Gene

KWMTBOMO00497  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012309

Annotation

hypothetical_protein_KGM_14041_[Danaus_plexippus]

Location

Bomo_Chr1(+):14245112-14263038      View in EpiBrowser

Full name

D-3-phosphoglycerate dehydrogenase      

Location in the cell

Cytoplasmic   Reliability : 3.12

CDS

ATGGTCGTGGACATTAAGTCGGTTTTGATCGTCGACGGGGTTGGCGCCAAGTGTGCCGAACTCCTCAACGCTTACGGAATCGCCACCACCACCAAGGCCAAGATCTCCAAGGAAGAACTTCTTATGGAGATACCCAACCACGACGCTCTGGTTGTGCGTTCAGCAACTCAAGTGACCAAAGAGGTGTTGGACGCAGGCGTGAAGCTGAAGGTGGTCGGTCGTGCTGGAGCTGGTGTGGACAACATCGACGTCGACTCCGCCGGTAAAAAGGGCGTCGGAGTGATCAACGCTCCGGGCGCCAATGCGCTGAGCGCGTGCGAGCTGACCTGCACGTTGATGTTGGTTCTGGCTCGCCACGTGGTCCCAGCTTCCACTGCGCTGAAGGCTGGCAGGTGGGACCGGGCTCTGTACACTGGCAGCGAGCTCGCTGGCAAGACCCTCGCCATCCTTGGCCTTGGCAGGGTCGGCCGCGAGGTGGCCACTAGGATGTACGCCTTCGGCATGAACATCATCGGATTCGACCCTTTCGTGTCTGCTGATCAGTGCGCCCAGTTCCATTGCACCAAGATGGAGCTGGAGGACATTTGGCCTCTAGCGGACTACATCACCCTGCACACTCCGCTCATTGAGTCTACTCGAAACTTTATCAATGCCGATGTCTTGAAGCAGTGCAAGAAAGGTGTGAAAATCATCAACGTGGGTAGAGGCGGGCTTATTCAAGAGACAGATTTCTTGCAGGCTCTGAAGTCTGGAAAGGTGGGCGGGGCTGCTCTGGACGTGTTCGAGCAGGAGCCGCCGACCGATCCTGTCACTTTGGAGATTATTCAGCAGCCTGCTGTAATTGCCACTCCACATCTGGGGGCCTCTACTAAGGAAGCTCAGGTGAGAGTTGGCCAGGAGATTGCTGAGCAGCTCGTGAACCTGGTGAAGCCGGGAACATTCCCGACTCTGCTGGCCGAAGTCACCCGTGTCTTGAACAAGTGA

Protein

MVVDIKSVLIVDGVGAKCAELLNAYGIATTTKAKISKEELLMEIPNHDALVVRSATQVTKEVLDAGVKLKVVGRAGAGVDNIDVDSAGKKGVGVINAPGANALSACELTCTLMLVLARHVVPASTALKAGRWDRALYTGSELAGKTLAILGLGRVGREVATRMYAFGMNIIGFDPFVSADQCAQFHCTKMELEDIWPLADYITLHTPLIESTRNFINADVLKQCKKGVKIINVGRGGLIQETDFLQALKSGKVGGAALDVFEQEPPTDPVTLEIIQQPAVIATPHLGASTKEAQVRVGQEIAEQLVNLVKPGTFPTLLAEVTRVLNK

Catalytic Activity

3-phospho-D-glycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH

Similarity

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Feature

chain  D-3-phosphoglycerate dehydrogenase

Uniprot

H9JRZ9   A0A2H1V4G2   A0A212EIB9   S4PGR3   A0A194QVM2   I4DKF7   + More
A0A2A4IV65   V5GY93   D6WJ70   A0A067RD67   A0A1W4W5R1   A0A2J7QXA7   A0A1B6KWA9   U4UBI0   R4FM92   A0A2P8Z920   A0A023F8D6   A0A0C9S0B9   A0A171AIF1   A0A1Y1ND23   A0A224XAR1   A0A069DUE6   A0A1B6DGC0   E0VA24   A0A154PAH1   A0A0V0G2X8   A0A182KNH8   Q7PWU4   A0A182I734   A0A1B0D0D3   A0A182P9P9   A0A0L7RAG6   E9IBW3   A0A182XDI8   A0A182VU63   A0A182JZS3   A0A0C9RCI9   A0A182Y969   A0A026WLB8   A0A336L0A5   A0A182V0G9   Q17AF8   A0A0K8T6R2   K7J831   Q5QBI6   T1PBK5   A0A1L8EEY2   E2AIV5   A0A1L8EFD3   A0A195CJ42   A0A182QJV7   A0A1I8N139   U5ENG6   A0A182IVW9   A0A1S3JFM7   A0A182ME70   A0A310S4Y9   A0A1B0BWX5   A0A1S3IXM8   A0A1I8PYZ6   A0A0L0BZ96   A0A151X8X3   A0A195BNA7   A0A195FCE7   E2C1N2   A0A158NKQ8   F4X3G7   A0A195DG64   Q1HR10   D3TRK9   B4QAC2   A0A2M4ALZ4   A0A336MLS5   Q3YMV7   B4HX27   A0A087ZP36   Q9VKI8   A0A1Q3FJW1   A0A1B0CNU9   A0A2R5L6U8   A0A0K8T7T3   A0A0M9A1N5   W5JV55   A0A2M4BTQ8   A0A2A3EQ97   B4LQG8   A0A2M3ZAD4   B4JPK0   B3N4K2   B4P181   Q29M32   B4G9U8   A0A1J1IU94   B0WPU3   B3MMW3   A0A1W4W545   A0A023ER31   A0A0K8UKK3   A0A3B0JBR7   W8BP66  

