Gene

KWMTBOMO00650  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003866

Annotation

phenylalanine_hydroxylase_[Bombyx_mori]

Location

Bomo_Chr1(+):20052875-20060295      View in EpiBrowser

Location in the cell

Cytoplasmic   Reliability : 2.492

CDS

ATGGACATCACGGCGAAGCAAATTGAACAACCCACGTCTGGCTCGCCTCCCGACAAGCCAAAATTGATGGAAGGTGGCAACTACATCCGCGAGGGTCGTGATTCTACCAAATCAACTTGGCTTCTGATTTCACCAGTCGCACCCGACGAGGCTGGCTCGTTAGCCAGATATTTAGGCATTTTCTCTTCTCATGGAGTCAACCTCAGTCACATTGAATCCAGATCTTCCACAAGGCGTCCAGGCTATGAGTTCATGGTTGAATGTGAACATGGTTCTGGAGATTTCGGAGCGGCCCTTGAAGAGCTGAAGAAGAATGTTGGATACCTAAATATTATTTCGAGAAACTATAAAGATAATCGATCCGCTGTTCCTTGGTTCCCACGTCGTATCCGCGACTTAGATCGCTTTGCCAACCAGATCCTCTCATACGGTGCCGAACTGGACTCTGATCACCCTGGATTTACCGATCCTGTTTACCGCGACCGCCGCAAATATTTCGCCGACATTGCATACAACTACAAGCACGGAGAGCCTCTGCCTTATGTGGAGTACACCAAAGAGGAGGTGGCCACCTGGGGTGTAGTTTTCCGGAAGTTGACAGAGCTCTACCCCACTCATGCCTGCAAAGAGCACAACCATGTCTTCCCGCTGCTGATCGAAAACTGTGGTTACAGGGACGACAACATTCCACAATTGGAAGATGTTTCTAACTTTTTGAGAGATAGCACCGGCTTCACTCTGCGGCCCGTGGCAGGACTTCTCTCGTCGCGTGACTTTCTGGCTGGACTTGCTTTTCGAGTGTTCCACAGCACCCAGTATATCAGACACCATTCAAGACCACTCTATACTCCGGAACCAGACGTGTGCCACGAATTGCTTGGACACGCCCCGCTTTTTGCGGATCCCGCCTTTGCACAATTCTCTCAAGAAATTGGTCTTGCGTCTCTAGGAGCTCCTGATGATTACATCGAGAAACTAGCCACGTGCTTCTGGTTCACGGTGGAGTTTGGTCTGTGCCGGCAAGAAGGTCAACTAAAGGCTTACGGCGCCGGTCTACTGTCGTCCTTCGGCGAGCTACAGTACTGTCTCTCAGACAAACCTGAGTTGAGAGAGTTTGACCCCGAGTCTACCGGGGGTACCAAGTATCCCATCACAGAATACCAGCCCGTCTATTTCGTTGCTAACAGCTTTGAAGATGCCCAGGAGAAGATGATAAAGTTTGCTCAAACGATCCCACGTGACTTTGGCGTCCGTTACAATCCCTACACGCAGAGCATTGACATTCTGGACTCCGCTCGCCAGATCAGGGTCCTGATGCGGGAGGTGCACCAAGAAATGGAGCTGCTGCTAAACGCTATGGACAAGTTGTAA

Protein

MDITAKQIEQPTSGSPPDKPKLMEGGNYIREGRDSTKSTWLLISPVAPDEAGSLARYLGIFSSHGVNLSHIESRSSTRRPGYEFMVECEHGSGDFGAALEELKKNVGYLNIISRNYKDNRSAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPVYRDRRKYFADIAYNYKHGEPLPYVEYTKEEVATWGVVFRKLTELYPTHACKEHNHVFPLLIENCGYRDDNIPQLEDVSNFLRDSTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFTVEFGLCRQEGQLKAYGAGLLSSFGELQYCLSDKPELREFDPESTGGTKYPITEYQPVYFVANSFEDAQEKMIKFAQTIPRDFGVRYNPYTQSIDILDSARQIRVLMREVHQEMELLLNAMDKL

Cofactor

Fe(2+)

