Gene

KWMTBOMO00489

Pre Gene Modal

BGIBMGA012293

Annotation

BXA7_BOMMO_RecName:_Full%3DBombyxin_A-7;_short=BBX-A7,4K-PTTH;_altname:_full=4K-prothoracicotropic_hormone

Location

Bomo_Chr1(-):14014437-14014977      View in EpiBrowser

Full name

Bombyxin A-7       + More
Bombyxin E-1      
Bombyxin A-9      
Bombyxin A      
Bombyxin A-3      
Bombyxin A-6      
Bombyxin G-1      
Bombyxin A-5      
Bombyxin A-4      
Bombyxin A-2      
Bombyxin A-1      
Bombyxin A-8      
Bombyxin B      
Bombyxin B-1 homolog      
Bombyxin B-3      
Bombyxin D-1      
Bombyxin B-1      
Bombyxin B-12      
Bombyxin B-7      
Bombyxin B-2      
Bombyxin B-4      
Bombyxin C-1      
Bombyxin B-6      
Bombyxin B-2 homolog      
Bombyxin B-10      
Bombyxin C-2      
Bombyxin B-8      
Bombyxin F-1      
Bombyxin B-9      
Bombyxin B-5      
Insulin-related peptide 4      
Insulin-related peptide 2      
Bombyxin B-11      
Bombyxin-related peptide A      
Insulin-related peptide 1      
Bombyxin A-3 homolog      

Alternative Name

4K-prothoracicotropic hormone
4K-prothoracicotropic hormone IV
Bombyxin IV
Bombyxin-II
ABRP

Location in the cell

Extracellular   Reliability : 3.587

CDS

ATGAAGACCGTCTTACTGATCGTTCTCCTGTTGACGATGTCTACGACCGCGTTAGAACAACAAAAACAAGCCCGTCATTATTGCGGGCGATTCCTGGCGCTAACGTTGGCTGACTTGTGCTGGGAGTATAAGCGCAGTGACGATTCGTACTACGATGGCAACAACCAGGACTTAACCGAGCCACCGAGCCCTCAGACGGCGGAGCACCGCATCCAGAAACGAGGTGTTGCTGATGACTGCTGCCTCCGCGCCTGCACTTTGGATGTACTGCTTTTATACTGTTAA

Protein

MKTVLLIVLLLTMSTTALEQQKQARHYCGRFLALTLADLCWEYKRSDDSYYDGNNQDLTEPPSPQTAEHRIQKRGVADDCCLRACTLDVLLLYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Direct protein sequencing   Disulfide bond   Hormone   Pyrrolidone carboxylic acid   Reference proteome   Secreted   Signal   3D-structure   Amidation   Neuropeptide  

Feature

peptide  Bombyxin A-7 B chain
propeptide  C peptide like
chain  Bombyxin A

Uniprot

H9JRY3   P26730   P21808   H9JRY4   P26732   H9JQX3   + More
P26726   P26729   O61271   P26728   P26727   P15411   Q17192   P26731   H9JR12   P33721   P26737   H9JY77   P26736   H9JY78   P26733   P29519   P26741   P26734   P26738   P15410   P26740   P33722   Q17194   P26735   P26742   H9JY76   H9JQX2   Q17193   A0A2H1WD29   A0A2H1WTS8   A0A2H1WLR7   H9JQX4   P91896   P26743   A0A2H1WD32   Q53X51   P26739   M4QC54   C0HKS5   B9A0V1   C0HKS4   A0A385H8W9   Q17196   O09209   H9JR11   A0A1B6MM39   Q4JJX8   A0A023EHB8   A0A385H8W6   A0A1B6FLK7   A0EZS0   A0A2H1WZT3   Q17CI7   A0A182GPE5   A0A1S4F886   A0A0L7KP19   Q17CI6   A0A1S4F823   A0A194RG26   A0A2H1WPT3   A0A212EPD8   A0A2H1WPS9   A0A1B6BZF9   A0A2H1WZM1   F6KMX2   A0A194RFE4   A0A385H8X0   A0A194Q5I3   C0HKS3   M4QEN0   A0A2P8YMI6   M4QNU1   A0A194RGH1   B0W8M1   P33720   A0A385H8W3   A0A2A4JKA0   A0A1Q3FG68   A0A1Q3FF89   A0A0L7KQ08   A0A2A4JKR2   A0A2W1BXR4   A0A1B6HNK2   A0A1Q3FG25   A0A1B6HP34   A0A1Q3FC17   A0A1Q3FBN3   A0A1Q3FEZ9   A0A2A4J1N6   M4QG01   A0A1Q3FCI0   A0A1B6HXG0   A0A2A4JGH3  

