Silkworm Genome Informatics Database

Gene

KWMTBOMO00708

Pre Gene Modal

BGIBMGA003228

Annotation

PREDICTED:_angiotensin-converting_enzyme-like_[Amyelois_transitella]

Location

Bomo_Chr2(+):889855-904091 View in EpiBrowser

Full name

Angiotensin-converting enzyme

Alternative Name

Dipeptidyl carboxypeptidase I
Kininase II

Location in the cell

Mitochondrial Reliability : 1.265 Nuclear Reliability : 1.139

CDS

ATGGGAACCAAAGTCGCTACGACGTTGTGCCTATGTTTTGCTTTCTACACACGACATGTGAAAACACAAGAATACTACAGAATGGGTACAAACACGAACTCGGGAGAAGCGATGCAGTTCTTGAGAGAATACGACAGAGAAGCATCCGGAATGTGCTATAGAGTCACAATGGCCCAGTGGAAGTTCGTAACCAACATAACAGAACATAATCGAAGACCTATGATGGACGAGCTGGCTCTGAGCTCGAAATTCGAGAGGCTATCTTGGAGAAAGGCTGCGGCCTATGACGCATCCAGGGTCTCCGATCCGCTGGCGAGGAGACAGCTGACTAAAATCTTACAAAGCAGCAGGGCCAGTTTACCCGATGATAAATTTTCTGAGCTCCAGCAACTCATAGCAGAGATGAAAGAGATATACAATTCAGCTAAAATCTGTCCGTACAGACAGAAGCCCTTCGATCCTCACATACCCAGGGTGTACTCGGACCTCACAAACCAGGGCTACACATTAGCCAACCAACCGTACCAACATTACCAGCCCTACACGGAGACCTCCGAATATTCCCAGTACTGCAACATGCAATTGGATCCAGAAATTTCCAGGATCCTTGCACATTCGAGGATCGAGAGTGAGTTGCTGTACGTGTGGAAGAATTTTAGAGAGCAGACCGGCCCGAAACTCAGGAATCGGTACATGAGATACGTTCAGCTGGTGAACCAAGCGGCGGTGAATGCAGGGTTCAGAGACGCAGGGGAACAAATGCGGGCCGCATACGAGGACCAGTCGTTTAGGGCCAACGTCGAAGAGATCTACAATCAGGTCGTGCCACTTTACAAGCAACTCTTCACTTACGTCAGACGCAGACTGTTCCAACGATACGGGGATGTGGCTCTCAGACCCGACGGGCCCATACCGGCTCATTTATTGGGCAACATGTGGGCGCAGAATTGGAAGTCCATCATGGATTTAGTTATGCCGTTCCCGCAGTCCCCAAACGTTGACGTCACGTCGGAGATGCTCAGAAAAGGATTCACTCCACTAAGAATGTTCCAAATGGCTGAAGAGTTCTACACGTCTATGGGCCTCAAGCCAGTCCCTCCTGAGTTCTGGCGAGGGTCGATGCTGGCGAGACCACAACAGCTGAGCGTGCAGTGCACCGCCAGCGCATGGGACTTTTGCAACAGAATCGACTATAGGATCAAACAGTGCACCGAAGTGACGATGCAGGACCTTGTTTCCACTCACCACGAGATGGCTCACATACAGTACTACCTGCAGTACGCTGATCAGCCCCAGCTGTTCAGGGACGGCGCGAATCCTGCGTTCCACGAGGCCGTGGCCAACGCGGCGACGCTGTCCGTGTACAACTTGGTGCATCTACAGCGGGTCGGGCTCTACCAGAACAAGAGTAGTGATCCATATGAAGTCAGCATAAACTTCCTGATGACGATGGCGCTGGAGAAGGTGGCCTACCTACCATTCGCTTTTATGGTGGACCAGTGGCGCTGGTGGGTCTTCGAGGAGGGTGTGGAGAACATGAACAAGCGCTGGTGGCAGATGAAGCTGCGGTACCAGGGTGTGATTCCGCCCGTTCCAAGAACCGAAGGTGATTTCGACCCTGGATCTAAATACCACATCATATCTGATCAGGAATACATAAAGTACTTCCTGGCGACGATCTTGGAGTTCCAAGTGTTCGAGCAGTTGTGCCACGCGGCGGGGCAGGGGGGACTCCTGCACGAGTGCGACGTGTACCGCAGCAGGGACGCCGGGAGACTGCTCAGCGACATCATGCAGCCGGGCTCTTCGAAATCTGCTTCGGACATCATCAGAACGATGACCAGGGGGAAAACGAACAGGATATCACCAGAAGCTCTGGTTAGATACTTCCGACCTTTGGAGTTGTGGCTCAGAGTCCAGAACAGGGAGGAGCCATTGGTGGGTTGGAACACTTCTCCCAGGGACTTGGCACTGTTCTCCCACTCAACGGATTCTGCAACAACTCAATTACTCTCGCACTCACTTCTGTACCTCTCATTAATAGCTAATGTTATGTTTTATTAA

