Gene

KWMTBOMO00748

Pre Gene Modal

BGIBMGA013336

Annotation

PREDICTED:_diacylglycerol_kinase_1_isoform_X1_[Papilio_xuthus]

Location

Bomo_Chr2(-):2286846-2342156      View in EpiBrowser

Full name

Diacylglycerol kinase       + More
Diacylglycerol kinase beta      

Alternative Name

90 kDa diacylglycerol kinase
Diglyceride kinase beta

Location in the cell

Nuclear   Reliability : 2.678

CDS

ATGCCTAATCCGGTCGGCGGCGGGTTCCAGTGGGACAAACTCTCGCCGGCCGAGTTTCAACAGCTCCAAGAATTAGCGTCATATTCCACGAGGAAGCTCCAAGATGTGCTCAACGAGTTTTGTGAGGTCAAGAAACAGAGTCCGGACGGGGATATTGACTATGAGGGGTTCCGGTGGTTTCTGGACACGTTCCTCGAGGTCTCCACGCCTGATGAACTCTCTAGACATTTGTTCCTGTCGTTTGTTCGGCGAGATCGCAGACCAGCGCTGCGGGAGATGGCGGCTGCTAGTTCCACTACCGCCTGCGCAGCGGTCACAGCCCATGCTGACCATCAGGTGAAACCAACGCTGGCTTCGAAGATCCACGGTCTGGCTGAGAGACTTCAGCAGCTGGGAAAGAGCTCCGCTGATTCGGTAGACGGTAGCGACAAGGGATCAAGAAGCAGAACCGGTAGCGTCCACCCCATGTTCACGGTGACCACGCATCCTTCGTACTCCTCCCACGAGCTCTGCTTGGACAGACGCAACGAGACCAGTCCCAGTCACAGTCAAATGTCGAGAAACTCCAGCAGAAAGAGCAGCAACTCAATGAGGGTGAACCAGTCTACTAAAATCGAAGACTTTAGACACCTAATGAGACGCTCGTCGACAGTAGAAGTACACACAGCCAGAGTCTCTCTCAAGGATATCGTCTGCTACCTCTCACTCCTAGAAGCAGGCAGACCTGAAGACAAGCTGGAGTTCATGTTTAGACTCTACGACACCGATGGTAACGGCGTACTGGACACTAACGAGATGGACTGCATCGTGAACCAGATGATGGCTGTCGCTGAATATCTAGGCTGGGAGACTTCTGAATTGAGGCCTATTTTACAAGATATGATGGTTGAGATAGACTATGACGCCGATGGGACGGTTTCTCTGGACGAATGGAAACGAGGCGGCATGACCACAATACCTCTGCTGGTTCTCTTGGGCTTGGATACTAACGTGAAAGAAGACGGCGAGCACGCGTGGAGATTAAAGCACTTCAGTAGACCAGCGTATTGCAATCTGTGCTTGAACATGCTCGTGGGGCTCGGGAAAAAGGGCTTGTGTTGCATTTTTTGCAAATTTACGGTACACGAGCGTTGCGTCCAGCGAGCACCGGCCTCTTGCATAGCCACTTATTCCAAGTCCAAGCGTGCTTCTGCCACACTTGCTCATCATTGGATCGAAGGAAATTGCCACGGAAAATGCGCTAGATGTCGGAAAAAGATCAAAGGCTACAACGGTATCACCGGCTTGCACTGTCGCTGGTGTCACATTACACTCCACAACCGTTGCGTGGGCGCGGCGGGCGGGGCGTGCACATTGGGTCGCCACGCGCCGCACATCCTGCCGCCCACCGCCATCCGTCCTCTCGTGCTCGACCGCCAACGCTCTCTGCCGCACCGACCGCAGCCTGACCAGCAAACACTGCCCACTTCAATATCGCTGCCGATCTCGATAGCCGCTGTTCCCGAAGAACGGAAGGACCAAAAGAAAGAGCCCAGAGCACCTCCCATATCATTCCAAGTAACTCCTCCTGAGGGGAGCTGCCCTTTACTAGTGTTCATAAACCCTAAGAGCGGAGGGCGACAAGGGTCCAGGGTTCTAAGGAAACTCCAATATATCTTGAACCCGAGACAGGTTCATGATATCACCAAAGGAGGACCTACACAAGGTCTGCAGATGTTCAAAGACGTGAAGAACTATCGTGTCATATGCTGCGGTGGAGACGGTACAGTTGGCTGGGTTCTGGAGACCATGGATAAGGTGCAAATGGAAACTCAGCCGGCGGTCGGGGTGATACCTCTAGGAACCGGAAATGATCTGGCGCGGTGTCTGCGGTGGGGAGGAGGTTATGAAGGTGAATCGATTCACAAAATACTGGACAAGATCGCCAGAGCGAGCACTGTGATGATGGACAGGTGGCAGATTATGGTGGAAAACTTGGCCATGGAGTGTGATCAGCCTCAAATGCCAGACTCGGCGCCTCATCCCACAACAGTGCCGTACAACATCATCAATAATTATTTCTCCATCGGCGTTGACGCCGCCATCTGCGTGAAGTTCCACACGGAGAGAGAAAGGAATCCGGACAAGTTCAGTTCTAGAATGAAGAACAAGCTGTGGTACTTTGAGTTCGCGACGTCGGAACAGTTCGCAGCCAGCTGCAAGAACTTACACGAGAACATCGATATTGTGTGCGACGGGTCGTCTCTTGAGCTGAAGAAGGGTCCGTCGCTGCAGGGCGTGGCGCTCCTCAACATCCCGTACGCGCACGGCGGCTCCAACCTGTGGGGCACCAGCGCGGCGCAGCGGCGGGGGCGCTTCCCGCAAGCGCAGCAAGACATCGGCGACAGAATGATCGAAGTGATCGGACTTGAGAATTGTCTACACATGGGTCAGGTGCGGACAGGCCTTCGAGCCTCCGGGCGAAGGTTGGCCCAGTGCAGCTCAATAACGATCACCACGAAGAGAATGTTCCCGATGCAGATTGACGGCGAGCCCTGGATGCAGCCTCCGTGCACGATCACAATCACTCATAAAAATCAAGTTCCGATGCTCATGGGACCAGAGCCAGAGAAAGGAAGAGGATTCTTCAAAATATTCACTCACTGTTAA

