Gene

KWMTBOMO00512

Annotation

PREDICTED:_neurocalcin_homolog_[Bombyx_mori]

Location

Bomo_Chr1(-):14783920-14787986      View in EpiBrowser

Full name

Neurocalcin homolog      

Location in the cell

Cytoplasmic   Reliability : 2.907

CDS

ATGGGTAAACAAAATAGTAAACTCAAGCCTGAAGTATTGGAGGATCTGAAACAGAATACGGAGTTTTCAGACGCAGAAATACAAGAATGGTACAAAGGATTCCTGAAGGACTGTCCCAGTGGCCATCTTTCCGTCGAAGAGTTCAAAAAGATATACGGGAATTTTTTCCCTTACGGTGACGCTAGTAAGTTCGCAGAACACGTATTCCGCACATTCGATGCGAACGGCGACGGGACTATAGATTTCAGAGAATTCCTGTGTGCACTTAGTGTGACGTCGCGCGGCAAGCTGGAACAAAAGTTAAAGTGGGCATTCTCCATGTATGACTTAGATGGAAACGGATACATCTCAAGGCAGGAGATGCTGGAAATCGTCACTGCCATTTACAAGATGGTGGGCTCCGTTATGAAGATGCCGGAAGATGAATCTACCCCAGAGAAACGCACCGACAAAATATTCCGTCAGATGGACAGGAACAAGGACGGAAAACTCTCCCTCGAGGAGTTCATAGAAGGAGCCAAGAGCGACCCTTCTATTGTACGGCTGCTCCAATGTGATCCCCAATCTCAGTGA

Protein

MGKQNSKLKPEVLEDLKQNTEFSDAEIQEWYKGFLKDCPSGHLSVEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFLCALSVTSRGKLEQKLKWAFSMYDLDGNGYISRQEMLEIVTAIYKMVGSVMKMPEDESTPEKRTDKIFRQMDRNKDGKLSLEEFIEGAKSDPSIVRLLQCDPQSQ

Description

Calcium-binding protein that is essential for promoting night-time sleep and inhibiting nocturnal hyperactivity (PubMed:7989365, PubMed:30865587). During the night-time it promotes sleep by limiting synaptic output from arousal- and wake-promoting neurons within the C01- and A05- domains that include the mushroom body, and the antennal mechanosensory and motor center (PubMed:30865587). Regulated by the circadian clock network and light-sensing circuits that include the CRY photoreceptor; it is likely that both of these internal and external cues are required to define the temporal window (the night-time) during which this protein functions (PubMed:30865587). Inhibits the phosphorylation of rhodopsin in a calcium-dependent manner (PubMed:8626592).

Similarity

Belongs to the recoverin family.

Keywords

Calcium   Complete proteome   Lipoprotein   Metal-binding   Myristate   Reference proteome   Repeat  

Feature

chain  Neurocalcin homolog

Uniprot

A0A2A4K583   A0A2H1VGM0   A0A212EID6   T1DQE8   A0A1Q3FCV4   U5EWG5   + More
A0A182YMN6   A0A2M4CSU5   A0A2M3ZBI7   A0A182I2T2   A0A2M4AWJ6   A0A182MSA4   A0A182QW79   A0A182UQ27   A0A182JZ50   B0WLJ1   A0A182WJP8   Q17DD3   A0A182KQR1   A0A182IM38   A0A182FG91   Q7QJ35   A0A182R3H3   A0A182GM84   A0A1J1III6   A0A1L8DM23   A0A1B0DPF3   A0A0K8TP37   A0A1W4W7Y2   A0A1I8M3K6   A0A1A9VEC8   A0A1B0BYY9   B4HBT0   B3M8R6   B4IIU1   B3NE21   B4QRE6   B4IUE1   P42325   A0A2M3ZBN2   D7EI08   A0A1Y1K1J3   A0A0C9RHF7   B4MXN8   A0A0A1WWK3   A0A0K8VXB8   W8AX40   A0A034WTZ2   A0A1B0F9T4   A0A336K594   A0A023EIT5   A0A0M5IYV4   B4J1C5   B4KXP7   K7IP72   A0A0C9RZM1   A0A0T6B8M9   A0A2J7RKX3   A0A2P8YZU5   A0A1I8NM34   A0A151J8X7   F4WKW7   A0A195BJE3   A0A2A3E7E2   V9IMJ2   A0A0M8ZWG3   A0A088AGM2   A0A151K151   E2C1S4   A0A158P3V5   E2AUC2   A0A151WSD4   B4LFN2   A0A1B6EUQ4   A0A1B6H7K7   A0A195CNA8   B7PX38   V5I5H2   A0A1I9WLM4   A0A026VUK0   A0A1B6LTD4   A0A023GI71   A0A224YJ01   A0A131YUR0   L7M547   A0A131XHN9   A0A067RMX2   A0A194QVN3   A0A194PGJ8   A0A1B6D6R2   A0A0F7VK52   A0A1W7RA23   A0A087T645   A0A0P4W9R7   A0A023F5V0   A0A069DQA9   A0A2R5LIB0   A0A2P6KSJ5   T1HKE1   A0A146MHQ1  

