Gene

KWMTBOMO00872  Validated by peptides from experiments

Annotation

chymotrypsin_inhibitor_SCI-III_precursor_[Bombyx_mori]

Location

Bomo_Chr2(+):5286701-5288869      View in EpiBrowser

Full name

Chymotrypsin inhibitor SCI-III       + More
Chymotrypsin inhibitor SCI-I      
Chymotrypsin inhibitor SCI-II      
Tissue factor pathway inhibitor      
Kunitz-type serine protease inhibitor conotoxin Cal9.1a      

Location in the cell

Extracellular   Reliability : 3.865

CDS

ATGTTGAGATCAGTGCTTTTTCTATTCGCGGGCGTTTTCTTCGCTGCGTGCTTGACATCGGTCATGAGTGATGAGCCAACGACGGACTTGCCGATATGCGAGCAGGCTTTTGGCGATGCGGGTCTTTGTTTCGGCTATATGAAACTATACTCGTACAACCAGGAGACGAAGAACTGTGAAGAATTCATTTACGGAGGCTGCCAAGGGAATGATAATCGTTTCAGCACATTGGCCGAATGCGAACAGAAATGCATAAACTAA

Protein

MLRSVLFLFAGVFFAACLTSVMSDEPTTDLPICEQAFGDAGLCFGYMKLYSYNQETKNCEEFIYGGCQGNDNRFSTLAECEQKCIN

Similarity

Belongs to the venom Kunitz-type family.

Keywords

Complete proteome   Direct protein sequencing   Disulfide bond   Protease inhibitor   Reference proteome   Serine protease inhibitor   Secreted   Signal   Toxin  

Feature

chain  Chymotrypsin inhibitor SCI-III
peptide  Kunitz-type serine protease inhibitor conotoxin Cal9.1a

Uniprot

Q86QT1   P07481   Q8I9K4   Q8WPI5   Q967V8   Q5MBP2   + More
P10831   P10832   F7B298   A0A085NHW9   A0A0B1PQW3   B3N367   B4MVB8   Q29ME6   B4G9D1   A0A085NHX2   D2Y488   A0A2R5LG69   Q5VJG2   F8K9Q3   A0A034WTW0   A0A2T7NZF0   E2BB26   B4MVC1   B4KJZ3   R7UKB1   I6UW93   W8CC99   B4JQI7   H2M3H0   A0A2A2M3Y4  

Pubmed

15477076    3072972    18464734    24929829    17994087    15632085    + More
21172372    15527983    24762651    20798317    23254933    23022284    24495485    17554307   

EMBL

AY167664    AAO17293.1    AF529176    AAN76278.1    AB062102    BAB83366.1    + More
AF361484    AAK52496.1    AY839231    AY839232    AAW30166.1    AAW30167.2    KL367498    KFD69065.1    KN538402    KHJ42567.1    CH954177    EDV57666.1    CH963857    EDW76463.1    CH379060    EAL33748.2    CH479180    EDW28961.1    KFD69068.1    GU306152    GGLE01004376    MBY08502.1    AY437082    AAR97367.1    FR734169    CBY65969.1    GBBR01000066    JAC58996.1    PZQS01000008    PVD26538.1    GL446901    EFN87117.1    EDW76466.2    CH933807    EDW12596.1    AMQN01008243    KB302535    ELU04243.1    JQ730814    AFN01659.1    GAMC01004066    JAC02490.1    CH916372    EDV99167.1    LIAE01005567    PAV93241.1   

Proteomes

UP000005204    UP000002279    UP000008711    UP000007798    UP000001819    UP000008744    + More
UP000245119    UP000008237    UP000009192    UP000014760    UP000001070    UP000001038    UP000218231   

PRIDE

Q86QT1    P07481    Q8I9K4    Q8WPI5    Q967V8    Q5MBP2    + More
P10831    P10832   

Pfam

PF00014   Kunitz_BPTI        + More
PF00090   TSP_1
PF05986   ADAM_spacer1
PF00095   WAP
PF08686   PLAC
PF07679   I-set

Interpro

IPR020901   Prtase_inh_Kunz-CS        + More
IPR036880   Kunitz_BPTI_sf       
IPR002223   Kunitz_BPTI       
IPR008296   TFPI-like       
IPR002557   Chitin-bd_dom       
IPR000980   SH2       
IPR036860   SH2_dom_sf       
IPR036383   TSP1_rpt_sf       
IPR013106   Ig_V-set       
IPR000884   TSP1_rpt       
IPR036179   Ig-like_dom_sf       
IPR010909   PLAC       
IPR003598   Ig_sub2       
IPR010294   ADAM_spacer1       
IPR013783   Ig-like_fold       
IPR000020   Anaphylatoxin/fibulin       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR013098   Ig_I-set       
IPR008197   WAP_dom       
IPR013273   ADAMTS/ADAMTS-like       
IPR036645   Elafin-like_sf       
IPR012674   Calycin       

SUPFAM

SSF57362   SSF57362        + More
SSF55550   SSF55550       
SSF57256   SSF57256       
SSF82895   SSF82895       
SSF48726   SSF48726       
SSF50814   SSF50814       

Gene 3D

4.10.410.10     3.30.505.10     2.20.100.10     2.60.40.10     4.10.75.10     2.40.128.20    

CDD

cd00109  KU

ProteinModelPortal

Q86QT1   P07481   Q8I9K4   Q8WPI5   Q967V8   Q5MBP2   + More
P10831   P10832   F7B298   A0A085NHW9   A0A0B1PQW3   B3N367   B4MVB8   Q29ME6   B4G9D1   A0A085NHX2   D2Y488   A0A2R5LG69   Q5VJG2   F8K9Q3   A0A034WTW0   A0A2T7NZF0   E2BB26   B4MVC1   B4KJZ3   R7UKB1   I6UW93   W8CC99   B4JQI7   H2M3H0   A0A2A2M3Y4  

PDB

5NMV     E-value=6.6398e-08,     Score=129

KEGG

100147699    no KO assigned | (RefSeq) Ci-13; chymotrypsin inhibitor CI13

GO

GO:0004867   GO:0005615   GO:0007596   GO:0008061   GO:0005576   GO:0006030   GO:0090729   GO:0008233   GO:0005886   GO:0009986   GO:0006508   GO:0015074   GO:0003676   GO:0005737   GO:0006396   GO:0000166   GO:0004887   GO:0003707   GO:0016021  

Subcellular location

Secreted  

SignalP

Position:   1 - 23,         Likelihood:  0.999176

 

 

Length:

86

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

15.28214

Exp number, first 60 AAs:

15.28214

Total prob of N-in:

0.74691

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  22

outside

23  -  86

 

 

Pi

234.843748

Theta

158.167737

Tajima's D

1.409583

CLR

0.027725

CSRT

0.770261486925654

Interpretation

Uncertain