Gene

KWMTBOMO00808

Pre Gene Modal

BGIBMGA009693

Annotation

PREDICTED:_angiotensin-converting_enzyme-like_[Amyelois_transitella]

Location

Bomo_Chr2(-):3340759-3345206      View in EpiBrowser

Full name

Angiotensin-converting enzyme      

Alternative Name

Dipeptidyl carboxypeptidase I
Kininase II

Location in the cell

Cytoplasmic   Reliability : 1.08 Nuclear   Reliability : 1.251

CDS

ATGACGGACACGTTTTGGCGCGAATCGGTTTTGACGCGGGAAAAACACGCACACGCGCGTTGTCATGGCGCCGCAGCCGACATGTTTAAAGATGGCGATTTCAGACTGCTCTATTGCTCCGGAACTACAAAGGAAGATCTTTATGTACTACATCATGAACTTGGTCACATACAATATTATATGGCATACGAAGACCAGCCTGCTATATTCAGACAAGCTAATACAGCGCTGCACGAGACAATAGGAGACTCTATAATGCTCGGTGCGTTTACACCGCAACATCTGCATAGGCTTGGTCTCATTACGGACCACGAACTGTATTCCAACGAACACAGCACTAGAGAAGACAATGACAATGTCAATAAACGTCACGACATCGATGAGAACATTGATGAGATAAAAAATCACGAAACCAAAGCAAAAAAGTTTGCCAATGATACTGCTAGAATTGAAAATGCTAAAAATTATGTTGATTACAATTCCAAAGCAAATAATACTAGAAGTTTTGATAACAAGCTCGCACTAGACGATGTACTTCTGTTCAAACAAGCCCTTAATAAAATACCGCAAATAGCCTTCGCATTAGTTTTGGAGGAGTACCGATGGAAGTATTTTGAGAATGGTCTGAGCAATTTGAATGGAGATTTTTGGGACATGGCCTTGGAATTACAAGGAATCGTTCCACCAGTCTATAGAGGCGAAGACTATTTTGACGCCGGAGCTAAATTTCATGTGCCAGACAACACTCCTTATGCACGATACTTCTTAAGCAGCTTCCTCCAGCACCAAGTTTACGAGACGCTGTGCAAAGCGGCAGTCTTCGGTCGGCGTAATGTCGACGAGCCCCTGCCTAGTACCATCAGAATGGACCGCTGCGACATTTACGGATCGAAGACCGTTGGCAGGATATTACAAGAAATAATGAAACCTGGCCACTCAAAACACTGGCGTGTCATCTTGAAGGCTGCGACGGGGATAGACGACATCTCTGGGGCAGCTCTGAAACGATACTACCGGCCGCTGTACAAGATATTAAACAAGATGGTTGCCCGATATCGGATTCCGATTGGCTGGTGA

Protein

MTDTFWRESVLTREKHAHARCHGAAADMFKDGDFRLLYCSGTTKEDLYVLHHELGHIQYYMAYEDQPAIFRQANTALHETIGDSIMLGAFTPQHLHRLGLITDHELYSNEHSTREDNDNVNKRHDIDENIDEIKNHETKAKKFANDTARIENAKNYVDYNSKANNTRSFDNKLALDDVLLFKQALNKIPQIAFALVLEEYRWKYFENGLSNLNGDFWDMALELQGIVPPVYRGEDYFDAGAKFHVPDNTPYARYFLSSFLQHQVYETLCKAAVFGRRNVDEPLPSTIRMDRCDIYGSKTVGRILQEIMKPGHSKHWRVILKAATGIDDISGAALKRYYRPLYKILNKMVARYRIPIGW

Description

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm (By similarity).
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity).

Catalytic Activity

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactor

Zn(2+)
chloride

Biophysicochemical Properties

0.6 mM for Hip-His-Leu
0.09 mM for angiotensin I

Similarity

Belongs to the peptidase M2 family.

Keywords

Alternative splicing   Carboxypeptidase   Cell membrane   Complete proteome   Cytoplasm   Glycoprotein   Hydrolase   Membrane   Metal-binding   Metalloprotease   Phosphoprotein   Polymorphism   Protease   Reference proteome   Repeat   Secreted   Signal   Transmembrane   Transmembrane helix   Zinc   Disulfide bond   Direct protein sequencing  

Feature

chain  Angiotensin-converting enzyme
propeptide  Removed in secreted form
splice variant  In isoform Testis-specific.

