Gene

KWMTBOMO00913

Pre Gene Modal

BGIBMGA009650

Annotation

PREDICTED:_mothers_against_decapentaplegic_homolog_3_[Papilio_polytes]

Location

Bomo_Chr2(-):6250268-6265506      View in EpiBrowser

Full name

Mothers against decapentaplegic homolog       + More
Mothers against decapentaplegic homolog 3      

Alternative Name

SMAD family member
SMAD family member 3

Transcription factor

MH1

Location in the cell

Nuclear   Reliability : 2.556

CDS

ATGTTCCCGTTAACTCCGCCGGTCGTGAAGCGATTGTTGGGCTGGAAAAAAGGACCCGAGGGATCGTCGGCCGCAGAAGATAAATGGTCCGAGAAGGCCGTAAAGAGTTTGGTAAAAAAATTAAAGAAAAGCGGGGCTTTAGAAGAGTTAGAAAGGGCAATCTCGAGTCAGAACAGTCATACGAAATGCGTTACGATACCCAGGGTGAAGCCGAATGAGAGTGGCATCAACGGACAGTACAGGAAAGGCCTACCGCATGTGGTTTACTGCAGACTCTGGCGTTGGCCTCAGTTACAGAGCCAACATGAACTGAAGCCAGTGGACCATTGCGAGTATGCATACCAGCTGAAGAAGGACGAGGTGTGCATTAATCCCTATCATTACAACAAAATCGATTCGCCTGCTCTTCCCCCGATCCTGGTGCGTCGCTGTAGCGAGGGCGAGGTCCGCGCCCCTCCGCCCTACGCCGACTACCACCAGCCAATACTGCACGAGCACCCTGACGTTGCCATGCAGTCTGGTACAGGACACAGCGCACTGTATCTCGAGGCTACACTTGCACAACACGTGCCGGGCAACACAACTGTACACGTGAGCTCCTCAACAGTGGAGACTCCGCCCCCAGGCTACATCAGCGAAGATGGAGACCCGATGGACCACAATGACAACATGAACCTCACACGTCTAAGTCCGTCACCTGGCGGCCTGGCGTCCGAGGCCTCGCCGGTGCTGTACCACGAGCCGGCGTTCTGGTGCAGCATCAGCTACTACGAGCTGAACACCAGGGTCGGGGAGACGTTCCACGCCTCGCAACCTTCCATCACGGTCGACGGATTCACCGACCCGAGCAATAGTGAGAGATTTTGTCTCGGCCTGCTTTCGAACGTGAACAGGAACGAAGTCGTCGAGCAAACGCGCAGACACATCGGGAAAGGAGTCCGGCTGTATTATATAGGGGGTGAGGTCTTCGCGGAGTGCCTGAGCGACTCCTCGATATTCGTGCAGAGTCCGAACTGCAACCAGCGCTATGGCTGGCATCCGGCCACCGTTTGTAAAATACCACCAGGTTGCAACTTGAAGATATTTAATAATCAAGAATTCGCGGCCCTCCTGTCGCAGTCGGTCTCGCAGGGGTTCGAAGCCGTCTTCCAGCTGACCAGGATGTGCACAATACGAATGAGCTTCGTCAAGGGGTGGGGGGCTGAATACAGACGGCAAACTGTAACTTCAACTCCGTGTTGGATCGAGCTGCATCTCAACGGTCCTCTGCAGTGGCTGGACAGAGTCCTCACACAGATGGGCTCTCCGCGTCTGCCGTGCTCCTCTATGTCCTAG

Protein

MFPLTPPVVKRLLGWKKGPEGSSAAEDKWSEKAVKSLVKKLKKSGALEELERAISSQNSHTKCVTIPRVKPNESGINGQYRKGLPHVVYCRLWRWPQLQSQHELKPVDHCEYAYQLKKDEVCINPYHYNKIDSPALPPILVRRCSEGEVRAPPPYADYHQPILHEHPDVAMQSGTGHSALYLEATLAQHVPGNTTVHVSSSTVETPPPGYISEDGDPMDHNDNMNLTRLSPSPGGLASEASPVLYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVFQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS

Description

Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity).

