Gene

KWMTBOMO00491  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012292

Annotation

PREDICTED:_ubiquitin_carboxyl-terminal_hydrolase_isozyme_L5_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr1(-):14039800-14052737      View in EpiBrowser

Full name

Ubiquitin carboxyl-terminal hydrolase      

Location in the cell

Cytoplasmic   Reliability : 3.021

CDS

ATGGATTCTGCCGGGGATTGGTGTCTCCTAGAGAGTGATCCTGGAGTTTTCACTCAGCTAATTCACAAATTTGGTGCCAAAGGTGTACAAGTTGAGGAACTGTGGACTATTGAAGACAGCATGTTTGAAAATTTGAGACCAGTGCATGGTCTCATTTTCCTGTTCAAGTATGTTAATTATGAAGAACCCGCTGGGCCTATTGTATCAGATGATCGCTTAGACAAAATATTTTTTGCCAAACAGGTTATCAATAATGCCTGCGCAACTCAAGCTGTAATCAGTCTCCTGTTAAATTGCAAACACCCAGATTTGGAACTTGGTCCTGAATTGACCAAACTGAAAGAATTCAGCATGACATTCGACTCGCGCATGAGAGGTCTCTCGTTAAGCAACTCACAGACTATACGCAGCGCACACAACTCAATGGCTCAACAGCCTCTCTTTGAAGTAGATCCTAAAATGCCTGCCAAAGATGAAGACGCCTATCATTTCATAGGATATATGCCAATTGATGGCCGTCTTTACGAACTGGATGGGCTACAAGAAGGTCCGATTGATCATGGTGCAGTTGCTCCGGAACAAGATTGGCTCGATGTTGTCCGTCCAATTATAATGAGAAGGATTAATGTATACACCGAAGGAGAAATTCACTTCAACTTGATGGCCCTCGTATCAGATCGTAAAATGATATATCAACGTCAGCTTGATACACTTCTTAATGAAACACAGTTGCTGGGTATGGAAACCGATGCTCTCGATACAGAAATAGCGAGACTGAGAATGTTGATTGATTATGAGGAAATAAAGATGGCAAAGTACAAACAGGAGTTGGTACGCAGGCGTCACAATTACATGCCGTTCATCATTAATTTGCTTCAAATACTGGCTAAGGAGAAGAAGCTGATGCCCCTGCTGGAGAAGGCCAAGGAGCGCGCTACCAAGCGGAGTCACAAGAAAATGAAAGTATAA

Protein

MDSAGDWCLLESDPGVFTQLIHKFGAKGVQVEELWTIEDSMFENLRPVHGLIFLFKYVNYEEPAGPIVSDDRLDKIFFAKQVINNACATQAVISLLLNCKHPDLELGPELTKLKEFSMTFDSRMRGLSLSNSQTIRSAHNSMAQQPLFEVDPKMPAKDEDAYHFIGYMPIDGRLYELDGLQEGPIDHGAVAPEQDWLDVVRPIIMRRINVYTEGEIHFNLMALVSDRKMIYQRQLDTLLNETQLLGMETDALDTEIARLRMLIDYEEIKMAKYKQELVRRRHNYMPFIINLLQILAKEKKLMPLLEKAKERATKRSHKKMKV

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Similarity

Belongs to the peptidase C12 family.

Uniprot

H9JRY2   A0A2H1VAA4   A0A212EQG4   A0A1E1WV99   A0A194QVL2   A0A2A4IUH2   + More
B2DBN6   A0A194PL71   A0A2J7QYF7   A0A182GIG1   U5EXX5   A0A1B6LFK0   A0A1B6CKN2   A0A023EQX2   D6WHM3   Q16RF6   A0A182PP48   A0A2R7WCP0   E0W0S3   A0A2P8Z3T0   A0A084WKJ6   B0WAM9   A0A293MUB2   W5JCU7   A0A2M3ZB04   A0A182SLF3   A0A0L0C8L0   A0A2M4AFG9   A0A1Q3F679   A0A182Y109   A0A182TNW3   A0A182LJF6   Q7Q728   A0A1Y1JTL2   A0A182HLZ2   V3ZUI0   A0A131XCB0   A0A2M4BU01   A0A224Z7H3   A0A182VCC7   A0A131ZA60   A0A182M0Q8   A0A1I8NPS9   A0A0V0G4Z8   T1DM54   A0A182WQW7   L7M3C8   A0A182X543   A0A182JY24   A0A182NM32   A0A067R6D1   A0A0P4X1K4   A0A0T6B272   A0A182R0J9   T1PNQ0   A0A1I8MJB6   B9VRB6   R4FLL1   A0A0K8TNJ7   A0A0K8U9T8   A0A069DSS4   A0A034WE06   A0A023FA18   A0A1A9WTA5   A0A224Z7E3   A0A0A1WPP9   A0A224XTE9   A0A023GKP6   G3MJU9   E9FUJ0   A0A131XTV2   B7P6T3   A0A2R5L8K1   K7J0N8   W8BQH6   A0A232F3R8   A0A3B4A0M5   A0A385MQ64   A0A0K8RE55   A0A1S3I7D4   A0A023FLF1   C1BIU4   A0A3P8ZFF2   A0A1A9Y047   A0A1A9ZKG1   H3D466   A0A1A7WMN5   A0A1A9UG24   A0A1B0BC56   A0A1A8KNB6   A0A1A8SE78   A0A1A8Q2R0   A0A1A8CXK7   A0A1A8AX75   A0A3B5KHX8   D3TPP8   A0A3B4ES32   A0A3P8R871   A0A3P9CGK5   A0A146P5D3  

