Gene

KWMTBOMO00652

Pre Gene Modal

BGIBMGA003867

Annotation

PREDICTED:_G-protein-signaling_modulator_2_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr1(+):20164404-20218200      View in EpiBrowser

Full name

S-adenosylmethionine sensor upstream of mTORC1      

Alternative Name

Probable methyltransferase BMT2 homolog

Location in the cell

Cytoplasmic   Reliability : 1.718 Nuclear   Reliability : 2.098

CDS

ATGTGTCTCGAGCTCGCTCTCGAAGGTGAGAGGCTCTGCAAGGCTGGCGACTGCAAAGCAGGAGTAGCCTTCTTCCAAGCGGCGATACAGGCGGGAACAGATGACCTACGCACCCTGAGCGCAATATACAGCCAAATGGGCAACGCTTATTTTTACCTTGGTGAATACCATAAAGCAGTGCAGTACCACCGACACGATCTAACTTTAGCAAGAACCATGAATGATAAGCTGGGCGAAGCCAAAGCTTCAGGTAATCTAGGCAACACCCTTAAAGTAATAGGAAAGTTCAATGAGGCCATACAGTGCTGCCTCCGACACCTGGAGATATCTCGCTCCCTGGGCGACAGAAATAGCGAGGGTAGAGCTCTGTACAACCTGGCCAACGTATACCATGCCCAAGGTAAACATCTGGGAAAGGTCGGACAAAACGATCCGGGACATTTTCCCCAAGAGGTGCGCGAATGCCTTTTACAAGCAGTCAACTATTATGAACAAAATTTGGTACTCATGCGTGAGCTGAACGATCGCCTAGCCATCGGTCGGGCTTGCGGCAACCTTGGAAACACTTACTACCTGCTTGGTGAATTTAATGTAGCTGTTCAGTACCACACGGAGCGACTGGAAATGGCCAAGGAATGTAAAGACAAGGCAGCCGAAAGACGCGCCCACAGCAATCTTGGAAACTCACACATTTTCCTCGGGCAGTTTGAGAACGCGGCCGATCATTACAAACAGACTTTGGCGATTGCCGAAGAATTAAAAGACGAAGCGGTGGTCGCACAAGCCTGCTACTCCTTAGGGAATACGTACACGTTACTCCGGGAGTATAGAATTGCGGAAGAGTACCATGCTAGGCACCTGGAGGCGGCCAGGAAGCTTCAGGATCGAGTTGGCGAAGGCAGGGCCTGTTGGTCTCTGGGCAACGCCCACGCGGCTCTCGGCAACCACGAGAAAGCATTGTATTATGCCATTGAACATTATACCATATCGAAAGAGATCTGTGATGTGCTGGGGATGGCCACGGCACAGATGAACATCAACGACCTCCGCAAGGTGCTCGGGCTCCCGCCGCTCGCCGAGACCGCCGCAGCTCAGCCCGCCCCGCCAGACCAAGCCGGCTCCAGCCAGACGCCCTTCAACGCCCTTCGTGTGAGGAGGCAGAGCATGGAACAGCTGTCCCTGATACAATTGACACCCGACGGTAAGAAGGACCCCGAGGACGCCCAGAAGAAAGCCGTGCTGATGCGTTCGGAATCCGAAGACAGCCCCATGGAGTCCTTCCTCGATCTGCTATCCAAATACCAATCCGAGAGGATGGATGAGCAGCGAGCCACCCTCGTGGAGACCAAAGAAATCCAAGAGACTCCCAAACCAACTGAGAAGCCGAAGCCCAGCTCCAGCAAACTGTTCCGCTCTTCCAGCAGCGGCAGCAAGCAGTACGATTCGAACGAGGCGCTCTTGGACATGATCACCGATCTCCAGTCCGAGCGCATGGACTCCCAGCGCGCCGAGCTGCGCCCGATCAAAAAGAAGCTGTCCAAGGAAATGAAGGGGACCTCGCTACCCGGCCTCCGCACCGCCCGCGTCGCCGGCGCCAAGCCGGAGGACGATTTCCTCGACATGATTGCTCGTGTACAGGGCACCCGGCTCGACGATCAACGGACCGAGATGCCTCGTCCCAAGGCCGACCCTCGTCCCAAGACCGTGCCCGATGACGATTTCTTCGCTCTGATCATGAGGGCCCAGTCTGGACGTATGGAGGACCAACGAGCTGCCATTCCGAAGCCGGCCGAGAACCGACAGAGCAAGCCGGCCCCCAAGCCGCGTAAATAG

Protein

MCLELALEGERLCKAGDCKAGVAFFQAAIQAGTDDLRTLSAIYSQMGNAYFYLGEYHKAVQYHRHDLTLARTMNDKLGEAKASGNLGNTLKVIGKFNEAIQCCLRHLEISRSLGDRNSEGRALYNLANVYHAQGKHLGKVGQNDPGHFPQEVRECLLQAVNYYEQNLVLMRELNDRLAIGRACGNLGNTYYLLGEFNVAVQYHTERLEMAKECKDKAAERRAHSNLGNSHIFLGQFENAADHYKQTLAIAEELKDEAVVAQACYSLGNTYTLLREYRIAEEYHARHLEAARKLQDRVGEGRACWSLGNAHAALGNHEKALYYAIEHYTISKEICDVLGMATAQMNINDLRKVLGLPPLAETAAAQPAPPDQAGSSQTPFNALRVRRQSMEQLSLIQLTPDGKKDPEDAQKKAVLMRSESEDSPMESFLDLLSKYQSERMDEQRATLVETKEIQETPKPTEKPKPSSSKLFRSSSSGSKQYDSNEALLDMITDLQSERMDSQRAELRPIKKKLSKEMKGTSLPGLRTARVAGAKPEDDFLDMIARVQGTRLDDQRTEMPRPKADPRPKTVPDDDFFALIMRAQSGRMEDQRAAIPKPAENRQSKPAPKPRK

Description

S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

Similarity

Belongs to the BMT2 family.

Uniprot

A0A1E1W3B1   H9J2Y0   A0A2H1WJV0   A0A2A4JQ38   A0A194QXQ7   A0A194PNK0   + More
A0A2P8XTP3   E0VT28   T1HV42   A0A067QMN4   A0A023F5F5   A0A2J7RIX7   A0A0P4VIV9   A0A069DV90   A0A212EKE1   N6THL1   A0A2H8TGF8   D6WEG2   A0A0A9YDJ9   A0A1W4XHA3   J9JZ96   A0A1S4EGW1   A0A2J7RIZ1   A0A1Y1JRY1   A0A3Q0J238   A0A1W4XRU7   A0A0A9YJN0   A0A1Q3FAH9   A0A1Q3FAP2   A0A1Q3FAL2   A0A0P6IVL0   A0A1Q3FAP3   A0A2S2PZV3   A0A1S4FKG9   B0WSA6   E9FQZ4   A0A1L8DLR2   A0A0P6AQT7   Q7PWG1   A0A3Q0J269   A0A1Y1JV02   A0A0P5W7S2   A0A0M9A5N8   A0A088A1H2   E2C2Q2   A0A026WI13   A0A154PMH8   A0A0L7QNN5   A0A182PVU5   A0A182M4F9   K7IUG1   A0A0K8TCG7   A0A182Y0H7   A0A195DTF7   A0A182RZB7   A0A164U0Q6   A0A2A3EJP5   A0A0C9QFA0   A0A195BLK8   Q16Y24   A0A195CCN6   A0A0J7L357   F4X2Q8   A0A195FVU9   Q16H10   A0A3L8DIJ5   E9J298   A0A182LMJ7   A0A182I7I7   A0A1J1JA02   B4QXH8   A0A182Q4N9   B4IGT6   A0A1S4H0I0   A0A1B6CEP6   A0A1B6E487   Q29BH6   B4GNY6   A0A182WXM2   A0A2M4BES0   B3LXJ2   B4JRY6   A0A2M4BEL2   B4M633   A0A0N7ZLK7   A0A0M3QXH9   A0A0K8VPI6   W8C4I9   A0A1B6EXM6   A0A2J7RIY8   A0A182FN86   A0A182JI38   A0A0K8TCW5   A0A182WGC1   A0A0A1WVH3   A0A0P4W3L7   A0A210QBM3   A0A182V7B0   A0A182NBJ6   A0A1S3KCE9  