Subunit

Interacts with SARA (SMAD anchor for receptor activation); form trimers with another SMAD3 and the co-SMAD SMAD4.

Similarity

Belongs to the dwarfin/SMAD family.

Keywords

Complete proteome   Cytoplasm   DNA-binding   Metal-binding   Nucleus   Phosphoprotein   Reference proteome   Transcription   Transcription regulation   Zinc  

Feature

chain  Mothers against decapentaplegic homolog 3

Uniprot

H9JJE9   A0A220QT60   A0A2H1VIR2   A0A194PTI1   A0A212F8N9   A0A0N1IH69   + More
U5EXD3   A0A1L8DMQ0   F8V242   A0A067QRP6   K7IP92   A0A195ET96   A0A158NVW1   A0A336LKU2   A0A0K8TML2   A0A0L7RBH0   A0A1E1XLS3   A0A1E1XFN2   A0A131Z076   A0A131XW48   E9G7J0   A0A131YYC5   A0A1B6KEL6   A0A2R5LI54   A0A1B6GH93   A0A087T8C0   A0A3B5KT50   A0A3B3XI70   M3ZMX8   J7FXQ7   A0A315W4G7   A0A087XSS2   A0A3B3DUI3   A0A3B3TZU3   A0A3P9P210   A0A3B5BG60   C3Y6V2   A0A142EFR7   A0A0F8CFE8   A0A3B4YLL3   A0A3B4TX57   A0A3P8TX98   A0A091EAG3   A0A0F7ZD79   A0A3P8PYH6   A0A3P8VEX9   A0A3B3CNI8   H2MLR1   A0A3P9J8K3   A0A3P8VN55   A0A3B5AWN7   I3KEB1   Q8AY15   A0A0P7V3D6   A0A1S3K8S6   A0A1V4JDJ5   A0A0Q3PU66   P84023   A0A3B4XS14   A0A3B4TGC7   A0A146Z4J3   A0A091GFE6   F6S0M0   A0A218V0C7   U3KEJ5   A0A3P9ILG9   H2LR51   A0A1A8LN14   A0A1A8VDT5   A0A1A8QAR2   A0A091TN31   A0A1A7X9E8   A0A1A7Z463   B2XS64   A0A1A8IPB1   A0A093JC11   A0A1S3K891   G3PJ40   A0A3P8VEY6   A0A3B4ZAV1   A0A384C4Z0   A0A1L8DLE1   A0A099YXV9   A0A091GCW3   A0A1U7TYB8   A0A2I4BN26   A0A091SZL2   A0A091PJT1   E0VAB2   A0A3B5KD16   H2UPJ8   A0A096MCX0   Q68EP5   A2PZA6   A0A1A8DS60   A0A1A8UG63   F6UYG1   Q90YE5   A0A1L8GSA7   A0A1A8MZ22  

Pubmed

19121390    26354079    22118469    21627820    24845553    20075255    + More
21347285    26369729    29209593    28503490    26830274    29652888    21292972    23542700    29703783    29451363    18563158    25835551    24487278    17554307    25186727    23594743    17495919    18330479    24813606    20566863    21551351    17101124    19892987    11404094    27762356   

