Gene

KWMTBOMO00859

Annotation

PREDICTED:_homeotic_protein_distal-less_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr2(-):4690761-4744558      View in EpiBrowser

Full name

Homeotic protein distal-less      

Alternative Name

Protein brista

Transcription factor

Homeobox

Location in the cell

Nuclear   Reliability : 4.736

CDS

ATGACATCACAGGATAACCTCGACCACCACCACCTGGGGGGCTCGCAGACCCCCCACGATATATCGAATTCAGCCAACTCGACCCCCACGAATGTGTCAAAATCTGCGTTTATAGAATTACAGCAGCACGGTTATGGGCCTTTCAAGGGGGGGTATCAGCATCCCCATCATTTCGGTAGTCCGGGGGGTCAGCAGAATCCTCACGAGGCATCAGGGTTTCCCAGTCCTAGATCATTAGGTTATCCTTTCCCTCCTATGCACCAAAACACGTATGGGTACCATTTAGGGTCTTACGCGCCGCAGTGTGCAAGTCCGCCCAAAGACGAGAAATGCGGTCTCTCGGACGATCCCGGTCTCCGCGTGAACGGCAAAGGGAAGAAGATGAGGAAGCCCCGCACAATATACTCCAGCCTTCAACTGCAACAGCTGAACAGGAGGTTCCAGAGGACGCAGTACCTCGCGCTACCAGAGCGGGCAGAGTTGGCGGCCAGCCTCGGACTAACGCAGACGCAGGTAAGTTGA

Protein

MTSQDNLDHHHLGGSQTPHDISNSANSTPTNVSKSAFIELQQHGYGPFKGGYQHPHHFGSPGGQQNPHEASGFPSPRSLGYPFPPMHQNTYGYHLGSYAPQCASPPKDEKCGLSDDPGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVS

Description

Transcription factor that plays a role in larval and adult appendage development. Specifies the identity of ventral appendages (including legs and antennae) and suppresses dorsal appendage development. Involved in patterning the distal-proximal limb axis. May control the adhesive properties of cells during limb morphogenesis. Also has a secondary role in the normal patterning of the wing margin.

Keywords

Alternative splicing   Complete proteome   Developmental protein   DNA-binding   Homeobox   Nucleus   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Homeotic protein distal-less
splice variant  In isoform B.

Uniprot

Q9TX42   A0A194R167   Q6IWM7   A0A0D3S0J9   A0A212ENJ0   Q95VX3   + More
Q8WRT8   A0A2Z6DQ67   A0A0D3S0F4   A0A194PT33   A0A2A4J7K9   B4X6Z7   A0A2H1VT44   A0A1B6FAV6   A0A182IKW0   A0A1B6CPJ5   A0A1B6L2D8   A0A182Y262   A0A1B6LCK2   A0A182II11   Q7PTF4   A0A182NZ04   A0A182VK49   A0A182XU98   A0A1W6GWZ2   A0A0K8SKT1   A0A182L384   A0A034WJE2   A0A0K8W1B8   A0A0K8VQ10   A0A0K8WMP1   W8BZ01   A0A1J1ITQ0   B4LN64   A0A0J9RL03   A0A0Q9WFJ6   B4IH92   B3NQZ9   B4QCK9   P20009   A0A1W4V1H5   P20009-2   A2VEF7   A0A0J9RKF8   A0A0Q5VYI1   B4PBV9   A0A0R1DTV4   B4J4C5   A0A0M4EKJ2   A0A1W4V082   A0A0A1X4Q1   A0A1W4UMZ4   A0A0A1WST2   A0A1I8MVV3   A0A1I8MVV0   A0A1I8P6X7   A0A1I8P6S5   A0A0L0BPR6   B4MPA7   B4KTK2   A0A3B0JGM8   Q28Z29   B4GIC8   B3MC35   A0A336M6W2   A0A0R3NNK2   A0A1A9V9P4   A0A1W4XKR1   A0A1B0CN62   A0A1A9WBB7   A0A1I8MVU4   A0A1I8P6U2   A0A1I8P6T1   A0A1I8MVU2   A0A1A9YDK1   A0A3Q0J0V4   A0A1B0BB12   A0A2R7W6F3   N6SY71   B3IWG0   A0A1B0FKQ2   A0A0C9QHP3   D6WRE0   A0A1Y1MUN0   Q9GPL3   Q2MHJ4   A0A2S2R447   A0A154PTJ9   J9L6R3   A0A1Q2SJQ0   A0A0H5AYY2   A0A2H8TVP1   B0I561   A0A2A3EHH7   A0A087ZMZ9  

