Gene

KWMTBOMO00726  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003238

Annotation

PREDICTED:_probable_NADH_dehydrogenase_[ubiquinone]_1_alpha_subcomplex_subunit_12_[Amyelois_transitella]

Location

Bomo_Chr2(+):1579896-1584598      View in EpiBrowser

Full name

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12       + More
Serine/threonine-protein phosphatase 2A activator      

Alternative Name

Phosphotyrosyl phosphatase activator

Location in the cell

Extracellular   Reliability : 1.303 Mitochondrial   Reliability : 1.664

CDS

ATGTCTCTGGGAAAGTTTTTAGCCCTCGACAAGCTAAGCAATTTTTTTAACGTAATTCGTCAGAACGGTGGTATAAGAGCCTCGTTGTATAAACTATACAGGCAGGACGATGTAAAGGACGGTGTTCTAGTTGGAGAAGACAAATATGGTAACAAATACTATGAGAACCCACGTTTCTTTTACAGCAGGAACAGATGGGTCGAGTACTCGGACAAGTATTACTTGAACTATGATGGAAGTCAGGTTCCCGCTGAATGGTTTGGTTGGCTACACTACAAAACCGATTTGCCTCCGCATCAGGATCCGAGTCGTCCCCACTACAAGTGGATGGCGGACCACACCGAAAATCTTTCTGGCACGACCGCCCAATATGTGCCGTACAGTACGACCCGACCCAAAGTGGAAGCCTGGGAGCCGAAACGCAAAGACAGTGTTTAA

Protein

MSLGKFLALDKLSNFFNVIRQNGGIRASLYKLYRQDDVKDGVLVGEDKYGNKYYENPRFFYSRNRWVEYSDKYYLNYDGSQVPAEWFGWLHYKTDLPPHQDPSRPHYKWMADHTENLSGTTAQYVPYSTTRPKVEAWEPKRKDSV

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Subunit

Complex I is composed of 45 different subunits.

Similarity

Belongs to the complex I NDUFA12 subunit family.
Belongs to the PTPA-type PPIase family.

Uniprot

H9J151   A0A2W1BR08   A0A2A4JNC4   A0A2H1W2E6   A0A194QZR7   A0A194PT81   + More
S4PTA1   A0A2R7W1X2   A0A067QUE7   A0A212FDH1   A0A0A9Z3S6   A0A146LY30   A0A1B0CW92   A0A0K8T375   A0A069DW08   A0A0P4VQY3   T1HN69   A0A146LNP5   A0A146LEA0   A0A2J7RA20   A0A224Y0T7   R4G4M7   A0A1B0DHU8   A0A0V0G8X9   D2A6F4   A0A182MD65   Q17M02   A0A182SL98   A0A023EGK7   A0A182RK31   A0A182Q7I9   A0A182NGR0   A0A084VSM7   A0A182V659   A0A1W4XQK1   A0A1Y9IW05   A0A182K1C7   A0A182X5U8   A0A1C7CZD0   A0A182U0R9   Q7Q8F5   A0A182IBI1   A0A1L8E0M2   W5J236   A0A1L8EHE4   A0A1I8PRP1   T1PEY0   A0A1J1IM65   A0A182P1M1   A0A2M4AEJ5   A0A2M3Z4W2   A0A1B6LZL4   A0A1I8MJ35   A0A2M4C2M4   W8C1Q7   A0A182F371   A0A034VWA4   A0A0C9RGY5   A0A0A1X7F9   A0A0L0CMB9   A0A0K8UDI9   A0A1A9XER4   A0A1B0C0P0   A0A1B0FH65   A0A1Q3FNF6   V5GT38   A0A1A9WKK0   B0XE21   A0A1A9V895   A0A1A9Z7X2   A0A026WT41   A0A0K8TTE2   A0A182JE99   A0A0L7RKB4   A0A195F279   U5ETD9   K7INC9   A0A158NG18   A0A1Y1L422   A0A151I1L3   B4N0E2   A0A0L7KT39   A0A2A3EHQ3   E9J5Y5   A0A195E806   A0A3B0KDY7   J3JX62   Q29KY1   B4GSM5   F4X6K1   B4KL35   A0A232EGE9   A0A336MVB2   A0A151ILK7   A0A1B6CJ33   B4JDB8   Q9VQD7   A0A151XB82   A0A0M4E7Z1   A0A0M3QU72  

