Gene

KWMTBOMO00614

Pre Gene Modal

BGIBMGA003851

Annotation

PREDICTED:_potassium_voltage-gated_channel_protein_Shaker_isoform_X11_[Bombyx_mori]

Location

Bomo_Chr1(+):19129809-19138152      View in EpiBrowser

Full name

Potassium voltage-gated channel protein Shaker      

Alternative Name

Protein minisleep

Location in the cell

PlasmaMembrane   Reliability : 4.761

CDS

ATGGTGAGCGGTTTGAAGTTCGAAACTCAGCTGCGTACATTGAACCAATTCCCGGAGACGTTGCTCGGGGACCCCTCCCGCCGAATACGATACTTCGACCCACTCCGGAACGAGTACTTCTTCGACCGGAACCGACCGTCTTTCGACGCCATCCTCTACTATTACCAAAGCGGAGGACGACTCCGTCGCCCGGTAAACGTCCCCTTGGACGTCTTTTCTGAAGAGATCAAGTTCTACGAACTGGGAGAGCAGGCCACCAACAAGTTCCGTGAGGATGAAGGTTTCATCAAGGAGGAAGAGAAGCCCCTTCCCTCCAACGAACGCCAGCGCAAAATCTGGCTGCTCTTCGAATACCCCGAGAGCTCCCAGGCCGCGCGCGTCGTTGCCATCATCTCGGTCTTCGTCATCCTCCTCTCCATCGTCATCTTCTGCCTGGAGACCCTTCCTGAATTCAAACACTACAAAGTCTTCAATACAACGACCAACGGCACGAAGATTGAGGAGGACGAGGTCCCGGATATCACCGATCCATTCTTCCTTATTGAAACACTCTGCATCATCTGGTTCACCTTCGAATTGATCGTGCGGTTCTTGGCGTGTCCCAACAAATTCAACTTCTTCAGAGACGTCATGAACATCATTGATATAATCGCCATTATCCCGTACTTCATCACCCTGGCGACCGTCGTTGCCGAGGAGGAAGACACTTTGAACCTACCGCGAGCTCCCGTATCTCCGCAAGATAAGTCCACCAACCAAGCCATGAGCCTGGCTATTCTGCGGGTAATCCGTCTCGTGCGGGTGTTCCGGATCTTCAAACTGTCCCGCCACTCGAAGGGATTGCAGATTCTTGGCAGGACGCTCAAGGCGTCCATGCGAGAACTTGGCCTGCTGATCTTCTTCCTGTTCATCGGTGTGGTGCTGTTTTCGTCTGCGGTGTACTTCGCTGAAGCCGGAAGCGAGAACAGCTTCTTCAAATCCATACCTGATGCGTTTTGGTGGGCGGTCGTGACAATGACGACCGTAGGATACGGAGACATGACGCCGGTCGGAGTCTGGGGGAAAATCGTGGGTTCGCTGTGCGCCATCGCCGGCGTGCTCACTATCGCCCTCCCCGTGCCCGTCATCGTCTCCAACTTCAACTACTTCTACCACCGCGAAACTGACCAGGAAGAGATGCAGTCCCAGAACTTCAACCACGTAACCAGCTGCCCCTACCTGCCGGGAACCATGGGCGAGCCCTACCTGATTTCAGGGCCAATACAGAAGAAGTCCTCTATGAGCGATGACTCCTCTTCTGAGATGATGGAGTTGGACGAGTCGGCCATGGCGTCCGAGCCGCAACTCGAGCAGAACCTGCGCCGCCTCCGCGAGGAGGAGAACCTTCTGCGCGAGCAGCAAGCCACCATGGAGGCCGGTGCGTTCGACGACATCGCCGCTCTGGAGCATCAGGACGCTCTGCGCCTCAACCAGGTTACTCATCTTTTTTACGTAATATCTTCATTAACCATTTACGGATACTAA

Protein

MVSGLKFETQLRTLNQFPETLLGDPSRRIRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGEQATNKFREDEGFIKEEEKPLPSNERQRKIWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELIVRFLACPNKFNFFRDVMNIIDIIAIIPYFITLATVVAEEEDTLNLPRAPVSPQDKSTNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTMGEPYLISGPIQKKSSMSDDSSSEMMELDESAMASEPQLEQNLRRLREEENLLREQQATMEAGAFDDIAALEHQDALRLNQVTHLFYVISSLTIYGY

Description

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A-type currents (PubMed:2448636). Plays a role in the regulation of sleep need or efficiency (PubMed:15858564).

Subunit

Homotetramer or heterotetramer of potassium channel proteins.

Similarity

Belongs to the potassium channel family.
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Shaker sub-subfamily.

Keywords

3D-structure   Alternative splicing   Cell membrane   Complete proteome   Glycoprotein   Ion channel   Ion transport   Membrane   Potassium   Potassium channel   Potassium transport   Reference proteome   RNA editing   Transmembrane   Transmembrane helix   Transport   Voltage-gated channel  

Feature

chain  Potassium voltage-gated channel protein Shaker
splice variant  In isoform Beta and isoform L.