Uniprot

H9JJJ2   A0A2A4J3I3   A0A1E1WUR5   A0A212FC18   A0A2H1VAI7   A0A0L7K436   + More
A0A194R0B3   Q16KU3   A0A0L7LGJ2   A0A1S4FXA3   A0A336KF21   A0A336MCD1   A0A1B0GPC4   A0A182JG90   A0A084VWX4   A0A182S888   A0A182WIQ8   A0A026WAE2   A0A182TY41   A0A182XZ84   E9JD70   W5JAF0   A0A182I3N8   Q7QJR1   A0A182NHM3   A0A182RFM6   A0A182FFW1   A0A182X6D2   A0A195CS67   A0A182KRS0   A0A182UVU7   A0A182LXR3   A0A0J7NJY6   A0A0P6H8Y7   A0A286Y4R9   A0A3Q0CPJ2   A0A2J7R0L7   B0WN26   A0A146YS94   P47820-2   A0A182QPM5   A0A0P6J8C8   A0A067R743   A0A0P5N2N7   A0A1U7Q259   Q50JE5   A0A0N8D234   A0A0P5KGY9   A0A3Q0CPK0   A0A0P6D911   A0A0P5E8B7   A0A0P5IEC3   A0A0P6DEY3   H0UWL7   A0A0P5K5W7   A0A0N8BQ75   A0A0N8CAT5   A0A0P5MRY9   A0A0P5RWM2   A0A0P5ZB98   A0A0P5I9S0   A0A0P5K938   A0A0P6D490   A0A0N8CAD6   A0A0P6E7W5   A0A0P5KCL7   A0A0P5KRD5   A0A0P5DD56   A0A0N8DEA2   A0A0N8BLQ7   A0A0P5JK30   A0A0P6BDD2   A0A0P6D328   A0A0P5JTZ9   A0A0P6CTS0   A0A0P5QMY1   A0A162D090   A0A0P5L464   A0A0P5RA08   A0A0P6D0P6   A0A0P5JPT1   A0A0P5KFR9   A0A0P5XTG4   A0A0P6F7B0   A0A0P5SB30   A0A0P6EJV7   A0A0P6DX31   A0A0P5M603   A0A287D9C6   P47820   A0A1B6E302   P09470-2   G5BDK0   A0A091D6K2   A0A3L7H8Z4   A0A2K6G9P9   A0A3B3BGN1   P12822-2   I3MDG2   B3MLX8  

EC Number

3.4.-.-

Pubmed

19121390    22118469    26227816    26354079    17510324    24438588    + More
24508170    25244985    21282665    20920257    23761445    12364791    14747013    17210077    20966253    21993624    8292044    12963491    15489334    15671045    22673903    24845553    17343204    2545691    2164636    2841312    2835538    7753170    8642790    15665832    16944957    17114649    21183079    23535237    21993625    29704459    29451363    1311831    2550457    1847388    6291514    6314908    1654880    1705622    2176870    8294466    7902354    17994087   

