Gene

KWMTBOMO00686  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003279

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_presequence_protease?_mitochondrial-like_[Bombyx_mori]

Location

Bomo_Chr2(-):510713-519875      View in EpiBrowser

Full name

Presequence protease, mitochondrial      

Location in the cell

Nuclear   Reliability : 2.798

CDS

ATGTATTCAAGACTGCGCAATGGTTTTCGGCAAACAGTTAAACACCGACTGGCTTCGCAAAGAAGTTACAGTAATGAGGTTTTGAGGAAAAAGGAAAATTTATCAAAAAATCTTCAAGTTGGGAAGACTATACATGGATTCCTTTGCACCGAAATCGAATCTATACAAGAATACAATATGACAGCTTATTTTTTAACCCACGAGAGAACCAAAACGGAATATTTGCATTTAGAGAGAGATGACTCAAATAATGTATTTTCTGTAGGTTTTCGCACAACTCCGTTAGATTCAATGGGCACTCCCCACATTCTAGAACACACAGTTTTATGCGGCTCAGAAAAATATCCAGTAAGAGATCCATTCTTCAAAATGCTGAACAGATCTTTGGCTACGTTCATGAATGCTCTAACAGGCCCAGATTATACATTCTATCCTTTTTCATCGCAAAATGAAATTGACTATCGTAATCTACAGAAAGTTTATTTGGATGCAGTCTTCAGACCTAATTTAACTAGACTAGATTTTTTACAAGAAGGCTGGAGATTAGAACATTCAAATTTGGAGGATAAAAATTCTGATTTGATTTTCAAAGGTGTAGTCTACAATGAAATGAAGGGAGCCTTTTCGGAGACAAGTTCGCTTTTTGGACAAAAATTCATTAATACAATTTTACCGAAAGGAACATATGGATATGTATCAGGAGGTGACCCGTTATGCATTCCTCAGCTAACTCATGAGCATTTAAAAAACTTCCATGCCACTTATTATCATCCTAGCAATTCAAGAATGTATTCGTATGGCAGTTTTCCATTAGAAGCCAACTTAAAGTTCATTAATGAAGCCTATCTGAGTAAATATGAATATTTAGATCCCAAGAACACTGTAGTTGCGAGTCAAGAACGTTGGAAGGAGCCAAGACGTGCAGAAATGAACTGCAGAGTAGACCAGTATGGTGGACCAGTAGAAAAACAGAATCAAATTGCCATAGGATATGTTATGTCGGACATTACTAATATTTATGAAACATTCACAATGCTAGCATTAGCGGAACTTATGATAATAGGACCGAATTCAGCATTTTACAAAAGCTTAATTGAGAAAAACATATCGGGAGGCTATAATTCTTTGACTGGCTATGAAAATCAGATAAGAGATACCATGTTTGTTGTTGGTCTCCGAGATGTTGAAACGTCAAAGTTTGAGACCATCGAGAAGATTGCAAATCAAACTTTAGAGGAAATATATGAGAAGGGCTTTGAGAAAGCTCATATTGAGAGTGTTTTACATGGCTTCGAGCTTTCTATTAAGCACCAATCACCAAAGTTTGGTTTAAATCTGCTTTTTAACCTAATGCCTCTCTGGAATCACAATGGGCCGATATTGAATGCTTTGAAGGTCAACAAACTTTTGGGGAGACTGAAGGAGAATCTAATGACTCCAAACTACGTAAAGAATATAATTGAAAAGTACTTTATTCAGAATAACCATAAGTTAGTTATGACTATGCTACCAGACCCAAAATTTGATGATGTCTTCAATGAAGCAGAATCTAAACTTCTGAAATCAAAAGTTTCGTCCTTAAGTGCTAACGATAAAGAAGCTATTTATAAAGAAGGCTTAGAGCTTTCCAAAGTTCAGAAGGAGGTGCAGAATCTTGATGTTTTACCATGTTTGAAAATGGAAGAGATCGTAGCGAACAAAACCGCCCCATCATTAAAACATTCTGTATCAGAAACCATACCACTGCAACTTTGTGAGGCGAATACAAATGGCGTAACATATTTCAAAGGAATCTTAGGCACCGACAGCTTGGGCGACAGTGAAAGAAAAATGCTTCCCTTTTTTAATTATATTTTAGATAAATTTGACACTAAGTCGTATAACTACCGTGATTTTGATAAGCATGTCAGCAAATGCACCTCTGGCCTGAGTGCAATTACACACATCACTGAGCATGTCGGGCAATCTGGTCAATATGAGCAGGGTATATTGATCAACAGTCATTGTTTGGACCACAATCTACCTAAAATGCTTGATATATGGCAGGAGATATTTAAAAAACCAAATTTTAGCAACAGCGAAAGAATGGCAATGCTTCTAAATAATTACTGTTCTTCGTTGACAAATGGGATAGTAAGCAGCGGTCACACTTATGCTGTACAGGCGGCCAGGTCTTTAATATCTTCTGTAGATGAATGCAAAGAGAACCTGCTGGGTATCCAACACGTCACGATCATGCAGGAAGTACAAAAAACACAGAAAACTGAAGATATACAGTCGGTAATAGAGAGCATATCAGAAAACGTACTTAAAGGGAATAATTTGCGAGCAGCATTCCATTATTGCAATACAAACAACGATGTCCACGAATACATCGATAAATTCTGCAAGGACCTGTGTAACGCTAATGATAATCAAGAAGTCAATCGCATTAATTGGACAGACTCTAAAAGTATGAACAAGGACAACCGCGGTATACATATAGCCATGAATATACCAGTGAATTTTTGCGCCAAAGTCATACCGACTGTTGCGTACACCCATCCGGATTACGCGAAGCTACGCGTGCTGTCAGTGTTCTTATCGTCGAAATACTTGCACCCGATCGTGCGAGAGCAGAACGGTGCTTACGGTGGCCGCGCCATGCTGTCCTTTGACGGAATCTTCAGTTACTATTCATACAGAGACCCAAATTCTAAAGTCACTTTGGACGTGTTCGACGAAACCGCCAATTGGTTGACAAAAAATGCGAATTTGATTGACGAACAAAACCTCTTCGAGTCCAAGCTAACTATAATGCAGCAAATGGACCAACCGATCGCGGAATACATGAAAGGAGTCGATCTGTTCCTGTACGGGCTGTCTTATGACCTTTGGAAGACGCAAAGGGAAAGAGTTTTGGCCGTGAAAAGCGAGGACTTGGTGGAAGTATGCTTGAAATATCTGACGAACGATAAATGGGCCGCTAAATGTGTAATCGGAGATGGTGGTGCACAGGATTTGAAGAAAGGGGATGAGATGTCTTTGCCTGAATCGTTTCAAGAGGACAGGCTATACTTCGAAGAATGCCTATCATACTTTCAAGATTATCAAAATCTATACAAACACCCGAACACAGAAATATTAGTTGAAAATGTTTTGCAACATATCATTTTGGGAGATTTATCTAAACACGATGTTTTAAATAATAATTTCGAGCTGAATTCAATCGAGGATGAAGTTATGATGAAAACATTTTTGGAGCGCACTCGGAGATTGACAGTGTGTCACGATGACGCTGTCAAAATTGGCGCGGAATTCGATCTCGACGCCCCAGTTGGCATTAAGAAAAAGTATGAAATTGTAAACTTAGCTAAAGAGATCAAAGGAATCTGTGAAGATGTAAACTGTGGGATGGTTGTGGATTTCGGGTCGGGTTTGGGCTATCTGGATCAATATTTACATTCTATTAGTCAAGTCAAAATCTTAGGTTTGGAATGTAACGACAGTCATTATGTCACCGCCAAAAAACGCCAAACGAAATACCACGAGAGTTCGTCAGAGCATATTGGCAGCACAGCCAACGAGTTGTGGAGATAA