EC Number

5.2.1.8

Pubmed

19121390    28756777    26354079    23622113    24845553    22118469    + More
25401762    26823975    26334808    27129103    18362917    19820115    17510324    24945155    26483478    24438588    20966253    12364791    14747013    17210077    20920257    23761445    25315136    24495485    25348373    25830018    26108605    24508170    26369729    20075255    21347285    28004739    17994087    26227816    21282665    22516182    23537049    15632085    21719571    28648823    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356   

EMBL

BABH01031374    BABH01031375    KZ150065    PZC74173.1    NWSH01001044    PCG72943.1    + More
ODYU01005900    SOQ47265.1    KQ460890    KPJ10947.1    KQ459593    KPI96522.1    GAIX01012398    JAA80162.1    KK854197    PTY12940.1    KK852999    KDR12671.1    AGBW02009033    OWR51815.1    GBHO01005606    JAG37998.1    GDHC01006754    JAQ11875.1    AJWK01032044    GBRD01005975    JAG59846.1    GBGD01003390    JAC85499.1    GDKW01001677    JAI54918.1    ACPB03020358    GDHC01009045    JAQ09584.1    GDHC01012680    JAQ05949.1    NEVH01006580    PNF37688.1    GFTR01002387    JAW14039.1    GAHY01001225    JAA76285.1    AJVK01034172    GECL01002285    JAP03839.1    KQ971347    EFA05745.1    AXCM01005884    CH477209    EAT47742.1    JXUM01151927    GAPW01005659    KQ571331    JAC07939.1    KXJ68202.1    AXCN02002079    ATLV01016091    KE525057    KFB40971.1    AAAB01008944    EAA10156.3    APCN01000703    GFDF01001888    JAV12196.1    ADMH02002210    ETN57796.1    GFDG01000734    JAV18065.1    KA647352    AFP61981.1    CVRI01000055    CRL01315.1    GGFK01005821    MBW39142.1    GGFM01002784    MBW23535.1    GEBQ01010850    JAT29127.1    GGFJ01010421    MBW59562.1    GAMC01000808    GAMC01000807    JAC05748.1    GAKP01012827    JAC46125.1    GBYB01012442    GBYB01012443    JAG82209.1    JAG82210.1    GBXI01007215    JAD07077.1    JRES01000186    KNC33493.1    GDHF01027610    GDHF01000211    JAI24704.1    JAI52103.1    JXJN01023698    CCAG010002037    GFDL01005981    JAV29064.1    GALX01003659    JAB64807.1    DS232798    EDS45793.1    KK107109    EZA59103.1    GDAI01000172    JAI17431.1    KQ414578    KOC71181.1    KQ981864    KYN34194.1    GANO01002818    JAB57053.1    ADTU01014889    GEZM01065539    JAV68432.1    KQ976580    KYM79897.1    CH963920    EDW77555.1    JTDY01006234    KOB66179.1    KZ288253    PBC30994.1    GL768221    EFZ11718.1    KQ979568    KYN20954.1    OUUW01000006    SPP81878.1    APGK01046266    BT127830    KB741050    KB631815    AEE62792.1    ENN74480.1    ERL86489.1    CH379061    EAL33043.1    CH479189    EDW25384.1    GL888818    EGI57961.1    CH933807    EDW12785.1    NNAY01004785    OXU17414.1    UFQS01000326    UFQS01002785    UFQT01000326    UFQT01002785    SSX02904.1    SSX34060.1    KQ977104    KYN05767.1    GEDC01023792    GEDC01016160    JAS13506.1    JAS21138.1    CH916368    EDW03291.1    AE014134    AAF51238.1    ACL82977.1    KQ982335    KYQ57604.1    CP012523    ALC38038.1    ALC40129.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000027135    UP000007151    + More
UP000092461    UP000015103    UP000235965    UP000092462    UP000007266    UP000075883    UP000008820    UP000075901    UP000069940    UP000249989    UP000075900    UP000075886    UP000075884    UP000030765    UP000075903    UP000192223    UP000075920    UP000075881    UP000076407    UP000075882    UP000075902    UP000007062    UP000075840    UP000000673    UP000095300    UP000183832    UP000075885    UP000095301    UP000069272    UP000037069    UP000092443    UP000092460    UP000092444    UP000091820    UP000002320    UP000078200    UP000092445    UP000053097    UP000075880    UP000053825    UP000078541    UP000002358    UP000005205    UP000078540    UP000007798    UP000037510    UP000242457    UP000078492    UP000268350    UP000019118    UP000030742    UP000001819    UP000008744    UP000007755    UP000009192    UP000215335    UP000078542    UP000001070    UP000000803    UP000075809    UP000092553   