Uniprot

H9J2W4   E9LP24   A0A194PLL7   A0A194QL53   A0A2A4JHA3   A0A2M4ASP2   + More
A0A2H1V1X8   A0A1S4EVA2   A0A348G660   A0A2M4ALN5   Q7QF14   Q17PT9   A0A0P8ZSJ5   B4NPI1   A0A1W4UMX6   B4I6L8   B3NWZ6   B4Q2M4   P08510   B4JJ88   A0A1W4UNF5   B4L2A7   B4M6S3   A0A182QK67   A0A0R1EDM7   A0A0Q9W6W6   T1HFA1   P08510-3   A0A1W4V0Q2   A0A0Q9W709   A0A0Q9X091   A0A0Q5T428   A0A0R1EIB4   A0A1W4UNG0   A0A0Q9WI52   A0A1I8MXT4   A0A1W4V1X9   A0A2S1ZNM0   A0A1W4V0Q7   A0A0Q9WEM3   A0A0Q9WYW2   A0A0Q9WNB8   A0A0Q9WPL7   A0A1W4WTF4   A0A1W4UMY0   A0A1W4V0P7   W8AV96   A0A1W4WUD3   A0A0Q9W771   A0A0Q9WN85   A0A1W4X4N1   F4WVX1   A0A1I8Q8D2   A0A026WWX1   F5HJN5   P08510-9   A0A1W4X4K0   A0A1W4X443   A0A1W4V0D3   A0A0Q9WVC7   A0A1W4X2C8   W8AJ67   A0A1I8MXT7   A0A151I5G4   A0A3L8D818   A0A151WRY2   A0A1I8Q8G9   A0A1I8Q8H1   A0A0S0X7Z4   A0A1I8Q8D6   A0A1W4UMY5   A0A195DUN5   D6WHV5   P08510-7   A0A1Y1L627   A0A0R1EC30   A0A151K1K0   A0A1W4V0D8   A0A1W4UNG5   A0A0R1EIL7   A0A0N8P0L6   A0A0P8Y7Q9   A0A0Q5T3U2   A0A0Q5TEG4   E2AQU3   A0A0Q9WNA1   A0A0R1EBV3   P08510-2   A0A224XNR1   A0A0R1ECH3   A0A0R1EC16   A0A0P9C1E9   A0A0P9AI13   A0A0Q5T3T6   A0A0Q5T3R9   A0A0Q5T6N6   A0A0Q5TJD7   A0A0P8XS21   A0A0R1EFN3   A0A0R1EJQ1  

Pubmed

19121390    21672063    26354079    12364791    17510324    17994087    + More
18057021    17550304    2441471    16453805    2456921    2448635    10731132    12537572    12537569    2440582    3272175    2448636    12907802    15858564    17893096    12023222    25315136    24495485    21719571    24508170    30249741    12537568    12537573    12537574    16110336    17569856    17569867    18362917    19820115    28004739    20798317   

EMBL

BABH01031285    HQ116693    ADV76532.1    KQ459605    KPI92000.1    KQ461196    + More
KPJ06303.1    NWSH01001383    PCG71455.1    GGFK01010472    MBW43793.1    ODYU01000091    SOQ34274.1    FX985601    BBF97933.1    GGFK01008369    MBW41690.1    AAAB01008846    EAA06439.5    CH477189    EAT48752.1    CH902630    KPU77466.1    CH964291    EDW86421.1    CH480823    EDW55966.1    CH954180    EDV46543.1    KQS30015.1    KQS30026.1    CM000162    EDX02665.1    KRK06900.1    KRK06902.1    KRK06905.1    M17211    X06184    X07131    X07132    X07133    X07134    X06742    AE014298    AY118398    BT050432    M17155    X78908    CH916370    EDV99640.1    CH933810    EDW07768.1    CH940653    EDW62490.1    KRF80680.1    KRF80687.1    AXCN02002242    AXCN02002243    AXCN02002244    KRK06894.1    KRF80682.1    ACPB03010323    KRF80684.1    KRF94202.1    KQS30029.1    KRK06892.1    KRK06898.1    KRK06904.1    KRF80686.1    MF359241    AWK26944.1    KRF80679.1    KRF94201.1    KRF94200.1    KRF94203.1    GAMC01017997    JAB88558.1    KRF80685.1    KRF94206.1    GL888402    EGI61652.1    KK107078    EZA60221.1    EGK96496.1    KRF94204.1    GAMC01017995    JAB88560.1    KQ976416    KYM90057.1    QOIP01000011    RLU16640.1    KQ982803    KYQ50557.1    ALI51156.1    KQ980322    KYN16561.1    KQ971321    EFA00701.2    GEZM01066536    JAV67820.1    KRK06909.1    KQ981236    KYN44316.1    KRK06906.1    KPU77468.1    KPU77467.1    KQS30028.1    KQS30021.1    GL441834    EFN64205.1    KRF94205.1    KRF94207.1    KRK06895.1    KRK06907.1    GFTR01006797    JAW09629.1    KRK06901.1    KRK06893.1    KPU77465.1    KPU77470.1    KQS30025.1    KQS30019.1    KQS30024.1    KQS30022.1    KPU77469.1    KPU77473.1    KRK06899.1    KRK06903.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007062    UP000008820    + More
UP000007801    UP000007798    UP000192221    UP000001292    UP000008711    UP000002282    UP000000803    UP000001070    UP000009192    UP000008792    UP000075886    UP000015103    UP000095301    UP000192223    UP000007755    UP000095300    UP000053097    UP000078540    UP000279307    UP000075809    UP000078492    UP000007266    UP000078541    UP000000311   

