Gene

KWMTBOMO00811

Pre Gene Modal

BGIBMGA009693

Annotation

PREDICTED:_angiotensin-converting_enzyme-like_[Bombyx_mori]

Location

Bomo_Chr2(-):3352798-3355746      View in EpiBrowser

Full name

Angiotensin-converting enzyme      

Alternative Name

Dipeptidyl carboxypeptidase I
Kininase II

Location in the cell

Mitochondrial   Reliability : 1.449 Nuclear   Reliability : 1.056

CDS

ATGGCAGCTACGGAAAACCTTGGAAGCAACGATGTTTTGTGCTTCAAAGGAGAAGATGATTTTGAAAAATTAATGAGTAGATCAAAGAATGAACGTGTTTTGAAATGGACTTGGATGGCTTGGCGGGAGGCGGTGTGTCGGACAATGGGAGCGCCTTATAAAGAACTGGTTGAAATTGAAAATGCAGCTGCCAGAAGGAACGGCTACAAAGACATCGGCGAGTCCTGGAGAGAGGAACAAGAAATTCCAAATTTAAAAAGTTTTTGTCGTCGCCTATACAAAAGCATAAGACCTTTATACAGGACGCTGCATGGTATCACCAGGTTCTTCCTTAGAAGGCATTACGGGGCAATTGTAGAAGAGACCGGGCCAATACCGGCTCATTTATTGGGAAATCTCTGGTCACAGAATTGGGAGCCGTTAACGGATCTAATAATAAAAAACACGTTGAATTTAGACGAACGCATACGAAGATCTAACTGGACCGTTCTGCATATGGTGAGGATAAAAAAACTAGAAGCTGATTAA

Protein

MAATENLGSNDVLCFKGEDDFEKLMSRSKNERVLKWTWMAWREAVCRTMGAPYKELVEIENAAARRNGYKDIGESWREEQEIPNLKSFCRRLYKSIRPLYRTLHGITRFFLRRHYGAIVEETGPIPAHLLGNLWSQNWEPLTDLIIKNTLNLDERIRRSNWTVLHMVRIKKLEAD

Description

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity).

Catalytic Activity

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactor

Zn(2+)
chloride

Biophysicochemical Properties

2.51 mM for Hip-His-Leu

Miscellaneous

Inhibitors of ACE are commonly used to treat hypertension and some types of renal and cardiac dysfunction.
The glycosidase activity probably uses different active site residues than the metalloprotease activity.

Similarity

Belongs to the peptidase M2 family.

Keywords

3D-structure   Alternative splicing   Carboxypeptidase   Cell membrane   Complete proteome   Cytoplasm   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Membrane   Metal-binding   Metalloprotease   Phosphoprotein   Polymorphism   Protease   Reference proteome   Repeat   Secreted   Signal   Transmembrane   Transmembrane helix   Zinc  

Feature

chain  Angiotensin-converting enzyme
propeptide  Removed in soluble form
splice variant  In isoform 4.
sequence variant  In dbSNP:rs13306087.

Uniprot

H9JJJ2   A0A2A4J3I3   A0A2H1VAI7   A0A212FC18   A0A194PSY9   A0A0L7LGJ2   + More
E2C639   A0A195CS67   A0A067R743   E9JD70   E2ARV1   A0A2J7R0L7   A0A026WAE2   A0A3L8DWH2   Q16KU3   A0A1S4FXA3   W5JAF0   A0A182FFW1   E0VHF1   A0A182TY41   A0A182P3K9   A0A182RFM6   A0A182UVU7   A0A1B0GPC4   A0A182WIQ8   A0A182X6D2   D6WRC2   T1HGC9   Q7QJR1   A0A182KRS0   A0A182I3N8   A0A182QPM5   A0A2K6G9P4   A0A2K6G9P9   A0A182LXR3   A0A182NHM3   A0A2K6G9P1   J3KTB8   A0A1S3GIY4   A0A1D5QY90   L5KPC7   A0A384CCH2   Q3HTU3   A0A2K5CQL4   A0A2R8PBI1   F6R5R2   A0A2K6BQE6   A0A2K5VX29   A0A1B0CRV9   A0A2Y9G5A0   A0A2I3N885   A0A2K6P2V7   A0A2U3YBQ9   A0A182XZ84   G1TYT4   A0A2K6K394   A0A2K5I5V9   A0A2K5XHN5   A0A2I2Y2C2   A0A2R8ZYP4   H2QDM6   F6X3S4   I6L9B3   A0A2K6TDD2   A0A2R8N4Y1   F6QVU8   A0A2K5CQL7   A0A2U3YC18   A0A2K6K3B6   A0A2J8UZC8   A0A2U3YBR9   A0A2K6TDC7   F7F5C6   A0A2U4C3T3   A0A2K5I630   U5L195   P12821-3   A0A2K5CQI8   A0A2K5XHN8   Q9GLN7-2   A0A2R8ZYP1   A0A2U3WBW4   A0A2Y9G4W0   G3RZY8   A0A2K5PZN4   D3DU13   A0A2U3WBV7   A0A2K5VWR1   A0A2K6BQJ6   P12821-4   A0A2K6K3D3   A0A2K6P2X8   A0A096P6D3   A0A2R8ZYN2   A0A2I3SKE0   A0A2K5I5V3   A0A2I2ZRS8   A0A2K5VWS6   A0A1D5QHM2  

