Gene

KWMTBOMO00905  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009779

Annotation

PREDICTED:_unconventional_myosin-Va_[Bombyx_mori]

Location

Bomo_Chr2(+):6114017-6136478      View in EpiBrowser

Full name

Unconventional myosin-Vb       + More
Unconventional myosin-Va      

Alternative Name

Dilute myosin heavy chain, non-muscle
Myosin heavy chain p190
Myosin-V

Location in the cell

Cytoplasmic   Reliability : 1.941

CDS

ATGACAACGAAGGAATTGTACACGAAGGGTGCCAGGATATGGGTGGAGCACCCGGAGAAGGTGTGGGAGAGCGCAACAGTAACATCCGACTATCGATCCGGCGTTCTCATCGTGAAACTAGACCAGACAGATGAAATAAGACAAATAACGATCAAAGATGAGAAACACATGCCCCCACTCCGGAACCCGTCGCTCCTCATCGGCCAAAATGATCTCACGTCACTATCGTACCTCCACGAGCCGGCGGTGCTGCATAATCTTAAAGTCAGATTCTGCGATCGTAACGCTATATACACCTACTGCGGGATCGTCCTCGTGGCCATCAATCCTTATTATGATCTTCCGATTTACGGCGATGAAACCATCATGGCGTATCGGGGCCAATCGATGGGCGATCTGGACCCTCACATATTCGCCGTCTCCGAAGAGGCCTACACCAAACTGGAGCGAGAAAGGAGTGATCAGAGTATCATAGTCAGCGGCGAGTCCGGTGCCGGGAAGACGGTGTCGGCAAAGTACGCCATGCGATACTTCGCAGCTGTCGGCGGCAACGTTAGCGAAACCCAGATCGAGAGGAAAGTGCTGGCTTCAAGTCCCATCATGGAGGCGATAGGCAATGCGAAGACAACCCGTAACGACAACTCATCGCGCTTCGGCAAGTTCATAGAGATACACTTCGACAGCCAGTACCGGATATCCGGGGCCAGCATGCGCACGTACCTGCTCGAGAAGTCGAGGGTGGTGTACCAGAGTCCCGGCGAGAGGAACTACCATATATTCTATCAGCTGTGTGCCGCTTCTGCTTTGATGCCTCATCTGAAGTTGGAACATCAAGACACATTACACTATTTGAATCAAGGCGGCAGTCCGAATATCGACGGAGTGGATGATCTAAAAGCTTTCAACGAAACTAGAAGCGCTTTAACTACTTTAGGCGTTACGGATTCGGAGCAGAGGGACATGTTCACCATCCTGGCCGCGATACTGCATCTCGGCAACGTCGCGCTGCTGTCCGAGGACCCCGACGCGGCGCCCGGAGCAGACTGCGAGGACGGAGCCTACATCAGCCCGACAGACGAGCACCTGACGCACGCGTGTTCGCTGCTGGGAGTGTCGCGCTTGGAGCTGTCGCGGTGGCTGAGTCATCGCCGCATCGCCTCCGCCCACGAGGTCATCGTCGCCAGGCTGGACGTGCAGCGCGCGGCGTGCGCCCGGGACGCGCTCGCCAAGAAGCTGTACGGGGAGCTGTTCGCGTGGCTCGTCACCGCAGTCAACCGCGCGCTCGACACCGGACACGCCAAGAAACACTTCATCGGCGTCCTCGACATCTACGGCTTCGAGACCTTCGAAATCAACTCGTTCGAACAGTTCTGCATCAACTACGCGAACGAGAAGCTCCAGCAGCAGTTCAACTCGCACGTGTTCAAACTCGAGCAGGACGAATATATAAAGGAAGAGATCTCGTGGGAGATGATTGACTTCTACGACAACCAGCCGTGCATAGACCTGATCGAGGACCGTCTGGGTGTCCTGGCGCTGCTCGACGAGGAGTGCCGCGTGCCGCAGGGCTCCGACACCGGCTTCGTGGCCAAGCTGCACCAGAAGTGCGCCGCCTACCCGCACTTCATGAAGCCGAGGTTCGGGAACCAGGCCTTCATAATAAAGCATTTCGCTGACAACGTGGAGTACCAGTCCGGCGGTTTCCTTGAGAAGAATCGTGACACAGTGTCGGAGGAACAGCTGGAGTGCATCAGGACAGCCACCAGCTGCCGCCTCATACACGTCATGCTGGAGTCGGAGCGCGCGGTAGACCGTCAGACCGCGACCCTGCCGCCGCCCTCCCGGAGGAGGACCACGCCCTCCGTGCCGATAACGAGTCTAACTAAAATCCAACTCAAAAATAGAAAATAA

