Gene

KWMTBOMO00638  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003892

Annotation

coatomer_protein_complex_subunit_beta_2_[Bombyx_mori]

Location

Bomo_Chr1(-):19753843-19766154      View in EpiBrowser

Full name

Coatomer subunit beta'       + More
Serine/threonine-protein phosphatase      

Alternative Name

Beta'-coat protein

Location in the cell

Cytoplasmic   Reliability : 1.135 Golgi   Reliability : 1.706

CDS

ATGCCTCTGCGTCTGGATATCAAGAGGAAGCTGACGGCGCGGTCGGACCGAGTGAAATGCGTCGACCAGCACCCGTCGGAACCCTGGCTGCTCTGCTCCCTGTATTCAGGAGACGTTAACATATGGAATTATGAGACTCACGCTCAAATTAAGAGATTTGAGGTATGTGATCTCCCGGTGAGATCAGCAAAGTTTGTTCCCCGGAAGAACTGGGTGATAACTGGCTCAGATGACATGCAGATACGTGTATTCAACTACAACACCCTGGAGAGGGTTCACTCATTTGAAGCACATTCGGATTATGTGCGATGCATAGCCGTTCATCCCACACAACCGTACATATTGACTTGCAGTGATGATCTCCTAATCAAATTGTGGAACTGGGACCGTAATTGGACATGTCAGCAAGTATTCGAAGGGCATACGCATTACGTAATGCAGATCGTTATCAACCCGAAGGATAACAATACCTTCGCAAGCGCAAGTCTCGACACTACTGTGAAGGTTTGGCAACTTGGTGCTTCTATATCGAACTTCACTTTAGAAGGTCACGAGAAAGGCGTCAACTGCGTGGACTATTATCATGGCGGTGACAAGCCCTACCTCATCAGTGGAGCTGATGACAGGCTCGTCAAAATATGGGATTACCAAAATAAGACATGTGTACAAACATTGGAAGGTCATGTTCAGAATGTATCAGCAGTATCATTCCACCCCGAGCTTCCGATCCTGCTAACCGGTTCTGAAGACGGCACCCTCAGAATATGGCACGCAGGCACCTACAGGCTCAAGTCTTCCCTAAATTATGGTTTCGAAAGAGTATGGACGATATCCACCATGCACGGTTCGAACAACGTCGCTGTAGGGTATGACGAAGGTACGATAATGATAAAAGTGGGCAGAGAAGAGCCTGCTATATCTATGGACGTGAACGGAGGAAAGATTATCTGTGCTAAGCACTCTGAATTGCAGCAGGTCAACTTGAAGGCTCTCCCTGAAGGCACAGAAATAAAGGACGGAGAGCGTGTACCAGTCGTTGCTAAAGACATGGGCTCCTGCGAGATATACCCACAAACGATAGCCCACAATCCGAACGGTAGATTCGTGGTGGTGTGCGGTGATGGTGAGTTCATCATATACACCGCGATGGCTCTGAGGAACAAGGCGTTCGGGACGGCCCAGGAGTTTGTATGGGCATTCGACAGCTCAGAGTATGCGACTCTAGAGAATTCATCTTCAGTTAAAGTCTTCAAGAATTTCAAGGAGAGAAAAAGCTTCAAGCCCGAGTACGGTGCTGAAGGTATATTCGGAGGTTACATGCTCGGCGTGAAGTCTATCAGCGGAGTAGCATTCTCGTTCTACGATTGGGAACATTTGGAACTGGTCAGACGTATTGAGATTCAGCCTCGTCACGTGTTTTGGTCTGAAAGCGGGAACCTTGTGTGTTTGGCTACCGATGAAACTTACTTCATCCTGAAGTACAACGCTGCCGTGGTGACCAGAGCAAGGGAGACTAATACCGACATTACTGAGGATGGAATTGAAGATGCGTTTGAGGTAGTTGGTGAAGTCAACGAAACAGTGAAGACAGGCATATGGGTCGGAGATTGCTTCATATATACCAACACACTGAACAGGATAAACTACTACGTCGGCGGTGAGATTGTAACGGTTGCGCATCTCGACCACACTATGTACATACTGGGATACGTTGCTAAGGAGAACAGATTATACCTAAACGACAAAGAGTTAAACATTGTTTCTTATTCATTACTACTATCTGTGCTGGAGTACCAGACAGCAGTGATGCGGGGCGATTTTGAGACTGCCGATCGTGTCCTACCCACAATTCCTACCGAGCATCGAACAAGGGTCGCACATTTCTTAGAAAAGCAGGGATTCAAACAACAAGCCCTAGCGGTTTCCACGGAGCCGGATCACCAGTTCGAGCTGGCGTTAGCGTTGGGAGAACTGGAGCGAGCCAAGCAGCTGGCTGAGGAGGCAGGCCTGGCAGAAGGTGTGGCGTCCAGGTCCTCTGCTGCCAGGTGGTCAAGATTGGGTTCCGCCGCCGCTGCTGCAGCCCAAACTGAACTTACCAAAACTTGTTACCACAATGCGCACGATTACAGTGCGTTACTACTCTTTGCCGTTAGCACTGGCGACAAGCCACTGCTACAGGAAGTGGCACGAATGTCCAGTGAATCTGGAGACGATAACATCGCGTTCGTAGCTCACTTCACACTGAACGACCTGGACCGCTGTCTTGAGCTTCTCATATCCAGAAATAAGCTGCCCGAAGCCGCATTCTTTGCCAGATCATACATTCCGTCTAAAATATGCGAAGTGGTGAAGATGTGGCGCGAATCAGTTGGTGCCACGAACAAGAAATCCGGTCAGTCATTAGCCGACCCGGTCAACTATGAGAATCTGTTTCCGGAATACAATATGACCCGGCAGACTTCGTAG