Protein

MYSRLRNGFRQTVKHRLASQRSYSNEVLRKKENLSKNLQVGKTIHGFLCTEIESIQEYNMTAYFLTHERTKTEYLHLERDDSNNVFSVGFRTTPLDSMGTPHILEHTVLCGSEKYPVRDPFFKMLNRSLATFMNALTGPDYTFYPFSSQNEIDYRNLQKVYLDAVFRPNLTRLDFLQEGWRLEHSNLEDKNSDLIFKGVVYNEMKGAFSETSSLFGQKFINTILPKGTYGYVSGGDPLCIPQLTHEHLKNFHATYYHPSNSRMYSYGSFPLEANLKFINEAYLSKYEYLDPKNTVVASQERWKEPRRAEMNCRVDQYGGPVEKQNQIAIGYVMSDITNIYETFTMLALAELMIIGPNSAFYKSLIEKNISGGYNSLTGYENQIRDTMFVVGLRDVETSKFETIEKIANQTLEEIYEKGFEKAHIESVLHGFELSIKHQSPKFGLNLLFNLMPLWNHNGPILNALKVNKLLGRLKENLMTPNYVKNIIEKYFIQNNHKLVMTMLPDPKFDDVFNEAESKLLKSKVSSLSANDKEAIYKEGLELSKVQKEVQNLDVLPCLKMEEIVANKTAPSLKHSVSETIPLQLCEANTNGVTYFKGILGTDSLGDSERKMLPFFNYILDKFDTKSYNYRDFDKHVSKCTSGLSAITHITEHVGQSGQYEQGILINSHCLDHNLPKMLDIWQEIFKKPNFSNSERMAMLLNNYCSSLTNGIVSSGHTYAVQAARSLISSVDECKENLLGIQHVTIMQEVQKTQKTEDIQSVIESISENVLKGNNLRAAFHYCNTNNDVHEYIDKFCKDLCNANDNQEVNRINWTDSKSMNKDNRGIHIAMNIPVNFCAKVIPTVAYTHPDYAKLRVLSVFLSSKYLHPIVREQNGAYGGRAMLSFDGIFSYYSYRDPNSKVTLDVFDETANWLTKNANLIDEQNLFESKLTIMQQMDQPIAEYMKGVDLFLYGLSYDLWKTQRERVLAVKSEDLVEVCLKYLTNDKWAAKCVIGDGGAQDLKKGDEMSLPESFQEDRLYFEECLSYFQDYQNLYKHPNTEILVENVLQHIILGDLSKHDVLNNNFELNSIEDEVMMKTFLERTRRLTVCHDDAVKIGAEFDLDAPVGIKKKYEIVNLAKEIKGICEDVNCGMVVDFGSGLGYLDQYLHSISQVKILGLECNDSHYVTAKKRQTKYHESSSEHIGSTANELWR

Description

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity).

Cofactor

Zn(2+)

Subunit

Homodimer.

Similarity

Belongs to the peptidase M16 family. PreP subfamily.

Keywords

Complete proteome   Hydrolase   Metal-binding   Metalloprotease   Mitochondrion   Protease   Reference proteome   Transit peptide   Zinc  

Feature

chain  Presequence protease, mitochondrial

Uniprot

A0A0L7LHC8   A0A2H1W6R8   A0A2W1C1V2   A0A212FAE2   A0A0N1ICM9   A0A194PVB3   + More
A0A182H7Q2   Q16MK3   A0A1S4FVU1   A0A1Q3FC10   A0A336KNG4   A0A336M954   A0A084WGK0   W5J6N1   A0A182IUV4   B0WCZ9   A0A182PMV6   A0A182FGF3   A0A2M4BBU2   A0A2M4A8U4   A0A2M4BBT7   A0A182LKC8   A0A182R103   Q7Q564   A0A182M5B6   A0A1B0CN86   A0A182R966   A0A182JU28   A0A182UZL9   A0A182U9C1   A0A182I4J6   A0A182X4J9   A0A182NI89   A0A182WBP9   A0A182Y2J1   A0A1B0GC92   A0A2M4BCL2   D6WT63   Q172U8   A0A1I8NAK7   A0A0L0C336   T1PJS7   A0A1I8NNH5   N6U0K3   A0A1B0B5B8   A0A1A9XQR5   A0A1B0A3P2   A0A1A9V231   A0A1A9X4R4   W8BEB1   A0A034WNK7   B4MIZ8   A0A0K8TWX8   A0A0A1WEQ7   A0A0J7L2C7   A0A0B4LES3   Q9V9E3   A0A1W4W039   A0A0J9R7C3   B4R4G3   A0A0J9R6F2   B4ISV3   E2AUJ1   B4IM47   B4KLS3   A0A0N0BKM9   B4J6H6   B4LPH0   B3N434   A0A2A3E120   Q293H1   A0A088ADA3   A0A310S9G4   A0A1W4XDQ5   B3MH58   A0A1Y1MI43   A0A1Y1MLI4   A0A3B0JTF4   A0A232ELQ3   A0A195BPX3   A0A158P3D7   B4GBI4   K7IQA1   N6T3D7   A0A151IIU2   A0A0M5J9W0   E2C3H2   E9IPF6   A0A195EZB5   A0A195DNC7   A0A3L8DTH1   A0A151WYL1   A0A1B0DLU7   A0A3B0J3S4   F4X5G1   A0A1B6DCM2   A0A162SU01   A0A154PJU4   A0A2P8YT83  