Protein

MPNPVGGGFQWDKLSPAEFQQLQELASYSTRKLQDVLNEFCEVKKQSPDGDIDYEGFRWFLDTFLEVSTPDELSRHLFLSFVRRDRRPALREMAAASSTTACAAVTAHADHQVKPTLASKIHGLAERLQQLGKSSADSVDGSDKGSRSRTGSVHPMFTVTTHPSYSSHELCLDRRNETSPSHSQMSRNSSRKSSNSMRVNQSTKIEDFRHLMRRSSTVEVHTARVSLKDIVCYLSLLEAGRPEDKLEFMFRLYDTDGNGVLDTNEMDCIVNQMMAVAEYLGWETSELRPILQDMMVEIDYDADGTVSLDEWKRGGMTTIPLLVLLGLDTNVKEDGEHAWRLKHFSRPAYCNLCLNMLVGLGKKGLCCIFCKFTVHERCVQRAPASCIATYSKSKRASATLAHHWIEGNCHGKCARCRKKIKGYNGITGLHCRWCHITLHNRCVGAAGGACTLGRHAPHILPPTAIRPLVLDRQRSLPHRPQPDQQTLPTSISLPISIAAVPEERKDQKKEPRAPPISFQVTPPEGSCPLLVFINPKSGGRQGSRVLRKLQYILNPRQVHDITKGGPTQGLQMFKDVKNYRVICCGGDGTVGWVLETMDKVQMETQPAVGVIPLGTGNDLARCLRWGGGYEGESIHKILDKIARASTVMMDRWQIMVENLAMECDQPQMPDSAPHPTTVPYNIINNYFSIGVDAAICVKFHTERERNPDKFSSRMKNKLWYFEFATSEQFAASCKNLHENIDIVCDGSSLELKKGPSLQGVALLNIPYAHGGSNLWGTSAAQRRGRFPQAQQDIGDRMIEVIGLENCLHMGQVRTGLRASGRRLAQCSSITITTKRMFPMQIDGEPWMQPPCTITITHKNQVPMLMGPEPEKGRGFFKIFTHC

Description

Exhibits high phosphorylation activity for long-chain diacylglycerols.

