Gene

KWMTBOMO00664

Pre Gene Modal

BGIBMGA003878

Annotation

PREDICTED:_G-protein_coupled_receptor_moody-like_[Papilio_machaon]

Location

Bomo_Chr1(+):20573644-20577309      View in EpiBrowser

Full name

G-protein coupled receptor moody      

Location in the cell

PlasmaMembrane   Reliability : 4.826

CDS

ATGCAGAGGGAGCGGCGAGGCGTGCGGGTTTACCCCGGCCTGCCCCGTCCTGCCCCGGCCGCCAGTCGCAGGCAGCAGTGGGTCCAGACGCACGCACCCGCCTCACTCGGCACTCCGTCACGCGACCAGCGTCTTGCAGTTCTTCATTTCGTCCGAGGGTGCTGGTCCCCGCACTGCGCGGCCGCCGTGCAGCAGCAGCTCGGGAGGAGGGCCACGGCGCGCGGAATCACCATGGAACCTGATGAAATATCAACAATGGATACATTACCTGTCAGCAATGTAAGTGACGCGGCGACATCAGAGCCGGCTCTGTTCCGGGAGTGTCCTTCGTTCGCAATCTACACTGCGGCAGGCTGCTGTTTCCTCATAGCCCTCATCGGCGTGCCGTTCAACGCGGTCACCATCATGGCCCTCGGCAAGTGTAAGCTGAAGGCGAAACCGGCATCTTTGTTTATAATGAACATGTGCGCGGCGGATCTGCTGCTGAGCGGAGTGCACGCCCCGTTGACGGGGCTGGCCCTGCTCCGCCGCACCTGGACGCTGGGCTCCGTGGCCCGGAGGTTGCTGCCCTTGTCGCGATTCGTTCTGCTGGCCACTTCTATGTTGTCTATGATGGCCATCAGTATCAGTCGGGTTATTTTAATCACGCAGCCAGCGATTTCAAATAGATTATTTTCGATGCGTAATGTTATTTTGATGGTGGTCACCATATGGTTTCTGGCAATAATGATGCTAATGCCAACCTGCTTTGGAATTTATGGACAGTTCGGACGCGATAATGTGACGGGATCGTACACGATTGTAGCAGATTCAGCGGGACGATCACCAAGAGCCATTTATTACATATTTACGTTTTTGACTTCATTTGCGACTTTGACCATTTGCTACACACGTTTATTCTACGAAGTACGGGACTCCTCGAAAAGATCAAATCGGAGCTCCGCGCCCCGCGGCGGCAGCTGGGCCACTCGTCCGCCCGTCGCGCGTGCTGCTCAGCCGCCCTCTGTGGACACTTCTCCTGCTGATCAGGAGATCGAGTCCACCGAAGGCGCCTCGACCTCATCGTCATCCGGCGCATCAGCGTTTCGTAACTTGGTCACCAAATTGAATACCATGCAGCTGTCCAAAAAGGACCGGAAGCTGATAATCATGATCGCTGCGATCTTGTGTTCCGTGTGGATATGCTACTTGCCGATGACTCTGGTGAAGATATTTGAAAAGGACGTGCCCGTTATTTTATTCCTTATTGGATACATCCTCGTGTACCTGGCGAGCTGTGTGAACCCTCTCGTGTACATGGTGCTGTCCCACGAGTACCGGGACGCGTACCGGGGCCTGTTCCGGTCTGTTCCCCCCCGCGCCCCCCGGTGGTGA

Protein

MQRERRGVRVYPGLPRPAPAASRRQQWVQTHAPASLGTPSRDQRLAVLHFVRGCWSPHCAAAVQQQLGRRATARGITMEPDEISTMDTLPVSNVSDAATSEPALFRECPSFAIYTAAGCCFLIALIGVPFNAVTIMALGKCKLKAKPASLFIMNMCAADLLLSGVHAPLTGLALLRRTWTLGSVARRLLPLSRFVLLATSMLSMMAISISRVILITQPAISNRLFSMRNVILMVVTIWFLAIMMLMPTCFGIYGQFGRDNVTGSYTIVADSAGRSPRAIYYIFTFLTSFATLTICYTRLFYEVRDSSKRSNRSSAPRGGSWATRPPVARAAQPPSVDTSPADQEIESTEGASTSSSSGASAFRNLVTKLNTMQLSKKDRKLIIMIAAILCSVWICYLPMTLVKIFEKDVPVILFLIGYILVYLASCVNPLVYMVLSHEYRDAYRGLFRSVPPRAPRW

Description

Required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors (By similarity).
Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in turn is necessary for the formation of septate junctions of sufficient length to achieve proper sealing of the nerve cord.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix   Alternative splicing  

Feature

chain  G-protein coupled receptor moody
splice variant  In isoform B.

Uniprot

H9J2Z1   A0A2A4JT05   A0A0N1IQF1   A0A194PHF0   A0A2H1X154   A0A2A4JSA0   + More
A0A212FJK1   A0A212FJK6   T1J3L2   A0A2P6JXK6   A0A1L8DJF4   A0A1A9USV9   A0A1L8DKD2   A0A2A4JK45   A0A1A9YJ93   A0A2H1WQP6   T1IMW7   A0A0L7LGA6   A0A226EJ45   A0A1B0DHW2   A0A0N1PKF2   A0A182NQC4   W8B2I3   A0A194PIC5   A0A182QGJ7   A0A2P8XU17   A0A336L7J0   A0A336MHX8   A0A336MMQ3   A0A336MKP8   A0A0R3NY35   Q29J90   B4H3X4   A0A182PGY8   A0A061QFZ2   A0A3B0JZT1   A0A0I9QPZ7   A0A2M4A3C9   B4M7T1   A0A2M4BRM8   A0A2M4BPA7   B4Q1C5   A0A2M4BPB7   A0A0M4F907   A0A034W324   A0A2M4A3E3   A0A2M4BNG5   Q9W534-2   A0A2M4CLL5   A0A2M4CMA4   B3P8U9   A0A336M990   A0A1Y9G764   M9MS14   A0A182FRQ9   W5JA65   A0A1Y9G885   A0A1Y9G768   A0A2M4CMF3   A0A0K8V0E3   A0A0K8V2F7   A0A1W4VEL6   B4I9N0   A0A182YB84   M9PDK4   Q9W534   A0A084W547   A0A0K8VJ00   B4NBW9   A0A182HL21   A0A182L9D6   A0A182UCS9   A0A0K8V414   A0A182WS71   A0A0Q9WMD7   B4L2K4   A0A182V9A5   A0A0A1X356   B3MYQ9   A0A0A1WR06   A0A2M3ZBB6   A0A182J2P3   A0A0A1WYP2   A0A182JTL8   A0A0L0CB57   A0A0P5LQ63   A0A1B0C8F2   E9HQ17   A0A0P6EHZ1   A0A1D2NH07   A0A0P6I2T5   A0A1B0BCU0  

Pubmed

19121390    26354079    22118469    26227816    24495485    29403074    + More
15632085    17994087    24952173    18057021    17550304    25348373    10731132    12537572    10731137    12537569    16213218    16213219    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20920257    23761445    25244985    24438588    20966253    25830018    26108605    21292972    27289101   

EMBL

BABH01031179    NWSH01000670    PCG74916.1    KQ459718    KPJ20244.1    KQ459604    + More
KPI92478.1    ODYU01012548    SOQ58936.1    PCG74915.1    AGBW02008254    OWR53911.1    OWR53912.1    JH431827    MWRG01089823    PRD18811.1    GFDF01007486    JAV06598.1    GFDF01007280    JAV06804.1    NWSH01001201    PCG72146.1    ODYU01010292    SOQ55296.1    JH431096    JTDY01001221    KOB74487.1    LNIX01000003    OXA57034.1    AJVK01061677    KPJ20243.1    GAMC01015309    GAMC01015307    JAB91248.1    KPI92479.1    AXCN02001525    PYGN01001348    PSN35490.1    UFQS01001227    UFQT01001227    SSX09835.1    SSX29558.1    SSX09837.1    SSX29560.1    SSX09834.1    SSX29557.1    SSX09836.1    SSX29559.1    CH379063    KRT05986.1    CH479207    EDW31075.1    GBFC01000021    JAC59317.1    OUUW01000003    SPP78251.1    BK008818    DAA64807.1    GGFK01001992    MBW35313.1    CH940653    EDW62848.1    KRF80822.1    GGFJ01006492    MBW55633.1    GGFJ01005775    MBW54916.1    CM000162    EDX01432.1    KRK06151.1    GGFJ01005776    MBW54917.1    CP012528    ALC48607.1    GAKP01009838    JAC49114.1    GGFK01001986    MBW35307.1    GGFJ01005454    MBW54595.1    AE014298    AL031765    AY121660    AAF45709.2    AAM51987.1    CAA21123.1    GGFL01002048    MBW66226.1    GGFL01002266    MBW66444.1    CH954183    EDV45554.1    KQS26020.1    UFQT01000746    SSX26914.1    ADV37619.1    ADV37620.1    ADMH02001952    ETN60303.1    GGFL01002267    MBW66445.1    GDHF01019993    JAI32321.1    GDHF01019579    JAI32735.1    CH480825    EDW43911.1    ADV37618.1    AGB95016.1    AGB95017.1    ATLV01020482    ATLV01020483    ATLV01020484    KE525302    KFB45341.1    GDHF01013477    JAI38837.1    CH964239    EDW82328.1    APCN01000879    GDHF01018647    JAI33667.1    CH933810    KRF93855.1    EDW06880.2    KRF93853.1    KRF93854.1    KRF93856.1    KRF93857.1    KRF93858.1    GBXI01009174    JAD05118.1    CH902632    EDV32753.1    KPU74120.1    GBXI01012803    JAD01489.1    GGFM01005009    MBW25760.1    AXCP01008715    GBXI01010764    JAD03528.1    JRES01000663    KNC29455.1    GDIQ01166778    JAK84947.1    AJWK01000535    AJWK01000536    GL732713    EFX66166.1    GDIQ01076346    LRGB01000359    JAN18391.1    KZS19551.1    LJIJ01000041    ODN04558.1    GDIQ01011374    JAN83363.1    JXJN01012114   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000078200    + More
UP000092443    UP000037510    UP000198287    UP000092462    UP000075884    UP000075886    UP000245037    UP000001819    UP000008744    UP000075885    UP000268350    UP000008792    UP000002282    UP000092553    UP000000803    UP000008711    UP000069272    UP000000673    UP000192221    UP000001292    UP000076408    UP000030765    UP000007798    UP000075840    UP000075882    UP000075902    UP000076407    UP000009192    UP000075903    UP000007801    UP000075880    UP000075881    UP000037069    UP000092461    UP000000305    UP000076858    UP000094527    UP000092460   

PRIDE

H9J2Z1    Q9W534    M9MS14    M9PDK4   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR000611   NPY_rcpt       

ProteinModelPortal

H9J2Z1   A0A2A4JT05   A0A0N1IQF1   A0A194PHF0   A0A2H1X154   A0A2A4JSA0   + More
A0A212FJK1   A0A212FJK6   T1J3L2   A0A2P6JXK6   A0A1L8DJF4   A0A1A9USV9   A0A1L8DKD2   A0A2A4JK45   A0A1A9YJ93   A0A2H1WQP6   T1IMW7   A0A0L7LGA6   A0A226EJ45   A0A1B0DHW2   A0A0N1PKF2   A0A182NQC4   W8B2I3   A0A194PIC5   A0A182QGJ7   A0A2P8XU17   A0A336L7J0   A0A336MHX8   A0A336MMQ3   A0A336MKP8   A0A0R3NY35   Q29J90   B4H3X4   A0A182PGY8   A0A061QFZ2   A0A3B0JZT1   A0A0I9QPZ7   A0A2M4A3C9   B4M7T1   A0A2M4BRM8   A0A2M4BPA7   B4Q1C5   A0A2M4BPB7   A0A0M4F907   A0A034W324   A0A2M4A3E3   A0A2M4BNG5   Q9W534-2   A0A2M4CLL5   A0A2M4CMA4   B3P8U9   A0A336M990   A0A1Y9G764   M9MS14   A0A182FRQ9   W5JA65   A0A1Y9G885   A0A1Y9G768   A0A2M4CMF3   A0A0K8V0E3   A0A0K8V2F7   A0A1W4VEL6   B4I9N0   A0A182YB84   M9PDK4   Q9W534   A0A084W547   A0A0K8VJ00   B4NBW9   A0A182HL21   A0A182L9D6   A0A182UCS9   A0A0K8V414   A0A182WS71   A0A0Q9WMD7   B4L2K4   A0A182V9A5   A0A0A1X356   B3MYQ9   A0A0A1WR06   A0A2M3ZBB6   A0A182J2P3   A0A0A1WYP2   A0A182JTL8   A0A0L0CB57   A0A0P5LQ63   A0A1B0C8F2   E9HQ17   A0A0P6EHZ1   A0A1D2NH07   A0A0P6I2T5   A0A1B0BCU0  

PDB

6IBL     E-value=4.96664e-09,     Score=146

KEGG

101745324    no KO assigned | (RefSeq) G-protein coupled receptor moody-like

GO

GO:0016021   GO:0004930   GO:0035095   GO:0005886   GO:0019991   GO:0005919   GO:0060857   GO:0007419   GO:0048148   GO:0048149   GO:0030866   GO:0007186   GO:0008366   GO:0004983   GO:0005634   GO:0005667   GO:0005737   GO:0004505   GO:0006559   GO:0004887  

Subcellular location

Cell membrane  

Length:

457

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

153.9492

Exp number, first 60 AAs:

0.048

Total prob of N-in:

0.18326

outside

1  -  112

TMhelix

113  -  135

inside

136  -  147

TMhelix

148  -  170

outside

171  -  192

TMhelix

193  -  215

inside

216  -  234

TMhelix

235  -  257

outside

258  -  278

TMhelix

279  -  301

inside

302  -  379

TMhelix

380  -  402

outside

403  -  411

TMhelix

412  -  434

inside

435  -  457

 

 

Pi

3.256948

Theta

7.453176

Tajima's D

-1.707434

CLR

0.109354

CSRT

0.0308484575771211

Interpretation

Uncertain