EC Number

3.4.24.-

Pubmed

26227816    28756777    22118469    26354079    26483478    17510324    + More
24438588    20920257    23761445    20966253    12364791    14747013    17210077    25244985    18362917    19820115    25315136    26108605    23537049    24495485    25348373    17994087    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    22936249    17550304    20798317    18057021    15632085    23185243    28004739    28648823    21347285    20075255    21282665    30249741    21719571    29403074   

EMBL

JTDY01001068    KOB74973.1    ODYU01006703    SOQ48779.1    KZ149912    PZC78083.1    + More
AGBW02009496    OWR50689.1    KQ460940    KPJ10608.1    KQ459593    KPI96699.1    JXUM01000444    CH477859    EAT35563.1    GFDL01009955    JAV25090.1    UFQS01000716    UFQT01000716    SSX06376.1    SSX26730.1    UFQS01000742    UFQT01000742    SSX06513.1    SSX26862.1    ATLV01023587    KE525344    KFB49344.1    ADMH02002104    ETN59058.1    DS231892    EDS44074.1    GGFJ01001374    MBW50515.1    GGFK01003864    MBW37185.1    GGFJ01001373    MBW50514.1    AXCN02000877    AAAB01008960    EAA11299.4    AXCM01001383    AJWK01019897    APCN01002316    CCAG010007832    GGFJ01001644    MBW50785.1    KQ971354    EFA07169.2    CH477430    EAT41081.1    JRES01000960    KNC26740.1    KA648208    AFP62837.1    APGK01054189    APGK01054190    KB741247    ENN72062.1    JXJN01008671    GAMC01006925    JAB99630.1    GAKP01001801    JAC57151.1    CH963719    EDW72087.1    GDHF01033724    GDHF01029931    JAI18590.1    JAI22383.1    GBXI01017342    JAC96949.1    LBMM01001281    KMQ96589.1    AE013599    AHN55937.1    AY102681    CM002911    KMY91594.1    CM000366    EDX17053.1    KMY91592.1    KMY91591.1    CH891608    EDW99535.2    GL442829    EFN62885.1    CH480926    EDW44094.1    CH933808    EDW09733.1    KRG04872.1    KQ435698    KOX80748.1    CH916367    EDW01977.1    CH940648    EDW61229.1    KRF79860.1    CH954177    EDV59928.2    KZ288467    PBC25398.1    CM000071    EAL24640.3    KRT01424.1    KQ762903    OAD55290.1    CH902619    EDV35817.1    KPU75842.1    GEZM01030775    JAV85333.1    GEZM01030773    JAV85335.1    OUUW01000001    SPP75971.1    NNAY01003517    OXU19286.1    KQ976432    KYM87542.1    ADTU01007654    CH479181    EDW31279.1    ENN72063.1    KQ977459    KYN02578.1    CP012524    ALC40681.1    GL452320    EFN77510.1    GL764503    EFZ17552.1    KQ981905    KYN33471.1    KQ980713    KYN14373.1    QOIP01000005    RLU23058.1    KQ982649    KYQ52990.1    AJVK01016557    AJVK01016558    AJVK01016559    SPP75985.1    GL888716    EGI58317.1    GEDC01013857    JAS23441.1    LRGB01000024    KZS21624.1    KQ434924    KZC11558.1    PYGN01000374    PSN47444.1   

Proteomes

UP000037510    UP000007151    UP000053240    UP000053268    UP000069940    UP000008820    + More
UP000030765    UP000000673    UP000075880    UP000002320    UP000075885    UP000069272    UP000075882    UP000075886    UP000007062    UP000075883    UP000092461    UP000075900    UP000075881    UP000075903    UP000075902    UP000075840    UP000076407    UP000075884    UP000075920    UP000076408    UP000092444    UP000007266    UP000095301    UP000037069    UP000095300    UP000019118    UP000092460    UP000092443    UP000092445    UP000078200    UP000091820    UP000007798    UP000036403    UP000000803    UP000192221    UP000000304    UP000002282    UP000000311    UP000001292    UP000009192    UP000053105    UP000001070    UP000008792    UP000008711    UP000242457    UP000001819    UP000005203    UP000192223    UP000007801    UP000268350    UP000215335    UP000078540    UP000005205    UP000008744    UP000002358    UP000078542    UP000092553    UP000008237    UP000078541    UP000078492    UP000279307    UP000075809    UP000092462    UP000007755    UP000076858    UP000076502    UP000245037   

