Gene

KWMTBOMO00718  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003261

Annotation

PREDICTED:_UBX_domain-containing_protein_4_[Bombyx_mori]

Location

Bomo_Chr2(-):1300467-1310215      View in EpiBrowser

Full name

UBX domain-containing protein 4      

Alternative Name

Erasin
UBX domain-containing protein 2

Location in the cell

Nuclear   Reliability : 3.288

CDS

ATGCGTTGGTACAACGGTAGCATCGCGGAGGCCGTGAATCTATCGAAACAGAGGAATACAATTTTCGTGGTTTTCATACAAGGTGACAATGACTTGTCCGACGAAATGTCATCGACGCTTAACGATGTTGTGGTCAGATCGAAACTCTCAAATGAATCAAACTTTCTGGCCGTCAATCTGAAGAGTGGATCAACCAACTATACACATTTCGCACAAATATATCAAATCGTGCCGGTGCCGTCATTATTCTTCATCGGCAGGAATGGTACTCCTCTCGAAGTGGTCTGCGCTGGTGTGGACGCCGACAATCTGTCCGCGAGGATCGATAGGATACTAGCGGAACATCGGCAAGAAAATCCGAAGATTAATGATCATTCAGATGCCTTCATCAAAGTATTAGACGAATATTCGGAGTCTGATAACTACGAGTTAGTCTGCGGCGATGAGATATGCGTGCGCGTGCCCAGGCCTAAGCACGACAAGCCGGGGCCCAGCCGGGACTCTGCCCCCCCAGCGGACGACTCCGCCTCACCGGCGGACGAATCGCCCGAGCCGACGGACAGCGAGGCCAACCAGCAGAAACCTTCGGGGATGGAGACCTTGACCGAAATAGAAGACAAGTTGGAACGCACCAAGCTACTGATAGAAGCGAGACGCAGAGAGAAAGAGGAGAAAGAGAAGGAGCTCGAAAAGCAGAGGGAGATAGAACGACGCGCCACCGGCAAAGGGGTCACGGAACTCAAGAAGTGGCAAGCGGAACAGGAACTGAAGCAGATACAAGAAGAGAGGAAACGGGAGAAGCTTGAAAACGAGCTCGCCCGGCAGCGGATCCTGCAGCAGATAGCGCAGGACCGGGCCGAGAGGCGCGCCCGGGACCTCGCCCCCGCGCCCCCAGACCCCAAGCCCGCGCCCCCCGCGCAACTGCCGGGAACAGCAGGGGGGGACGGCGCGGGGGCGCGCGTGCAGTTCAAGCTGCCCGACGGCTCCTCGCACTCGGCGCAGTTCGCGGCCGACGCCACCGTGGAGGACCTGCGCGCGCACGTCAGCCGCAGCGCACAGCTGCAGCCGTCCAGCTTCACGCTGTGGACGGCGTTCCCGCGGCGCGAGCTGACGGCGGGGGCGGAGTCCCTGGCGGCGCAGGGGCTGGTCCCGTCGGGCGCCGTGCTGGTGCTGCCCGTGCGCGCCGCACCCCCCGCGCCCGCACTCACTTCCTCCTTCGCCTCGCTGCTCGCATTCTTCTCGAGCCTGTTCTCGACCCTCGTGCTGGAGCCGAGCCAGCAGGTCTACCAGTGGATCAGATCTAGGCTGTTCCCCCCGGCGGCGCCGCGCTCCCCCGATCCCCACTCTCCCTCCCGCGCGGCGCCCCCCGGCCTGCGCCGGAGGGGGAACGTGCACCGTCTGCCCGGGGACACCGGGGCTAGCGACGACAACAACACCTGGAACGATAAATCTCGACTGGAGCCCAGCTGA

Protein

MRWYNGSIAEAVNLSKQRNTIFVVFIQGDNDLSDEMSSTLNDVVVRSKLSNESNFLAVNLKSGSTNYTHFAQIYQIVPVPSLFFIGRNGTPLEVVCAGVDADNLSARIDRILAEHRQENPKINDHSDAFIKVLDEYSESDNYELVCGDEICVRVPRPKHDKPGPSRDSAPPADDSASPADESPEPTDSEANQQKPSGMETLTEIEDKLERTKLLIEARRREKEEKEKELEKQREIERRATGKGVTELKKWQAEQELKQIQEERKREKLENELARQRILQQIAQDRAERRARDLAPAPPDPKPAPPAQLPGTAGGDGAGARVQFKLPDGSSHSAQFAADATVEDLRAHVSRSAQLQPSSFTLWTAFPRRELTAGAESLAAQGLVPSGAVLVLPVRAAPPAPALTSSFASLLAFFSSLFSTLVLEPSQQVYQWIRSRLFPPAAPRSPDPHSPSRAAPPGLRRRGNVHRLPGDTGASDDNNTWNDKSRLEPS

Description

Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.