Catalytic Activity

a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)

Similarity

Belongs to the eukaryotic diacylglycerol kinase family.

Keywords

Alternative splicing   ATP-binding   Calcium   Complete proteome   Cytoplasm   Kinase   Metal-binding   Nucleotide-binding   Phosphoprotein   Polymorphism   Reference proteome   Repeat   Transferase   Zinc   Zinc-finger  

Feature

chain  Diacylglycerol kinase beta
splice variant  In isoform 2.
sequence variant  In dbSNP:rs34616903.

Uniprot

A0A194PZ99   A0A194R029   A0A0K2S343   H9JUX3   A0A2A4J370   A0A087ZMS3   + More
A0A3L8DCW2   A0A158NTM4   F4WSF1   A0A2A4J7Q7   A0A154PGA3   A0A1W4XJJ5   A0A1W4XKP6   A0A310SBY0   A0A026WJE9   A0A195ERV3   A0A1W4XJK0   A0A0L7RC29   A0A2A3E5B7   A0A1Y1K6F7   A0A151X3Q3   E2AXF7   A0A067RCJ5   A0A195BQ84   T1J4I9   A0A1W4XKG8   E2BKU8   T1ID18   E0VZ55   A0A1Y1KA40   A0A0P5XEF8   A0A1W7RAP3   A0A0P6H8X4   U4UEK8   E9H738   A0A1D2MP71   A0A210Q1M3   A0A1S3IRW2   N6UGH4   A0A2T7PUZ1   A0A1S3IPX2   A0A2R5L6H7   A0A1S3IQC2   E9IYH8   A0A1D1URY8   A0A1W0WBN0   A0A1W0WBI2   A0A0P5KC03   R7TZB0   A0A1S3IPW8   A0A1S3IQS8   A0A0P6C0W9   A0A0N8BDM6   A0A091HYU1   I3JHD4   A0A2Y9DMN4   A0A3P8NU32   A0A2Y9R8W3   F6ZFB7   A0A2K6C2Q0   A0A2K5KKT8   A0A2K5KKT3   A0A3P8NUA1   A0A2Y9DMK8   A0A337SXK4   A0A099Z8E5   A0A218V7R6   A0A3B4T403   A0A093IHD0   H0YWD4   B5MBY2   B7Z9A9   A0A3B4T4C0   U3K5V3   A0A091F352   A0A2Y9R8C8   A0A1S3FTV9   A0A287CTF2   G3RD41   A0A2U4B1M9   A0A2Y9T240   A0A2Y9H5U1   A0A2Y9H7J9   A0A2U3XIE8   A0A2U3VXH8   Q9Y6T7   Q6NS52-2   A0A2I2ZRH6   G1MD26   A0A2I3G9Q7   A0A2Y9DMN8   A0A2R9BEZ0   A0A2Y9H156   A0A2Y9JH57   A0A2Y9JMC4   H2RDM1   K1QAV3   B5MCD5  

EC Number

2.7.1.107

Pubmed

26354079    19121390    30249741    21347285    21719571    24508170    + More
28004739    20798317    24845553    20566863    23537049    21292972    27289101    28812685    21282665    27649274    23254933    25186727    17975172    20360741    12853948    22398555    12690205    15489334    9872452    16141072    12693553    21183079    20010809    22722832    16136131    22992520   