Protein

MGTKVATTLCLCFAFYTRHVKTQEYYRMGTNTNSGEAMQFLREYDREASGMCYRVTMAQWKFVTNITEHNRRPMMDELALSSKFERLSWRKAAAYDASRVSDPLARRQLTKILQSSRASLPDDKFSELQQLIAEMKEIYNSAKICPYRQKPFDPHIPRVYSDLTNQGYTLANQPYQHYQPYTETSEYSQYCNMQLDPEISRILAHSRIESELLYVWKNFREQTGPKLRNRYMRYVQLVNQAAVNAGFRDAGEQMRAAYEDQSFRANVEEIYNQVVPLYKQLFTYVRRRLFQRYGDVALRPDGPIPAHLLGNMWAQNWKSIMDLVMPFPQSPNVDVTSEMLRKGFTPLRMFQMAEEFYTSMGLKPVPPEFWRGSMLARPQQLSVQCTASAWDFCNRIDYRIKQCTEVTMQDLVSTHHEMAHIQYYLQYADQPQLFRDGANPAFHEAVANAATLSVYNLVHLQRVGLYQNKSSDPYEVSINFLMTMALEKVAYLPFAFMVDQWRWWVFEEGVENMNKRWWQMKLRYQGVIPPVPRTEGDFDPGSKYHIISDQEYIKYFLATILEFQVFEQLCHAAGQGGLLHECDVYRSRDAGRLLSDIMQPGSSKSASDIIRTMTRGKTNRISPEALVRYFRPLELWLRVQNREEPLVGWNTSPRDLALFSHSTDSATTQLLSHSLLYLSLIANVMFY

Description

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.

Catalytic Activity

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactor

Zn(2+)
chloride

Similarity

Belongs to the peptidase M2 family.

Keywords

Alternative splicing Carboxypeptidase Cell membrane Complete proteome Cytoplasm Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Phosphoprotein Protease Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix Zinc

Feature

chain  Angiotensin-converting enzyme
propeptide  Removed in secreted form
splice variant  In isoform Testis-specific.

