Gene

KWMTBOMO00534

Pre Gene Modal

BGIBMGA012266

Annotation

PREDICTED:_glucuronyltransferase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr1(-):15605342-15615345      View in EpiBrowser

Full name

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase       + More
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase S      

Alternative Name

Beta-1,3-glucuronyltransferase S
Glucuronosyltransferase S
UDP-glucuronosyltransferase S

Location in the cell

PlasmaMembrane   Reliability : 2.542

CDS

ATGAAATCAATTTGTTTACTTAAGAAAGTTTTTGTGATGGCTATATTCCTTTGTACATTTTTCTTAGTGTTTTTCTGGGCAAATATGCAAATTTTAAACTTGAATGGAGTAGACACCGCCCTGATATCAAAAATGAGGCCACTGCATGTGAAGAGCAGATTGTGTCATGTTAATTTAATTGACGGCAGAAATCATAACGAAGCTATAGCGAATAAGAGCGATTTGAAAATGATATATTACATCACGCCGACTTATCCAAGACCAGAACAGATTCCAGAGTTAACTAGGCTTGGCCACACATTGATGCACGTGCCTCGGATACATTGGATCATTGCAGACGACCAGTCTTTGTGTTCAACCAATGTTCTCAATTTACTTAGGCGGACGGGCTTGCCATTCACACATATTTCCAGTCCAAAGCCATACGTGTACAAAGGTACAAACTTCCCGCGTGGCGTTTCGAACAGACGTGCAGCCCTGGTTTGGTTGCGGGAGAACGTTCGAGAAGGAGTCATGTACTTTGGCGATGACGATAATACAGTAGACTTACAGCTATTCGATGAAATAAGGCGTACCAAGAAGGTATCCATGTTTCCCGTAGGGCTCATTGGTGATTACGGTATTTCGGCGCCCATCATCAAAGACGGAAAGGTCGTCGCCTTTTTCGACTCATGGCCGGGGTCTAGAACATTCCCTGTCGATATGGCAGGATTCGCTGTCAACATAGAGTTCCTGACTCCGACGGCCACAATGCCTTACTCAGCTGGCCACGAGGAAGATAAGTTTTTAATGAGTTTAGGAATAAAATTAGACGACATTGAACCGTTAGCCGATAATTGTTCAAAGGTTTTAGTTTGGCACACGAAAACTGTAAAGTTTAAAAAACCCAACCTTAAAATCGATATCGAAAGAATTAGCAAGTTACCGAAGTACGAGGATTTCGCTAATCTTTTAAAAGAAACTTCTAGGTTAGGTATGGCCGGAATATTCTCGAAAAATGGTAGTAAAACTTTCATAATTAAAGATAGGAAGACCTTTGAACCCTTAAGCCTTCTGCCCACTTTGGTATAA

Protein

MKSICLLKKVFVMAIFLCTFFLVFFWANMQILNLNGVDTALISKMRPLHVKSRLCHVNLIDGRNHNEAIANKSDLKMIYYITPTYPRPEQIPELTRLGHTLMHVPRIHWIIADDQSLCSTNVLNLLRRTGLPFTHISSPKPYVYKGTNFPRGVSNRRAALVWLRENVREGVMYFGDDDNTVDLQLFDEIRRTKKVSMFPVGLIGDYGISAPIIKDGKVVAFFDSWPGSRTFPVDMAGFAVNIEFLTPTATMPYSAGHEEDKFLMSLGIKLDDIEPLADNCSKVLVWHTKTVKFKKPNLKIDIERISKLPKYEDFANLLKETSRLGMAGIFSKNGSKTFIIKDRKTFEPLSLLPTLV

Description

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity.

Catalytic Activity

3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP

Cofactor

Mn(2+)

Similarity

Belongs to the glycosyltransferase 43 family.

Keywords

Alternative splicing   Complete proteome   Glycoprotein   Golgi apparatus   Manganese   Membrane   Metal-binding   Phosphoprotein   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
splice variant  In isoform a.