Pubmed

7953552    26354079    22118469    11797007    25244985    12364791    + More
14747013    17210077    20966253    25348373    24495485    17994087    22936249    1358457    10731132    12537572    2564639    12537569    9303541    9778507    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    25830018    25315136    26108605    15632085    23537049    18362917    19820115    28004739    11124123    27989519    20449607   

EMBL

KQ460890    KPJ10995.1    AY616435    AAT39558.1    KP120517    AJS19035.1    + More
AGBW02013642    OWR43046.1    AF404110    AAK97630.1    AF404825    AAL69325.1    LC033901    BBD71106.1    KP120518    AJS19036.1    KQ459593    KPI96576.1    NWSH01002506    PCG68117.1    EF362786    ABP35643.1    ODYU01004288    SOQ44000.1    GECZ01022505    JAS47264.1    GEDC01021919    GEDC01019408    JAS15379.1    JAS17890.1    GEBQ01022176    JAT17801.1    GEBQ01018587    JAT21390.1    APCN01001490    AAAB01008807    EAA03995.4    KX449133    ARM20313.1    GBRD01012419    JAG53405.1    GAKP01004168    JAC54784.1    GDHF01007433    JAI44881.1    GDHF01011340    JAI40974.1    GDHF01000084    JAI52230.1    GAMC01008054    JAB98501.1    CVRI01000059    CRL03098.1    CH940648    EDW60068.1    CM002911    KMY96447.1    KRF79216.1    CH480838    EDW49268.1    CH954179    EDV57082.1    CM000362    EDX08625.1    KMY96446.1    S47947    AE013599    AY113370    BT030126    ABN49265.1    ACL83212.1    KMY96448.1    KQS63147.1    CM000158    EDW92613.1    KRK00604.1    CH916367    EDW01607.1    CP012524    ALC41917.1    GBXI01008185    JAD06107.1    GBXI01012727    JAD01565.1    JRES01001567    KNC21963.1    CH963849    EDW73946.1    CH933808    EDW08563.2    OUUW01000001    SPP74510.1    CM000071    EAL25786.2    CH479183    EDW36248.1    CH902619    EDV37222.2    UFQT01000543    SSX25121.1    KRT02551.1    AJWK01019842    AJWK01019843    AJWK01019844    AJWK01019845    JXJN01011270    JXJN01011271    KK854331    PTY14741.1    APGK01052158    APGK01052159    APGK01052160    APGK01052161    KB741211    ENN72734.1    AB365073    BAG49469.1    CCAG010022550    CCAG010022551    GBYB01000087    JAG69854.1    KQ971351    EFA07478.1    GEZM01023730    JAV88210.1    AF317551    AAG39634.1    AB200969    BAE78537.1    GGMS01015535    MBY84738.1    KQ435105    KZC14678.1    ABLF02037685    LC199492    BAW79361.1    LC010622    BAR93875.1    GFXV01006511    MBW18316.1    AB378321    BAG06741.1    KZ288242    PBC31253.1   

Proteomes

UP000053240    UP000007151    UP000053268    UP000218220    UP000075880    UP000076408    + More
UP000075840    UP000007062    UP000075884    UP000075903    UP000076407    UP000075882    UP000183832    UP000008792    UP000001292    UP000008711    UP000000304    UP000000803    UP000192221    UP000002282    UP000001070    UP000092553    UP000095301    UP000095300    UP000037069    UP000007798    UP000009192    UP000268350    UP000001819    UP000008744    UP000007801    UP000078200    UP000192223    UP000092461    UP000091820    UP000092443    UP000079169    UP000092460    UP000019118    UP000092444    UP000007266    UP000076502    UP000007819    UP000242457    UP000005203   

