Gene

KWMTBOMO00640

Pre Gene Modal

BGIBMGA003862

Annotation

PREDICTED:_H(+)/Cl(-)_exchange_transporter_5_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr1(+):19793115-19822042      View in EpiBrowser

Full name

Chloride channel protein      

Location in the cell

PlasmaMembrane   Reliability : 4.921

CDS

ATGGAGAGGTTTCCTTTGAAGTCGTCAGTAACAAAAACAGGAATGACTTATCAATCAGTTTACAAAAAGGGCGCAAACACTGCGAATGGGCGTGGTGCTCATAGCGGTGAGGATGAAATGGTAGATATCACGCCGGGCCTCCAGCAAGCGGCGGACGGCGTCACCACACCCACAAGCCACGGAACCTTCCAGATCTACGAACAAGGAAGCCGAAATTCCGCGAGCAGCACTCATTCATACATTGCTCAGTTTTTCGGATCGTCGACAGGGGACACAATTATGTTCTCAGGAATGCAAGGTGATGATGATATTCCTGGAATTGGACAATATGAAGATTTCCATACTATTGATTGGCAAAGAGATATTGCGAGAGATCGCATGCGACATAGATATATTGTGAAGAAGAGGCAGGACTCAATATGGGATTTAATCAAAGGTGCCCATGATGCCTGGTCTGGATGGGTTTGTGTATTGCTTGTGGGAGTAGCAACTGGGATAGTGGCAGGAGTAATTGACATTGGTGCCTCATGGATGACAGATCTCAAATTTGGAATTTGTCCAGCTGCATTTTGGTTTAATCGAGAACAATGCTGCTGGTCAGACACAAATACTACATTCGACAGTGGGAATTGCTCACAGTGGCTCACCTGGCCTCAAGTTTTTGGCGACCGAGGTGATGGTGCTGGAGCTTACATCATCAGTTATCTCTTTTATATATTATGGGCTTTGATATTCGCTGCACTTTCAGCGTCGCTCGTAAGAATGTTCGCGCCCTATGCATGTGGCTCTGGTATCCCCGAAATTAAGACCATACTAAGTGGTTTCATTATCCGAGGCTACCTCGGCAAGTGGACCCTTATCATCAAAGTGGTAGGACTCATACTGTCTGTGTCATCGGGACTGTCTTTGGGGAAGGAAGGACCTATGGTGCACATTGCCAGCTGCCTTGGTAACATTCTATCATACCTGTTTCCGAAATACGGTCGCAACGAGGCCAAGAAGCGCGAGATCCTGTCCGCCGCCGCCGCCGCCGGAGTGTCCGTCGCATTCGGAGCTCCCATCGGTGGAGTACTCTTCAGTCTGGAAGAGGTATCGTACTATTTCCCGCTGAAGACCCTTTGGCGTTCGTTCTTCTGCGCTTTGATTGCCGCCTTCATACTGCGCTCAATCAATCCGTTCGGCAACGAGCACTCCGTGTTGTTCTTCGTCGAGTACAACAAGCCCTGGATCTTCTTCGAACTCATTCCGTTTGTTGGCCTCGGTATTATCGGGGGTTGCATCGCTACGATCTTCATAAAAGCGAATATCTATTGGTGTCGTTACCGGAAGTACTCGAAGCTGGGACAGTATCCGGTGACTGAAGTGCTGGTCGTGACGCTGATCACCGCCATCCTTGCCTACCCGAACCCATACACGCGCATGAACACCAGCGAACTCATATACCTGCTTTTTAACCAGTGCGGGATCTCTAACTCGGATCCTTTGTGTGACTACAATCGTAACTTCACCGATGCGAATTCGGCGATAGAGAAGGCGGCAGCCGGTGCTGGGGTGTACCGCGCTATCTGGCTGCTGGTACTCGCTCTGGTCTTCAAGCTGGTCGTCACCATCTTCACGTTCGGTATCAAGGTGCCGTGTGGACTGTTCATACCCAGCCTCGCGCTCGGAGCCATTGCTGGCAGGATTGTGGGCATCGGTGTCGAACAAATGGCATATACCTATCCGAAGATCTGGCTTTTCTCCGGTGAATGTTCAACCGGCGATGACTGTATAACTCCTGGACTATACGCGATGGTTGGAGCGGCGGCTGTACTCGGTGGAGTCACGCGGATGACCGTTTCGCTCGTTGTTATAATGTTCGAGTTGACCGGCGGGGTTCGTTACATCGTGCCCCTAATGGCGGCCGCCATGGCCTCCAAGTGGGTGGGAGACGCTTTGGGTAGACAAGGCATATATGACGCACACATCGCTCTGAACGGATATCCGTTTCTCGATAGCAAAGATGAATTCCAGCACACATCTCTCGCCGCCGACGTCATGCAACCTAAACGGAATGAAACTTTATCTGTAATAACTCAAGATTCGATGACCGTTGATGATGTGGAGACCCTGCTTAAGGAGACCGAACACAATGGGTATCCTGTTGTTGTGTCTAAGGAATCTCAGTACCTTGTTGGATTTGTGCTCCGACGGGATTTGAATCTTGCTATTGCAAACGCACGCCGCACCATCGAAGGCATCACTGGTCAATCTGTTGTGATCTTTGCCGGTAACGTTGCTCCTCCGCCGGGCCCGCCACCGTACCTCCAGCTCAGCCGCATCCTCGACATGGCTCCCATCACTGTCACCGATCAGACTCCCATGGAAACGGTTGTTGACATGTTCAGAAAATTGGGACTCCGCCAGACTCTGGTCACACATAACGGGCGGCTGCTCGGTGTCATCACTAAGAAGGACGTGCTCCGTCACGTGAAACATATGGACAACGAGGACCCGAGCTCAGTAATGTTTAACTGA