Subunit

Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.

Keywords

3D-structure   Complete proteome   Endoplasmic reticulum   Membrane   Nucleus   Phosphoprotein   Reference proteome   Unfolded protein response  

Feature

chain  UBX domain-containing protein 4

Uniprot

A0A1E1WGY6   A0A2W1BA47   A0A2A4J1P3   A0A2J7Q2U4   A0A1W4X7J3   D6WRD2   + More
A0A1A9UVT0   D3TPU2   A0A1A9XTW1   A0A1B0AQ51   A0A1A9ZMR3   A0A2A3EJ89   V9IH56   A0A087ZN16   H3AHI8   A0A1J1I8N1   A0A1A9WCE7   A0A0L0BSY6   A0A1I8QCH6   A0A0A1WRA9   V5GGA2   A0A218V3A8   A0A1L8EVJ3   A0A0R4J078   Q8VCH8   A0A034W169   A0A0K8UDU5   A0A069DZ80   R7TX54  

Pubmed

28756777    18362917    19820115    20353571    9215903    26108605    + More
25830018    27762356    12040188    17242355    19468303    21183079    16141072    15489334    16968747    25348373    26334808    23254933   

EMBL

GDQN01004799    JAT86255.1    KZ150190    PZC72419.1    NWSH01003829    PCG65789.1    + More
NEVH01019077    PNF22904.1    KQ971351    EFA06551.2    CCAG010021538    EZ423444    ADD19720.1    JXJN01001674    KZ288242    PBC31256.1    JR047577    AEY60448.1    AFYH01169246    CVRI01000043    CRK96074.1    JRES01001407    KNC23157.1    GBXI01013116    JAD01176.1    GALX01005477    JAB62989.1    MUZQ01000060    OWK60453.1    CM004482    OCT63364.1    AC161809    CH466520    EDL39753.1    AK075716    AK147795    BC019795    GAKP01010523    JAC48429.1    GDHF01027596    JAI24718.1    GBGD01001105    JAC87784.1    AMQN01011776    KB309090    ELT95555.1   

Proteomes

UP000218220    UP000235965    UP000192223    UP000007266    UP000078200    UP000092444    + More
UP000092443    UP000092460    UP000092445    UP000242457    UP000005203    UP000008672    UP000183832    UP000091820    UP000037069    UP000095300    UP000197619    UP000186698    UP000000589    UP000014760   

PRIDE

Q8VCH8   

Pfam

PF00789   UBX

Interpro

IPR036249   Thioredoxin-like_sf        + More
IPR029071   Ubiquitin-like_domsf       
IPR001012   UBX_dom       

SUPFAM

SSF54236   SSF54236        + More
SSF52833   SSF52833       

ProteinModelPortal

A0A1E1WGY6   A0A2W1BA47   A0A2A4J1P3   A0A2J7Q2U4   A0A1W4X7J3   D6WRD2   + More
A0A1A9UVT0   D3TPU2   A0A1A9XTW1   A0A1B0AQ51   A0A1A9ZMR3   A0A2A3EJ89   V9IH56   A0A087ZN16   H3AHI8   A0A1J1I8N1   A0A1A9WCE7   A0A0L0BSY6   A0A1I8QCH6   A0A0A1WRA9   V5GGA2   A0A218V3A8   A0A1L8EVJ3   A0A0R4J078   Q8VCH8   A0A034W169   A0A0K8UDU5   A0A069DZ80   R7TX54  

PDB

2KXJ     E-value=1.20978e-06,     Score=126

KEGG

101745030    no KO assigned | (RefSeq) UBX domain-containing protein 4

GO

GO:0016021   GO:0005783   GO:0030433   GO:0005829   GO:0005635   GO:0005789   GO:0006986   GO:0005515   GO:0004482   GO:0005524   GO:0006370   GO:0019012   GO:0050661   GO:0006559   GO:0004887  

Subcellular location

Endoplasmic reticulum membrane   Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.   With evidence from 3 publications.
Nucleus envelope   Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.   With evidence from 3 publications.

Length:

489

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.77873

Exp number, first 60 AAs:

0.00266

Total prob of N-in:

0.00819

outside

1  -  489

 

 

Pi

158.564694

Theta

136.953006

Tajima's D

0.56802

CLR

0.77148

CSRT

0.531773411329434

Interpretation

Uncertain