Protein

MTTKELYTKGARIWVEHPEKVWESATVTSDYRSGVLIVKLDQTDEIRQITIKDEKHMPPLRNPSLLIGQNDLTSLSYLHEPAVLHNLKVRFCDRNAIYTYCGIVLVAINPYYDLPIYGDETIMAYRGQSMGDLDPHIFAVSEEAYTKLERERSDQSIIVSGESGAGKTVSAKYAMRYFAAVGGNVSETQIERKVLASSPIMEAIGNAKTTRNDNSSRFGKFIEIHFDSQYRISGASMRTYLLEKSRVVYQSPGERNYHIFYQLCAASALMPHLKLEHQDTLHYLNQGGSPNIDGVDDLKAFNETRSALTTLGVTDSEQRDMFTILAAILHLGNVALLSEDPDAAPGADCEDGAYISPTDEHLTHACSLLGVSRLELSRWLSHRRIASAHEVIVARLDVQRAACARDALAKKLYGELFAWLVTAVNRALDTGHAKKHFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQDEYIKEEISWEMIDFYDNQPCIDLIEDRLGVLALLDEECRVPQGSDTGFVAKLHQKCAAYPHFMKPRFGNQAFIIKHFADNVEYQSGGFLEKNRDTVSEEQLECIRTATSCRLIHVMLESERAVDRQTATLPPPSRRRTTPSVPITSLTKIQLKNRK

Description

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (By similarity).

Subunit

Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with RAB11FIP2 (By similarity). Interacts with RAB11A and RAB8A (By similarity). Found in a complex with CFTR and RAB11A (By similarity). Interacts with NPC1L1 (By similarity). Interacts with LIMA1 (PubMed:29880681).
May be a homodimer, which associates with multiple calmodulin or myosin light chains.

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Keywords

Actin-binding   Alternative splicing   ATP-binding   Calmodulin-binding   Coiled coil   Complete proteome   Cytoplasm   Motor protein   Myosin   Nucleotide-binding   Phosphoprotein   Protein transport   Reference proteome   Repeat   Transport   3D-structure   Direct protein sequencing   Golgi apparatus   Membrane  

Feature

chain  Unconventional myosin-Vb
splice variant  In isoform 3.

Uniprot

H9JJS8   A0A194PUG4   A0A2H1V2L1   D6WQH7   V5G7A5   K7IV32   + More
A0A088AGS8   A0A1B6FZ72   A0A195CUA2   V9IC23   A0A3L8DE04   A0A158NQ81   A0A1Y1MHK0   A0A154P7I5   E2AL94   A0A232FB52   A0A0N0U3P1   A0A0J7L868   A0A195FNW2   A0A1B6I9C2   A0A2A3E8F5   A0A151WYN4   A0A0L7R6N9   A0A0L7R6Y3   A0A195DEK4   E2A5K9   A0A026WN41   E2B2T6   A0A0P4W5R4   A0A0P4WGV2   F6K356   U4UQP3   N6TJX6   A0A0F7VJF0   A0A0C9QSS3   A0A0C9QTC4   A0A182QG83   E0VAZ3   A0A195BJ13   A0A182MMU4   A0A0A1WZ66   A0A0A1X3X1   A0A0K8W7J1   A0A0K8U9G9   A0A182LKT9   A0A0K2VG83   W8B8Y3   W8B4M8   A0A0P5P9E7   A0A0P4Y350   A0A0P6HK55   A0A0P6FW99   A0A0P5LPI2   A0A0N8CXS1   A0A0P5IF88   A0A0P5VR14   A0A0P5RKE3   A0A0P5RPT9   A0A0N8C7R8   A0A3B0J347   A0A0N8CE72   E9H736   A0A3B0J2M3   A0A0K8SQI6   A0A0A9ZGU3   A0A0P6CNX1   A0A182JIC1   A0A0A1X772   A0A0P6EJY1   A0A0Q9XLC5   B4KQ96   A0A0K8WJ51   A0A1L8I2T7   A0A1Q3G1V7   B4H8K7   B4J9Z7   P21271   P21271-3   Q28YI2   N6W4L9   A0A0T6BA34   A0A0Q9XHH8   F6WHW2   A0A182G783   A0A182RR43   Q02440   A0A1D5PRP3   A0A0P6BUJ9   A0A182V3H7   A0A182I464   G1PV90   A0A182WC09   A0A1B6DXB9   A0A2M4CPU8   A0A3Q0CRB3   G5E8G6   Q7Q5E6   G3X9Y9   A0A0L0CAC5  

Pubmed

19121390    26354079    18362917    19820115    20075255    30249741    + More
21347285    28004739    20798317    28648823    24508170    22846366    23537049    20566863    25830018    20966253    24495485    21292972    25401762    17994087    27762356    15489334    15368895    2236059    21183079    29880681    15632085    20431018    26483478    1383040    1469047    21993624    26319212    12040188    19468303    12364791    26108605   