EMBL

BABH01017456    BABH01017457    BABH01017458    BABH01017459    BABH01017460    NWSH01003593    + More
PCG66074.1    GDQN01000332    JAT90722.1    AGBW02009238    OWR51282.1    ODYU01001260    SOQ37224.1    JTDY01010996    KOB57768.1    KQ460890    KPJ10964.1    CH477938    EAT34915.1    JTDY01001279    KOB74311.1    UFQS01000388    UFQT01000388    SSX03476.1    SSX23841.1    UFQS01000676    UFQT01000676    SSX06097.1    SSX26453.1    AJVK01033349    ATLV01017806    KE525192    KFB42468.1    KK107295    EZA53025.1    GL771866    EFZ09138.1    ADMH02001692    ETN61407.1    APCN01000215    AAAB01008807    EAA03963.4    KQ977329    KYN03578.1    AXCM01000215    LBMM01004121    KMQ92795.1    GDIQ01023023    JAN71714.1    AAKN02045203    AAKN02045204    NEVH01008227    PNF34382.1    DS232006    EDS31445.1    GCES01029357    JAR56966.1    U03708    U03734    AF201331    AF201332    AF539425    BC085760    AF532783    AF532784    AXCN02000593    GEBF01003132    JAO00501.1    KK852657    KDR19225.1    GDIQ01155660    JAK96065.1    AB212958    GDIP01076375    JAM27340.1    GDIQ01184247    JAK67478.1    GDIQ01081683    JAN13054.1    GDIP01145318    JAJ78084.1    GDIQ01215581    JAK36144.1    GDIQ01081681    JAN13056.1    GDIQ01188997    JAK62728.1    GDIQ01155659    JAK96066.1    GDIQ01097979    JAL53747.1    GDIQ01152850    JAK98875.1    GDIQ01096070    JAL55656.1    GDIP01048483    JAM55232.1    GDIQ01215580    JAK36145.1    GDIQ01188996    JAK62729.1    GDIQ01083182    JAN11555.1    GDIQ01099171    JAL52555.1    GDIQ01066633    JAN28104.1    GDIQ01185993    JAK65732.1    GDIQ01187596    JAK64129.1    GDIP01157869    JAJ65533.1    GDIP01042231    JAM61484.1    GDIQ01165403    JAK86322.1    GDIQ01201837    JAK49888.1    GDIP01023304    JAM80411.1    GDIQ01084631    JAN10106.1    GDIQ01198887    JAK52838.1    GDIQ01087879    JAN06858.1    GDIQ01162550    GDIQ01112065    JAL39661.1    LRGB01000007    KZS21929.1    GDIQ01184246    JAK67479.1    GDIQ01103821    JAL47905.1    GDIQ01084632    JAN10105.1    GDIQ01200191    JAK51534.1    GDIQ01185994    JAK65731.1    GDIP01067677    JAM36038.1    GDIQ01060232    JAN34505.1    GDIQ01096069    JAL55657.1    GDIQ01068589    JAN26148.1    GDIQ01086184    JAN08553.1    GDIQ01184245    JAK67480.1    AGTP01052565    GEDC01004986    JAS32312.1    J04946    J04947    M55333    M61094    BC040404    J03940    JH169663    EHB07361.1    KN122870    KFO27694.1    RAZU01000248    RLQ62355.1    X62551    J05041    M58579    M58580    CH902620    EDV31806.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000037510    UP000053240    UP000008820    + More
UP000092462    UP000075880    UP000030765    UP000075901    UP000075920    UP000053097    UP000075902    UP000076408    UP000000673    UP000075840    UP000007062    UP000075884    UP000075900    UP000069272    UP000076407    UP000078542    UP000075882    UP000075903    UP000075883    UP000036403    UP000005447    UP000189706    UP000235965    UP000002320    UP000002494    UP000075886    UP000027135    UP000076858    UP000005215    UP000000589    UP000006813    UP000028990    UP000273346    UP000233160    UP000261560    UP000001811    UP000007801   

PRIDE

H9JJJ2    P47820    Q50JE5    P09470    P12822   

Pfam

PF01401   Peptidase_M2        + More
PF12928   tRNA_int_end_N2
PF02935   COX7C

Interpro

IPR001548   Peptidase_M2        + More
IPR024336   tRNA_splic_suSen54_N       
IPR004202   COX7C/Cox8       
IPR036636   COX7C/Cox8_sf       