EC Number

3.4.19.12

Pubmed

19121390    22118469    26354079    18712529    26483478    24945155    + More
18362917    19820115    17510324    20566863    29403074    24438588    20920257    23761445    26108605    25244985    20966253    12364791    14747013    17210077    28004739    23254933    28049606    28797301    26830274    25576852    24845553    25315136    26369729    26334808    25348373    25474469    25830018    22216098    21292972    20075255    24495485    28648823    25463417    25069045    15496914    21551351    20353571    25186727   

EMBL

BABH01016939    BABH01016940    ODYU01001491    SOQ37768.1    AGBW02013269    OWR43726.1    + More
GDQN01004867    GDQN01000114    JAT86187.1    JAT90940.1    KQ461108    KPJ09005.1    NWSH01006566    PCG63361.1    AB264721    BAG30795.1    KQ459605    KPI91855.1    NEVH01009093    PNF33612.1    JXUM01011979    JXUM01030441    KQ560885    KQ560342    KXJ80478.1    KXJ82952.1    GANO01000720    JAB59151.1    GEBQ01017511    JAT22466.1    GEDC01023259    JAS14039.1    GAPW01002577    JAC11021.1    KQ971331    EEZ99725.1    CH477712    EAT36993.1    KK854627    PTY17443.1    AAZO01006830    DS235862    EEB19229.1    PYGN01000208    PSN51161.1    ATLV01024123    KE525349    KFB50740.1    DS231873    EDS41583.1    GFWV01019674    MAA44402.1    ADMH02001883    ETN60654.1    GGFM01004958    MBW25709.1    JRES01000850    KNC27734.1    GGFK01006205    MBW39526.1    GFDL01011975    JAV23070.1    AAAB01008960    EAA11802.2    GEZM01101438    JAV52654.1    APCN01004280    KB203470    ESO84586.1    GEFH01004569    JAP64012.1    GGFJ01007388    MBW56529.1    GFPF01013083    MAA24229.1    GEDV01000852    JAP87705.1    AXCM01005810    GECL01002985    JAP03139.1    GAMD01000081    JAB01510.1    GACK01007401    JAA57633.1    KK852714    KDR17906.1    GDRN01027813    JAI67634.1    LJIG01016121    KRT81551.1    AXCN02002327    KA647066    KA649713    KA649715    AFP64344.1    FJ595021    ACM43511.1    ACPB03013647    GAHY01001338    JAA76172.1    GDAI01001664    JAI15939.1    GDHF01028966    JAI23348.1    GBGD01002167    JAC86722.1    GAKP01006028    JAC52924.1    GBBI01000868    JAC17844.1    GFPF01013043    MAA24189.1    GBXI01013797    JAD00495.1    GFTR01005043    JAW11383.1    GBBM01001720    JAC33698.1    JO842150    AEO33767.1    GL732525    EFX88738.1    GEFM01006795    JAP69001.1    ABJB011067020    ABJB011080114    DS647752    EEC02305.1    GGLE01001698    MBY05824.1    GAMC01003075    JAC03481.1    NNAY01001035    OXU25401.1    MG462699    AYA62525.1    GADI01004378    JAA69430.1    GBBK01002989    JAC21493.1    BT074523    ACO08947.1    HADW01005822    HADX01009792    SBP07222.1    JXJN01011850    HAEE01013693    SBR33743.1    HAEH01014265    HAEI01013490    SBS15959.1    HAEF01011676    HAEG01010689    SBR87786.1    HADZ01019624    HAEA01001632    SBP83565.1    HADY01020586    HAEJ01004709    SBP59071.1    CCAG010023540    EZ423400    ADD19676.1    GCES01147285    GCES01146836    GCES01003729    JAQ39037.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000218220    UP000053268    UP000235965    + More
UP000069940    UP000249989    UP000007266    UP000008820    UP000075885    UP000009046    UP000245037    UP000030765    UP000002320    UP000000673    UP000075901    UP000037069    UP000076408    UP000075902    UP000075882    UP000007062    UP000075840    UP000030746    UP000075903    UP000075883    UP000095300    UP000075920    UP000076407    UP000075881    UP000075884    UP000027135    UP000075886    UP000095301    UP000015103    UP000091820    UP000000305    UP000001555    UP000002358    UP000215335    UP000261520    UP000085678    UP000265140    UP000092443    UP000092445    UP000007303    UP000078200    UP000092460    UP000005226    UP000092444    UP000261460    UP000265100    UP000265160   