Uniprot

H9J141 A0A2H1VCI1 A0A0N0PBH1 A0A2J7PIV4 K7IUY3 A0A067QYP8 + More
A0A232EV05 A0A0N0U3H4 D6WQI3 A0A0L7R6A0 A0A182NTL2 A0A0A9YW22 A0A2K8JUW1 A0A087ZN26 A0A3L8DIR7 A0A182QRI7 A0A336KCL5 W5JBS9 A0A336M107 A0A182HCY4 A0A084W5Z3 E2BY36 A0A182RJ90 T1HHZ5 A0A1S4F7H9 A0A2S2QF02 A0A182PD20 A0A1J1IA51 A0A182W7G0 A0A026W9K0 A0A182F1J7 A0A182HV24 A0A182LX35 A0A182L1X8 A0A182WT27 A0A1S4GWX3 E0VAB8 Q7Q3Q3 F4X0N8 A0A195D8I9 A0A1W4XAY2 A0A182XZW3 A0A182SKN0 A0A195F8G4 A0A151WYD6 A0A195D1T0 A0A1S4KB65 A0A158NCZ0 Q17D90 A0A195B874 J9JZ11 B0XAQ1 A0A182JCQ2 A0A182U6Z5 A0A182VIT4 E9GU43 A0A0C9RMS6 A0A162PAD4 A0A0P4XKM2 A0A0P5DWJ9 A0A0P5KP31 A0A0P5J1U9 A0A0N8APF5 A0A182JRU2 A0A2R7W4Q8 A0A087TSS0 A0A1S5QMZ5 A0A0P5FLU7 A0A2L2Y254 A0A0P5AG10 T1KX65 A0A0N8AZC2 A0A1W7RA02 A0A218QXF0 E9GIV2 A0A087UCM7 A0A0P6HIG7 A0A1E1WWB8 A0A0P5FWE4 A0A0N7ZQD9 A0A1L8ESF5 A0A0P5NKM2 A0A0P5W4G4 A0A0P5CWD0 A0A0P5YQN8 E9GJE7 A0A1S3GIY4 A0A2P6LB87 C8UZT5 A0A2I4D5S0 A0A0P5P2U5 A0A287D9C6 P09470-2 A0A0P6AG22 F6PS42 A0A091K6Q9 B0JZU8 A0A0P5MF77 V9K8C1

EC Number

3.4.-.-

Pubmed

19121390 26354079 20075255 24845553 28648823 18362917 + More
19820115 25401762 30249741 20920257 23761445 26483478 24438588 20798317 24508170 20966253 12364791 20566863 21719571 25244985 21347285 17510324 21292972 26561354 27762356 19656189 2545691 2164636 15489334 2841312 2835538 7753170 8642790 15665832 16944957 17114649 21183079 23535237 20431018 24402279

EMBL

BABH01031438 BABH01031439 ODYU01001823 SOQ38553.1 KQ460940 KPJ10634.1 + More
NEVH01024955 PNF16258.1 AAZX01001184 KK853098 KDR11409.1 NNAY01002067 OXU22173.1 KQ435896 KOX69221.1 KQ971354 EFA06070.2 KQ414646 KOC66368.1 GBHO01007200 JAG36404.1 KY031094 ATU82845.1 QOIP01000007 RLU20345.1 AXCN02000795 UFQS01000301 UFQT01000301 SSX02634.1 SSX23008.1 ADMH02001688 ETN61426.1 SSX02637.1 SSX23011.1 JXUM01128495 KQ567323 KXJ69480.1 ATLV01020706 KE525305 KFB45637.1 GL451412 EFN79409.1 ACPB03000437 GGMS01006897 MBY76100.1 CVRI01000044 CRK96610.1 KK107347 EZA52351.1 APCN01002491 AXCM01008268 AAAB01008964 DS235005 EEB10324.1 EAA12487.4 GL888498 EGI60030.1 KQ981135 KYN09210.1 KQ981744 KYN36349.1 KQ982650 KYQ52898.1 KQ977012 KYN06359.1 ADTU01012086 CH477298 EAT44339.1 KQ976558 KYM80706.1 ABLF02009924 ABLF02009925 DS232592 EDS43840.1 GL732565 EFX76973.1 GBYB01014732 JAG84499.1 LRGB01000512 KZS18675.1 GDIP01240539 JAI82862.1 GDIP01150573 JAJ72829.1 GDIQ01206910 JAK44815.1 GDIQ01208158 JAK43567.1 GDIQ01255819 JAJ95905.1 KK854315 PTY14559.1 KK116576 KFM68159.1 KR068494 AMO02511.1 GDIQ01255121 JAJ96603.1 IAAA01001533 IAAA01001534 IAAA01001535 IAAA01001536 IAAA01001537 IAAA01001538 IAAA01001539 IAAA01001540 LAA02269.1 GDIP01199380 JAJ24022.1 CAEY01000676 GDIQ01228083 JAK23642.1 GFAH01000425 JAV47964.1 GEUW01000012 JAW07033.1 GL732547 EFX80591.1 KK119224 KFM75116.1 GDIQ01018429 JAN76308.1 GEMQ01000103 JAT91086.1 GDIQ01254826 JAJ96898.1 GDIP01222825 JAJ00577.1 CM004482 OCT62272.1 GDIQ01140929 JAL10797.1 GDIP01091235 LRGB01001253 JAM12480.1 KZS13268.1 GDIP01164551 JAJ58851.1 GDIP01055046 JAM48669.1 EFX80442.1 MWRG01000537 PRD35844.1 BN001299 CAX63316.1 GDIQ01138775 JAL12951.1 AGTP01052565 J04946 J04947 M55333 M61094 BC040404 J03940 GDIP01031200 JAM72515.1 AAMC01075651 AAMC01075652 AAMC01075653 KK544282 KFP31838.1 BC159326 AAI59327.1 GDIQ01180368 JAK71357.1 JW861420 AFO93937.1