EMBL

KQ459593    KPI96480.1    KQ460890    KPJ10889.1    AB999997    BAS21453.1    + More
BABH01040760    BABH01040761    NWSH01003755    PCG65852.1    QOIP01000010    RLU17973.1    ADTU01026033    ADTU01026034    ADTU01026035    ADTU01026036    ADTU01026037    ADTU01026038    ADTU01026039    ADTU01026040    GL888321    EGI62868.1    NWSH01002674    PCG67698.1    KQ434899    KZC10881.1    KQ764145    OAD54595.1    KK107171    EZA56115.1    KQ981993    KYN30985.1    KQ414617    KOC68378.1    KZ288363    PBC26927.1    GEZM01091198    JAV57049.1    KQ982562    KYQ54848.1    GL443549    EFN61881.1    KK852727    KDR17623.1    KQ976424    KYM88670.1    JH431845    GL448826    EFN83697.1    ACPB03024605    ACPB03024606    DS235849    EEB18661.1    GEZM01091197    JAV57050.1    GDIP01074283    JAM29432.1    GFAH01000185    JAV48204.1    GDIQ01023013    JAN71724.1    KB632052    ERL88335.1    GL732599    EFX72450.1    LJIJ01000766    ODM94692.1    NEDP02005240    OWF42627.1    APGK01036200    APGK01036201    APGK01036202    APGK01036203    APGK01036204    APGK01036205    KB740937    ENN77757.1    PZQS01000002    PVD37197.1    GGLE01000911    MBY05037.1    GL767018    EFZ14349.1    BDGG01000001    GAU88928.1    MTYJ01000141    OQV12577.1    OQV12576.1    GDIQ01186446    JAK65279.1    AMQN01010248    KB307403    ELT98962.1    GDIP01007572    JAM96143.1    GDIQ01188051    JAK63674.1    KL218015    KFP01142.1    AERX01023956    AERX01023957    AERX01023958    AANG04003224    KL891452    KGL78779.1    MUZQ01000031    OWK62054.1    KL215714    KFV66151.1    ABQF01013448    ABQF01013449    ABQF01013450    ABQF01013451    ABQF01013452    ABQF01013453    AC005039    AC005248    AC006045    AC006150    AC011229    AC073258    AC105459    AK304719    BAH14245.1    AGTO01000092    AGTO01010212    KK718434    KFO56295.1    AGTP01054159    AGTP01054160    AGTP01054161    AGTP01054162    AGTP01054163    AGTP01054164    AGTP01054165    AGTP01054166    AGTP01054167    AGTP01054168    CABD030049949    CABD030049950    CABD030049951    CABD030049952    CABD030049953    CABD030049954    CABD030049955    CABD030049956    CABD030049957    CABD030049958    AX032742    CH236948    CH471073    BC105005    AB018261    AK139408    BC070461    AK122355    ACTA01115218    ACTA01123218    ACTA01131218    ACTA01139218    ACTA01147217    ACTA01155216    ACTA01163215    ACTA01171213    ACTA01179211    ACTA01187209    ADFV01001320    ADFV01001321    ADFV01001322    ADFV01001323    ADFV01001324    ADFV01001325    ADFV01001326    ADFV01001327    ADFV01001328    ADFV01001329    AJFE02088040    AJFE02088041    AJFE02088042    AJFE02088043    AJFE02088044    AJFE02088045    AJFE02088046    AJFE02088047    AJFE02088048    AJFE02088049    AACZ04068638    AACZ04068642    AC147975    AC188408    AC188412    AC190238    AC192126    NBAG03000259    PNI57915.1    JH818313    EKC31033.1   

Proteomes

UP000053268    UP000053240    UP000005204    UP000218220    UP000005203    UP000279307    + More
UP000005205    UP000007755    UP000076502    UP000192223    UP000053097    UP000078541    UP000053825    UP000242457    UP000075809    UP000000311    UP000027135    UP000078540    UP000008237    UP000015103    UP000009046    UP000030742    UP000000305    UP000094527    UP000242188    UP000085678    UP000019118    UP000245119    UP000186922    UP000014760    UP000054308    UP000005207    UP000248480    UP000265100    UP000008225    UP000233120    UP000233060    UP000011712    UP000053641    UP000197619    UP000261420    UP000053875    UP000007754    UP000005640    UP000016665    UP000052976    UP000081671    UP000005215    UP000001519    UP000245320    UP000248484    UP000248481    UP000245341    UP000245340    UP000000589    UP000008912    UP000001073    UP000240080    UP000248482    UP000002277    UP000005408   

PRIDE

H9JUX3    B5MBY2    B7Z9A9    Q9Y6T7    Q6NS52    B5MCD5    + More

Pfam

PF00781   DAGK_cat        + More
PF00609   DAGK_acc
PF00130   C1_1
PF13499   EF-hand_7
PF14513   DAG_kinase_N
PF13202   EF-hand_5

