Gene

KWMTBOMO00545  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012336

Annotation

lactate_dehydrogenase_[Bombyx_mori]

Location

Bomo_Chr1(+):16116700-16127502      View in EpiBrowser

Full name

L-lactate dehydrogenase      

Location in the cell

Cytoplasmic   Reliability : 1.359 Mitochondrial   Reliability : 1.282

CDS

ATGGCGACAAACAACACCAACGGGCATTGCGAGAACTACCACAAGATGGAGTCCCTGAAGAAGCTGTTCCAGCCCGTGCACGAGAAGGTGGACGAAACTTGGAGCAAGGTGACCATTGTCGGGGTCGGTCAGGTTGGGATGGCCGCAGCTTTCTCTATGCTGACGCAGAATGTTACGAATAACATCGCTCTAGTAGACATGATGGCTGACAAATTGAAAGGAGAGATGATGGACCTGCAGCACGGATCAGCATTCATGAGGAACGCCAAGATCCAATCTAGTACGGATTATTCTATAACAGCTGGCTCGAAGATCTGCGTGGTTACTGCTGGTGTTCGACAACGCGAAGGTGAATCTCGTCTCGATCTCGTGCAGAGAAACACCGATGTTCTTAAACAAATAATCCCGCAGCTGATAAAGTACAGTCCGGACACAATATTGGTGATCGCCAGTAACCCCGTGGATATTCTGACGTATGTTACGTGGAAGATTAGCGGGCTGCCCAAGCACCGCGTCATCGGGTCCGGCACTAACTTGGACTCGGCACGGTTCCGTTACCTGCTGTCGGACAGGCTCGGTATCGCTACCACGTCCTGCCACGGCTACATCATCGGCGAACACGGAGACAGCAGCGTTCCAGTATGGTCTGCAGTAAACATAGCGGGAGTACGCCTCAGTGATCTCAACAATCAGATCGGAACCGACGACGATCCTGAGAACTGGAAGGAGCTTCACGAGAATGTCGTGAAAAGTGCTTACGAAGTCATCAAACTGAAGGGGTACACTTCCTGGGCTATCGGACTGTCGCTGGCTCAGATCGTGAGGGCTATACTCACGAACGCTAACAGCGTTCACGCGGTCTCTACTTATCTCAAGGGCGAGCACGGCATCGAAGACGAAGTATTCTTGTCGCTGCCGTGCGTGTTGAGTCACTGTGGAGTCTCTGACGTCATCCGCCAGCCTCTAACCGAACTTGAAGTGGCACAGCTTCGGAAATCTGCTAAAGTCATGGCTAAAGTGCAGAACGACATTAAATTCTAA

Protein

MATNNTNGHCENYHKMESLKKLFQPVHEKVDETWSKVTIVGVGQVGMAAAFSMLTQNVTNNIALVDMMADKLKGEMMDLQHGSAFMRNAKIQSSTDYSITAGSKICVVTAGVRQREGESRLDLVQRNTDVLKQIIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSAVNIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTELEVAQLRKSAKVMAKVQNDIKF

Catalytic Activity

(S)-lactate + NAD(+) = H(+) + NADH + pyruvate

Subunit

Homotetramer.

Similarity

Belongs to the LDH/MDH superfamily.
Belongs to the LDH/MDH superfamily. LDH family.

Keywords

Complete proteome   Cytoplasm   NAD   Oxidoreductase   Reference proteome  

Feature

chain  L-lactate dehydrogenase

Uniprot

A7LBQ0   A0A212EKH7   A0A194R3C8   A0A194PLZ3   A0A2Z5U750   A0A2A4K4S0   + More
A0A1L8E0T1   A0A1B0GME5   A0A1W5YLL0   B0X5J3   A0A1Q3FSB9   A0A182XNL4   A0A1W5YLK3   A0A0M4F297   B0XBA2   W8C3Q7   A0A182PSY9   A0A0A1X778   A0A182NNJ5   A0A182UW01   A0A182LHZ5   Q7Q981   A0A182HXQ7   Q16ND1   A0A182Q983   A0A023ENR9   A0A0A1X8S0   E2AWN0   A0A1W5YLK5   B4KVP9   A0A182UF79   A0A182YBS7   A0A182RKJ0   A0A0N0BIH8   E2C744   A0A182WCU6   A0A182MMA4   A0A1Y1LEN4   A0A034WG20   A0A2M4AXA4   A0A034WAY2   A0A1A9WG64   T1DN51   A0A336MNZ3   B4PJN3   B4QJD3   A0A195BJ78   A0A0K8WAP3   B5RJQ0   Q95028   A0A0K8W7A9   B3NGH0   F4X535   B3M9Z0   A0A182G976   A0A1W4V9Z3   Q32KE6   B4MM53   A0A3B0KJ77   T1P9J0   Q29FH9   B4LI89   A0A0R3P2E0   B4HUT4   A0A067QM11   A0A2M4BUQ1   A0A0Q9WJ03   A0A0K8TLG7   A0A1I8PL33   A0A182JRF2   A0A182J9A7   A0A3L8E292   A0A0L0CPC7   A0A0C9RB25   A0A1J1IQY3   A0A1A9Z2V0   D3TMP6   A0A1A9UJ90   B4IXY2   A0A310SE24   A0A1B6GJH6   A0A1B0G927   A0A1A9XJJ1   A0A0K8TMX1   K7J616   A0A182GI23   A0A1B6EQX6   A0A1B6F8P4   A0A026W644   A0A0P5BJL1   A0A0P5PUP7   A0A0P5GHI2   A0A164LZ80   A0A0N8CUU8   A0A0P5K1S2   A0A0J7LAF5   A0A0P5M5W4   E0W1P5   B7XH74   C6L1J5  