EMBL

BABH01017772    BABH01017773    KY328719    ASK12087.1    ODYU01002789    SOQ40717.1    + More
KQ459593    KPI96622.1    AGBW02009700    OWR50091.1    KQ460280    KPJ16324.1    GANO01000124    JAB59747.1    GFDF01006440    JAV07644.1    JN006979    AEI25997.1    KK853098    KDR11392.1    KQ981993    KYN31104.1    ADTU01027543    ADTU01027544    ADTU01027545    ADTU01027546    ADTU01027547    ADTU01027548    UFQT01000004    SSX17279.1    GDAI01002195    JAI15408.1    KQ414617    KOC68091.1    GFAA01003398    JAU00037.1    GFAC01001108    JAT98080.1    GEDV01004375    JAP84182.1    GEFM01004283    GEGO01001769    JAP71513.1    JAR93635.1    GL732534    EFX84472.1    GEDV01004374    JAP84183.1    GEBQ01030077    JAT09900.1    GGLE01004969    MBY09095.1    GECZ01007957    JAS61812.1    KK113918    KFM61359.1    JX103494    AFP57672.1    NHOQ01000384    PWA30499.1    AYCK01006720    GG666488    EEN64062.1    KT900137    AMQ47456.1    KQ042192    KKF18150.1    KK717966    KFO53469.1    GBEX01001891    JAI12669.1    AERX01005350    CR352307    CR927368    BC129150    AY134492    AAI29151.1    AAN08606.1    JARO02004087    KPP69180.1    LSYS01007908    OPJ70323.1    LMAW01000980    KQK84747.1    AY391265    GCES01025591    JAR60732.1    KL448190    KFO81115.1    MUZQ01000079    OWK59419.1    AGTO01000581    HAEF01008251    SBR46235.1    HAEJ01017569    SBS58026.1    HAEH01010710    SBR90407.1    KK457768    KFQ77398.1    HADW01013034    SBP14434.1    HADW01004168    HADX01015072    SBP37304.1    EU137731    ABX57736.1    HAED01012719    SBQ99117.1    KL205903    KFV76434.1    GFDF01006822    JAV07262.1    KL887587    KGL74979.1    KL448063    KFO79778.1    KK491972    KFQ63773.1    KK675067    KFQ08157.1    DS235005    EEB10318.1    AYCK01014919    BC080156    AAH80156.1    AB267397    BAF45857.1    HAEA01007174    SBQ35654.1    HADY01018552    HAEJ01005666    SBS46123.1    BC169420    BC170316    AJ311059    CM004470    AAI69420.1    CAC38118.1    OCT89841.1    CM004471    OCT86733.1    HAEF01020939    HAEG01013589    SBR62098.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000027135    UP000002358    + More
UP000078541    UP000005205    UP000053825    UP000000305    UP000054359    UP000261380    UP000261480    UP000002852    UP000028760    UP000261560    UP000261500    UP000242638    UP000261400    UP000001554    UP000261360    UP000261420    UP000265080    UP000052976    UP000265100    UP000265120    UP000001038    UP000265180    UP000265200    UP000005207    UP000000437    UP000034805    UP000192224    UP000085678    UP000190648    UP000051836    UP000000539    UP000053760    UP000002280    UP000197619    UP000016665    UP000053584    UP000007635    UP000261680    UP000291021    UP000053641    UP000189704    UP000192220    UP000009046    UP000005226    UP000002281    UP000186698   

PRIDE

H9JJE9   

Pfam

PF03165   MH1        + More
PF03166   MH2

Interpro

IPR017855   SMAD-like_dom_sf        + More
IPR013019   MAD_homology_MH1       
IPR001132   SMAD_dom_Dwarfin-type       
IPR036578   SMAD_MH1_sf       
IPR008984   SMAD_FHA_dom_sf       
IPR013790   Dwarfin       
IPR003619   MAD_homology1_Dwarfin-type       

