Gene
KWMTBOMO00903
Annotation
SIFamide_precursor_[Bombyx_mori]
Full name
Neuropeptide SIFamide
+ More
SIFamide-related peptide
Neuropeptide IMFamide
FMRFamide-related neuropeptides
SIFamide-related peptide
Neuropeptide IMFamide
FMRFamide-related neuropeptides
Alternative Name
TYRKPPFNGSIF-amide
AYKKPPFNGSIF-amide
AYKKPPFNGSIF-amide
Location in the cell
Extracellular Reliability : 1.468 PlasmaMembrane Reliability : 1.213
Sequence
CDS
ATGCGCGCCGACCTGATTTATTTCATGTTTCTCGTGATTATTTTGACGTTGGCAACAATTGAAGCAACGTACAGAAAACCACCTTTCAATGGATCGATTTTCGGGAAGCGAAATAACGTAGAGAATGATTCTTCGGGCAGAGCGATTGCAGCGTTATGTGAAATCACTACCGAAACTTGCCAGGCTTGGTATCAGGCTTTGGAGAGTCAGTAA
Protein
MRADLIYFMFLVIILTLATIEATYRKPPFNGSIFGKRNNVENDSSGRAIAALCEITTETCQAWYQALESQ
Summary
Description
Ligand for the neuropeptide SIFamide receptor.
Ligand for the neuropeptide SIFamide receptor (PubMed:16378592). Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination (PubMed:17126293, PubMed:26469541). Also involved in promoting sleep (PubMed:24658384).
GYRKPPFNGSIF-amide may be involved in olfaction and contraction of hindgut.
Ligand for the neuropeptide SIFamide receptor (PubMed:16378592). Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination (PubMed:17126293, PubMed:26469541). Also involved in promoting sleep (PubMed:24658384).
GYRKPPFNGSIF-amide may be involved in olfaction and contraction of hindgut.
Similarity
Belongs to the FARP (FMRFamide related peptide) family.
Keywords
Amidation
Cleavage on pair of basic residues
Direct protein sequencing
Neuropeptide
Secreted
Signal
Complete proteome
Reference proteome
Behavior
Glycoprotein
Feature
peptide Neuropeptide SIFamide
Uniprot
B3IUC7
M4QEM6
C0HKV8
A0A0S1U0F6
A0A194QZR6
A0A194PT72
+ More
A0A385H900 A0A1I8N4A9 A0A1I8NTC4 A0A1B0FN31 A0A1B0AH03 A0A1A9YDA0 A0A1B0B6I1 A0A240SWE5 D6WT77 A0A240SYM7 U4UED8 A0A034WM50 A0A336MLL6 A0A345BEF2 U3U8T5 A0A2A3EJN8 A0A026W8G3 B4KQ60 E2ASG4 A0A1Q3FS99 V9IML1 A0A1S3CVV7 B4LJI8 A0A151JAR6 B4J814 A0A158NCY6 A0A023ED68 A0A0M8ZZ52 Q16UM4 B3MG86 A0A1E1G7V9 A0A2H1V3Y6 C0HKU0 A0A087ZMZ7 C7E6V5 B4NLH5 K7JPC8 A0A0L7R661 A0A232ERG7 W5JA80 B4PBD2 A0A1B2AKW2 B4IH42 B3NQU7 B4QC21 Q6IGX9 A0A1W4WB88 A0A195D0B1 A0A195B903 A0A182FER3 A0A3B0J3C8 B5E199 A0A385H8W0 A0A0S1U2C1 B3IUC8 A0A1W4WV12 T1IZI5 M4QEL7 A0A2U8JAH3 W0UTB3 A0A212FKA6 A0A1C8Y949 Q867W1 J9M924 A0A0L7LJA7 A7Y330 A0A076L100 A0A2P6KIF4 A0A0S2YRA5 G4V2X8 A0A087UFV7 B7QHG6 A0A194PTH9 A0A226ET42