Pubmed

22118469    25244985    17510324    20966253    12364791    14747013    + More
17210077    26483478    26369729    25315136    17994087    22936249    17550304    7989365    10731132    12537572    12537569    8626592    30865587    18362917    19820115    28004739    25830018    24495485    25348373    24945155    18057021    20075255    29403074    21719571    20798317    21347285    25765539    27538518    24508170    30249741    28797301    26830274    25576852    28049606    24845553    26354079    25474469    26334808    26823975   

EMBL

NWSH01000146    PCG79078.1    ODYU01002454    SOQ39966.1    AGBW02014676    OWR41237.1    + More
GAMD01002564    JAA99026.1    GFDL01009658    JAV25387.1    GANO01001425    JAB58446.1    GGFL01004219    MBW68397.1    GGFM01005112    MBW25863.1    APCN01000180    GGFK01011846    MBW45167.1    AXCM01006292    AXCN02000543    DS231986    EDS30510.1    CH477297    EAT44357.1    AXCP01006038    AAAB01008807    EAA04175.4    EDO64633.1    EDO64634.1    JXUM01073965    JXUM01073966    KQ562804    KXJ75091.1    CVRI01000054    CRL00045.1    GFDF01006575    JAV07509.1    AJVK01008074    AJVK01008075    GDAI01001692    JAI15911.1    JXJN01022897    CH479267    EDW39524.1    CH902618    EDV41067.2    CH480844    EDW49862.1    CH954178    EDV52445.1    CM000363    CM002912    EDX11159.1    KMZ00671.1    CM000159    CH891888    EDW95243.1    EDX00005.1    U15735    AE014296    AY071612    GGFM01005119    MBW25870.1    DS497669    EFA12929.1    GEZM01095819    GEZM01095818    JAV55324.1    GBYB01012637    JAG82404.1    CH963876    EDW76807.1    GBXI01011060    JAD03232.1    GDHF01024738    GDHF01014793    GDHF01008788    JAI27576.1    JAI37521.1    JAI43526.1    GAMC01013062    GAMC01013061    GAMC01013060    JAB93495.1    GAKP01001293    GAKP01001292    GAKP01001291    JAC57660.1    CCAG010018359    UFQS01000127    UFQT01000127    SSX00146.1    SSX20526.1    GAPW01004732    JAC08866.1    CP012525    ALC44298.1    CH916366    EDV97994.1    CH933809    EDW19754.1    KRG06801.1    GBYB01005054    GBYB01011649    GBYB01014886    GBYB01014895    JAG74821.1    JAG81416.1    JAG84653.1    JAG84662.1    LJIG01009130    KRT83695.1    NEVH01002704    PNF41494.1    PYGN01000263    PSN49758.1    KQ979480    KYN21244.1    GL888206    EGI65209.1    KQ976453    KYM85306.1    KZ288344    PBC27667.1    JR052298    AEY61669.1    KQ435840    KOX71456.1    KQ981292    KYN43126.1    GL451984    EFN78102.1    ADTU01008584    GL442815    EFN62979.1    KQ982783    KYQ50701.1    CH940647    EDW70350.1    KRF84867.1    KRF84868.1    GECZ01028316    JAS41453.1    GECU01037113    GECU01035109    JAS70593.1    JAS72597.1    KQ977513    KYN02198.1    ABJB010718017    DS811420    EEC11160.1    GANP01000360    GEFM01003776    JAB84108.1    JAP72020.1    KU932408    APA34044.1    KK107847    QOIP01000005    EZA47427.1    RLU23136.1    GEBQ01013036    JAT26941.1    GBBM01002690    JAC32728.1    GFPF01006471    MAA17617.1    GEDV01006209    JAP82348.1    GACK01006047    JAA58987.1    GEFH01002866    JAP65715.1    KK852573    KDR21074.1    KQ461108    KPJ09025.1    KQ459605    KPI91834.1    GEDC01031291    GEDC01015924    JAS06007.1    JAS21374.1    LN830691    CFW94200.1    GFAH01000387    JAV48002.1    KK113608    KFM60584.1    GDRN01076412    JAI62897.1    GBBI01002154    JAC16558.1    GBGD01003087    JAC85802.1    GGLE01005103    MBY09229.1    MWRG01005972    PRD29268.1    ACPB03012308    GDHC01013605    GDHC01000353    JAQ05024.1    JAQ18276.1   