PRIDE

H9J151    Q9VQD7   

Pfam

PF05071   NDUFA12        + More
PF03095   PTPA

Interpro

IPR007763   NDUFA12        + More
IPR004327   Phstyr_phstse_ac       
IPR037218   PTPA_sf       

SUPFAM

SSF140984   SSF140984       

CDD

cd04087  PTPA

ProteinModelPortal

H9J151   A0A2W1BR08   A0A2A4JNC4   A0A2H1W2E6   A0A194QZR7   A0A194PT81   + More
S4PTA1   A0A2R7W1X2   A0A067QUE7   A0A212FDH1   A0A0A9Z3S6   A0A146LY30   A0A1B0CW92   A0A0K8T375   A0A069DW08   A0A0P4VQY3   T1HN69   A0A146LNP5   A0A146LEA0   A0A2J7RA20   A0A224Y0T7   R4G4M7   A0A1B0DHU8   A0A0V0G8X9   D2A6F4   A0A182MD65   Q17M02   A0A182SL98   A0A023EGK7   A0A182RK31   A0A182Q7I9   A0A182NGR0   A0A084VSM7   A0A182V659   A0A1W4XQK1   A0A1Y9IW05   A0A182K1C7   A0A182X5U8   A0A1C7CZD0   A0A182U0R9   Q7Q8F5   A0A182IBI1   A0A1L8E0M2   W5J236   A0A1L8EHE4   A0A1I8PRP1   T1PEY0   A0A1J1IM65   A0A182P1M1   A0A2M4AEJ5   A0A2M3Z4W2   A0A1B6LZL4   A0A1I8MJ35   A0A2M4C2M4   W8C1Q7   A0A182F371   A0A034VWA4   A0A0C9RGY5   A0A0A1X7F9   A0A0L0CMB9   A0A0K8UDI9   A0A1A9XER4   A0A1B0C0P0   A0A1B0FH65   A0A1Q3FNF6   V5GT38   A0A1A9WKK0   B0XE21   A0A1A9V895   A0A1A9Z7X2   A0A026WT41   A0A0K8TTE2   A0A182JE99   A0A0L7RKB4   A0A195F279   U5ETD9   K7INC9   A0A158NG18   A0A1Y1L422   A0A151I1L3   B4N0E2   A0A0L7KT39   A0A2A3EHQ3   E9J5Y5   A0A195E806   A0A3B0KDY7   J3JX62   Q29KY1   B4GSM5   F4X6K1   B4KL35   A0A232EGE9   A0A336MVB2   A0A151ILK7   A0A1B6CJ33   B4JDB8   Q9VQD7   A0A151XB82   A0A0M4E7Z1   A0A0M3QU72  

PDB

5LDX     E-value=6.37851e-26,     Score=285

KEGG

101739119    K11352 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12 | (RefSeq) probable NADH dehydr

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005743   GO:0070469   GO:0008137   GO:0009055   GO:0016021   GO:0006979   GO:0005747   GO:0016020   GO:0019211   GO:0005737   GO:0003755   GO:0003954   GO:0006120   GO:0004812   GO:0005524   GO:0006418   GO:0006559   GO:0004887  

PANTHER

PTHR12910   PTHR10012  

Subcellular location

Mitochondrion inner membrane  
Cytoplasm  

Length:

145

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000670000000000001

Exp number, first 60 AAs:

0.00049

Total prob of N-in:

0.02723

outside

1  -  145

 

 

Pi

160.509603

Theta

172.721597

Tajima's D

-0.957378

CLR

0.100676

CSRT

0.149742512874356

Interpretation

Uncertain