Proteomes

UP000005204 UP000053240 UP000235965 UP000002358 UP000027135 UP000215335 + More
UP000053105 UP000007266 UP000053825 UP000075884 UP000005203 UP000279307 UP000075886 UP000000673 UP000069940 UP000249989 UP000030765 UP000008237 UP000075900 UP000015103 UP000075885 UP000183832 UP000075920 UP000053097 UP000069272 UP000075840 UP000075883 UP000075882 UP000076407 UP000009046 UP000007062 UP000007755 UP000078492 UP000192223 UP000076408 UP000075901 UP000078541 UP000075809 UP000078542 UP000005205 UP000008820 UP000078540 UP000007819 UP000002320 UP000075880 UP000075902 UP000075903 UP000000305 UP000076858 UP000075881 UP000054359 UP000015104 UP000186698 UP000081671 UP000192220 UP000005215 UP000000589 UP000008143

PRIDE

H9J141 P09470

Pfam

PF01401   Peptidase_M2        + More
PF06916   DUF1279
PF01281   Ribosomal_L9_N
PF00046   Homeodomain
PF10058   zinc_ribbon_10
PF02735   Ku
PF08785   Ku_PK_bind

Interpro

IPR001548   Peptidase_M2        + More
IPR009688   DUF1279
IPR009027   Ribosomal_L9/RNase_H1_N
IPR036935   Ribosomal_L9_N_sf
IPR020070   Ribosomal_L9_N
IPR017970   Homeobox_CS
IPR001356   Homeobox_dom
IPR009057   Homeobox-like_sf
IPR020479   Homeobox_metazoa
IPR019273   Lunapark_dom
IPR036465   vWFA_dom_sf
IPR014893   Ku_PK_bind
IPR024193   Ku80
IPR036494   Ku_C_sf
IPR006164   Ku70/Ku80_beta-barrel_dom
IPR016194   SPOC-like_C_dom_sf
IPR013087   Znf_C2H2_type