Protein

MPLRLDIKRKLTARSDRVKCVDQHPSEPWLLCSLYSGDVNIWNYETHAQIKRFEVCDLPVRSAKFVPRKNWVITGSDDMQIRVFNYNTLERVHSFEAHSDYVRCIAVHPTQPYILTCSDDLLIKLWNWDRNWTCQQVFEGHTHYVMQIVINPKDNNTFASASLDTTVKVWQLGASISNFTLEGHEKGVNCVDYYHGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHVQNVSAVSFHPELPILLTGSEDGTLRIWHAGTYRLKSSLNYGFERVWTISTMHGSNNVAVGYDEGTIMIKVGREEPAISMDVNGGKIICAKHSELQQVNLKALPEGTEIKDGERVPVVAKDMGSCEIYPQTIAHNPNGRFVVVCGDGEFIIYTAMALRNKAFGTAQEFVWAFDSSEYATLENSSSVKVFKNFKERKSFKPEYGAEGIFGGYMLGVKSISGVAFSFYDWEHLELVRRIEIQPRHVFWSESGNLVCLATDETYFILKYNAAVVTRARETNTDITEDGIEDAFEVVGEVNETVKTGIWVGDCFIYTNTLNRINYYVGGEIVTVAHLDHTMYILGYVAKENRLYLNDKELNIVSYSLLLSVLEYQTAVMRGDFETADRVLPTIPTEHRTRVAHFLEKQGFKQQALAVSTEPDHQFELALALGELERAKQLAEEAGLAEGVASRSSAARWSRLGSAAAAAAQTELTKTCYHNAHDYSALLLFAVSTGDKPLLQEVARMSSESGDDNIAFVAHFTLNDLDRCLELLISRNKLPEAAFFARSYIPSKICEVVKMWRESVGATNKKSGQSLADPVNYENLFPEYNMTRQTS

Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

Catalytic Activity

H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate

Subunit

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Similarity

Belongs to the WD repeat COPB2 family.
Belongs to the PPP phosphatase family.

Keywords

Complete proteome   Cytoplasm   Cytoplasmic vesicle   ER-Golgi transport   Golgi apparatus   Membrane   Protein transport   Reference proteome   Repeat   Transport   WD repeat  

Feature

chain  Coatomer subunit beta'

Uniprot

D2Y4R4   H9J305   A0A2A4JZZ5   A0A2W1BKE4   A0A0L7LIR9   A0A212EQN9   + More
A0A2H1V837   A0A2J7RFK6   A0A2J7RFK8   S4P9N9   A0A2P8Z0B3   E0VFG2   A0A1I9WLI7   A0A1B6HK00   A0A1B6K4X4   A0A1L8DVV7   A0A1B0CCI7   A0A182Q053   A0A182J9X3   A0A182WCQ1   U5EY35   A0A084W9Q2   A0A182NNG0   A0A182PNY6   A0A182FLV9   A0A182YHZ6   Q7PMU5   A0A2M3ZFC0   A0A2M4A0Z2   A0A2M4BC82   A0A2M4BC79   A0A182XCR5   A0A182UTU8   A0A182LI42   A0A182HXL6   W8B6J1   A0A2M4BC86   A0A1S4FC95   A0A2M4CTI4   A0A1Q3FXS0   Q177S9   A0A1Q3FXB1   A0A1Q3FXB8   A0A0T6AYP3   A0A0K8VVI5   A0A034WUA5   A0A0A1XH06   A0A1Q3G2V1   B4KK62   A0A2M4CS41   A0A1Q3FXF5   A0A023EX50   A0A1Q3FXC3   A0A1I8M0Y2   B3NAX4   A0A1Y1NNE2   B4M969   B4IEK8   B4P360   A0A1D2MSC8   A0A1W4UV54   A0A1J1IYG9   A0A0J9R1Y4   A0A182JUS7   A0A0L0BLR4   A0A1I8NQQ4   A0A336LNK6   B4JP79   B4Q4S9   Q29P92   A0A0M5J1W8   B3MV95   B4MWG5   F7A7Q0   A0A2S2P3V5   O62621   Q4VA86   Q7ZTR0   J9K5D3   A0A3B0KJ50   F7CHE0   A0A1B0G409   U4UNZ3   N6TRR4   G1KBX2   E1C016   A0A1B0B7L4   E2C5N9   A0A1A9Y0K5   A0A226PTX1   A0A336LRS3   A0A1A9W071   A0A3B3SD06   H0Z4A5   A0A091QSS0   A0A232F5G7   A0A2S2R565   W5U8Z9   A0A2D0RC65   A0A3B3UFV2  