Pubmed

19121390    26354079    29403074    20566863    24845553    25474469    + More
27129103    26334808    22118469    23537049    18362917    19820115    25401762    26823975    28004739    26999592    17510324    21292972    12364791    20798317    24508170    20075255    25244985    21719571    30249741    21282665    20966253    17994087    15632085    24495485    25830018    28812685   

EMBL

GDQN01009586    JAT81468.1    BABH01031212    ODYU01009120    SOQ53318.1    NWSH01000836    + More
PCG73929.1    KQ460953    KPJ10323.1    KQ459599    KPI94319.1    PYGN01001366    PSN35366.1    DS235759    EEB16534.1    ACPB03018893    KK853156    KDR10512.1    GBBI01002338    JAC16374.1    NEVH01003011    PNF40798.1    GDKW01001754    JAI54841.1    GBGD01000906    JAC87983.1    AGBW02014274    OWR41951.1    APGK01026647    KB740635    KB632195    ENN79909.1    ERL89968.1    GFXV01001392    MBW13197.1    KQ971318    EFA00406.2    GBHO01013890    GBHO01013888    GBHO01013886    GBRD01002571    GDHC01012135    JAG29714.1    JAG29716.1    JAG29718.1    JAG63250.1    JAQ06494.1    ABLF02009781    PNF40797.1    GEZM01102118    JAV51952.1    GBHO01013889    GBHO01013887    GBHO01013885    GBRD01002572    JAG29715.1    JAG29717.1    JAG29719.1    JAG63249.1    GFDL01010485    JAV24560.1    GFDL01010463    JAV24582.1    GFDL01010420    JAV24625.1    GDUN01000717    JAN95202.1    GFDL01010456    JAV24589.1    GGMS01001229    MBY70432.1    DS232067    EDS33736.1    GL732523    EFX90280.1    GFDF01006777    JAV07307.1    GDIP01027515    JAM76200.1    AAAB01008984    EAA14880.4    GEZM01102119    JAV51951.1    GDIP01090097    JAM13618.1    KQ435748    KOX76463.1    GL452203    EFN77737.1    KK107238    EZA54744.1    KQ434978    KZC13043.1    KQ414851    KOC60235.1    AXCM01006472    AAZX01008038    GBRD01002573    JAG63248.1    KQ980489    KYN15824.1    LRGB01001654    KZS10949.1    KZ288241    PBC31261.1    GBYB01002074    JAG71841.1    KQ976450    KYM85687.1    CH477527    EAT39510.1    KQ977957    KYM98475.1    LBMM01001122    KMQ96884.1    GL888591    EGI59254.1    KQ981219    KYN44432.1    CH478216    EAT33528.1    QOIP01000007    RLU20237.1    GL767834    EFZ13039.1    APCN01003409    CVRI01000075    CRL08700.1    CM000364    EDX14664.1    AXCN02000674    CH480837    EDW49054.1    GEDC01025385    JAS11913.1    GEDC01004567    JAS32731.1    CM000070    EAL27022.1    CH479186    EDW38869.1    GGFJ01002352    MBW51493.1    CH902617    EDV43886.1    CH916373    EDV94526.1    GGFJ01002344    MBW51485.1    CH940652    EDW59109.1    GDIP01233481    JAI89920.1    CP012526    ALC45953.1    GDHF01031339    GDHF01025535    GDHF01023549    GDHF01011520    JAI20975.1    JAI26779.1    JAI28765.1    JAI40794.1    GAMC01005479    JAC01077.1    GECZ01027139    JAS42630.1    PNF40799.1    GBRD01002570    JAG63251.1    GBXI01011762    JAD02530.1    GDRN01090458    JAI60468.1    NEDP02004270    OWF46128.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000245037    UP000009046    + More
UP000015103    UP000027135    UP000235965    UP000007151    UP000019118    UP000030742    UP000007266    UP000192223    UP000007819    UP000079169    UP000002320    UP000000305    UP000007062    UP000053105    UP000005203    UP000008237    UP000053097    UP000076502    UP000053825    UP000075885    UP000075883    UP000002358    UP000076408    UP000078492    UP000075900    UP000076858    UP000242457    UP000078540    UP000008820    UP000078542    UP000036403    UP000007755    UP000078541    UP000279307    UP000075882    UP000075840    UP000183832    UP000000304    UP000075886    UP000001292    UP000001819    UP000008744    UP000076407    UP000007801    UP000001070    UP000008792    UP000092553    UP000069272    UP000075880    UP000075920    UP000242188    UP000075903    UP000075884    UP000085678   