SUPFAM

SSF55658   SSF55658        + More
SSF46689   SSF46689
SSF101420   SSF101420
SSF100939   SSF100939
SSF53300   SSF53300

Gene 3D

3.40.5.10 1.25.40.240 2.40.290.10 3.40.50.410

CDD

cd06461  M2_ACE
cd00086  homeodomain
cd00873  KU80

ProteinModelPortal

H9J141 A0A2H1VCI1 A0A0N0PBH1 A0A2J7PIV4 K7IUY3 A0A067QYP8 + More
A0A232EV05 A0A0N0U3H4 D6WQI3 A0A0L7R6A0 A0A182NTL2 A0A0A9YW22 A0A2K8JUW1 A0A087ZN26 A0A3L8DIR7 A0A182QRI7 A0A336KCL5 W5JBS9 A0A336M107 A0A182HCY4 A0A084W5Z3 E2BY36 A0A182RJ90 T1HHZ5 A0A1S4F7H9 A0A2S2QF02 A0A182PD20 A0A1J1IA51 A0A182W7G0 A0A026W9K0 A0A182F1J7 A0A182HV24 A0A182LX35 A0A182L1X8 A0A182WT27 A0A1S4GWX3 E0VAB8 Q7Q3Q3 F4X0N8 A0A195D8I9 A0A1W4XAY2 A0A182XZW3 A0A182SKN0 A0A195F8G4 A0A151WYD6 A0A195D1T0 A0A1S4KB65 A0A158NCZ0 Q17D90 A0A195B874 J9JZ11 B0XAQ1 A0A182JCQ2 A0A182U6Z5 A0A182VIT4 E9GU43 A0A0C9RMS6 A0A162PAD4 A0A0P4XKM2 A0A0P5DWJ9 A0A0P5KP31 A0A0P5J1U9 A0A0N8APF5 A0A182JRU2 A0A2R7W4Q8 A0A087TSS0 A0A1S5QMZ5 A0A0P5FLU7 A0A2L2Y254 A0A0P5AG10 T1KX65 A0A0N8AZC2 A0A1W7RA02 A0A218QXF0 E9GIV2 A0A087UCM7 A0A0P6HIG7 A0A1E1WWB8 A0A0P5FWE4 A0A0N7ZQD9 A0A1L8ESF5 A0A0P5NKM2 A0A0P5W4G4 A0A0P5CWD0 A0A0P5YQN8 E9GJE7 A0A1S3GIY4 A0A2P6LB87 C8UZT5 A0A2I4D5S0 A0A0P5P2U5 A0A287D9C6 P09470-2 A0A0P6AG22 F6PS42 A0A091K6Q9 B0JZU8 A0A0P5MF77 V9K8C1

PDB

4C2Q E-value=1.20708e-139, Score=1275

KEGG

101745756 K01283 peptidyl-dipeptidase A [EC:3.4.15.1] | (RefSeq) angiotensin-converting enzyme-like

GO

GO:0008237 GO:0016021 GO:0004180 GO:0046872 GO:0008241 GO:0016020 GO:0005886 GO:0008239 GO:0005615 GO:0008238 GO:0006355 GO:0043565 GO:0005634 GO:0004386 GO:0003684 GO:0006303 GO:0043564 GO:0000723 GO:0006310 GO:0042162 GO:0003676 GO:1902033 GO:0048286 GO:0010815 GO:0031711 GO:0050729 GO:0035814 GO:0097225 GO:0031100 GO:0031526 GO:0008144 GO:0009925 GO:0010629 GO:0043065 GO:1900086 GO:0043171 GO:0070062 GO:0008217 GO:0031404 GO:0042310 GO:0045777 GO:0031982 GO:0004175 GO:0097756 GO:0003084 GO:0008270 GO:0070573 GO:0050769 GO:0050482 GO:0007283 GO:0042755 GO:0032092 GO:0060177 GO:0051019 GO:0010608 GO:0014910 GO:0032091 GO:0060047 GO:0002446 GO:0003081 GO:0042447 GO:0008233 GO:0005764 GO:0090281 GO:0005768 GO:0001822 GO:0050435 GO:0071838 GO:0019233 GO:0008240 GO:0009897 GO:0061098 GO:0032496 GO:0046325 GO:2000170 GO:0006518 GO:0060978 GO:0003779 GO:0009792 GO:0031434 GO:1903597 GO:0005737 GO:0006508 GO:0005667 GO:0004505 GO:0006559 GO:0004887

PANTHER

PTHR10514

Subcellular location

Nucleus
Secreted
Cell membrane
Cytoplasm

SignalP

Position: 1 - 22, Likelihood: 0.626550

Length:

687

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.3732

Exp number, first 60 AAs:

0.03752

Total prob of N-in:

0.00304

outside

1 - 687

Pi

256.663878

Theta

151.177367

Tajima's D

1.93203

CLR

0.014521

CSRT

0.868006599670016

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics