Gene

KWMTBOMO00526

Pre Gene Modal

BGIBMGA012270

Annotation

PREDICTED:_transmembrane_protein_198_[Papilio_machaon]

Location

Bomo_Chr1(-):15382989-15405459      View in EpiBrowser

Full name

Transmembrane protein 198      

Location in the cell

PlasmaMembrane   Reliability : 4.926

CDS

ATGTCAGAAGTGGGTCAACTGGTACCACCAGTGACCCATAGTCGGCCAAACATGACATACAAATTCAATGGACCCCACATTGAAGATTCATTTTGCACTTCGATCGATACCAACTATGATCCCATTATAAGCATAATATGTGCTATGTATATTGCATTTGGGATTGTGTACACGCTATTTGGCTATCGCTGTTTCAAAGCCAGTATGTTTTTGACTGGTTTCACTTTTGGCTCTGCTGTTGTATATCTCATATGCCTACAAGAGTACCTGATGCCTCCTTATGGTAATGTCGGAGTTGCGCTTTGCGCGGGATTACTCTTCGGTCTCATCACCATGCTGATACAGTACGTTGGGCTGTTCATGACTGGTTTCCACACCGGACTTTTGCTGGCTATAGCTGGACTGGCCGTCTACGATCACTTCTTGGACAAAAGACCGACTGCGTATTGGATGTGCGTTGTGGTGCTGCTATGCTCCGGTATATTTTTCGCAGTTATCAACTTATACTGGAAGAAAGTTCTAACAATCTTCGGAACGAGCGTGTACGGCGGTGCAATAATAGCTACCTCCCTGGACTACTTCTTTGAAAGAATGATGATGCTAAAATGGTTATGGGAGCGTGCGAAGTTGGAACCAGCCGTGGCTCCACCGTGTCGCATGTCTTGGTTGACGTTGGCAGCCTGGCCTGCTGCAGCCATCGTGGGACTCACAGCGCAATGCGCGCTCACGGCCACCGGAATCTACCACGAGCAAAGTATAAGCGCTCAGAAACGACGCCTCAAAGCTCAGCAGACCCGTCCGATCACACGCGAGCAACGAGCCGAGATGAAGCAACGCAAGTACCGATATCTGTACCAAGTGCGCACCGCTCACGGAGATGTTATATCCCAGTCATACGTTCAAGCGCTACAGAAGAAAGCTCAATGCGGGAACTGGAGTGGCGAGTGTAGCACGCTGCAGAGCGACTCGACCCACTTGACCGTGCTCGCTGGCTCCGAACAAGCCCCGCCCACTGACTCCGACGACGACTTGAACCAAATCAGAGCAGCGCATTAA

Protein

MSEVGQLVPPVTHSRPNMTYKFNGPHIEDSFCTSIDTNYDPIISIICAMYIAFGIVYTLFGYRCFKASMFLTGFTFGSAVVYLICLQEYLMPPYGNVGVALCAGLLFGLITMLIQYVGLFMTGFHTGLLLAIAGLAVYDHFLDKRPTAYWMCVVVLLCSGIFFAVINLYWKKVLTIFGTSVYGGAIIATSLDYFFERMMMLKWLWERAKLEPAVAPPCRMSWLTLAAWPAAAIVGLTAQCALTATGIYHEQSISAQKRRLKAQQTRPITREQRAEMKQRKYRYLYQVRTAHGDVISQSYVQALQKKAQCGNWSGECSTLQSDSTHLTVLAGSEQAPPTDSDDDLNQIRAAH

Description

Promotes lrp6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of lrp6 further enhancing its activity. Required for neural crest formation.

Subunit

Interacts with lrp6. Interacts with casein kinases.

Similarity

Belongs to the TMEM198 family.

Keywords

Cell membrane   Complete proteome   Cytoplasmic vesicle   Developmental protein   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Wnt signaling pathway  

Feature

chain  Transmembrane protein 198

Uniprot

H9JRW0   A0A194QU48   A0A194PGM6   A0A212EKI4   V5GUG0   A0A0T6AVC6   + More
D6WJY5   A0A1Y1M4J5   A0A1Y1M593   E0VBR6   A0A1B6ING9   A0A1B6LWA3   A0A1B6G9D2   A0A2P8YCG6   A0A2J7PJC9   A0A2P6KHW0   A0A1B6JNK9   T1J8G7   A0A1B6KQG6   A0A087U8A5   A0A0A9WV57   A0A224Z109   L7M970   A0A131XHI3   A0A131YM13   A0A1E1XSB5   A0A0N7ZC21   A0A023GIH6   G3MMD2   A0A069DS84   A0A2R5LJW3   A0A023F642   A0A2P2I4Z5   A0A0V0GC96   A0A224XGS2   N6U6C6   B7QGL7   A0A293L5F1   L7LT32   A0A0L8FWX0   A0A0L8FX70   T1IEN4   V5HSB0   V4C685   A0A0L8FWS9   R7UHI8   A0A210PWQ5   A0A0L8FXW2   D3PI57   A0A0C9SDQ2   A0A2T7PB02   A0A0B6XXS5   C1BNN1   K1PCE7   U4TTP8   C3YW41   A0A1S3H0B3   A0A1S3KF08   A0A0P7V294   Q6DFQ7   A0A2C9JMU1   A0A1L8HHZ2   H3B7S6   A0A091RL62   A0A091HJA8   A0A1L8ENN1   H3DIE6   T1KY71   A0A2D0R9A7   W5M9I0   W5U7Y2   A0A3P8VXM3   A0A3B4C639   A0A3B3RKF7   A0A1L8H9U0   A0A1S3MUK7   H3C9C8   A0A1L8H9P4   A0A091GDD9   A0A3N0XV13   I3J8P8   A0A087YJM9   A0A3B3UQH6   A0A3B3YH67   A0A3B1JKR7   E7EZQ2   A0A099ZZ89   A0A091RVH9   G1NFF1   Q66IY2  

Pubmed

19121390    26354079    22118469    18362917    19820115    28004739    + More
20566863    29403074    25401762    26823975    28797301    25576852    28049606    26830274    29209593    22216098    26334808    25474469    23537049    25765539    23254933    28812685    26131772    22992520    18563158    20431018    21536646    15562597    27762356    9215903    15496914    23127152    24487278    29240929    25186727    25329095    23594743    20838655   

EMBL

BABH01017045    BABH01017046    BABH01017047    KQ461108    KPJ08997.1    KQ459605    + More
KPI91864.1    AGBW02014274    OWR41993.1    GALX01003164    JAB65302.1    LJIG01022728    KRT79025.1    KQ971342    EFA03643.1    GEZM01040940    JAV80702.1    GEZM01040941    JAV80701.1    DS235035    EEB10822.1    GECU01023726    GECU01019259    JAS83980.1    JAS88447.1    GEBQ01012018    JAT27959.1    GECZ01010729    JAS59040.1    PYGN01000705    PSN41947.1    NEVH01024949    PNF16442.1    MWRG01011528    PRD25912.1    GECU01006855    JAT00852.1    JH431954    GEBQ01026289    JAT13688.1    KK118691    KFM73594.1    GBHO01034355    GBHO01032288    GDHC01019113    GDHC01013966    JAG09249.1    JAG11316.1    JAP99515.1    JAQ04663.1    GFPF01008616    MAA19762.1    GACK01004612    JAA60422.1    GEFH01003440    JAP65141.1    GEDV01008942    JAP79615.1    GFAA01001593    JAU01842.1    GDRN01074490    JAI63232.1    GBBM01001712    JAC33706.1    JO843033    AEO34650.1    GBGD01002372    JAC86517.1    GGLE01005668    MBY09794.1    GBBI01002038    JAC16674.1    IACF01003455    LAB69071.1    GECL01000520    JAP05604.1    GFTR01004741    JAW11685.1    APGK01037927    KB740949    ENN77185.1    ABJB010990296    DS932186    EEC17989.1    GFWV01001997    MAA26727.1    GACK01010059    JAA54975.1    KQ425649    KOF69182.1    KOF69184.1    ACPB03011512    GANP01003299    JAB81169.1    KB201324    ESO97149.1    KOF69181.1    AMQN01001321    KB301364    ELU05665.1    NEDP02005435    OWF40921.1    KOF69180.1    BT121313    HACA01020058    ADD38243.1    CDW37419.1    GBZX01001722    JAG91018.1    PZQS01000005    PVD30582.1    HACG01001798    CEK48663.1    BT076210    ACO10634.1    JH817487    EKC21482.1    KB631641    ERL84894.1    GG666559    EEN55495.1    JARO02001551    KPP75118.1    AAMC01034906    AAMC01034907    AAMC01034908    BC076677    CM004468    OCT95699.1    AFYH01034095    AFYH01034096    AFYH01034097    KK820690    KFQ39992.1    KL217462    KFO95299.1    CM004483    OCT60963.1    CAEY01000699    AHAT01018652    JT407638    AHH38058.1    CM004469    OCT92825.1    OCT92824.1    KL447299    KFO72187.1    RJVU01059775    ROJ66286.1    AERX01013233    AYCK01016602    BX322554    KL869907    KGL86433.1    KK709426    KFQ32397.1    BC081144    AAH81144.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000007266    UP000009046    + More
UP000245037    UP000235965    UP000054359    UP000019118    UP000001555    UP000053454    UP000015103    UP000030746    UP000014760    UP000242188    UP000245119    UP000005408    UP000030742    UP000001554    UP000085678    UP000034805    UP000192224    UP000008143    UP000076420    UP000186698    UP000008672    UP000054308    UP000007303    UP000015104    UP000221080    UP000018468    UP000265120    UP000261440    UP000261540    UP000087266    UP000053760    UP000005207    UP000028760    UP000261500    UP000261480    UP000018467    UP000000437    UP000053858    UP000001645   