EC Number

1.1.1.27

Pubmed

19121390    20852941    22118469    26354079    24495485    25830018    + More
20966253    12364791    14747013    17210077    17510324    24945155    20798317    17994087    18057021    25244985    28004739    25348373    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    9094207    21719571    26483478    25315136    15632085    24845553    26369729    30249741    26108605    20353571    20075255    24508170    20566863    19647052    19892987   

EMBL

BABH01017107    EU000385    EU334850    ABS18410.1    ABY60854.1    AGBW02014274    + More
OWR41965.1    KQ460953    KPJ10346.1    KQ459599    KPI94347.1    AP017491    BBB06759.1    NWSH01000183    PCG78662.1    GFDF01001777    JAV12307.1    AJVK01011430    AJVK01011431    KX147667    ARI45071.1    DS232382    EDS40930.1    GFDL01004703    JAV30342.1    KX147665    ARI45069.1    CP012525    ALC45207.1    DS232622    EDS44193.1    GAMC01005964    JAC00592.1    GBXI01007133    JAD07159.1    AAAB01008905    EAA09690.2    APCN01005337    CH477829    EAT35843.1    AXCN02001915    GAPW01002521    JAC11077.1    GBXI01007157    JAD07135.1    GL443346    EFN62194.1    KX147666    ARI45070.1    CH933809    EDW18423.1    KQ435729    KOX77688.1    GL453303    EFN76243.1    AXCM01011455    GEZM01057941    JAV72083.1    GAKP01006264    GAKP01006263    JAC52688.1    GGFK01011907    MBW45228.1    GAKP01006261    JAC52691.1    GAMD01003180    JAA98410.1    UFQT01001695    SSX31455.1    CM000159    EDW93632.1    CM000363    CM002912    EDX09442.1    KMY97913.1    KQ976464    KYM84496.1    GDHF01004394    JAI47920.1    BT044524    AE014296    ACH95298.1    AGB94169.1    U68038    GDHF01005589    JAI46725.1    CH954178    EDV51136.1    GL888687    EGI58429.1    CH902618    EDV41210.1    KPU79002.1    JXUM01048950    JXUM01048951    JXUM01048952    JXUM01048953    JXUM01048954    KQ561584    KXJ78096.1    BT023933    ABB36437.1    CH963847    EDW73062.1    OUUW01000009    SPP85151.1    KA644830    AFP59459.1    CH379067    EAL31276.1    CH940647    EDW69656.1    KRT07361.1    CH480817    EDW50705.1    KK853182    KDR10168.1    GGFJ01007530    MBW56671.1    KRF84499.1    GDAI01002602    JAI15001.1    QOIP01000001    RLU26756.1    JRES01000089    KNC34223.1    GBYB01005520    JAG75287.1    CVRI01000058    CRL02639.1    EZ422698    ADD18974.1    CH916366    EDV96503.1    KQ762833    OAD55417.1    GECZ01009267    GECZ01007192    JAS60502.1    JAS62577.1    CCAG010002964    GDAI01001909    JAI15694.1    JXUM01065106    JXUM01065107    KQ562330    KXJ76135.1    GECZ01029636    GECZ01012506    GECZ01012328    JAS40133.1    JAS57263.1    JAS57441.1    GECZ01023184    GECZ01022006    GECZ01003330    GECZ01002734    JAS46585.1    JAS47763.1    JAS66439.1    JAS67035.1    KK107388    EZA51478.1    GDIP01184048    JAJ39354.1    GDIQ01144089    JAL07637.1    GDIQ01240964    JAK10761.1    LRGB01003123    KZS04571.1    GDIP01096663    JAM07052.1    GDIQ01196068    JAK55657.1    LBMM01000085    KMR05025.1    GDIQ01184318    JAK67407.1    DS235873    EEB19627.1    AB477534    BAH11456.1    JL616405    AB472336    AEH58612.1    BAH86734.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000053268    UP000218220    UP000092462    + More
UP000002320    UP000076407    UP000092553    UP000075885    UP000075884    UP000075903    UP000075882    UP000007062    UP000075840    UP000008820    UP000075886    UP000000311    UP000009192    UP000075902    UP000076408    UP000075900    UP000053105    UP000008237    UP000075920    UP000075883    UP000091820    UP000002282    UP000000304    UP000078540    UP000000803    UP000008711    UP000007755    UP000007801    UP000069940    UP000249989    UP000192221    UP000007798    UP000268350    UP000095301    UP000001819    UP000008792    UP000001292    UP000027135    UP000095300    UP000075881    UP000075880    UP000279307    UP000037069    UP000183832    UP000092445    UP000078200    UP000001070    UP000092444    UP000092443    UP000002358    UP000053097    UP000076858    UP000036403    UP000009046    UP000002281   