PRIDE

B4X6Z7    P20009   

Pfam

PF00046   Homeodomain

Interpro

IPR017970   Homeobox_CS        + More
IPR001356   Homeobox_dom       
IPR000047   HTH_motif       
IPR020479   Homeobox_metazoa       
IPR009057   Homeobox-like_sf       

SUPFAM

SSF46689   SSF46689       

CDD

cd00086  homeodomain

ProteinModelPortal

Q9TX42   A0A194R167   Q6IWM7   A0A0D3S0J9   A0A212ENJ0   Q95VX3   + More
Q8WRT8   A0A2Z6DQ67   A0A0D3S0F4   A0A194PT33   A0A2A4J7K9   B4X6Z7   A0A2H1VT44   A0A1B6FAV6   A0A182IKW0   A0A1B6CPJ5   A0A1B6L2D8   A0A182Y262   A0A1B6LCK2   A0A182II11   Q7PTF4   A0A182NZ04   A0A182VK49   A0A182XU98   A0A1W6GWZ2   A0A0K8SKT1   A0A182L384   A0A034WJE2   A0A0K8W1B8   A0A0K8VQ10   A0A0K8WMP1   W8BZ01   A0A1J1ITQ0   B4LN64   A0A0J9RL03   A0A0Q9WFJ6   B4IH92   B3NQZ9   B4QCK9   P20009   A0A1W4V1H5   P20009-2   A2VEF7   A0A0J9RKF8   A0A0Q5VYI1   B4PBV9   A0A0R1DTV4   B4J4C5   A0A0M4EKJ2   A0A1W4V082   A0A0A1X4Q1   A0A1W4UMZ4   A0A0A1WST2   A0A1I8MVV3   A0A1I8MVV0   A0A1I8P6X7   A0A1I8P6S5   A0A0L0BPR6   B4MPA7   B4KTK2   A0A3B0JGM8   Q28Z29   B4GIC8   B3MC35   A0A336M6W2   A0A0R3NNK2   A0A1A9V9P4   A0A1W4XKR1   A0A1B0CN62   A0A1A9WBB7   A0A1I8MVU4   A0A1I8P6U2   A0A1I8P6T1   A0A1I8MVU2   A0A1A9YDK1   A0A3Q0J0V4   A0A1B0BB12   A0A2R7W6F3   N6SY71   B3IWG0   A0A1B0FKQ2   A0A0C9QHP3   D6WRE0   A0A1Y1MUN0   Q9GPL3   Q2MHJ4   A0A2S2R447   A0A154PTJ9   J9L6R3   A0A1Q2SJQ0   A0A0H5AYY2   A0A2H8TVP1   B0I561   A0A2A3EHH7   A0A087ZMZ9  

PDB

4RDU     E-value=2.05651e-09,     Score=144

KEGG

101736212    K18488 homeobox protein DLX2 | (RefSeq) homeotic protein distal-less

GO

GO:0043565   GO:0006355   GO:0005634   GO:0003677   GO:0006357   GO:0003700   GO:0000978   GO:0021553   GO:0016319   GO:0048728   GO:0007449   GO:0042048   GO:0045893   GO:0008587   GO:0007469   GO:0007480   GO:0035114   GO:0007479   GO:0007485   GO:0035215   GO:0010092   GO:0010629   GO:0048264   GO:0007487   GO:0016021   GO:0006741   GO:0005737   GO:0006396   GO:0000166   GO:0004887   GO:0003707  

Subcellular location

Nucleus  

Length:

173

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00055

Exp number, first 60 AAs:

0

Total prob of N-in:

0.18552

outside

1  -  173

 

 

Pi

232.669545

Theta

173.953629

Tajima's D

1.389706

CLR

0.138862

CSRT

0.760861956902155

Interpretation

Uncertain