PRIDE

H9JRW0   

Pfam

PF13886   DUF4203

Interpro

IPR040236   TMEM198        + More
IPR025256   DUF4203       
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       

SUPFAM

SSF103473   SSF103473       

CDD

cd06174  MFS

ProteinModelPortal

H9JRW0   A0A194QU48   A0A194PGM6   A0A212EKI4   V5GUG0   A0A0T6AVC6   + More
D6WJY5   A0A1Y1M4J5   A0A1Y1M593   E0VBR6   A0A1B6ING9   A0A1B6LWA3   A0A1B6G9D2   A0A2P8YCG6   A0A2J7PJC9   A0A2P6KHW0   A0A1B6JNK9   T1J8G7   A0A1B6KQG6   A0A087U8A5   A0A0A9WV57   A0A224Z109   L7M970   A0A131XHI3   A0A131YM13   A0A1E1XSB5   A0A0N7ZC21   A0A023GIH6   G3MMD2   A0A069DS84   A0A2R5LJW3   A0A023F642   A0A2P2I4Z5   A0A0V0GC96   A0A224XGS2   N6U6C6   B7QGL7   A0A293L5F1   L7LT32   A0A0L8FWX0   A0A0L8FX70   T1IEN4   V5HSB0   V4C685   A0A0L8FWS9   R7UHI8   A0A210PWQ5   A0A0L8FXW2   D3PI57   A0A0C9SDQ2   A0A2T7PB02   A0A0B6XXS5   C1BNN1   K1PCE7   U4TTP8   C3YW41   A0A1S3H0B3   A0A1S3KF08   A0A0P7V294   Q6DFQ7   A0A2C9JMU1   A0A1L8HHZ2   H3B7S6   A0A091RL62   A0A091HJA8   A0A1L8ENN1   H3DIE6   T1KY71   A0A2D0R9A7   W5M9I0   W5U7Y2   A0A3P8VXM3   A0A3B4C639   A0A3B3RKF7   A0A1L8H9U0   A0A1S3MUK7   H3C9C8   A0A1L8H9P4   A0A091GDD9   A0A3N0XV13   I3J8P8   A0A087YJM9   A0A3B3UQH6   A0A3B3YH67   A0A3B1JKR7   E7EZQ2   A0A099ZZ89   A0A091RVH9   G1NFF1   Q66IY2  

KEGG

101745930    no KO assigned | (RefSeq) transmembrane protein 198

GO

GO:0016021   GO:0016055   GO:0007275   GO:0031410   GO:0012506   GO:0005886   GO:0090263  

PANTHER

PTHR31247  

Subcellular location

Membrane  
Cell membrane  
Cytoplasmic vesicle  

Length:

351

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

147.84218

Exp number, first 60 AAs:

20.0422

Total prob of N-in:

0.01054

POSSIBLE N-term signal

sequence

outside

1  -  40

TMhelix

41  -  60

inside

61  -  66

TMhelix

67  -  86

outside

87  -  89

TMhelix

90  -  109

inside

110  -  115

TMhelix

116  -  138

outside

139  -  147

TMhelix

148  -  170

inside

171  -  172

TMhelix

173  -  195

outside

196  -  225

TMhelix

226  -  248

inside

249  -  351

 

 

Pi

23.221972

Theta

19.695238

Tajima's D

-1.029573

CLR

0.005006

CSRT

0.135243237838108

Interpretation

Uncertain