Gene

KWMTBOMO00522

Pre Gene Modal

BGIBMGA012321

Annotation

PREDICTED:_autophagy-related_protein_13_homolog_[Papilio_xuthus]

Location

Bomo_Chr1(+):15256030-15263592      View in EpiBrowser

Full name

Autophagy-related protein 13       + More
Autophagy-related protein 13 homolog      

Location in the cell

Nuclear   Reliability : 3.203

CDS

ATGGCAGCATCGAATTCAGAAATTCAAGAACGCTGCCGTTTGTATAAGTTCACCAAAGTTTTGACTTTAAAAGTTGCACAGATTGTGGTCCAGAGCAGGAAAGGAAAGAAAATCAGTCAAGATTTTAAACCACAAAATGGTGTTGATTCTACACCACCTTTGCAATGGTTCAACCTATCAATCCCTGATGAACCTGGAGTTAATGAAGAAACAAAGCGTGTCCTCAATGGAGAAGTAGTTGATGCATTGTCCAAAGTTTTGTCCATAGAAATTACACTTCGAACTACAGATGGTGATGAAATGGTACTTGAATTGTGGACAGTGAAACTGACGACTGCAAGTGAAATATGTTCACCTTCTACAATATACTACAGAATGGGTGTAATGCTTAAGTCGACATTGACAATTTCGCGCATAACCCCAGCATATAAACTTGCACGCACTCAACATAAAGAGACATACAAGATATCCCACCGAATATTTAGCGGAGAACCAAATTTTGAAAAATTGGGAGAGAATCGAAGAAACATCAAAATTAGTGAACTGCGTACACCAATTGGTACAATCACTATTGGTGTATCATACAGGACAAAGATGACAATCTTGCCCGAAGATCGGCCAAAGTTTACATATGGAATAACAACTAGTGGTCATGACATTATGGTTAAGAGTGATCATTTCAAGGATACTCCTAAAAAGAAGAGAGGGTATGAGAAGAAGGAACTTGATCTTTCAAAACCATTAACAAATGCAGCTTTTGTGGATAAAGTTAAAATGCAGGAATTACAGGACTCTTTATGTGAGCAGCTACCACCAGAACCACCGATGACATGGCTCATAGCAGAGAGAGAACAAATCGATAAAAAATTGCAGAATCTCGATATTTGTAAAGTAGCAGATGCGGAGGATCCAACAGCGAAACTTCTAGCGGATGCTGCAAAAACGGCCACGACATCCGCATCAAGCTATGCTGCCAGCAAAGCAATAGATATTCCAAGGGCGAACGCGGGGGATCAGTGCAAGCGCATAATGGAGTTTCCGTTCGCCGAAGGAAGCCCGATCGCGGACCTGGCTAATTTCTACAACGAATGCCTTCAAGCTAGAGCGATGACGAAAGAGTGGAAAGACTTCGCCGATACCGCCGCCATCTCGACCGATTCCGATACTCTTTCCAAGCAGTTGAAGATGTTTGAGGATGCCGTACCGGAATTCGACAGTATGGTCGCTTCAATGTGCAACAGCGCCGAAGGAGGATCCGAGAATTAA

Protein

MAASNSEIQERCRLYKFTKVLTLKVAQIVVQSRKGKKISQDFKPQNGVDSTPPLQWFNLSIPDEPGVNEETKRVLNGEVVDALSKVLSIEITLRTTDGDEMVLELWTVKLTTASEICSPSTIYYRMGVMLKSTLTISRITPAYKLARTQHKETYKISHRIFSGEPNFEKLGENRRNIKISELRTPIGTITIGVSYRTKMTILPEDRPKFTYGITTSGHDIMVKSDHFKDTPKKKRGYEKKELDLSKPLTNAAFVDKVKMQELQDSLCEQLPPEPPMTWLIAEREQIDKKLQNLDICKVADAEDPTAKLLADAAKTATTSASSYAASKAIDIPRANAGDQCKRIMEFPFAEGSPIADLANFYNECLQARAMTKEWKDFADTAAISTDSDTLSKQLKMFEDAVPEFDSMVASMCNSAEGGSEN

Description

Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1-Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells.