EC Number

3.1.3.16

Pubmed

20967265    19121390    28756777    26227816    22118469    23622113    + More
29403074    20566863    27538518    24438588    25244985    12364791    14747013    17210077    20966253    24495485    17510324    25348373    25830018    17994087    24945155    25315136    28004739    17550304    27289101    22936249    26108605    15632085    20431018    10731132    12537572    12537569    23537049    20798317    24621616    29240929    20360741    28648823    23127152   

EMBL

GU322817    ADB66736.1    BABH01031234    NWSH01000328    PCG77379.1    KZ150031    + More
PZC74741.1    JTDY01000913    KOB75463.1    AGBW02013268    OWR43771.1    ODYU01001171    SOQ37005.1    NEVH01004410    PNF39618.1    PNF39619.1    GAIX01003684    JAA88876.1    PYGN01000257    PSN49934.1    DS235111    EEB12118.1    KU932371    APA34007.1    GECU01032709    JAS74997.1    GECU01001200    JAT06507.1    GFDF01003541    JAV10543.1    AJWK01006819    AJWK01006820    AXCN02001910    GANO01000562    JAB59309.1    ATLV01021852    KE525324    KFB46946.1    AAAB01008968    EAA13197.5    GGFM01006506    MBW27257.1    GGFK01001069    MBW34390.1    GGFJ01001514    MBW50655.1    GGFJ01001513    MBW50654.1    APCN01005322    GAMC01017639    JAB88916.1    GGFJ01001515    MBW50656.1    GGFL01003960    MBW68138.1    GFDL01002762    JAV32283.1    CH477371    EAT42439.1    GFDL01002805    JAV32240.1    GFDL01002804    JAV32241.1    LJIG01022550    KRT79981.1    GDHF01009430    JAI42884.1    GAKP01000768    JAC58184.1    GBXI01003613    JAD10679.1    GFDL01000959    JAV34086.1    CH933807    EDW11580.1    GGFL01003959    MBW68137.1    GFDL01002768    JAV32277.1    GAPW01000132    JAC13466.1    GFDL01002808    JAV32237.1    CH954177    EDV58688.1    GEZM01001384    JAV97896.1    CH940654    EDW57745.1    CH480831    EDW46035.1    CM000157    EDW88302.1    LJIJ01000607    ODM95916.1    CVRI01000064    CRL05331.1    CM002910    KMY90088.1    JRES01001667    KNC21065.1    UFQT01000094    SSX19662.1    CH916372    EDV98709.1    CM000361    EDX04917.1    CH379058    EAL34401.1    CP012523    ALC39968.1    CH902624    EDV33160.1    CH963857    EDW76106.1    AAMC01022146    GGMR01010957    MBY23576.1    AJ006523    AJ006524    AE014134    BT023906    AY119527    BC096500    AAH96500.1    BC041755    AAH41755.1    ABLF02038821    OUUW01000010    SPP85776.1    CCAG010019758    KB632305    ERL91846.1    APGK01054266    KB741248    ENN71955.1    JXJN01009682    GL452776    EFN76750.1    AWGT02000013    OXB83525.1    SSX19661.1    ABQF01044960    KK706482    KFQ30610.1    NNAY01000931    OXU25852.1    GGMS01015948    MBY85151.1    JT408753    AHH38448.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000007151    UP000235965    UP000245037    + More
UP000009046    UP000092461    UP000075886    UP000075880    UP000075920    UP000030765    UP000075884    UP000075885    UP000069272    UP000076408    UP000007062    UP000076407    UP000075903    UP000075882    UP000075840    UP000008820    UP000009192    UP000095301    UP000008711    UP000008792    UP000001292    UP000002282    UP000094527    UP000192221    UP000183832    UP000075881    UP000037069    UP000095300    UP000001070    UP000000304    UP000001819    UP000092553    UP000007801    UP000007798    UP000008143    UP000000803    UP000007819    UP000268350    UP000092444    UP000030742    UP000019118    UP000001646    UP000092460    UP000008237    UP000092443    UP000198419    UP000091820    UP000261540    UP000007754    UP000215335    UP000221080    UP000261500   