EC Number

3.4.-.-

Pubmed

19121390    22118469    26354079    26227816    20798317    24845553    + More
21282665    24508170    30249741    17510324    20920257    23761445    20566863    18362917    19820115    12364791    14747013    17210077    20966253    16625196    17431167    23258410    25362486    25244985    21993624    22398555    22722832    16136131    15489334    2849100    2547653    2554286    10319862    14702039    2558109    9642152    1649623    8755737    9013598    10769174    10969042    10924499    11076943    12386153    12459472    12542396    15151696    15671045    16335952    19159218    21269460    12540854    15236580    16476442    10099885    10391210    11551873    14694062    15534175    15277638    16116425    25787250    11013071    11181995   

EMBL

BABH01017456    BABH01017457    BABH01017458    BABH01017459    BABH01017460    NWSH01003593    + More
PCG66074.1    ODYU01001260    SOQ37224.1    AGBW02009238    OWR51282.1    KQ459593    KPI96541.1    JTDY01001279    KOB74311.1    GL452916    EFN76582.1    KQ977329    KYN03578.1    KK852657    KDR19225.1    GL771866    EFZ09138.1    GL442175    EFN63834.1    NEVH01008227    PNF34382.1    KK107295    EZA53025.1    QOIP01000003    RLU24850.1    CH477938    EAT34915.1    ADMH02001692    ETN61407.1    DS235169    EEB12807.1    AJVK01033349    KQ971351    EFA06546.2    ACPB03020413    ACPB03020414    AAAB01008807    EAA03963.4    APCN01000215    AXCN02000593    AXCM01000215    AC113554    JSUE03017170    JSUE03017171    KB030661    ELK12483.1    DQ195091    ABA40748.1    AQIA01028261    AJWK01025349    AHZZ02010522    AHZZ02010523    AAGW02039959    CABD030036630    CABD030036631    AJFE02035554    AJFE02035555    AJFE02035556    AJFE02035557    AACZ04070149    AACZ04070150    NBAG03000001    PNJ01391.1    BC036375    AAH36375.1    NDHI03003438    PNJ50625.1    KC153308    AGV55421.1    J04144    M26657    X16295    AF118569    AY436326    AK301988    EU332840    AB208971    AF193486    AF193462    AF193464    AF193463    AF193465    AF193467    AF193469    AF193471    AF193473    AF193482    AF193481    AF193480    AF193479    AF193478    AF193477    AF193476    AF193475    AF193474    AF193485    AF193484    AF193483    AF193472    AF193470    AF193468    AF193466    CH471109    EAW94321.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000037510    UP000008237    + More
UP000078542    UP000027135    UP000000311    UP000235965    UP000053097    UP000279307    UP000008820    UP000000673    UP000069272    UP000009046    UP000075902    UP000075885    UP000075900    UP000075903    UP000092462    UP000075920    UP000076407    UP000007266    UP000015103    UP000007062    UP000075882    UP000075840    UP000075886    UP000233160    UP000075883    UP000075884    UP000005640    UP000081671    UP000006718    UP000010552    UP000261680    UP000233020    UP000008225    UP000233120    UP000233100    UP000092461    UP000248481    UP000028761    UP000233200    UP000245341    UP000076408    UP000001811    UP000233180    UP000233080    UP000233140    UP000001519    UP000240080    UP000002277    UP000233220    UP000245320    UP000245340    UP000233040   

PRIDE

H9JJJ2    J3KTB8    F6X3S4    I6L9B3    P12821    Q9GLN7    + More
D3DU13   

Pfam

PF01401   Peptidase_M2        + More
PF02935   COX7C

Interpro

IPR001548   Peptidase_M2        + More
IPR004202   COX7C/Cox8       
IPR036636   COX7C/Cox8_sf       