PRIDE

H9J2W4    P08510   

Pfam

PF00520   Ion_trans        + More
PF02214   BTB_2

Interpro

IPR003131   T1-type_BTB        + More
IPR027359   Volt_channel_dom_sf       
IPR028325   VG_K_chnl       
IPR003968   K_chnl_volt-dep_Kv       
IPR003972   K_chnl_volt-dep_Kv1       
IPR005821   Ion_trans_dom       
IPR004053   K_chnl_volt-dep_Kv1.6       
IPR011333   SKP1/BTB/POZ_sf       
IPR000210   BTB/POZ_dom       
IPR004048   K_chnl_volt-dep_Kv1.1       

SUPFAM

SSF54695   SSF54695       

Gene 3D

1.20.120.350    

ProteinModelPortal

H9J2W4   E9LP24   A0A194PLL7   A0A194QL53   A0A2A4JHA3   A0A2M4ASP2   + More
A0A2H1V1X8   A0A1S4EVA2   A0A348G660   A0A2M4ALN5   Q7QF14   Q17PT9   A0A0P8ZSJ5   B4NPI1   A0A1W4UMX6   B4I6L8   B3NWZ6   B4Q2M4   P08510   B4JJ88   A0A1W4UNF5   B4L2A7   B4M6S3   A0A182QK67   A0A0R1EDM7   A0A0Q9W6W6   T1HFA1   P08510-3   A0A1W4V0Q2   A0A0Q9W709   A0A0Q9X091   A0A0Q5T428   A0A0R1EIB4   A0A1W4UNG0   A0A0Q9WI52   A0A1I8MXT4   A0A1W4V1X9   A0A2S1ZNM0   A0A1W4V0Q7   A0A0Q9WEM3   A0A0Q9WYW2   A0A0Q9WNB8   A0A0Q9WPL7   A0A1W4WTF4   A0A1W4UMY0   A0A1W4V0P7   W8AV96   A0A1W4WUD3   A0A0Q9W771   A0A0Q9WN85   A0A1W4X4N1   F4WVX1   A0A1I8Q8D2   A0A026WWX1   F5HJN5   P08510-9   A0A1W4X4K0   A0A1W4X443   A0A1W4V0D3   A0A0Q9WVC7   A0A1W4X2C8   W8AJ67   A0A1I8MXT7   A0A151I5G4   A0A3L8D818   A0A151WRY2   A0A1I8Q8G9   A0A1I8Q8H1   A0A0S0X7Z4   A0A1I8Q8D6   A0A1W4UMY5   A0A195DUN5   D6WHV5   P08510-7   A0A1Y1L627   A0A0R1EC30   A0A151K1K0   A0A1W4V0D8   A0A1W4UNG5   A0A0R1EIL7   A0A0N8P0L6   A0A0P8Y7Q9   A0A0Q5T3U2   A0A0Q5TEG4   E2AQU3   A0A0Q9WNA1   A0A0R1EBV3   P08510-2   A0A224XNR1   A0A0R1ECH3   A0A0R1EC16   A0A0P9C1E9   A0A0P9AI13   A0A0Q5T3T6   A0A0Q5T3R9   A0A0Q5T6N6   A0A0Q5TJD7   A0A0P8XS21   A0A0R1EFN3   A0A0R1EJQ1  

PDB

2A79     E-value=6.05135e-135,     Score=1233

KEGG

101745029    K04874 potassium voltage-gated channel Shaker-related subfamily A member 1 | (RefSeq) potassium volt

GO

GO:0051260   GO:0008076   GO:0005249   GO:0034765   GO:0030431   GO:0048675   GO:0045838   GO:0007637   GO:0008345   GO:0048047   GO:0060025   GO:0001508   GO:0045938   GO:0009584   GO:1903351   GO:0022843   GO:0045187   GO:0007611   GO:0006813   GO:0048150   GO:0016021   GO:0050909   GO:0007619   GO:0071805   GO:0005251   GO:0005267   GO:0005244   GO:0005216   GO:0006811   GO:0016020   GO:0030246   GO:0007169   GO:0055085  

PANTHER

PTHR11537:SF104   PTHR11537  

Subcellular location

Cell membrane  

Length:

507

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

138.33651

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.88218

inside

1  -  126

TMhelix

127  -  149

outside

150  -  177

TMhelix

178  -  200

inside

201  -  294

TMhelix

295  -  317

outside

318  -  331

TMhelix

332  -  354

inside

355  -  355

TMhelix

356  -  378

outside

379  -  507

 

 

Pi

18.820489

Theta

17.868116

Tajima's D

0.224611

CLR

0.045231

CSRT

0.443777811109445

Interpretation

Uncertain