PRIDE

H9J2Y0   

Pfam

PF13176   TPR_7        + More
PF02188   GoLoco
PF07721   TPR_4
PF13181   TPR_8
PF11968   Bmt2

Interpro

IPR011990   TPR-like_helical_dom_sf        + More
IPR019734   TPR_repeat       
IPR013026   TPR-contain_dom       
IPR011717   TPR-4       
IPR003109   GoLoco_motif       
IPR029063   SAM-dependent_MTases       
IPR021867   Bmt2/SAMTOR       

SUPFAM

SSF48452   SSF48452        + More
SSF53335   SSF53335       

Gene 3D

1.25.40.10    

ProteinModelPortal

A0A1E1W3B1   H9J2Y0   A0A2H1WJV0   A0A2A4JQ38   A0A194QXQ7   A0A194PNK0   + More
A0A2P8XTP3   E0VT28   T1HV42   A0A067QMN4   A0A023F5F5   A0A2J7RIX7   A0A0P4VIV9   A0A069DV90   A0A212EKE1   N6THL1   A0A2H8TGF8   D6WEG2   A0A0A9YDJ9   A0A1W4XHA3   J9JZ96   A0A1S4EGW1   A0A2J7RIZ1   A0A1Y1JRY1   A0A3Q0J238   A0A1W4XRU7   A0A0A9YJN0   A0A1Q3FAH9   A0A1Q3FAP2   A0A1Q3FAL2   A0A0P6IVL0   A0A1Q3FAP3   A0A2S2PZV3   A0A1S4FKG9   B0WSA6   E9FQZ4   A0A1L8DLR2   A0A0P6AQT7   Q7PWG1   A0A3Q0J269   A0A1Y1JV02   A0A0P5W7S2   A0A0M9A5N8   A0A088A1H2   E2C2Q2   A0A026WI13   A0A154PMH8   A0A0L7QNN5   A0A182PVU5   A0A182M4F9   K7IUG1   A0A0K8TCG7   A0A182Y0H7   A0A195DTF7   A0A182RZB7   A0A164U0Q6   A0A2A3EJP5   A0A0C9QFA0   A0A195BLK8   Q16Y24   A0A195CCN6   A0A0J7L357   F4X2Q8   A0A195FVU9   Q16H10   A0A3L8DIJ5   E9J298   A0A182LMJ7   A0A182I7I7   A0A1J1JA02   B4QXH8   A0A182Q4N9   B4IGT6   A0A1S4H0I0   A0A1B6CEP6   A0A1B6E487   Q29BH6   B4GNY6   A0A182WXM2   A0A2M4BES0   B3LXJ2   B4JRY6   A0A2M4BEL2   B4M633   A0A0N7ZLK7   A0A0M3QXH9   A0A0K8VPI6   W8C4I9   A0A1B6EXM6   A0A2J7RIY8   A0A182FN86   A0A182JI38   A0A0K8TCW5   A0A182WGC1   A0A0A1WVH3   A0A0P4W3L7   A0A210QBM3   A0A182V7B0   A0A182NBJ6   A0A1S3KCE9  

PDB

5A7D     E-value=2.08936e-140,     Score=1281

KEGG

101745607    K15837 G-protein signaling modulator 2 | (RefSeq) G-protein-signaling modulator 2

GO

GO:0042802   GO:0030695   GO:0008168   GO:0016021   GO:0019904   GO:0055059   GO:0000132   GO:0045179   GO:0005515   GO:0009072   GO:0008152   GO:0016597   GO:0004505   GO:0006559   GO:0004887  

Length:

610

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00408

Exp number, first 60 AAs:

0.00211

Total prob of N-in:

0.00025

outside

1  -  610

 

 

Pi

22.898133

Theta

18.286145

Tajima's D

-1.329349

CLR

0.075213

CSRT

0.0834458277086146

Interpretation

Uncertain