A0A385H900 A0A1I8N4A9 A0A1I8NTC4 A0A1B0FN31 A0A1B0AH03 A0A1A9YDA0 A0A1B0B6I1 A0A240SWE5 D6WT77 A0A240SYM7 U4UED8 A0A034WM50 A0A336MLL6 A0A345BEF2 U3U8T5 A0A2A3EJN8 A0A026W8G3 B4KQ60 E2ASG4 A0A1Q3FS99 V9IML1 A0A1S3CVV7 B4LJI8 A0A151JAR6 B4J814 A0A158NCY6 A0A023ED68 A0A0M8ZZ52 Q16UM4 B3MG86 A0A1E1G7V9 A0A2H1V3Y6 C0HKU0 A0A087ZMZ7 C7E6V5 B4NLH5 K7JPC8 A0A0L7R661 A0A232ERG7 W5JA80 B4PBD2 A0A1B2AKW2 B4IH42 B3NQU7 B4QC21 Q6IGX9 A0A1W4WB88 A0A195D0B1 A0A195B903 A0A182FER3 A0A3B0J3C8 B5E199 A0A385H8W0 A0A0S1U2C1 B3IUC8 A0A1W4WV12 T1IZI5 M4QEL7 A0A2U8JAH3 W0UTB3 A0A212FKA6 A0A1C8Y949 Q867W1 J9M924 A0A0L7LJA7 A7Y330 A0A076L100 A0A2P6KIF4 A0A0S2YRA5 G4V2X8 A0A087UFV7 B7QHG6 A0A194PTH9 A0A226ET42
Pubmed
29466015
26354079
30171635
25315136
18362917
19820115
+ More
23537049 25348373 23932938 24508170 30249741 17994087 20798317 25641051 21347285 24945155 26483478 17510324 20958806 20075255 28648823 20920257 23761445 17550304 22936249 10731132 12537572 14709175 15219831 16378592 17126293 24658384 26469541 15632085 27924858 22118469 14723891 26227816 18308319 26592767 19824085
23537049 25348373 23932938 24508170 30249741 17994087 20798317 25641051 21347285 24945155 26483478 17510324 20958806 20075255 28648823 20920257 23761445 17550304 22936249 10731132 12537572 14709175 15219831 16378592 17126293 24658384 26469541 15632085 27924858 22118469 14723891 26227816 18308319 26592767 19824085
EMBL
AB298923
BAG50362.1
KC340937
AGH25569.1
KT005992
ALM30343.1
+ More
KQ460890 KPJ11038.1 KQ459593 KPI96616.1 MH028128 AXY04297.1 CCAG010014920 JXJN01009092 KQ971354 EFA07409.1 AJVK01059044 KB632322 ERL92324.1 GAKP01003510 JAC55442.1 UFQT01001614 SSX31166.1 MF765484 AXF48204.1 AB817280 BAO00977.1 KZ288242 PBC31251.1 KK107347 QOIP01000007 EZA52345.1 RLU20085.1 CH933808 EDW09188.1 GL442298 EFN63630.1 GFDL01004610 JAV30435.1 JR053277 AEY61896.1 MG550188 AWT50622.1 CH940648 EDW61556.2 KQ979266 KYN22052.1 CH916367 EDW02244.1 ADTU01012083 JXUM01086664 JXUM01090606 GAPW01006812 KQ563852 KQ563583 JAC06786.1 KXJ73167.1 KXJ73634.1 KQ435818 KOX72529.1 CH477618 EAT38218.1 CH902619 EDV37789.1 LC146524 BAV78828.1 ODYU01000382 SOQ35072.1 GQ253922 ACT35307.1 CH964274 EDW85214.1 AAZX01001191 KQ414646 KOC66362.1 NNAY01002644 OXU20876.1 ADMH02002049 ETN59760.1 CM000158 EDW92564.1 KX531964 ANY27774.1 CH480838 EDW49218.1 CH954179 EDV57030.1 CM000362 CM002911 EDX08576.1 KMY96377.1 AF376801 AE013599 BT030932 BT030951 BT030970 BT032699 BK003637 AAO15386.1 ABV82333.1 DAA02335.1 KQ977012 KYN06355.1 KQ976558 KYM80712.1 OUUW01000001 SPP73743.1 CM000071 EDY69487.2 MH028089 AXY04258.1 KT005973 ALM30324.1 AB298924 BAG50363.1 