SUPFAM

SSF81427   SSF81427       

Gene 3D

4.10.49.10    

CDD

cd00929  Cyt_c_Oxidase_VIIc
cd06461  M2_ACE

ProteinModelPortal

H9JJJ2   A0A2A4J3I3   A0A1E1WUR5   A0A212FC18   A0A2H1VAI7   A0A0L7K436   + More
A0A194R0B3   Q16KU3   A0A0L7LGJ2   A0A1S4FXA3   A0A336KF21   A0A336MCD1   A0A1B0GPC4   A0A182JG90   A0A084VWX4   A0A182S888   A0A182WIQ8   A0A026WAE2   A0A182TY41   A0A182XZ84   E9JD70   W5JAF0   A0A182I3N8   Q7QJR1   A0A182NHM3   A0A182RFM6   A0A182FFW1   A0A182X6D2   A0A195CS67   A0A182KRS0   A0A182UVU7   A0A182LXR3   A0A0J7NJY6   A0A0P6H8Y7   A0A286Y4R9   A0A3Q0CPJ2   A0A2J7R0L7   B0WN26   A0A146YS94   P47820-2   A0A182QPM5   A0A0P6J8C8   A0A067R743   A0A0P5N2N7   A0A1U7Q259   Q50JE5   A0A0N8D234   A0A0P5KGY9   A0A3Q0CPK0   A0A0P6D911   A0A0P5E8B7   A0A0P5IEC3   A0A0P6DEY3   H0UWL7   A0A0P5K5W7   A0A0N8BQ75   A0A0N8CAT5   A0A0P5MRY9   A0A0P5RWM2   A0A0P5ZB98   A0A0P5I9S0   A0A0P5K938   A0A0P6D490   A0A0N8CAD6   A0A0P6E7W5   A0A0P5KCL7   A0A0P5KRD5   A0A0P5DD56   A0A0N8DEA2   A0A0N8BLQ7   A0A0P5JK30   A0A0P6BDD2   A0A0P6D328   A0A0P5JTZ9   A0A0P6CTS0   A0A0P5QMY1   A0A162D090   A0A0P5L464   A0A0P5RA08   A0A0P6D0P6   A0A0P5JPT1   A0A0P5KFR9   A0A0P5XTG4   A0A0P6F7B0   A0A0P5SB30   A0A0P6EJV7   A0A0P6DX31   A0A0P5M603   A0A287D9C6   P47820   A0A1B6E302   P09470-2   G5BDK0   A0A091D6K2   A0A3L7H8Z4   A0A2K6G9P9   A0A3B3BGN1   P12822-2   I3MDG2   B3MLX8  

PDB

4C2N     E-value=3.68163e-48,     Score=483

KEGG

101744965    K01283 peptidyl-dipeptidase A [EC:3.4.15.1] | (RefSeq) angiotensin-converting enzyme-like

GO

GO:0016020   GO:0008237   GO:0004180   GO:0046872   GO:0008241   GO:0016021   GO:0004129   GO:0008238   GO:0005615   GO:0005886   GO:0019233   GO:0034616   GO:0001822   GO:0090281   GO:0003081   GO:0008584   GO:0001666   GO:0014910   GO:0031667   GO:0005737   GO:0097066   GO:0009792   GO:1904045   GO:0007565   GO:0060978   GO:0006518   GO:0007420   GO:0046325   GO:0032496   GO:0008217   GO:0043171   GO:0043065   GO:0009925   GO:0008144   GO:0008239   GO:0071333   GO:0031526   GO:0042493   GO:0031100   GO:0097225   GO:0035814   GO:0050729   GO:0010815   GO:0071548   GO:0048286   GO:0042755   GO:0030324   GO:0050769   GO:0007568   GO:0003084   GO:0097756   GO:0031982   GO:0045777   GO:0042310   GO:0005576   GO:0031434   GO:1903597   GO:0061098   GO:2000170   GO:0005768   GO:0050435   GO:0071838   GO:0008240   GO:0009897   GO:0032091   GO:0060047   GO:0002446   GO:0042447   GO:0005764   GO:0050482   GO:0007283   GO:0032092   GO:0060177   GO:0051019   GO:0010608   GO:0031404   GO:0004175   GO:0008270   GO:0010629   GO:1900086   GO:0070062   GO:1902033   GO:0031711   GO:0070573   GO:0008233   GO:0003779   GO:0002027   GO:0045938   GO:0003007   GO:0030431   GO:0006508   GO:0007178   GO:0004675   GO:0006559   GO:0004887  

PANTHER

PTHR10514  

Subcellular location

Secreted  
Cell membrane   Detected in both cell membrane and cytoplasm in neurons.   With evidence from 2 publications.
Cytoplasm   Detected in both cell membrane and cytoplasm in neurons.   With evidence from 2 publications.

Length:

358

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00491

Exp number, first 60 AAs:

9e-05

Total prob of N-in:

0.02275

outside

1  -  358

 

 

Pi

183.364039

Theta

153.90457

Tajima's D

1.278135

CLR

0

CSRT

0.734363281835908

Interpretation

Uncertain