PRIDE

D2Y4R4    H9J305    O62621   

Pfam

PF04053   Coatomer_WDAD        + More
PF00400   WD40
PF00149   Metallophos
PF04177   TAP42

Interpro

IPR017986   WD40_repeat_dom        + More
IPR011044   Quino_amine_DH_bsu       
IPR006692   Coatomer_WD-assoc_reg       
IPR036322   WD40_repeat_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR020472   G-protein_beta_WD-40_rep       
IPR016453   COPB2       
IPR011048   Haem_d1_sf       
IPR013026   TPR-contain_dom       
IPR011990   TPR-like_helical_dom_sf       
IPR019734   TPR_repeat       
IPR029052   Metallo-depent_PP-like       
IPR006186   Ser/Thr-sp_prot-phosphatase       
IPR004843   Calcineurin-like_PHP_ApaH       
IPR038511   TAP42/TAP46-like_sf       
IPR007304   TAP46-like       

SUPFAM

SSF50969   SSF50969        + More
SSF50978   SSF50978       
SSF51004   SSF51004       
SSF48452   SSF48452       

Gene 3D

2.130.10.10     1.25.40.10     3.60.21.10     1.25.40.540    

ProteinModelPortal

D2Y4R4   H9J305   A0A2A4JZZ5   A0A2W1BKE4   A0A0L7LIR9   A0A212EQN9   + More
A0A2H1V837   A0A2J7RFK6   A0A2J7RFK8   S4P9N9   A0A2P8Z0B3   E0VFG2   A0A1I9WLI7   A0A1B6HK00   A0A1B6K4X4   A0A1L8DVV7   A0A1B0CCI7   A0A182Q053   A0A182J9X3   A0A182WCQ1   U5EY35   A0A084W9Q2   A0A182NNG0   A0A182PNY6   A0A182FLV9   A0A182YHZ6   Q7PMU5   A0A2M3ZFC0   A0A2M4A0Z2   A0A2M4BC82   A0A2M4BC79   A0A182XCR5   A0A182UTU8   A0A182LI42   A0A182HXL6   W8B6J1   A0A2M4BC86   A0A1S4FC95   A0A2M4CTI4   A0A1Q3FXS0   Q177S9   A0A1Q3FXB1   A0A1Q3FXB8   A0A0T6AYP3   A0A0K8VVI5   A0A034WUA5   A0A0A1XH06   A0A1Q3G2V1   B4KK62   A0A2M4CS41   A0A1Q3FXF5   A0A023EX50   A0A1Q3FXC3   A0A1I8M0Y2   B3NAX4   A0A1Y1NNE2   B4M969   B4IEK8   B4P360   A0A1D2MSC8   A0A1W4UV54   A0A1J1IYG9   A0A0J9R1Y4   A0A182JUS7   A0A0L0BLR4   A0A1I8NQQ4   A0A336LNK6   B4JP79   B4Q4S9   Q29P92   A0A0M5J1W8   B3MV95   B4MWG5   F7A7Q0   A0A2S2P3V5   O62621   Q4VA86   Q7ZTR0   J9K5D3   A0A3B0KJ50   F7CHE0   A0A1B0G409   U4UNZ3   N6TRR4   G1KBX2   E1C016   A0A1B0B7L4   E2C5N9   A0A1A9Y0K5   A0A226PTX1   A0A336LRS3   A0A1A9W071   A0A3B3SD06   H0Z4A5   A0A091QSS0   A0A232F5G7   A0A2S2R565   W5U8Z9   A0A2D0RC65   A0A3B3UFV2  

PDB

5NZV     E-value=0,     Score=3114

KEGG

100379187    K17302 coatomer subunit beta' | (RefSeq) COPB2; coatomer protein complex subunit beta 2

GO

GO:0030663   GO:0005198   GO:0016192   GO:0030117   GO:0006886   GO:0000139   GO:0016740   GO:0016021   GO:0030126   GO:0006891   GO:0006890   GO:0006888   GO:0010883   GO:0005795   GO:0004721   GO:0061053   GO:0030903   GO:0009966   GO:1901998   GO:0005515   GO:0043565   GO:0003677   GO:0003707   GO:0004887  

Subcellular location

Golgi apparatus membrane   The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.   With evidence from 2 publications.
Cytoplasmic vesicle   The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.   With evidence from 2 publications.
COPI-coated vesicle membrane   The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.   With evidence from 2 publications.
Cytoplasm   The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.   With evidence from 1 publications.

Length:

821

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11821

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.00109

outside

1  -  821

 

 

Pi

19.383756

Theta

21.133973

Tajima's D

0.087548

CLR

0.000188

CSRT

0.396030198490075

Interpretation

Uncertain