PRIDE

Q9V9E3   

Pfam

PF13679   Methyltransf_32        + More
PF08367   M16C_assoc
PF05193   Peptidase_M16_C
PF00675   Peptidase_M16
PF12796   Ank_2
PF00023   Ank
PF02204   VPS9

Interpro

IPR011249   Metalloenz_LuxS/M16        + More
IPR025714   Methyltranfer_dom       
IPR007863   Peptidase_M16_C       
IPR013578   Peptidase_M16C_assoc       
IPR011765   Pept_M16_N       
IPR029063   SAM-dependent_MTases       
IPR002110   Ankyrin_rpt       
IPR036770   Ankyrin_rpt-contain_sf       
IPR020683   Ankyrin_rpt-contain_dom       
IPR037191   VPS9_dom_sf       
IPR003123   VPS9       
IPR001431   Pept_M16_Zn_BS       

SUPFAM

SSF63411   SSF63411        + More
SSF53335   SSF53335       
SSF109993   SSF109993       
SSF48403   SSF48403       

Gene 3D

1.20.1050.80     1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

A0A0L7LHC8   A0A2H1W6R8   A0A2W1C1V2   A0A212FAE2   A0A0N1ICM9   A0A194PVB3   + More
A0A182H7Q2   Q16MK3   A0A1S4FVU1   A0A1Q3FC10   A0A336KNG4   A0A336M954   A0A084WGK0   W5J6N1   A0A182IUV4   B0WCZ9   A0A182PMV6   A0A182FGF3   A0A2M4BBU2   A0A2M4A8U4   A0A2M4BBT7   A0A182LKC8   A0A182R103   Q7Q564   A0A182M5B6   A0A1B0CN86   A0A182R966   A0A182JU28   A0A182UZL9   A0A182U9C1   A0A182I4J6   A0A182X4J9   A0A182NI89   A0A182WBP9   A0A182Y2J1   A0A1B0GC92   A0A2M4BCL2   D6WT63   Q172U8   A0A1I8NAK7   A0A0L0C336   T1PJS7   A0A1I8NNH5   N6U0K3   A0A1B0B5B8   A0A1A9XQR5   A0A1B0A3P2   A0A1A9V231   A0A1A9X4R4   W8BEB1   A0A034WNK7   B4MIZ8   A0A0K8TWX8   A0A0A1WEQ7   A0A0J7L2C7   A0A0B4LES3   Q9V9E3   A0A1W4W039   A0A0J9R7C3   B4R4G3   A0A0J9R6F2   B4ISV3   E2AUJ1   B4IM47   B4KLS3   A0A0N0BKM9   B4J6H6   B4LPH0   B3N434   A0A2A3E120   Q293H1   A0A088ADA3   A0A310S9G4   A0A1W4XDQ5   B3MH58   A0A1Y1MI43   A0A1Y1MLI4   A0A3B0JTF4   A0A232ELQ3   A0A195BPX3   A0A158P3D7   B4GBI4   K7IQA1   N6T3D7   A0A151IIU2   A0A0M5J9W0   E2C3H2   E9IPF6   A0A195EZB5   A0A195DNC7   A0A3L8DTH1   A0A151WYL1   A0A1B0DLU7   A0A3B0J3S4   F4X5G1   A0A1B6DCM2   A0A162SU01   A0A154PJU4   A0A2P8YT83  

PDB

4RPU     E-value=0,     Score=1887

KEGG

101746465    K06972 presequence protease [EC:3.4.24.-] | (RefSeq) presequence protease, mitochondrial-like

GO

GO:0046872   GO:0008237   GO:0006508   GO:0003824   GO:0008233   GO:0004222   GO:0005759   GO:0005739   GO:0016485   GO:0016787   GO:0005667   GO:0005737   GO:0004505   GO:0006559   GO:0004887   GO:0016021  

Subcellular location

Mitochondrion  

Length:

1192

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0865400000000001

Exp number, first 60 AAs:

0.0005

Total prob of N-in:

0.00375

outside

1  -  1192

 

 

Pi

256.075575

Theta

183.619253

Tajima's D

0.938659

CLR

0.047539

CSRT

0.64166791660417

Interpretation

Uncertain