Protein

MERFPLKSSVTKTGMTYQSVYKKGANTANGRGAHSGEDEMVDITPGLQQAADGVTTPTSHGTFQIYEQGSRNSASSTHSYIAQFFGSSTGDTIMFSGMQGDDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSIWDLIKGAHDAWSGWVCVLLVGVATGIVAGVIDIGASWMTDLKFGICPAAFWFNREQCCWSDTNTTFDSGNCSQWLTWPQVFGDRGDGAGAYIISYLFYILWALIFAALSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLIIKVVGLILSVSSGLSLGKEGPMVHIASCLGNILSYLFPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFILRSINPFGNEHSVLFFVEYNKPWIFFELIPFVGLGIIGGCIATIFIKANIYWCRYRKYSKLGQYPVTEVLVVTLITAILAYPNPYTRMNTSELIYLLFNQCGISNSDPLCDYNRNFTDANSAIEKAAAGAGVYRAIWLLVLALVFKLVVTIFTFGIKVPCGLFIPSLALGAIAGRIVGIGVEQMAYTYPKIWLFSGECSTGDDCITPGLYAMVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKDEFQHTSLAADVMQPKRNETLSVITQDSMTVDDVETLLKETEHNGYPVVVSKESQYLVGFVLRRDLNLAIANARRTIEGITGQSVVIFAGNVAPPPGPPPYLQLSRILDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKHMDNEDPSSVMFN

Similarity

Belongs to the chloride channel (TC 2.A.49) family.

Feature

chain  Chloride channel protein

Uniprot

A0A2A4K0E0   A0A2A4JZE1   H9J2X5   A0A2H1VYK4   A0A2A4JZF9   A0A2A4K006   + More
A0A1Y1K9R4   A0A194QXZ7   A0A336MTH3   A0A084WJP7   A0A182NJQ7   A0A182UT73   A0A182IKJ7   A0A3F2YS02   Q7Q6L5   Q17K86   A0A1S4EZP2   A0A3F2YS04   A0A182JRP5   A0A336MNN9   A0A182PHY9   A0A182QAB8   A0A182HWG9   A0A182SH22   A0A182RN01   A0A1Y1KA08   A0A2M4A7S7   A0A2M4A7U4   A0A1Y1K9N0   A0A1Y1KEZ1   W5J5H3   A0A182GME0   U5EIW3   V5GIB8   A0A1L8DF40   A0A182Y252   A0A2M4AAA1   A0A2J7PW34   A0A1W4WN47   A0A2J7PW41   A0A1L8DEW6   A0A067RLM4   A0A2J7PW37   A0A2A3E7Q1   A0A2J7PW36   B0WCM4   A0A088A776   A0A1W4WYZ0   A0A1W4WN61   A0A0C9S005   E2BWU6   A0A182L374   A0A195CVH7   A0A1Q3FEP5   A0A026WIM1   A0A3L8DFY2   A0A151X2A9   A0A154PC07   A0A1Q3FEN8   A0A0C9RB63   A0A182MS92   A0A1L8DDV0   A0A0C9RKD1   N6U4L6   D6WEX6   A0A0M8ZQ22   A0A1J1IEZ1   A0A182FHU9   A0A1Y0AWN2   E2A7M7   T1PCG6   F4WZJ2   A0A158NHA1   A0A0L0BQ37   A0A195DRD7   A0A195ET15   A0A195BXU1   A0A1I8PWN6   A0A0A1WZ08   A0A1I8PWS3   A0A034VPS9   A0A034VRM4   A0A0A1WIT1   A0A2J7PW40   A0A1B0B6Z7   B4GQU3   A0A0Q9WJ86   A0A1B0G3B8   A0A1A9YIC1   B4L0Z1   A0A3B0KED0   B3NDR6   Q2M106   B3M627   A0A0Q9XBT3   B4IU51   B4LGQ8   A0A0Q9XBT6   C9QP60   A0A0A9VY74  