PRIDE

H9JRY2   

Pfam

PF18031   UCH_C        + More
PF01088   Peptidase_C12

Interpro

IPR017390   Ubiquitinyl_hydrolase_UCH37        + More
IPR001578   Peptidase_C12_UCH       
IPR036959   Peptidase_C12_UCH_sf       
IPR041507   UCH_C       
IPR038765   Papain-like_cys_pep_sf       
IPR033837   UCH37       

SUPFAM

SSF54001   SSF54001       

Gene 3D

3.40.532.10    

CDD

cd02255  Peptidase_C12

ProteinModelPortal

H9JRY2   A0A2H1VAA4   A0A212EQG4   A0A1E1WV99   A0A194QVL2   A0A2A4IUH2   + More
B2DBN6   A0A194PL71   A0A2J7QYF7   A0A182GIG1   U5EXX5   A0A1B6LFK0   A0A1B6CKN2   A0A023EQX2   D6WHM3   Q16RF6   A0A182PP48   A0A2R7WCP0   E0W0S3   A0A2P8Z3T0   A0A084WKJ6   B0WAM9   A0A293MUB2   W5JCU7   A0A2M3ZB04   A0A182SLF3   A0A0L0C8L0   A0A2M4AFG9   A0A1Q3F679   A0A182Y109   A0A182TNW3   A0A182LJF6   Q7Q728   A0A1Y1JTL2   A0A182HLZ2   V3ZUI0   A0A131XCB0   A0A2M4BU01   A0A224Z7H3   A0A182VCC7   A0A131ZA60   A0A182M0Q8   A0A1I8NPS9   A0A0V0G4Z8   T1DM54   A0A182WQW7   L7M3C8   A0A182X543   A0A182JY24   A0A182NM32   A0A067R6D1   A0A0P4X1K4   A0A0T6B272   A0A182R0J9   T1PNQ0   A0A1I8MJB6   B9VRB6   R4FLL1   A0A0K8TNJ7   A0A0K8U9T8   A0A069DSS4   A0A034WE06   A0A023FA18   A0A1A9WTA5   A0A224Z7E3   A0A0A1WPP9   A0A224XTE9   A0A023GKP6   G3MJU9   E9FUJ0   A0A131XTV2   B7P6T3   A0A2R5L8K1   K7J0N8   W8BQH6   A0A232F3R8   A0A3B4A0M5   A0A385MQ64   A0A0K8RE55   A0A1S3I7D4   A0A023FLF1   C1BIU4   A0A3P8ZFF2   A0A1A9Y047   A0A1A9ZKG1   H3D466   A0A1A7WMN5   A0A1A9UG24   A0A1B0BC56   A0A1A8KNB6   A0A1A8SE78   A0A1A8Q2R0   A0A1A8CXK7   A0A1A8AX75   A0A3B5KHX8   D3TPP8   A0A3B4ES32   A0A3P8R871   A0A3P9CGK5   A0A146P5D3  

PDB

4WLR     E-value=1.28274e-107,     Score=995

KEGG

101742611    K05610 ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12] | (RefSeq) ubiquitin carboxyl-termina

GO

GO:0016579   GO:0004843   GO:0006511   GO:0000502   GO:0005737   GO:0031011   GO:1904888   GO:0070628   GO:0005622   GO:0030126   GO:0005488   GO:0003677   GO:0003707   GO:0007169   GO:0016021  

PANTHER

PTHR10589  

Length:

322

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01791

Exp number, first 60 AAs:

0.00041

Total prob of N-in:

0.02234

outside

1  -  322

 

 

Pi

22.864515

Theta

22.457961

Tajima's D

-0.917705

CLR

0.053493

CSRT

0.155242237888106

Interpretation

Uncertain