AFFK01020457 KC340927 AGH25559.1 MH211002 AWK57544.1 HG326274 CDG15340.1 AGBW02008086 OWR54173.1 KX273323 AOH96653.1 AB036712 AB036713 BAC55939.1 ABLF02035181 JTDY01000896 KOB75515.1 EU117384 ABV21807.1 KF433807 AII98128.1 MWRG01011183 PRD26097.1 KR078361 ALQ28576.1 GU016327 ADO00265.1 KK119629 KFM76246.1 ABJB010961237 GQ214556 DS939604 ADD92393.1 EEC18288.1 KPI96617.1 LNIX01000002 OXA59776.1
KQ460890 KPJ11038.1 KQ459593 KPI96616.1 MH028128 AXY04297.1 CCAG010014920 JXJN01009092 KQ971354 EFA07409.1 AJVK01059044 KB632322 ERL92324.1 GAKP01003510 JAC55442.1 UFQT01001614 SSX31166.1 MF765484 AXF48204.1 AB817280 BAO00977.1 KZ288242 PBC31251.1 KK107347 QOIP01000007 EZA52345.1 RLU20085.1 CH933808 EDW09188.1 GL442298 EFN63630.1 GFDL01004610 JAV30435.1 JR053277 AEY61896.1 MG550188 AWT50622.1 CH940648 EDW61556.2 KQ979266 KYN22052.1 CH916367 EDW02244.1 ADTU01012083 JXUM01086664 JXUM01090606 GAPW01006812 KQ563852 KQ563583 JAC06786.1 KXJ73167.1 KXJ73634.1 KQ435818 KOX72529.1 CH477618 EAT38218.1 CH902619 EDV37789.1 LC146524 BAV78828.1 ODYU01000382 SOQ35072.1 GQ253922 ACT35307.1 CH964274 EDW85214.1 AAZX01001191 KQ414646 KOC66362.1 NNAY01002644 OXU20876.1 ADMH02002049 ETN59760.1 CM000158 EDW92564.1 KX531964 ANY27774.1 CH480838 EDW49218.1 CH954179 EDV57030.1 CM000362 CM002911 EDX08576.1 KMY96377.1 AF376801 AE013599 BT030932 BT030951 BT030970 BT032699 BK003637 AAO15386.1 ABV82333.1 DAA02335.1 KQ977012 KYN06355.1 KQ976558 KYM80712.1 OUUW01000001 SPP73743.1 CM000071 EDY69487.2 MH028089 AXY04258.1 KT005973 ALM30324.1 AB298924 BAG50363.1 AFFK01020457 KC340927 AGH25559.1 MH211002 AWK57544.1 HG326274 CDG15340.1 AGBW02008086 OWR54173.1 KX273323 AOH96653.1 AB036712 AB036713 BAC55939.1 ABLF02035181 JTDY01000896 KOB75515.1 EU117384 ABV21807.1 KF433807 AII98128.1 MWRG01011183 PRD26097.1 KR078361 ALQ28576.1 GU016327 ADO00265.1 KK119629 KFM76246.1 ABJB010961237 GQ214556 DS939604 ADD92393.1 EEC18288.1 KPI96617.1 LNIX01000002 OXA59776.1
Proteomes
UP000053240
UP000053268
UP000095301
UP000095300
UP000092444
UP000092445
+ More
UP000092443 UP000092460 UP000091820 UP000007266 UP000092462 UP000030742 UP000242457 UP000053097 UP000279307 UP000009192 UP000000311 UP000079169 UP000008792 UP000078492 UP000001070 UP000005205 UP000069940 UP000249989 UP000053105 UP000008820 UP000007801 UP000005203 UP000007798 UP000002358 UP000053825 UP000215335 UP000000673 UP000002282 UP000001292 UP000008711 UP000000304 UP000000803 UP000192221 UP000078542 UP000078540 UP000069272 UP000268350 UP000001819 UP000192223 UP000007151 UP000007819 UP000037510 UP000054359 UP000001555 UP000198287