Subunit

Interacts with Atg1.

Similarity

Belongs to the ATG13 family. Metazoan subfamily.

Keywords

Autophagy   Complete proteome   Cytoplasm   Phosphoprotein   Reference proteome  

Feature

chain  Autophagy-related protein 13 homolog

Uniprot

A0A2A4JYG5   A0A2H1W515   A0A194QVK7   A0A194PES2   A0A0L7LDJ7   A0A212EKI8   + More
A0A1E1WSR5   A0A194QEL5   A0A0N1PIT3   A0A1J1IX18   A0A2H1W5V8   A0A2A4JXB2   A0A067QS73   A0A1E1WL78   A0A2P8Y802   D6WFS6   A0A088AJZ1   A0A2A3EK01   A0A154PSY9   A0A310SEA5   A0A0L7RJK7   A0A232ET24   A0A1L8DV56   A0A1L8DVK6   U5EL05   A0A0A9WT81   A0A195CP19   A0A026VZU1   F4WE30   A0A1Q3G2Y3   A0A1Q3G3G6   A0A151K0C2   A0A146LPQ7   Q177Z0   A0A0H3UAL5   A0A3L8D5G8   A0A0L7KI75   Q9VHR6   A0A2M4CRX2   A0A2M4CRU8   B3P4Y2   A0A1J1J630   A0A2M4BKK7   B4PT54   B4HLK7   A0A2M4A1K5   A0A1W4VHP6   A0A2J7PMP5   A0A212FIG9   A0A0M4EES6   B4QYL3   B3M0F1   A0A0M9AC92   A0A0A1X1I5   T1IPJ1   Q298R4   A0A0K8V099   Q7Q6R5   A0A2Y9D0T3   B4LYY6   B4JV55   E0W0V2   A0A151IR64   A0A0L0C0Y2  

Pubmed

26354079    26227816    22118469    24845553    29403074    18362917    + More
19820115    28648823    25401762    24508170    21719571    26823975    17510324    26136688    30249741    10731132    12537572    12537569    18327897    19225150    20713604    17994087    17550304    25830018    15632085    12364791    14747013    17210077    20566863    26108605   

EMBL

NWSH01000394    PCG76718.1    ODYU01006344    SOQ48113.1    KQ461108    KPJ09000.1    + More
KQ459605    KPI91861.1    JTDY01001578    KOB73475.1    AGBW02014274    OWR41996.1    GDQN01000965    JAT90089.1    KQ459054    KPJ03922.1    KQ460047    KPJ17991.1    CVRI01000063    CRL04695.1    ODYU01006546    SOQ48485.1    NWSH01000450    PCG76328.1    KK853018    KDR12447.1    GDQN01003364    GDQN01003281    GDQN01003118    GDQN01000958    JAT87690.1    JAT87773.1    JAT87936.1    JAT90096.1    PYGN01000819    PSN40375.1    KQ971319    EEZ99590.2    KZ288238    PBC31361.1    KQ435191    KZC15035.1    KQ766578    OAD53683.1    KQ414579    KOC71142.1    NNAY01002343    OXU21509.1    GFDF01003760    JAV10324.1    GFDF01003759    JAV10325.1    GANO01001632    JAB58239.1    GBHO01033906    GBRD01009677    JAG09698.1    JAG56147.1    KQ977481    KYN02390.1    KK107558    EZA48976.1    GL888102    EGI67468.1    GFDL01000885    JAV34160.1    GFDL01000729    JAV34316.1    KQ981296    KYN43107.1    GDHC01010012    JAQ08617.1    CH477368    EAT42494.1    KJ778621    AIH07030.1    QOIP01000012    RLU15640.1    JTDY01009683    KOB63047.1    AE014297    AY061109    GGFL01003889    MBW68067.1    GGFL01003888    MBW68066.1    CH954181    EDV49926.1    CVRI01000067    CRL06934.1    GGFJ01004393    MBW53534.1    CM000160    EDW96515.1    CH480815    EDW43034.1    GGFK01001373    MBW34694.1    NEVH01023969    PNF17596.1    AGBW02008391    OWR53518.1    CP012526    ALC46554.1    CM000364    EDX13771.1    CH902617    EDV43157.1    KQ435703    KOX80323.1    GBXI01009667    JAD04625.1    JH431263    CM000070    EAL27891.2    GDHF01019967    JAI32347.1    AAAB01008960    EAA10737.4    APCN01001506    CH940650    EDW68089.1    CH916374    EDV91375.1    DS235862    EEB19258.1    KQ981144    KYN09147.1    JRES01001062    KNC25906.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000037510    UP000007151    UP000183832    + More
UP000027135    UP000245037    UP000007266    UP000005203    UP000242457    UP000076502    UP000053825    UP000215335    UP000078542    UP000053097    UP000007755    UP000078541    UP000008820    UP000279307    UP000000803    UP000008711    UP000002282    UP000001292    UP000192221    UP000235965    UP000092553    UP000000304    UP000007801    UP000053105    UP000001819    UP000007062    UP000075840    UP000008792    UP000001070    UP000009046    UP000078492    UP000037069   