Pubmed

19121390    28004739    26354079    24438588    12364791    14747013    + More
17210077    17510324    20920257    23761445    26483478    25244985    24845553    20798317    20966253    24508170    30249741    23537049    18362917    19820115    28341416    25315136    21719571    21347285    26108605    25830018    25348373    17994087    15632085    18057021    17550304    25401762   

EMBL

NWSH01000328    PCG77388.1    PCG77385.1    BABH01031233    ODYU01005251    SOQ45919.1    + More
PCG77387.1    PCG77389.1    GEZM01088448    JAV58193.1    KQ460953    KPJ10347.1    UFQT01000040    UFQT01001876    SSX18586.1    SSX32073.1    ATLV01024046    KE525348    KFB50441.1    APCN01001491    AAAB01008960    EAA11899.4    CH477227    EAT47099.1    SSX32074.1    AXCN02000515    GEZM01088447    GEZM01088445    JAV58194.1    GGFK01003522    MBW36843.1    GGFK01003536    MBW36857.1    GEZM01088449    JAV58192.1    GEZM01088446    JAV58195.1    ADMH02002165    ETN58115.1    JXUM01014075    JXUM01014076    JXUM01014077    KQ560393    KXJ82652.1    GANO01002472    JAB57399.1    GALX01004662    JAB63804.1    GFDF01009087    JAV04997.1    GGFK01004402    MBW37723.1    NEVH01020938    PNF20545.1    PNF20549.1    GFDF01009082    JAV05002.1    KK852550    KDR21510.1    PNF20547.1    KZ288353    PBC27312.1    PNF20548.1    DS231889    EDS43675.1    GBYB01013726    JAG83493.1    GL451188    EFN79810.1    KQ977259    KYN04542.1    GFDL01009027    JAV26018.1    KK107231    EZA54949.1    QOIP01000009    RLU19083.1    KQ982585    KYQ54386.1    KQ434869    KZC09353.1    GFDL01009029    JAV26016.1    GBYB01013724    JAG83491.1    AXCM01004096    GFDF01009529    JAV04555.1    GBYB01013727    JAG83494.1    APGK01043033    KB741011    ENN75556.1    KQ971318    EFA00320.2    KQ435916    KOX68790.1    CVRI01000047    CRK97566.1    KY921814    ART29403.1    GL437365    EFN70548.1    KA645633    AFP60262.1    GL888479    EGI60436.1    ADTU01001635    JRES01001546    KNC22121.1    KQ980612    KYN15069.1    KQ981979    KYN31373.1    KQ976398    KYM92761.1    GBXI01010411    JAD03881.1    GAKP01014473    GAKP01014471    JAC44479.1    GAKP01014472    JAC44480.1    GBXI01016019    JAC98272.1    PNF20546.1    JXJN01009324    CH479188    EDW40128.1    CH940647    KRF84956.1    CCAG010013759    CH933809    EDW18148.1    OUUW01000009    SPP84649.1    CH954178    EDV52199.2    CH379069    EAL30770.2    CH902618    EDV40743.2    KPU78741.1    KRG06000.1    CH891783    EDW99914.2    EDW70523.2    KRG05999.1    BT099942    ACX36518.1    GBHO01042472    GBHO01022630    GBHO01022625    GBHO01005800    JAG01132.1    JAG20974.1    JAG20979.1    JAG37804.1   

Proteomes

UP000218220    UP000005204    UP000053240    UP000030765    UP000075884    UP000075903    + More
UP000075880    UP000075840    UP000007062    UP000008820    UP000075881    UP000075885    UP000075886    UP000075901    UP000075900    UP000000673    UP000069940    UP000249989    UP000076408    UP000235965    UP000192223    UP000027135    UP000242457    UP000002320    UP000005203    UP000008237    UP000075882    UP000078542    UP000053097    UP000279307    UP000075809    UP000076502    UP000075883    UP000019118    UP000007266    UP000053105    UP000183832    UP000069272    UP000000311    UP000095301    UP000007755    UP000005205    UP000037069    UP000078492    UP000078541    UP000078540    UP000095300    UP000092460    UP000008744    UP000008792    UP000092444    UP000092443    UP000009192    UP000268350    UP000008711    UP000001819    UP000007801    UP000002282   

