFP7   A0A0C9QXR0   T1WH07   A0A0P4VQ25   A0A023F6V5   A0A067R7M8   E0VN64   A0A224XN21   A0A0V0G644   A0A0T6ATP6   A0A146LRX9   T1PGB8   A0A0K8TTC2   A0A1I8MQ55   A0A023G3H2   V5I095   A0A1I8NVP5   A0A0P4VWT9   A0A1A9WD34   A0A1B0FB59   A0A1A9XQX3   A0A1A9UP39   A0A1B0ANS9   A0A1J1IF60   A0A1A9ZC07   A0A023FTB8   B4IXV3   A0A1S6KZB6   A0A1L8DZJ4   B4LBA6   B4KVE3   A0A0M4EFH0   A0A0K8VIM5   A0A034VG52   A0A023FEK5   W8B278   B4N2Z9   A0A224YSH6   A0A131YGJ4   A0A1E1X3W2   B3M7H8   B4QNL7   B5DP84   A0A131XS85   B3NEZ6   A0A1W4W1H7   A0A1D2NAK0   B4HTG3   B4PDB7   Q9VZX9   A0A226E7E8   A0A2R5L861   A0A0M8ZTI7   A0A3B0KI33   A0A293M2X2   A0A1S3JWD0   A0A210R3S1   A0A0L8HLB5   A0A1S3JXE6   A0A1S3JXH3   A0A1S3JWR1   A0A1S3JXG6   K1S4H5   A0A3P9JZJ3   A0A3P9GYB8   H2M594   A0A3P9LN00  

EC Number

3.3.1.1

Pubmed

19121390    26354079    21282665    20798317    30249741    24508170    + More
20075255    28648823    21719571    23973411    27129103    25474469    24845553    20566863    26823975    26369729    25315136    25765539    17994087    24330026    25348373    24495485    28797301    26830274    28503490    22936249    15632085    28049606    27289101    17550304    10731132    12537572    27313316    28812685    22992520    17554307   

EMBL

BABH01017875    KQ459593    KPI96659.1    NWSH01002481    PCG68205.1    KQ460296    + More
KPJ16277.1    GL766908    EFZ14493.1    GL437918    EFN69832.1    LBMM01001449    KMQ96292.1    QOIP01000008    RLU19707.1    KQ434977    KZC12904.1    KQ976424    KYM88585.1    KZ288291    PBC29204.1    KK107274    EZA53738.1    KQ977041    KYN06135.1    NNAY01001442    OXU23963.1    GEBQ01024742    JAT15235.1    KQ414617    KOC68211.1    GBYB01002973    JAG72740.1    KQ978983    KYN26833.1    GL888275    EGI63439.1    KQ981993    KYN30897.1    GBYB01011972    JAG81739.1    GL452770    EFN76809.1    GEBQ01002797    JAT37180.1    GECZ01028289    JAS41480.1    UFQT01000184    SSX21225.1    GEBQ01018715    JAT21262.1    GEBQ01017732    JAT22245.1    KQ982562    KYQ54931.1    GEDC01031374    GEDC01027851    JAS05924.1    JAS09447.1    GEDC01012863    GEDC01009275    JAS24435.1    JAS28023.1    GBYB01000475    JAG70242.1    KC579453    KP689346    AGU16824.1    AKO63328.1    GDKW01002022    JAI54573.1    GBBI01001752    JAC16960.1    KK852888    KDR14336.1    DS235332    EEB14784.1    GFTR01007005    JAW09421.1    GECL01002569    JAP03555.1    LJIG01022833    KRT78482.1    GDHC01008048    JAQ10581.1    KA647734    AFP62363.1    GDAI01000192    JAI17411.1    GBBM01007064    JAC28354.1    GANP01002071    JAB82397.1    GDRN01090752    JAI60418.1    CCAG010006108    JXJN01000945    CVRI01000048    CRK98851.1    GBBL01002641    JAC24679.1    CH916366    EDV96474.1    KC223174    AQT27077.1    GFDF01002196    JAV11888.1    CH940647    EDW69694.1    CH933809    EDW18386.1    CP012525    ALC43630.1    ALC44696.1    GDHF01013575    JAI38739.1    GAKP01017860    JAC41092.1    GBBK01005168    JAC19314.1    GAMC01011316    GAMC01011315    JAB95240.1    CH964062    EDW78738.1    GFPF01005788    MAA16934.1    GEDV01010114    JAP78443.1    GFAC01005467    JAT93721.1    CH902618    EDV39876.1    CM000363    CM002912    EDX08980.1    KMY97194.1    CH379068    EDY73335.2    GEFH01000150    JAP68431.1    CH954178    EDV50338.1    LJIJ01000129    ODN02016.1    CH480817    EDW50234.1    CM000159    EDW93897.1    AE014296    BT057981    BT010277    AAQ23595.1    ACM16691.1    LNIX01000006    OXA53278.1    GGLE01001546    MBY05672.1    KQ435851    KOX70825.1    OUUW01000009    SPP85416.1    GFWV01009649    GFWV01021436    MAA34378.1    NEDP02000506    OWF55720.1    KQ417897    KOF89929.1    JH816160    EKC42316.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000000311    UP000036403    + More
UP000279307    UP000076502    UP000078540    UP000005203    UP000242457    UP000053097    UP000078542    UP000002358    UP000215335    UP000053825    UP000078492    UP000007755    UP000078541    UP000008237    UP000192223    UP000075809    UP000027135    UP000009046    UP000095301    UP000095300    UP000091820    UP000092444    UP000092443    UP000078200    UP000092460    UP000183832    UP000092445    UP000001070    UP000008792    UP000009192    UP000092553    UP000007798    UP000007801    UP000000304    UP000001819    UP000008711    UP000192221    UP000094527    UP000001292    UP000002282    UP000000803    UP000198287    UP000053105    UP000268350    UP000085678    UP000242188    UP000053454    UP000005408    UP000265180    UP000265200    UP000001038   