SUPFAM

SSF49879   SSF49879        + More
SSF56366   SSF56366       

Gene 3D

2.60.200.10     3.90.520.10    

ProteinModelPortal

H9JJE9   A0A220QT60   A0A2H1VIR2   A0A194PTI1   A0A212F8N9   A0A0N1IH69   + More
U5EXD3   A0A1L8DMQ0   F8V242   A0A067QRP6   K7IP92   A0A195ET96   A0A158NVW1   A0A336LKU2   A0A0K8TML2   A0A0L7RBH0   A0A1E1XLS3   A0A1E1XFN2   A0A131Z076   A0A131XW48   E9G7J0   A0A131YYC5   A0A1B6KEL6   A0A2R5LI54   A0A1B6GH93   A0A087T8C0   A0A3B5KT50   A0A3B3XI70   M3ZMX8   J7FXQ7   A0A315W4G7   A0A087XSS2   A0A3B3DUI3   A0A3B3TZU3   A0A3P9P210   A0A3B5BG60   C3Y6V2   A0A142EFR7   A0A0F8CFE8   A0A3B4YLL3   A0A3B4TX57   A0A3P8TX98   A0A091EAG3   A0A0F7ZD79   A0A3P8PYH6   A0A3P8VEX9   A0A3B3CNI8   H2MLR1   A0A3P9J8K3   A0A3P8VN55   A0A3B5AWN7   I3KEB1   Q8AY15   A0A0P7V3D6   A0A1S3K8S6   A0A1V4JDJ5   A0A0Q3PU66   P84023   A0A3B4XS14   A0A3B4TGC7   A0A146Z4J3   A0A091GFE6   F6S0M0   A0A218V0C7   U3KEJ5   A0A3P9ILG9   H2LR51   A0A1A8LN14   A0A1A8VDT5   A0A1A8QAR2   A0A091TN31   A0A1A7X9E8   A0A1A7Z463   B2XS64   A0A1A8IPB1   A0A093JC11   A0A1S3K891   G3PJ40   A0A3P8VEY6   A0A3B4ZAV1   A0A384C4Z0   A0A1L8DLE1   A0A099YXV9   A0A091GCW3   A0A1U7TYB8   A0A2I4BN26   A0A091SZL2   A0A091PJT1   E0VAB2   A0A3B5KD16   H2UPJ8   A0A096MCX0   Q68EP5   A2PZA6   A0A1A8DS60   A0A1A8UG63   F6UYG1   Q90YE5   A0A1L8GSA7   A0A1A8MZ22  

PDB

1KHX     E-value=9.8448e-113,     Score=1041

KEGG

101738552    K04500 mothers against decapentaplegic homolog 2/3 | (RefSeq) mothers against decapentaplegic homolo

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04144    Endocytosis - Bombyx mori (domestic silkworm)
04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0007179   GO:0005737   GO:0003677   GO:0005667   GO:0003700   GO:0007498   GO:0060215   GO:0006355   GO:0043565   GO:0000987   GO:0046872   GO:0071141   GO:0032332   GO:0005886   GO:0002520   GO:0048340   GO:0045429   GO:0071144   GO:0000122   GO:1902895   GO:0048589   GO:0007183   GO:0050678   GO:0008270   GO:0070878   GO:0050776   GO:0030878   GO:0032909   GO:0031490   GO:0030308   GO:0001657   GO:0061045   GO:0042803   GO:0043425   GO:0043235   GO:0046982   GO:0060395   GO:0031962   GO:0048617   GO:0010718   GO:0050728   GO:0019049   GO:0005829   GO:0005160   GO:0097191   GO:0070410   GO:0045216   GO:0030618   GO:0002076   GO:0042110   GO:0019901   GO:0001947   GO:0005654   GO:0043130   GO:0006955   GO:0070412   GO:0048701   GO:0045599   GO:0019902   GO:0009880   GO:1901203   GO:0070306   GO:0033689   GO:0051481   GO:0005518   GO:0001889   GO:0035259   GO:0045668   GO:0031625   GO:0007050   GO:0051098   GO:0001756   GO:0000790   GO:0003712   GO:0001666   GO:0005637   GO:0001707   GO:0006919   GO:0016202   GO:0017015   GO:0045930   GO:0007492   GO:0017151   GO:0001102   GO:0001228   GO:0000978   GO:0001701   GO:0060039   GO:0038092   GO:0005622   GO:0005515   GO:0000166   GO:0004887   GO:0003707   GO:0016021  

PANTHER

PTHR13703  

Subcellular location

Cytoplasm  
Nucleus  

Length:

444

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00379

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00071

outside

1  -  444

 

 

Pi

245.182118

Theta

163.773767

Tajima's D

1.32497

CLR

0.197952

CSRT

0.747112644367782

Interpretation

Uncertain