SUPFAM

SSF81427   SSF81427       

Gene 3D

4.10.49.10    

CDD

cd06461  M2_ACE
cd00929  Cyt_c_Oxidase_VIIc

ProteinModelPortal

H9JJJ2   A0A2A4J3I3   A0A2H1VAI7   A0A212FC18   A0A194PSY9   A0A0L7LGJ2   + More
E2C639   A0A195CS67   A0A067R743   E9JD70   E2ARV1   A0A2J7R0L7   A0A026WAE2   A0A3L8DWH2   Q16KU3   A0A1S4FXA3   W5JAF0   A0A182FFW1   E0VHF1   A0A182TY41   A0A182P3K9   A0A182RFM6   A0A182UVU7   A0A1B0GPC4   A0A182WIQ8   A0A182X6D2   D6WRC2   T1HGC9   Q7QJR1   A0A182KRS0   A0A182I3N8   A0A182QPM5   A0A2K6G9P4   A0A2K6G9P9   A0A182LXR3   A0A182NHM3   A0A2K6G9P1   J3KTB8   A0A1S3GIY4   A0A1D5QY90   L5KPC7   A0A384CCH2   Q3HTU3   A0A2K5CQL4   A0A2R8PBI1   F6R5R2   A0A2K6BQE6   A0A2K5VX29   A0A1B0CRV9   A0A2Y9G5A0   A0A2I3N885   A0A2K6P2V7   A0A2U3YBQ9   A0A182XZ84   G1TYT4   A0A2K6K394   A0A2K5I5V9   A0A2K5XHN5   A0A2I2Y2C2   A0A2R8ZYP4   H2QDM6   F6X3S4   I6L9B3   A0A2K6TDD2   A0A2R8N4Y1   F6QVU8   A0A2K5CQL7   A0A2U3YC18   A0A2K6K3B6   A0A2J8UZC8   A0A2U3YBR9   A0A2K6TDC7   F7F5C6   A0A2U4C3T3   A0A2K5I630   U5L195   P12821-3   A0A2K5CQI8   A0A2K5XHN8   Q9GLN7-2   A0A2R8ZYP1   A0A2U3WBW4   A0A2Y9G4W0   G3RZY8   A0A2K5PZN4   D3DU13   A0A2U3WBV7   A0A2K5VWR1   A0A2K6BQJ6   P12821-4   A0A2K6K3D3   A0A2K6P2X8   A0A096P6D3   A0A2R8ZYN2   A0A2I3SKE0   A0A2K5I5V3   A0A2I2ZRS8   A0A2K5VWS6   A0A1D5QHM2  

PDB

6H5W     E-value=7.46976e-29,     Score=312

KEGG

101744965    K01283 peptidyl-dipeptidase A [EC:3.4.15.1] | (RefSeq) angiotensin-converting enzyme-like

GO

GO:0016020   GO:0008237   GO:0004180   GO:0046872   GO:0008241   GO:0016021   GO:0004129   GO:0005886   GO:0005615   GO:0008238   GO:0071838   GO:0050435   GO:0001822   GO:0005768   GO:0009897   GO:0008240   GO:0060047   GO:0032091   GO:0005764   GO:0042447   GO:0003081   GO:0002446   GO:1903597   GO:0031434   GO:0061098   GO:2000170   GO:0010629   GO:0008144   GO:0070062   GO:0043171   GO:1900086   GO:0031711   GO:1902033   GO:0007283   GO:0050482   GO:0010608   GO:0051019   GO:0060177   GO:0032092   GO:0031404   GO:0008270   GO:0003084   GO:0004175   GO:0008239   GO:0045777   GO:0032943   GO:0003779   GO:0001974   GO:0019229   GO:0006508   GO:0060218   GO:0014910   GO:0002019   GO:0002474   GO:0097746   GO:0005576   GO:0070573   GO:0008217   GO:0002003   GO:0005737   GO:0007178   GO:0004675   GO:0006559   GO:0004887  

PANTHER

PTHR10514  

Subcellular location

Secreted  
Cell membrane   Detected in both cell membrane and cytoplasm in neurons.   With evidence from 10 publications.
Cytoplasm   Detected in both cell membrane and cytoplasm in neurons.   With evidence from 10 publications.

Length:

175

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00247

Exp number, first 60 AAs:

0

Total prob of N-in:

0.11916

outside

1  -  175

 

 

Pi

248.807034

Theta

125.535225

Tajima's D

2.954712

CLR

0.005054

CSRT

0.977601119944003

Interpretation

Uncertain