EMBL

BABH01017761    BABH01017762    KQ459593    KPI96618.1    ODYU01000382    SOQ35071.1    + More
KQ971354    EFA06975.2    GALX01002476    JAB65990.1    AAZX01001194    GECZ01014290    JAS55479.1    KQ977279    KYN04261.1    JR039293    JR039294    AEY58619.1    AEY58620.1    QOIP01000009    RLU18383.1    ADTU01022924    ADTU01022925    GEZM01031022    JAV85121.1    KQ434822    KZC07080.1    GL440553    EFN65790.1    NNAY01000532    OXU27842.1    KQ435896    KOX69324.1    LBMM01000310    KMR01422.1    KQ981382    KYN42143.1    GECU01024162    JAS83544.1    KZ288326    PBC27980.1    KQ982652    KYQ52811.1    KQ414646    KOC66513.1    KOC66516.1    KQ980934    KYN11323.1    GL436993    EFN71292.1    KK107148    EZA57445.1    GL445235    EFN90001.1    GDRN01089957    JAI60556.1    GDRN01089955    JAI60557.1    HM212671    ADM15669.1    KB632326    ERL92471.1    APGK01035149    APGK01035150    APGK01035151    KB740923    ENN78188.1    LN830727    CFW94236.1    GBYB01003692    JAG73459.1    GBYB01006959    JAG76726.1    AXCN02000461    DS235019    EEB10549.1    KQ976464    KYM84426.1    AXCM01004568    GBXI01010584    JAD03708.1    GBXI01008248    JAD06044.1    GDHF01005267    JAI47047.1    GDHF01029304    JAI23010.1    HACA01031851    CDW49212.1    GAMC01013037    JAB93518.1    GAMC01013038    JAB93517.1    GDIQ01141357    JAL10369.1    GDIP01235456    JAI87945.1    GDIQ01018624    JAN76113.1    GDIQ01041893    JAN52844.1    GDIQ01170346    GDIQ01136811    GDIQ01030299    LRGB01003163    JAK81379.1    KZS03930.1    GDIP01088479    JAM15236.1    GDIQ01214230    JAK37495.1    GDIP01096726    JAM06989.1    GDIQ01108817    JAL42909.1    GDIQ01106568    JAL45158.1    GDIQ01106515    JAL45211.1    OUUW01000001    SPP75705.1    GDIP01140471    JAL63243.1    GL732599    EFX72449.1    SPP75704.1    GBRD01010430    GBRD01007165    JAG55394.1    GBHO01000214    GBHO01000213    JAG43390.1    JAG43391.1    GDIQ01090022    JAN04715.1    GBXI01007769    JAD06523.1    GDIQ01061683    JAN33054.1    CH933808    KRG04531.1    EDW09224.1    GDHF01001133    JAI51181.1    CM004466    OCU02687.1    GFDL01001250    JAV33795.1    CH479223    EDW35042.1    CH916367    EDW02584.1    BC011494    BC046444    BC118525    AK173102    M55253    CM000071    EAL25983.2    ENO01762.2    LJIG01002798    KRT84142.1    KRG04530.1    AAMC01059172    AAMC01059173    AAMC01059174    AAMC01059175    AAMC01059176    AAMC01059177    AAMC01059178    AAMC01059179    JXUM01047023    JXUM01047024    JXUM01047025    JXUM01047026    JXUM01047027    JXUM01047028    X67251    Z11718    GDIP01017260    JAM86455.1    APCN01002280    AAPE02009051    AAPE02009052    GEDC01028278    GEDC01006987    JAS09020.1    JAS30311.1    GGFL01003159    MBW67337.1    AC147992    AC148001    AC148002    CH466528    EDL09524.1    AAAB01008960    EAA11777.4    EDL09522.1    JRES01000780    KNC28384.1   

Proteomes

UP000005204    UP000053268    UP000007266    UP000002358    UP000005203    UP000078542    + More
UP000279307    UP000005205    UP000076502    UP000000311    UP000215335    UP000053105    UP000036403    UP000078541    UP000242457    UP000075809    UP000053825    UP000078492    UP000053097    UP000008237    UP000030742    UP000019118    UP000075886    UP000009046    UP000078540    UP000075883    UP000075882    UP000076858    UP000268350    UP000000305    UP000075880    UP000009192    UP000186698    UP000008744    UP000001070    UP000000589    UP000001819    UP000008143    UP000069940    UP000075900    UP000000539    UP000075903    UP000075840    UP000001074    UP000075920    UP000189706    UP000007062    UP000037069   

PRIDE

H9JJS8    P21271    Q02440   

Pfam

PF00063   Myosin_head        + More
PF00612   IQ
PF01843   DIL
PF02736   Myosin_N