PRIDE

H9JJV7    Q9VZX9   

Pfam

PF05221   AdoHcyase        + More
PF00670   AdoHcyase_NAD
PF01607   CBM_14

Interpro

IPR020082   S-Ado-L-homoCys_hydrolase_CS        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR015878   Ado_hCys_hydrolase_NAD-bd       
IPR042172   Adenosylhomocyst_ase-like_sf       
IPR000043   Adenosylhomocysteinase-like       
IPR002557   Chitin-bd_dom       
IPR036508   Chitin-bd_dom_sf       

SUPFAM

SSF51735   SSF51735        + More
SSF57625   SSF57625       

Gene 3D

3.40.50.1480    

CDD

cd00401  SAHH

ProteinModelPortal

H9JJV7   A0A194PV76   A0A2A4J7Z0   A0A0N1IPS8   E9IY47   E2A9N0   + More
A0A0J7L0H2   A0A3L8DGY3   A0A154PN64   A0A195BQ05   A0A087ZTP9   A0A2A3ECJ8   A0A026WCS3   A0A195CZQ0   K7IY01   A0A232F080   A0A1B6KUW3   A0A0L7RBS6   A0A0C9PP62   A0A195EF15   F4WQS6   A0A195ESL2   A0A0C9RFQ2   E2C5J6   A0A1W4X3X7   A0A1B6MML8   A0A1B6EU97   A0A336LTI0   A0A1W4X2R5   A0A1B6LC53   A0A1B6LEW7   A0A151X3G4   A0A1B6BY01   A0A1B6DFP7   A0A0C9QXR0   T1WH07   A0A0P4VQ25   A0A023F6V5   A0A067R7M8   E0VN64   A0A224XN21   A0A0V0G644   A0A0T6ATP6   A0A146LRX9   T1PGB8   A0A0K8TTC2   A0A1I8MQ55   A0A023G3H2   V5I095   A0A1I8NVP5   A0A0P4VWT9   A0A1A9WD34   A0A1B0FB59   A0A1A9XQX3   A0A1A9UP39   A0A1B0ANS9   A0A1J1IF60   A0A1A9ZC07   A0A023FTB8   B4IXV3   A0A1S6KZB6   A0A1L8DZJ4   B4LBA6   B4KVE3   A0A0M4EFH0   A0A0K8VIM5   A0A034VG52   A0A023FEK5   W8B278   B4N2Z9   A0A224YSH6   A0A131YGJ4   A0A1E1X3W2   B3M7H8   B4QNL7   B5DP84   A0A131XS85   B3NEZ6   A0A1W4W1H7   A0A1D2NAK0   B4HTG3   B4PDB7   Q9VZX9   A0A226E7E8   A0A2R5L861   A0A0M8ZTI7   A0A3B0KI33   A0A293M2X2   A0A1S3JWD0   A0A210R3S1   A0A0L8HLB5   A0A1S3JXE6   A0A1S3JXH3   A0A1S3JWR1   A0A1S3JXG6   K1S4H5   A0A3P9JZJ3   A0A3P9GYB8   H2M594   A0A3P9LN00  

PDB

3GVP     E-value=0,     Score=1888

KEGG

101737039    K01251 adenosylhomocysteinase [EC:3.3.1.1] | (RefSeq) putative adenosylhomocysteinase 3

PATHWAY

00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004013   GO:0006730   GO:0006030   GO:0008061   GO:0005576   GO:0019510   GO:0005829   GO:0016787   GO:0033353   GO:0051287   GO:0007275   GO:0004812   GO:0006418   GO:0004887   GO:0003707   GO:0016021  

PANTHER

PTHR23420  

Length:

479

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.58565

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00296

outside

1  -  479

 

 

Pi

284.713288

Theta

150.101655

Tajima's D

2.431592

CLR

0.010463

CSRT

0.934353282335883

Interpretation

Uncertain