PRIDE

H9J2X5    C9QP60   

Pfam

PF00654   Voltage_CLC        + More
PF00571   CBS
PF01027   Bax1-I
PF00642   zf-CCCH

Interpro

IPR001807   Cl-channel_volt-gated        + More
IPR014743   Cl-channel_core       
IPR000644   CBS_dom       
IPR006214   Bax_inhibitor_1-related       
IPR036855   Znf_CCCH_sf       
IPR000571   Znf_CCCH       

SUPFAM

SSF81340   SSF81340        + More
SSF90229   SSF90229       

Gene 3D

1.10.3080.10    

ProteinModelPortal

A0A2A4K0E0   A0A2A4JZE1   H9J2X5   A0A2H1VYK4   A0A2A4JZF9   A0A2A4K006   + More
A0A1Y1K9R4   A0A194QXZ7   A0A336MTH3   A0A084WJP7   A0A182NJQ7   A0A182UT73   A0A182IKJ7   A0A3F2YS02   Q7Q6L5   Q17K86   A0A1S4EZP2   A0A3F2YS04   A0A182JRP5   A0A336MNN9   A0A182PHY9   A0A182QAB8   A0A182HWG9   A0A182SH22   A0A182RN01   A0A1Y1KA08   A0A2M4A7S7   A0A2M4A7U4   A0A1Y1K9N0   A0A1Y1KEZ1   W5J5H3   A0A182GME0   U5EIW3   V5GIB8   A0A1L8DF40   A0A182Y252   A0A2M4AAA1   A0A2J7PW34   A0A1W4WN47   A0A2J7PW41   A0A1L8DEW6   A0A067RLM4   A0A2J7PW37   A0A2A3E7Q1   A0A2J7PW36   B0WCM4   A0A088A776   A0A1W4WYZ0   A0A1W4WN61   A0A0C9S005   E2BWU6   A0A182L374   A0A195CVH7   A0A1Q3FEP5   A0A026WIM1   A0A3L8DFY2   A0A151X2A9   A0A154PC07   A0A1Q3FEN8   A0A0C9RB63   A0A182MS92   A0A1L8DDV0   A0A0C9RKD1   N6U4L6   D6WEX6   A0A0M8ZQ22   A0A1J1IEZ1   A0A182FHU9   A0A1Y0AWN2   E2A7M7   T1PCG6   F4WZJ2   A0A158NHA1   A0A0L0BQ37   A0A195DRD7   A0A195ET15   A0A195BXU1   A0A1I8PWN6   A0A0A1WZ08   A0A1I8PWS3   A0A034VPS9   A0A034VRM4   A0A0A1WIT1   A0A2J7PW40   A0A1B0B6Z7   B4GQU3   A0A0Q9WJ86   A0A1B0G3B8   A0A1A9YIC1   B4L0Z1   A0A3B0KED0   B3NDR6   Q2M106   B3M627   A0A0Q9XBT3   B4IU51   B4LGQ8   A0A0Q9XBT6   C9QP60   A0A0A9VY74  

PDB

2JA3     E-value=6.13519e-56,     Score=554

KEGG

101743586    K05012 chloride channel 3/4/5 | (RefSeq) H(+)/Cl(-) exchange transporter 3

GO

GO:0016021   GO:0005247   GO:0005769   GO:0005794   GO:0005768   GO:0008021   GO:0005887   GO:0097401   GO:0015299   GO:0005886   GO:0031404   GO:0046872   GO:0055037   GO:0048388   GO:0003014   GO:0006821   GO:0016020   GO:0005216   GO:0006355   GO:0043565   GO:0003677   GO:0003707   GO:0004887   GO:0055085  

Subcellular location

Membrane  

Length:

838

Number of predicted TMHs:

11

Exp number of AAs in TMHs:

231.49545

Exp number, first 60 AAs:

0.00036

Total prob of N-in:

0.98702

inside

1  -  150

TMhelix

151  -  173

outside

174  -  230

TMhelix

231  -  253

inside

254  -  274

TMhelix

275  -  297

outside

298  -  306

TMhelix

307  -  324

inside

325  -  336

TMhelix

337  -  359

outside

360  -  409

TMhelix

410  -  432

inside

433  -  444

TMhelix

445  -  467

outside

468  -  519

TMhelix

520  -  542

inside

543  -  548

TMhelix

549  -  571

outside

572  -  590

TMhelix

591  -  608

inside

609  -  614

TMhelix

615  -  637

outside

638  -  838

 

 

Pi

21.465294

Theta

19.804493

Tajima's D

0.219408

CLR

0.063803

CSRT

0.437578121093945

Interpretation

Uncertain