EC Number

1.1.1.95

Pubmed

19121390    22118469    23622113    26354079    22651552    18362917    + More
19820115    24845553    23537049    29403074    25474469    28004739    26334808    20566863    20966253    12364791    14747013    17210077    21282665    25244985    24508170    30249741    17510324    26823975    20075255    20798317    25315136    26108605    21347285    21719571    17204158    20353571    17994087    22936249    15917496    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20920257    23761445    17550304    15632085    24945155    24495485   

EMBL

BABH01016959    ODYU01000621    SOQ35721.1    AGBW02014676    OWR41229.1    GAIX01003542    + More
JAA89018.1    KQ461108    KPJ09015.1    AK401775    BAM18397.1    NWSH01006960    PCG63174.1    GALX01003083    JAB65383.1    KQ971343    EFA03163.1    KK852714    KDR17898.1    NEVH01009382    PNF33217.1    GEBQ01024231    GEBQ01001962    JAT15746.1    JAT38015.1    KB632006    ERL87946.1    ACPB03000861    GAHY01001083    JAA76427.1    PYGN01000142    PSN52991.1    GBBI01001140    JAC17572.1    GBYB01013986    JAG83753.1    GEMB01001027    JAS02120.1    GEZM01005964    JAV95844.1    GFTR01006950    JAW09476.1    GBGD01001136    JAC87753.1    GEDC01012562    JAS24736.1    DS235004    EEB10230.1    KQ434857    KZC08895.1    GECL01003675    JAP02449.1    AAAB01008984    EAA14798.3    APCN01003352    AJVK01002406    AJVK01002407    AJVK01002408    KQ414619    KOC67756.1    GL762137    EFZ21969.1    GBYB01006025    JAG75792.1    KK107183    QOIP01000011    EZA55894.1    RLU17036.1    UFQS01001504    UFQT01001504    SSX11288.1    SSX30856.1    CH477336    EAT43202.1    GBRD01004597    GDHC01012072    GDHC01005236    JAG61224.1    JAQ06557.1    JAQ13393.1    AY752825    AAV84238.1    KA645490    AFP60119.1    GFDG01001527    JAV17272.1    GL439905    EFN66634.1    GFDG01001526    JAV17273.1    KQ977649    KYN00745.1    AXCN02002096    GANO01004101    JAB55770.1    AXCM01010448    KQ773583    OAD52377.1    JXJN01021993    JRES01001119    KNC25377.1    KQ982409    KYQ56812.1    KQ976439    KYM86703.1    KQ981693    KYN37877.1    GL451937    EFN78208.1    ADTU01018966    GL888613    EGI58995.1    KQ980886    KYN11832.1    DQ440284    ABF18317.1    EZ424061    ADD20337.1    CM000361    CM002910    EDX04677.1    KMY89713.1    GGFK01008492    MBW41813.1    UFQT01000750    SSX26958.1    DQ062769    AAY56642.1    CH480818    EDW52572.1    AE014134    AY058282    DQ062768    AAF53080.1    AAL13511.1    AAY56641.1    GFDL01007135    JAV27910.1    AJWK01020943    GGLE01001076    MBY05202.1    GBRD01004596    JAG61225.1    KQ435784    KOX74576.1    ADMH02000358    ETN66840.1    GGFJ01007253    MBW56394.1    KZ288204    PBC33309.1    CH940649    EDW63418.1    GGFM01004743    MBW25494.1    CH916372    EDV98830.1    CH954177    EDV58914.1    CM000157    EDW88056.1    CH379060    EAL33863.1    CH479180    EDW29128.1    CVRI01000058    CRL02694.1    DS232030    EDS32531.1    CH902620    EDV30988.1    GAPW01002504    JAC11094.1    GDHF01025444    JAI26870.1    OUUW01000004    SPP79485.1    GAMC01005853    JAC00703.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000218220    UP000007266    UP000027135    + More
UP000192223    UP000235965    UP000030742    UP000015103    UP000245037    UP000009046    UP000076502    UP000075882    UP000007062    UP000075840    UP000092462    UP000075885    UP000053825    UP000076407    UP000075920    UP000075881    UP000076408    UP000053097    UP000279307    UP000075903    UP000008820    UP000002358    UP000000311    UP000078542    UP000075886    UP000095301    UP000075880    UP000085678    UP000075883    UP000092460    UP000095300    UP000037069    UP000075809    UP000078540    UP000078541    UP000008237    UP000005205    UP000007755    UP000078492    UP000000304    UP000001292    UP000005203    UP000000803    UP000092461    UP000053105    UP000000673    UP000242457    UP000008792    UP000001070    UP000008711    UP000002282    UP000001819    UP000008744    UP000183832    UP000002320    UP000007801    UP000192221    UP000268350   