PRIDE

Q9VHR6   

Pfam

PF10033   ATG13        + More
PF01883   FeS_assembly_P

Interpro

IPR036570   HORMA_dom_sf        + More
IPR018731   Atg13_N       
IPR040182   ATG13       
IPR039796   MIP18       
IPR034904   FSCA_dom_sf       
IPR002744   MIP18-like       

SUPFAM

SSF117916   SSF117916       

Gene 3D

3.30.900.10     3.30.300.130    

ProteinModelPortal

A0A2A4JYG5   A0A2H1W515   A0A194QVK7   A0A194PES2   A0A0L7LDJ7   A0A212EKI8   + More
A0A1E1WSR5   A0A194QEL5   A0A0N1PIT3   A0A1J1IX18   A0A2H1W5V8   A0A2A4JXB2   A0A067QS73   A0A1E1WL78   A0A2P8Y802   D6WFS6   A0A088AJZ1   A0A2A3EK01   A0A154PSY9   A0A310SEA5   A0A0L7RJK7   A0A232ET24   A0A1L8DV56   A0A1L8DVK6   U5EL05   A0A0A9WT81   A0A195CP19   A0A026VZU1   F4WE30   A0A1Q3G2Y3   A0A1Q3G3G6   A0A151K0C2   A0A146LPQ7   Q177Z0   A0A0H3UAL5   A0A3L8D5G8   A0A0L7KI75   Q9VHR6   A0A2M4CRX2   A0A2M4CRU8   B3P4Y2   A0A1J1J630   A0A2M4BKK7   B4PT54   B4HLK7   A0A2M4A1K5   A0A1W4VHP6   A0A2J7PMP5   A0A212FIG9   A0A0M4EES6   B4QYL3   B3M0F1   A0A0M9AC92   A0A0A1X1I5   T1IPJ1   Q298R4   A0A0K8V099   Q7Q6R5   A0A2Y9D0T3   B4LYY6   B4JV55   E0W0V2   A0A151IR64   A0A0L0C0Y2  

PDB

5C50     E-value=1.35563e-28,     Score=315

KEGG

105842568    no KO assigned | (RefSeq) uncharacterized LOC105842568

GO

GO:1990316   GO:0000045   GO:0032147   GO:0034727   GO:0000422   GO:0019901   GO:0034497   GO:0019887   GO:0000407   GO:0005829   GO:0000423   GO:0019898   GO:0016236   GO:0006914   GO:0106035   GO:0045850   GO:0035096   GO:0060729   GO:0010506   GO:0008270   GO:0043565   GO:0005524   GO:0005488   GO:0003677   GO:0003707   GO:0007169   GO:0016021  

PANTHER

PTHR13430   PTHR12377  

Subcellular location

Cytoplasm   Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.   With evidence from 1 publications.
Cytosol   Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.   With evidence from 1 publications.
Preautophagosomal structure   Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.   With evidence from 1 publications.

Length:

421

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0607

Exp number, first 60 AAs:

0.04639

Total prob of N-in:

0.01004

outside

1  -  421

 

 

Pi

3.148629

Theta

14.814897

Tajima's D

-1.49968

CLR

0.03653

CSRT

0.0576971151442428

Interpretation

Uncertain