Interpro

IPR027417   P-loop_NTPase        + More
IPR036103   MYSc_Myo5       
IPR001609   Myosin_head_motor_dom       
IPR008989   Myosin_S1_N       
IPR000048   IQ_motif_EF-hand-BS       
IPR036961   Kinesin_motor_dom_sf       
IPR004009   Myosin_N       
IPR002710   Dilute_dom       
IPR037990   Myo5b_CBD       
IPR037988   Myo5a_CBD       

SUPFAM

SSF50084   SSF50084        + More
SSF52540   SSF52540       

Gene 3D

2.30.30.360     3.40.850.10    

CDD

cd01380  MYSc_Myo5
cd15477  Myo5b_CBD
cd15478  Myo5a_CBD

ProteinModelPortal

H9JJS8   A0A194PUG4   A0A2H1V2L1   D6WQH7   V5G7A5   K7IV32   + More
A0A088AGS8   A0A1B6FZ72   A0A195CUA2   V9IC23   A0A3L8DE04   A0A158NQ81   A0A1Y1MHK0   A0A154P7I5   E2AL94   A0A232FB52   A0A0N0U3P1   A0A0J7L868   A0A195FNW2   A0A1B6I9C2   A0A2A3E8F5   A0A151WYN4   A0A0L7R6N9   A0A0L7R6Y3   A0A195DEK4   E2A5K9   A0A026WN41   E2B2T6   A0A0P4W5R4   A0A0P4WGV2   F6K356   U4UQP3   N6TJX6   A0A0F7VJF0   A0A0C9QSS3   A0A0C9QTC4   A0A182QG83   E0VAZ3   A0A195BJ13   A0A182MMU4   A0A0A1WZ66   A0A0A1X3X1   A0A0K8W7J1   A0A0K8U9G9   A0A182LKT9   A0A0K2VG83   W8B8Y3   W8B4M8   A0A0P5P9E7   A0A0P4Y350   A0A0P6HK55   A0A0P6FW99   A0A0P5LPI2   A0A0N8CXS1   A0A0P5IF88   A0A0P5VR14   A0A0P5RKE3   A0A0P5RPT9   A0A0N8C7R8   A0A3B0J347   A0A0N8CE72   E9H736   A0A3B0J2M3   A0A0K8SQI6   A0A0A9ZGU3   A0A0P6CNX1   A0A182JIC1   A0A0A1X772   A0A0P6EJY1   A0A0Q9XLC5   B4KQ96   A0A0K8WJ51   A0A1L8I2T7   A0A1Q3G1V7   B4H8K7   B4J9Z7   P21271   P21271-3   Q28YI2   N6W4L9   A0A0T6BA34   A0A0Q9XHH8   F6WHW2   A0A182G783   A0A182RR43   Q02440   A0A1D5PRP3   A0A0P6BUJ9   A0A182V3H7   A0A182I464   G1PV90   A0A182WC09   A0A1B6DXB9   A0A2M4CPU8   A0A3Q0CRB3   G5E8G6   Q7Q5E6   G3X9Y9   A0A0L0CAC5  

PDB

1W7J     E-value=0,     Score=1925

KEGG

101736113    K10357 myosin V | (RefSeq) unconventional myosin-Va

GO

GO:0005524   GO:0016459   GO:0051015   GO:0003774   GO:0003779   GO:0016021   GO:0005516   GO:0007291   GO:0043025   GO:0045856   GO:0006886   GO:0030899   GO:0047497   GO:0030048   GO:0032027   GO:0016028   GO:0042052   GO:0031475   GO:0030898   GO:0048471   GO:0099003   GO:0005903   GO:0050804   GO:0050775   GO:0098871   GO:0017137   GO:0098978   GO:1903078   GO:0032880   GO:0098944   GO:0016197   GO:0043005   GO:0045773   GO:0035255   GO:0015031   GO:0005886   GO:1903543   GO:0043197   GO:0032991   GO:0045179   GO:0016887   GO:0099159   GO:0016192   GO:0098685   GO:0060997   GO:0099639   GO:0008361   GO:0098856   GO:0048546   GO:0043588   GO:0061564   GO:0072659   GO:0032593   GO:0032869   GO:0060001   GO:0000146   GO:0031941   GO:0000139   GO:0005737   GO:0006396   GO:0000166   GO:0004887   GO:0003707  

Subcellular location

Cytoplasm  
Golgi apparatus membrane  

Length:

636

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

13.60193

Exp number, first 60 AAs:

0

Total prob of N-in:

0.63503

outside

1  -  636

 

 

Pi

414.000504

Theta

185.101712

Tajima's D

2.723521

CLR

0.260582

CSRT

0.964551772411379

Interpretation

Possibly Balancing Selection