Proteomes

UP000218220    UP000007151    UP000076408    UP000075840    UP000075883    UP000075886    + More
UP000075903    UP000075881    UP000002320    UP000075920    UP000008820    UP000075882    UP000075880    UP000069272    UP000007062    UP000075900    UP000069940    UP000249989    UP000183832    UP000092462    UP000192221    UP000095301    UP000078200    UP000092460    UP000008744    UP000007801    UP000001292    UP000008711    UP000000304    UP000002282    UP000000803    UP000007266    UP000007798    UP000092444    UP000092553    UP000001070    UP000009192    UP000002358    UP000235965    UP000245037    UP000095300    UP000078492    UP000007755    UP000078540    UP000242457    UP000053105    UP000005203    UP000078541    UP000008237    UP000005205    UP000000311    UP000075809    UP000008792    UP000078542    UP000001555    UP000053097    UP000279307    UP000027135    UP000053240    UP000053268    UP000054359    UP000015103   

PRIDE

P42325   

Pfam

PF00036   EF-hand_1        + More
PF13499   EF-hand_7
PF13405   EF-hand_6

Interpro

IPR011992   EF-hand-dom_pair        + More
IPR002048   EF_hand_dom       
IPR028846   Recoverin       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF47473   SSF47473       

CDD

cd00051  EFh

ProteinModelPortal

A0A2A4K583   A0A2H1VGM0   A0A212EID6   T1DQE8   A0A1Q3FCV4   U5EWG5   + More
A0A182YMN6   A0A2M4CSU5   A0A2M3ZBI7   A0A182I2T2   A0A2M4AWJ6   A0A182MSA4   A0A182QW79   A0A182UQ27   A0A182JZ50   B0WLJ1   A0A182WJP8   Q17DD3   A0A182KQR1   A0A182IM38   A0A182FG91   Q7QJ35   A0A182R3H3   A0A182GM84   A0A1J1III6   A0A1L8DM23   A0A1B0DPF3   A0A0K8TP37   A0A1W4W7Y2   A0A1I8M3K6   A0A1A9VEC8   A0A1B0BYY9   B4HBT0   B3M8R6   B4IIU1   B3NE21   B4QRE6   B4IUE1   P42325   A0A2M3ZBN2   D7EI08   A0A1Y1K1J3   A0A0C9RHF7   B4MXN8   A0A0A1WWK3   A0A0K8VXB8   W8AX40   A0A034WTZ2   A0A1B0F9T4   A0A336K594   A0A023EIT5   A0A0M5IYV4   B4J1C5   B4KXP7   K7IP72   A0A0C9RZM1   A0A0T6B8M9   A0A2J7RKX3   A0A2P8YZU5   A0A1I8NM34   A0A151J8X7   F4WKW7   A0A195BJE3   A0A2A3E7E2   V9IMJ2   A0A0M8ZWG3   A0A088AGM2   A0A151K151   E2C1S4   A0A158P3V5   E2AUC2   A0A151WSD4   B4LFN2   A0A1B6EUQ4   A0A1B6H7K7   A0A195CNA8   B7PX38   V5I5H2   A0A1I9WLM4   A0A026VUK0   A0A1B6LTD4   A0A023GI71   A0A224YJ01   A0A131YUR0   L7M547   A0A131XHN9   A0A067RMX2   A0A194QVN3   A0A194PGJ8   A0A1B6D6R2   A0A0F7VK52   A0A1W7RA23   A0A087T645   A0A0P4W9R7   A0A023F5V0   A0A069DQA9   A0A2R5LIB0   A0A2P6KSJ5   T1HKE1   A0A146MHQ1  

PDB

5T7C     E-value=5.61267e-93,     Score=866

KEGG

101744872    no KO assigned | (RefSeq) neurocalcin homolog

GO

GO:0005509   GO:0045938   GO:1902848   GO:0016174   GO:0003676   GO:0004634   GO:0006096   GO:0005488   GO:0003677   GO:0003707   GO:0007169   GO:0016021  

PANTHER

PTHR23055  

Length:

190

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00092

Exp number, first 60 AAs:

0

Total prob of N-in:

0.15830

outside

1  -  190

 

 

Pi

17.363152

Theta

18.471115

Tajima's D

-0.551463

CLR

0

CSRT

0.231688415579221

Interpretation

Uncertain