Uniprot

H9JRV6   B5A9M8   A0A2A4J695   A0A194QUI9   A0A1E1WHQ8   A0A2H1V9Z4   + More
A0A212EKH4   A0A194PET1   A0A067RD25   A0A2P8Z5Y6   A0A2J7PNA8   A0A1B6LFL3   A0A1S3CUY6   A0A1B6EZJ1   A0A1B6BXY2   A0A1B0C836   A0A1L8E213   A0A1Q3F083   Q17BE2   A0A1Q3F0X4   A0A182KEA7   A0A1Q3F126   A0A182IPX0   A0A182M4K6   A0A1Q3EZJ8   A0A1Q3F1I9   A0A1Q3F075   A0A336LV95   A0A182QZC4   A0A182V4K2   A0A182X609   A0A084VJ92   A0A182U069   A0A182R2J4   A0A1Y9GKD1   A0A1S4GZB1   Q17BE4   A0A182IB33   A0A2M4AY11   B0WPV1   U5EGY0   A0A2M3ZBP9   A0A182PTY9   A0A182NT56   A0A2M3ZBK1   A0A182WA06   A0A2S2QEC9   A0A2M4BR33   A0A2H8TJQ4   A0A1J1IG96   A0A2M4CQ49   W5JCX8   Q5CAS4   J9JQS1   A0A1A9V9N1   A0A1B0A4Y3   A0A2S2P568   Q29NA9   A0A0R3NRT8   A0A1W4VHW5   A0A1W4VVE3   A0A1W4VUM4   A0A1W4W2A1   A0A1I8P808   A0A0K8UDI5   A0A1W4VW77   B3MUX2   A0A1A9W007   A0A1I8MSQ4   Q5CAS3   A0A3B0JX87   A0A1A9XGW8   A0A1B0BUW9   B4NY61   A0A3B0JUA3   A0A1I8MSQ6   T1PHC2   B4Q7U6   C6SUZ1   A0A182G278   Q9VLA1-2   A0A1I8P852   C0PTW3   B3N8G2   A0A2Z5Y5E9   Q9VLA1   A0A1B0GQ87   E1JHC8   A0A0R1DS95   A0A0P8XXU3   A0A3B0JUA0   B4HW83   A0A0J9TJL6   A0A0A1XBQ6   A0A0M3QTK1   W8BLI9   A0A0L0BL08  

EC Number

2.4.1.135

Pubmed

19121390    26354079    22118469    24845553    29403074    17510324    + More
24438588    12364791    20920257    23761445    15632085    17994087    25315136    17550304    26483478    10731132    12537572    12537569    12511570    18327897    29499182    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    25830018    24495485    26108605   

EMBL

BABH01017062    BABH01017063    EU827503    ACF31554.2    NWSH01002712    PCG67637.1    + More
KQ461108    KPJ08989.1    GDQN01004618    JAT86436.1    ODYU01001436    SOQ37621.1    AGBW02014274    OWR41984.1    KQ459605    KPI91871.1    KK852715    KDR17861.1    PYGN01000181    PSN51915.1    NEVH01023955    PNF17820.1    GEBQ01017623    JAT22354.1    GECZ01026293    JAS43476.1    GEDC01031156    JAS06142.1    AJWK01000126    GFDF01001326    JAV12758.1    GFDL01014083    JAV20962.1    CH477322    EAT43601.1    GFDL01013843    JAV21202.1    GFDL01013857    JAV21188.1    AXCM01000090    GFDL01014318    JAV20727.1    GFDL01013630    JAV21415.1    GFDL01014080    JAV20965.1    UFQT01000114    SSX20257.1    AXCN02000729    ATLV01013476    KE524860    KFB38036.1    APCN01000637    AAAB01008944    EAT43602.1    GGFK01012314    MBW45635.1    DS232030    EDS32539.1    GANO01003250    JAB56621.1    GGFM01005139    MBW25890.1    GGFM01005183    MBW25934.1    GGMS01006891    MBY76094.1    GGFJ01006378    MBW55519.1    GFXV01002406    MBW14211.1    CVRI01000047    CRK98564.1    GGFL01003133    MBW67311.1    ADMH02001599    ETN61901.1    AJ889609    CAI63867.1    ABLF02019600    ABLF02019602    GGMR01012022    MBY24641.1    CH379060    EAL33433.2    KRT03826.1    GDHF01027615    JAI24699.1    CH902624    EDV33037.2    AJ889610    CAI63868.1    OUUW01000010    SPP85683.1    JXJN01020958    CM000157    EDW88663.1    SPP85684.1    KA648227    AFP62856.1    CM000361    EDX04378.1    BT088983    ACT88124.1    JXUM01039461    JXUM01039462    JXUM01039463    JXUM01039464    JXUM01039465    JXUM01039466    JXUM01039467    KQ561205    KXJ79350.1    AE014134    AY058399    AB080696    AAF52795.2    BT071808    ACN58571.1    CH954177    EDV58385.1    LC146675    BBC62124.1    AJVK01006586    AJVK01006587    BT133218    ACZ94212.1    AFA28459.1    KRJ97968.1    KPU74267.1    SPP85685.1    CH480818    EDW52278.1    CM002910    KMY89295.1    GBXI01011999    GBXI01005433    JAD02293.1    JAD08859.1    CP012523    ALC39053.1    GAMC01006883    JAB99672.1    JRES01001704    KNC20732.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000027135    + More
UP000245037    UP000235965    UP000079169    UP000092461    UP000008820    UP000075881    UP000075880    UP000075883    UP000075886    UP000075903    UP000076407    UP000030765    UP000075902    UP000075900    UP000075840    UP000002320    UP000075885    UP000075884    UP000075920    UP000183832    UP000000673    UP000007819    UP000078200    UP000092445    UP000001819    UP000192221    UP000095300    UP000007801    UP000091820    UP000095301    UP000268350    UP000092443    UP000092460    UP000002282    UP000000304    UP000069940    UP000249989    UP000000803    UP000008711    UP000092462    UP000001292    UP000092553    UP000037069   