PRIDE

A7LBQ0    Q95028    Q32KE6   

Pfam

PF00056   Ldh_1_N        + More
PF02866   Ldh_1_C

Interpro

IPR015955   Lactate_DH/Glyco_Ohase_4_C        + More
IPR001557   L-lactate/malate_DH       
IPR022383   Lactate/malate_DH_C       
IPR011304   L-lactate_DH       
IPR036291   NAD(P)-bd_dom_sf       
IPR018177   L-lactate_DH_AS       
IPR001236   Lactate/malate_DH_N       

SUPFAM

SSF56327   SSF56327        + More
SSF51735   SSF51735       

Gene 3D

3.90.110.10    

ProteinModelPortal

A7LBQ0   A0A212EKH7   A0A194R3C8   A0A194PLZ3   A0A2Z5U750   A0A2A4K4S0   + More
A0A1L8E0T1   A0A1B0GME5   A0A1W5YLL0   B0X5J3   A0A1Q3FSB9   A0A182XNL4   A0A1W5YLK3   A0A0M4F297   B0XBA2   W8C3Q7   A0A182PSY9   A0A0A1X778   A0A182NNJ5   A0A182UW01   A0A182LHZ5   Q7Q981   A0A182HXQ7   Q16ND1   A0A182Q983   A0A023ENR9   A0A0A1X8S0   E2AWN0   A0A1W5YLK5   B4KVP9   A0A182UF79   A0A182YBS7   A0A182RKJ0   A0A0N0BIH8   E2C744   A0A182WCU6   A0A182MMA4   A0A1Y1LEN4   A0A034WG20   A0A2M4AXA4   A0A034WAY2   A0A1A9WG64   T1DN51   A0A336MNZ3   B4PJN3   B4QJD3   A0A195BJ78   A0A0K8WAP3   B5RJQ0   Q95028   A0A0K8W7A9   B3NGH0   F4X535   B3M9Z0   A0A182G976   A0A1W4V9Z3   Q32KE6   B4MM53   A0A3B0KJ77   T1P9J0   Q29FH9   B4LI89   A0A0R3P2E0   B4HUT4   A0A067QM11   A0A2M4BUQ1   A0A0Q9WJ03   A0A0K8TLG7   A0A1I8PL33   A0A182JRF2   A0A182J9A7   A0A3L8E292   A0A0L0CPC7   A0A0C9RB25   A0A1J1IQY3   A0A1A9Z2V0   D3TMP6   A0A1A9UJ90   B4IXY2   A0A310SE24   A0A1B6GJH6   A0A1B0G927   A0A1A9XJJ1   A0A0K8TMX1   K7J616   A0A182GI23   A0A1B6EQX6   A0A1B6F8P4   A0A026W644   A0A0P5BJL1   A0A0P5PUP7   A0A0P5GHI2   A0A164LZ80   A0A0N8CUU8   A0A0P5K1S2   A0A0J7LAF5   A0A0P5M5W4   E0W1P5   B7XH74   C6L1J5  

PDB

1T2F     E-value=1.1313e-120,     Score=1108

KEGG

100124423    K00016 L-lactate dehydrogenase [EC:1.1.1.27] | (RefSeq) Ldh; lactate dehydrogenase

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00640    Propanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004459   GO:0005975   GO:0005737   GO:0019752   GO:0007525   GO:0007520   GO:0016491   GO:0003824   GO:0016616   GO:0030246   GO:0007169   GO:0016021   GO:0055114  

Subcellular location

Cytoplasm  

Length:

346

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.36660000000001

Exp number, first 60 AAs:

3.08462

Total prob of N-in:

0.20349

outside

1  -  346

 

 

Pi

23.826275

Theta

24.807229

Tajima's D

0.006771

CLR

0.023639

CSRT

0.375431228438578

Interpretation

Uncertain