PRIDE

H9JRZ9    Q9VKI8   

Pfam

PF02826   2-Hacid_dh_C        + More
PF00389   2-Hacid_dh
PF00025   Arf

Interpro

IPR029752   D-isomer_DH_CS1        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR006139   D-isomer_2_OHA_DH_cat_dom       
IPR006140   D-isomer_DH_NAD-bd       
IPR029753   D-isomer_DH_CS       
IPR006236   PGDH       
IPR029009   ASB_dom_sf       
IPR027417   P-loop_NTPase       
IPR006689   Small_GTPase_ARF/SAR       
IPR005225   Small_GTP-bd_dom       

SUPFAM

SSF51735   SSF51735        + More
SSF143548   SSF143548       
SSF52540   SSF52540       

Gene 3D

3.30.1330.90    

ProteinModelPortal

H9JRZ9   A0A2H1V4G2   A0A212EIB9   S4PGR3   A0A194QVM2   I4DKF7   + More
A0A2A4IV65   V5GY93   D6WJ70   A0A067RD67   A0A1W4W5R1   A0A2J7QXA7   A0A1B6KWA9   U4UBI0   R4FM92   A0A2P8Z920   A0A023F8D6   A0A0C9S0B9   A0A171AIF1   A0A1Y1ND23   A0A224XAR1   A0A069DUE6   A0A1B6DGC0   E0VA24   A0A154PAH1   A0A0V0G2X8   A0A182KNH8   Q7PWU4   A0A182I734   A0A1B0D0D3   A0A182P9P9   A0A0L7RAG6   E9IBW3   A0A182XDI8   A0A182VU63   A0A182JZS3   A0A0C9RCI9   A0A182Y969   A0A026WLB8   A0A336L0A5   A0A182V0G9   Q17AF8   A0A0K8T6R2   K7J831   Q5QBI6   T1PBK5   A0A1L8EEY2   E2AIV5   A0A1L8EFD3   A0A195CJ42   A0A182QJV7   A0A1I8N139   U5ENG6   A0A182IVW9   A0A1S3JFM7   A0A182ME70   A0A310S4Y9   A0A1B0BWX5   A0A1S3IXM8   A0A1I8PYZ6   A0A0L0BZ96   A0A151X8X3   A0A195BNA7   A0A195FCE7   E2C1N2   A0A158NKQ8   F4X3G7   A0A195DG64   Q1HR10   D3TRK9   B4QAC2   A0A2M4ALZ4   A0A336MLS5   Q3YMV7   B4HX27   A0A087ZP36   Q9VKI8   A0A1Q3FJW1   A0A1B0CNU9   A0A2R5L6U8   A0A0K8T7T3   A0A0M9A1N5   W5JV55   A0A2M4BTQ8   A0A2A3EQ97   B4LQG8   A0A2M3ZAD4   B4JPK0   B3N4K2   B4P181   Q29M32   B4G9U8   A0A1J1IU94   B0WPU3   B3MMW3   A0A1W4W545   A0A023ER31   A0A0K8UKK3   A0A3B0JBR7   W8BP66  

PDB

2G76     E-value=3.7035e-87,     Score=819

KEGG

101743755    K00058 D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] | (RefS

PATHWAY

00260    Glycine, serine and threonine metabolism - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0016616   GO:0051287   GO:0004617   GO:0006520   GO:0006564   GO:0005525   GO:0008152   GO:0004634   GO:0006096   GO:0005488   GO:0003677   GO:0003707   GO:0007169   GO:0016021   GO:0055114  

Length:

327

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.15617

Exp number, first 60 AAs:

0.06961

Total prob of N-in:

0.01992

outside

1  -  327

 

 

Pi

19.294018

Theta

20.992976

Tajima's D

-0.71102

CLR

0.008499

CSRT

0.194640267986601

Interpretation

Uncertain