PRIDE

H9JRV6    B5A9M8    Q9VLA1    C0PTW3   

Pfam

PF03360   Glyco_transf_43        + More
PF01347   Vitellogenin_N
PF09172   DUF1943
PF06448   DUF1081

Interpro

IPR029044   Nucleotide-diphossugar_trans        + More
IPR005027   Glyco_trans_43       
IPR001747   Lipid_transpt_N       
IPR015819   Lipid_transp_b-sht_shell       
IPR011030   Lipovitellin_superhlx_dom       
IPR015255   Vitellinogen_open_b-sht       
IPR009454   Lipid_transpt_open_b-sht       
IPR015816   Vitellinogen_b-sht_N       

SUPFAM

SSF53448   SSF53448        + More
SSF48431   SSF48431       
SSF56968   SSF56968       

Gene 3D

3.90.550.10     1.25.10.20     2.30.230.10    

CDD

cd00218  GlcAT-I

ProteinModelPortal

H9JRV6   B5A9M8   A0A2A4J695   A0A194QUI9   A0A1E1WHQ8   A0A2H1V9Z4   + More
A0A212EKH4   A0A194PET1   A0A067RD25   A0A2P8Z5Y6   A0A2J7PNA8   A0A1B6LFL3   A0A1S3CUY6   A0A1B6EZJ1   A0A1B6BXY2   A0A1B0C836   A0A1L8E213   A0A1Q3F083   Q17BE2   A0A1Q3F0X4   A0A182KEA7   A0A1Q3F126   A0A182IPX0   A0A182M4K6   A0A1Q3EZJ8   A0A1Q3F1I9   A0A1Q3F075   A0A336LV95   A0A182QZC4   A0A182V4K2   A0A182X609   A0A084VJ92   A0A182U069   A0A182R2J4   A0A1Y9GKD1   A0A1S4GZB1   Q17BE4   A0A182IB33   A0A2M4AY11   B0WPV1   U5EGY0   A0A2M3ZBP9   A0A182PTY9   A0A182NT56   A0A2M3ZBK1   A0A182WA06   A0A2S2QEC9   A0A2M4BR33   A0A2H8TJQ4   A0A1J1IG96   A0A2M4CQ49   W5JCX8   Q5CAS4   J9JQS1   A0A1A9V9N1   A0A1B0A4Y3   A0A2S2P568   Q29NA9   A0A0R3NRT8   A0A1W4VHW5   A0A1W4VVE3   A0A1W4VUM4   A0A1W4W2A1   A0A1I8P808   A0A0K8UDI5   A0A1W4VW77   B3MUX2   A0A1A9W007   A0A1I8MSQ4   Q5CAS3   A0A3B0JX87   A0A1A9XGW8   A0A1B0BUW9   B4NY61   A0A3B0JUA3   A0A1I8MSQ6   T1PHC2   B4Q7U6   C6SUZ1   A0A182G278   Q9VLA1-2   A0A1I8P852   C0PTW3   B3N8G2   A0A2Z5Y5E9   Q9VLA1   A0A1B0GQ87   E1JHC8   A0A0R1DS95   A0A0P8XXU3   A0A3B0JUA0   B4HW83   A0A0J9TJL6   A0A0A1XBQ6   A0A0M3QTK1   W8BLI9   A0A0L0BL08  

PDB

2D0J     E-value=2.67969e-51,     Score=510

KEGG

100174850    K10812 beta-1,3-glucuronyltransferase [EC:2.4.1.135 2.4.1.-] | (RefSeq) glucuronyltransferase

GO

GO:0015018   GO:0006486   GO:0000139   GO:0046872   GO:0016021   GO:0046988   GO:0046987   GO:0009101   GO:0006688   GO:0030166   GO:0046989   GO:0005319   GO:0016020   GO:0004559   GO:0005975   GO:0003824   GO:0006013   GO:0015923   GO:0030246   GO:0007169  

PANTHER

PTHR10896  

Subcellular location

Golgi apparatus membrane  

Length:

356

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.13473

Exp number, first 60 AAs:

21.82198

Total prob of N-in:

0.91317

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  356

 

 

Pi

2.046429

Theta

13.002571

Tajima's D

-2.162954

CLR

0.174511

CSRT

0.00594970251487426

Interpretation

Uncertain