UP000092443 UP000092460 UP000091820 UP000007266 UP000092462 UP000030742 UP000242457 UP000053097 UP000279307 UP000009192 UP000000311 UP000079169 UP000008792 UP000078492 UP000001070 UP000005205 UP000069940 UP000249989 UP000053105 UP000008820 UP000007801 UP000005203 UP000007798 UP000002358 UP000053825 UP000215335 UP000000673 UP000002282 UP000001292 UP000008711 UP000000304 UP000000803 UP000192221 UP000078542 UP000078540 UP000069272 UP000268350 UP000001819 UP000192223 UP000007151 UP000007819 UP000037510 UP000054359 UP000001555 UP000198287
ProteinModelPortal
B3IUC7
M4QEM6
C0HKV8
A0A0S1U0F6
A0A194QZR6
A0A194PT72
+ More
A0A385H900 A0A1I8N4A9 A0A1I8NTC4 A0A1B0FN31 A0A1B0AH03 A0A1A9YDA0 A0A1B0B6I1 A0A240SWE5 D6WT77 A0A240SYM7 U4UED8 A0A034WM50 A0A336MLL6 A0A345BEF2 U3U8T5 A0A2A3EJN8 A0A026W8G3 B4KQ60 E2ASG4 A0A1Q3FS99 V9IML1 A0A1S3CVV7 B4LJI8 A0A151JAR6 B4J814 A0A158NCY6 A0A023ED68 A0A0M8ZZ52 Q16UM4 B3MG86 A0A1E1G7V9 A0A2H1V3Y6 C0HKU0 A0A087ZMZ7 C7E6V5 B4NLH5 K7JPC8 A0A0L7R661 A0A232ERG7 W5JA80 B4PBD2 A0A1B2AKW2 B4IH42 B3NQU7 B4QC21 Q6IGX9 A0A1W4WB88 A0A195D0B1 A0A195B903 A0A182FER3 A0A3B0J3C8 B5E199 A0A385H8W0 A0A0S1U2C1 B3IUC8 A0A1W4WV12 T1IZI5 M4QEL7 A0A2U8JAH3 W0UTB3 A0A212FKA6 A0A1C8Y949 Q867W1 J9M924 A0A0L7LJA7 A7Y330 A0A076L100 A0A2P6KIF4 A0A0S2YRA5 G4V2X8 A0A087UFV7 B7QHG6 A0A194PTH9 A0A226ET42
A0A385H900 A0A1I8N4A9 A0A1I8NTC4 A0A1B0FN31 A0A1B0AH03 A0A1A9YDA0 A0A1B0B6I1 A0A240SWE5 D6WT77 A0A240SYM7 U4UED8 A0A034WM50 A0A336MLL6 A0A345BEF2 U3U8T5 A0A2A3EJN8 A0A026W8G3 B4KQ60 E2ASG4 A0A1Q3FS99 V9IML1 A0A1S3CVV7 B4LJI8 A0A151JAR6 B4J814 A0A158NCY6 A0A023ED68 A0A0M8ZZ52 Q16UM4 B3MG86 A0A1E1G7V9 A0A2H1V3Y6 C0HKU0 A0A087ZMZ7 C7E6V5 B4NLH5 K7JPC8 A0A0L7R661 A0A232ERG7 W5JA80 B4PBD2 A0A1B2AKW2 B4IH42 B3NQU7 B4QC21 Q6IGX9 A0A1W4WB88 A0A195D0B1 A0A195B903 A0A182FER3 A0A3B0J3C8 B5E199 A0A385H8W0 A0A0S1U2C1 B3IUC8 A0A1W4WV12 T1IZI5 M4QEL7 A0A2U8JAH3 W0UTB3 A0A212FKA6 A0A1C8Y949 Q867W1 J9M924 A0A0L7LJA7 A7Y330 A0A076L100 A0A2P6KIF4 A0A0S2YRA5 G4V2X8 A0A087UFV7 B7QHG6 A0A194PTH9 A0A226ET42
Ontologies
GO
Topology
Subcellular location
Secreted
SignalP
Position: 1 - 22,
Likelihood: 0.981870
Length:
70
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
19.2619
Exp number, first 60 AAs:
19.25905
Total prob of N-in:
0.89985
POSSIBLE N-term signal
sequence
inside
1 - 4
TMhelix
5 - 24
outside
25 - 70
Population Genetic Test Statistics
Pi
288.338062
Theta
166.68444
Tajima's D
2.383428
CLR
0.0082
CSRT
0.934203289835508
Interpretation
Uncertain