Uniprot

F2VQ04   A0A2W1BI33   A0A2A4JPK1   A0A2H1VKC0   A0A173DWC6   A0A0G3VGS7   + More
A0A1E1WEP3   Q2V0P9   A0A212EKD7   A0A1E1W9V0   A0A194PMU5   A0A142F421   A0A0N9DUU8   K7JAJ5   A0A0L7L9Y0   A0A0C9RUV9   A0A026WAH0   E9RJV0   E9IE68   A0A290WIX5   E2AY33   A0A1Y1M530   I3WD95   V9IHE9   A0A067RFY9   E2C764   A0A2M3ZH89   A0A2J7QFF8   A0A2M4CTF1   T1E8D8   A0A2M4A4L2   A0A2M3ZHD2   A0A2M4A4T1   Q8I901   W5JVC1   Q5MR21   A0A182L2Y9   A0A182QSN3   A0A2M4A4Z6   A0A2M4BN68   A0A0N0BIE9   Q7PIP2   A0A182JHG8   A0A2M4A4W0   A0A182MPM0   A0A182RZS9   A0A182FCB9   A0A182PMJ0   A0A182NIR4   A0A1B0D5T8   A0A232ENU2   D6WIQ7   A0A182WKT5   A0A1W4WN76   A7UTU7   A0A182XMS5   A0A182VMJ7   A0A034WBG5   A0A182HWN2   A0A0L7RH61   A0A088A9G8   A0A0A1XF68   A0A1L8E384   A0A1Q3G132   U5EJU9   A0A1Y1M8N2   W8BF18   A0A2J7QFK2   A0A182U1P1   A0A084WA49   A0A0L0BY41   V5SK50   A0A182GU55   A0A1B6IC19   A0A0K8VLS5   A0A195D375   A0A1B6DQ32   A0A0A1XR12   A0A0A9X798   A0A2A3EGK0   A0A182STI2   B4LHC1   A0A0K8TVR8   E0VT40   A0A182YD50   F4WUR1   B3M966   B4MY17   Q7Q6R7   B3NF88   A0A336M311   B4KUN0   A0A0M4EG87   A0A0A9X4U7   A0A1W4VA89   A0A195FIQ4   B0W3Y2   A0A3B0JY36   B4J120   B4PCB5  

Pubmed

19121390    28756777    16360951    22118469    26354079    26974346    + More
26371082    20075255    26227816    24508170    30249741    21282665    20798317    28004739    24845553    12609519    17510324    20920257    23761445    15544946    20966253    12364791    14747013    17210077    28648823    18362917    19820115    25348373    25830018    24495485    24438588    26108605    26483478    25401762    17994087    20566863    25244985    21719571    17550304   

EMBL

BABH01031220    BABH01031221    GU953670    ADM33594.1    KZ150031    PZC74729.1    + More
NWSH01000836    PCG73931.1    ODYU01003024    SOQ41270.1    KU645526    KU645527    ANG60538.1    KP657631    RSAL01000033    AKL78856.1    RVE51467.1    GDQN01005635    JAT85419.1    AB220983    BAE66652.1    AGBW02014274    OWR41947.1    GDQN01007335    JAT83719.1    KQ459599    KPI94313.1    KT946791    AMQ67550.1    KT781080    ALF12135.1    AAZX01001759    AAZX01007265    JTDY01002019    KOB72308.1    GBYB01011441    JAG81208.1    KK107323    QOIP01000002    EZA52626.1    RLU25522.1    AB618096    BAJ83477.1    GL762558    EFZ21127.1    KX951493    ATD50587.1    GL443762    EFN61629.1    GEZM01040229    JAV80929.1    JQ782583    AFL02790.1    JR045793    AEY60057.1    KK852529    KDR21968.1    GL453340    EFN76177.1    GGFM01007132    MBW27883.1    NEVH01015298    PNF27322.1    GGFL01004425    MBW68603.1    GAMD01002858    JAA98732.1    GGFK01002349    MBW35670.1    GGFM01007134    MBW27885.1    GGFK01002327    MBW35648.1    AY099427    CH477897    AAM28250.1    EJY57984.1    ADMH02000342    ETN66905.1    AY571966    AAT78350.1    AXCN02000420    GGFK01002397    MBW35718.1    GGFJ01005303    MBW54444.1    KQ435730    KOX77562.1    AAAB01008960    EAA44070.4    GGFK01002449    MBW35770.1    AXCM01004081    AJVK01000346    NNAY01003088    OXU20001.1    KQ971321    EEZ99507.1    EDO63721.1    GAKP01006036    JAC52916.1    APCN01001511    KQ414594    KOC70149.1    GBXI01004690    JAD09602.1    GFDF01001129    JAV12955.1    GFDL01001569    JAV33476.1    GANO01002085    JAB57786.1    GEZM01040228    JAV80930.1    GAMC01014704    JAB91851.1    PNF27323.1    ATLV01022043    KE525327    KFB47093.1    JRES01001162    KNC24940.1    KF647642    AHB50504.1    JXUM01018346    KQ560510    KXJ82056.1    GECU01033917    GECU01023276    JAS73789.1    JAS84430.1    GDHF01012516    JAI39798.1    KQ976885    KYN07353.1    GEDC01009516    JAS27782.1    GBXI01000548    JAD13744.1    GBHO01028942    GBHO01028941    GBRD01001959    JAG14662.1    JAG14663.1    JAG63862.1    KZ288254    PBC30840.1    CH940647    EDW70634.1    GDHF01033936    JAI18378.1    DS235759    EEB16546.1    GL888375    EGI62058.1    CH902618    EDV40050.1    CH963876    EDW77006.1    EAA10731.4    CH954178    EDV50430.1    UFQT01000473    SSX24635.1    CH933809    EDW18258.1    CP012525    ALC43390.1    GBHO01028944    GBHO01028943    GBRD01001957    JAG14660.1    JAG14661.1    JAG63864.1    KQ981523    KYN40251.1    DS231833    EDS32279.1    OUUW01000012    SPP86975.1    CH916366    EDV96875.1    CM000159    EDW93800.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053268    UP000002358    + More
UP000037510    UP000053097    UP000279307    UP000000311    UP000027135    UP000008237    UP000235965    UP000008820    UP000000673    UP000075882    UP000075886    UP000053105    UP000007062    UP000075880    UP000075883    UP000075900    UP000069272    UP000075885    UP000075884    UP000092462    UP000215335    UP000007266    UP000075920    UP000192223    UP000076407    UP000075903    UP000075840    UP000053825    UP000005203    UP000075902    UP000030765    UP000037069    UP000069940    UP000249989    UP000078542    UP000242457    UP000075901    UP000008792    UP000009046    UP000076408    UP000007755    UP000007801    UP000007798    UP000008711    UP000009192    UP000092553    UP000192221    UP000078541    UP000002320    UP000268350    UP000001070    UP000002282   