Interpro

IPR001206   Diacylglycerol_kinase_cat_dom        + More
IPR018247   EF_Hand_1_Ca_BS       
IPR029477   DAG_kinase_typeI_N       
IPR000756   Diacylglycerol_kin_accessory       
IPR038199   DGK_typeI_N_sf       
IPR002219   PE/DAG-bd       
IPR037607   DGK       
IPR011992   EF-hand-dom_pair       
IPR002048   EF_hand_dom       
IPR017438   ATP-NAD_kinase_N       
IPR016064   NAD/diacylglycerol_kinase_sf       

SUPFAM

SSF111331   SSF111331        + More
SSF47473   SSF47473       

Gene 3D

1.10.238.110     3.40.50.10330    

CDD

cd00029  C1
cd00051  EFh

ProteinModelPortal

A0A194PZ99   A0A194R029   A0A0K2S343   H9JUX3   A0A2A4J370   A0A087ZMS3   + More
A0A3L8DCW2   A0A158NTM4   F4WSF1   A0A2A4J7Q7   A0A154PGA3   A0A1W4XJJ5   A0A1W4XKP6   A0A310SBY0   A0A026WJE9   A0A195ERV3   A0A1W4XJK0   A0A0L7RC29   A0A2A3E5B7   A0A1Y1K6F7   A0A151X3Q3   E2AXF7   A0A067RCJ5   A0A195BQ84   T1J4I9   A0A1W4XKG8   E2BKU8   T1ID18   E0VZ55   A0A1Y1KA40   A0A0P5XEF8   A0A1W7RAP3   A0A0P6H8X4   U4UEK8   E9H738   A0A1D2MP71   A0A210Q1M3   A0A1S3IRW2   N6UGH4   A0A2T7PUZ1   A0A1S3IPX2   A0A2R5L6H7   A0A1S3IQC2   E9IYH8   A0A1D1URY8   A0A1W0WBN0   A0A1W0WBI2   A0A0P5KC03   R7TZB0   A0A1S3IPW8   A0A1S3IQS8   A0A0P6C0W9   A0A0N8BDM6   A0A091HYU1   I3JHD4   A0A2Y9DMN4   A0A3P8NU32   A0A2Y9R8W3   F6ZFB7   A0A2K6C2Q0   A0A2K5KKT8   A0A2K5KKT3   A0A3P8NUA1   A0A2Y9DMK8   A0A337SXK4   A0A099Z8E5   A0A218V7R6   A0A3B4T403   A0A093IHD0   H0YWD4   B5MBY2   B7Z9A9   A0A3B4T4C0   U3K5V3   A0A091F352   A0A2Y9R8C8   A0A1S3FTV9   A0A287CTF2   G3RD41   A0A2U4B1M9   A0A2Y9T240   A0A2Y9H5U1   A0A2Y9H7J9   A0A2U3XIE8   A0A2U3VXH8   Q9Y6T7   Q6NS52-2   A0A2I2ZRH6   G1MD26   A0A2I3G9Q7   A0A2Y9DMN8   A0A2R9BEZ0   A0A2Y9H156   A0A2Y9JH57   A0A2Y9JMC4   H2RDM1   K1QAV3   B5MCD5  

PDB

6IIE     E-value=1.54725e-33,     Score=361

KEGG

101741961    K00901 diacylglycerol kinase (ATP) [EC:2.7.1.107] | (RefSeq) diacylglycerol kinase 1

PATHWAY

00561    Glycerolipid metabolism - Bombyx mori (domestic silkworm)
00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0005509   GO:0003951   GO:0007205   GO:0004143   GO:0035556   GO:0005886   GO:0046339   GO:0046834   GO:0046486   GO:0098978   GO:0099175   GO:0050804   GO:0009617   GO:0098685   GO:0030168   GO:0005829   GO:0005737   GO:0016020   GO:0016301   GO:0006418   GO:0006559   GO:0004887   GO:0016021  

PANTHER

PTHR11255  

Subcellular location

Cytoplasm  

Length:

882

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02176

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00005

outside

1  -  882

 

 

Pi

210.767856

Theta

151.362032

Tajima's D

1.386417

CLR

0.04074

CSRT

0.757662116894155

Interpretation

Uncertain