PRIDE

F2VQ04   

Pfam

PF00351   Biopterin_H        + More
PF01842   ACT

Interpro

IPR001273   ArAA_hydroxylase        + More
IPR041912   Euk_PheOH_cat       
IPR002912   ACT_dom       
IPR019774   Aromatic-AA_hydroxylase_C       
IPR019773   Tyrosine_3-monooxygenase-like       
IPR036329   Aro-AA_hydroxylase_C_sf       
IPR005961   Phe-4-hydroxylase_tetra       
IPR036951   ArAA_hydroxylase_sf       
IPR018301   ArAA_hydroxylase_Fe/CU_BS       

SUPFAM

SSF56534   SSF56534       

Gene 3D

1.10.800.10    

CDD

cd03347  eu_PheOH

ProteinModelPortal

F2VQ04   A0A2W1BI33   A0A2A4JPK1   A0A2H1VKC0   A0A173DWC6   A0A0G3VGS7   + More
A0A1E1WEP3   Q2V0P9   A0A212EKD7   A0A1E1W9V0   A0A194PMU5   A0A142F421   A0A0N9DUU8   K7JAJ5   A0A0L7L9Y0   A0A0C9RUV9   A0A026WAH0   E9RJV0   E9IE68   A0A290WIX5   E2AY33   A0A1Y1M530   I3WD95   V9IHE9   A0A067RFY9   E2C764   A0A2M3ZH89   A0A2J7QFF8   A0A2M4CTF1   T1E8D8   A0A2M4A4L2   A0A2M3ZHD2   A0A2M4A4T1   Q8I901   W5JVC1   Q5MR21   A0A182L2Y9   A0A182QSN3   A0A2M4A4Z6   A0A2M4BN68   A0A0N0BIE9   Q7PIP2   A0A182JHG8   A0A2M4A4W0   A0A182MPM0   A0A182RZS9   A0A182FCB9   A0A182PMJ0   A0A182NIR4   A0A1B0D5T8   A0A232ENU2   D6WIQ7   A0A182WKT5   A0A1W4WN76   A7UTU7   A0A182XMS5   A0A182VMJ7   A0A034WBG5   A0A182HWN2   A0A0L7RH61   A0A088A9G8   A0A0A1XF68   A0A1L8E384   A0A1Q3G132   U5EJU9   A0A1Y1M8N2   W8BF18   A0A2J7QFK2   A0A182U1P1   A0A084WA49   A0A0L0BY41   V5SK50   A0A182GU55   A0A1B6IC19   A0A0K8VLS5   A0A195D375   A0A1B6DQ32   A0A0A1XR12   A0A0A9X798   A0A2A3EGK0   A0A182STI2   B4LHC1   A0A0K8TVR8   E0VT40   A0A182YD50   F4WUR1   B3M966   B4MY17   Q7Q6R7   B3NF88   A0A336M311   B4KUN0   A0A0M4EG87   A0A0A9X4U7   A0A1W4VA89   A0A195FIQ4   B0W3Y2   A0A3B0JY36   B4J120   B4PCB5  

PDB

5DEN     E-value=1.14921e-155,     Score=1411

KEGG

101742825    K00500 phenylalanine-4-hydroxylase [EC:1.14.16.1] | (RefSeq) PAH; phenylalanine hydroxylase

PATHWAY

00360    Phenylalanine metabolism - Bombyx mori (domestic silkworm)
00400    Phenylalanine, tyrosine and tryptophan biosynthesis - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0004505   GO:0005506   GO:0006559   GO:0016714   GO:0009072   GO:0006571   GO:0004510   GO:0007616   GO:0006726   GO:0004497   GO:0008152   GO:0016597   GO:0004887   GO:0016021   GO:0055114  

PANTHER

PTHR11473  

Length:

456

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01564

Exp number, first 60 AAs:

0.00866

Total prob of N-in:

0.01363

outside

1  -  456

 

 

Pi

18.632803

Theta

16.454665

Tajima's D

0.587299

CLR

0.121972

CSRT

0.549772511374431

Interpretation

Uncertain