Pubmed

19121390    8683595    16593744    9253178    1515030    2674935    + More
7473749    9732555    2708384    1601275    9401466    29466015    30171635    8673077    24945155    16934367    17510324    26483478    26227816    26354079    22118469    17559850    29403074    28756777   

EMBL

BABH01016939    D00772    D00773    D78138    D00776    BABH01028595    + More
M26069    D00771    AB010380    AB010381    D00770    D00769    J04727    M26068    D00340    D00774    D00775    D13923    D00778    BABH01042454    D00797    AB003905    BABH01042456    D00789    D00782    D00783    D00779    D00790    D00791    J04728    D00781    D13924    D00787    D00792    D00784    BABH01028597    D00777    BAA00673.1    ODYU01007848    SOQ50980.1    ODYU01011005    SOQ56475.1    ODYU01009526    SOQ54023.1    BABH01028594    AB001049    AB001050    D00785    ODYU01007998    SOQ50979.1    SOQ51243.1    D00786    BAA00682.1    D00780    KC340940    AGH25572.1    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    MH028097    AXY04266.1    D00788    D63147    D63146    GEBQ01002995    JAT36982.1    DQ080209    AAY84557.1    GAPW01005354    JAC08244.1    MH028092    AXY04261.1    GECZ01018697    JAS51072.1    DQ845755    ABI64121.1    ODYU01012310    SOQ58561.1    CH477308    EAT44034.1    JXUM01078336    JXUM01078337    JXUM01078338    KQ563059    KXJ74559.1    JTDY01007633    JTDY01000351    KOB65058.1    KOB77585.1    DQ845756    ABI64122.1    EAT44035.1    KQ460211    KPJ16547.1    ODYU01010158    SOQ55080.1    AGBW02013503    OWR43321.1    SOQ55081.1    GEDC01030647    JAS06651.1    SOQ58560.1    HQ451072    AEE43936.1    KPJ16548.1    MH028093    AXY04262.1    KQ459583    KPI98655.1    KC340942    AGH25574.1    PYGN01000490    PSN45461.1    KC340941    AGH25573.1    KPJ16544.1    DS231859    EDS39071.1    D13925    MH028095    AXY04264.1    NWSH01001233    PCG72024.1    GFDL01008510    JAV26535.1    GFDL01008831    JAV26214.1    KOB65059.1    PCG72023.1    KZ149928    PZC77476.1    GECU01031447    JAS76259.1    GFDL01008539    JAV26506.1    GECU01031259    JAS76447.1    GFDL01010002    JAV25043.1    GFDL01010137    JAV24908.1    GFDL01008922    JAV26123.1    NWSH01003834    PCG65779.1    KC340943    AGH25575.1    GFDL01009760    JAV25285.1    GECU01028338    JAS79368.1    NWSH01001540    PCG70919.1   

Proteomes

UP000005204    UP000008820    UP000069940    UP000249989    UP000037510    UP000053240    + More
UP000007151    UP000053268    UP000245037    UP000002320    UP000218220   

PRIDE

H9JRY3    P26730    P21808    H9JRY4    P26732    H9JQX3    + More
P26726    P26729    O61271    P26728    P26727    P15411    P26731    H9JR12    P26737    H9JY77    P26736    H9JY78    P26733    P29519    P26741    P26734    P26738    P15410    P26740    Q17194    P26735    P26742    H9JY76    H9JQX2    Q17193    H9JQX4    P91896    P26743    P26739    B9A0V1    Q17196    H9JR11   

Pfam

PF00049   Insulin

Interpro

IPR022353   Insulin_CS        + More
IPR036438   Insulin-like_sf       
IPR016179   Insulin-like       
IPR040228   Insulin-relat-peptide_inver       
IPR022352   Insulin_family       
IPR017097   Bombyxin       
IPR030680   Bombyxin_A       
IPR027285   Bombyxin_B       
IPR016724   Insulin-rel_pep       

SUPFAM

SSF56994   SSF56994       

ProteinModelPortal

H9JRY3   P26730   P21808   H9JRY4   P26732   H9JQX3   + More
P26726   P26729   O61271   P26728   P26727   P15411   Q17192   P26731   H9JR12   P33721   P26737   H9JY77   P26736   H9JY78   P26733   P29519   P26741   P26734   P26738   P15410   P26740   P33722   Q17194   P26735   P26742   H9JY76   H9JQX2   Q17193   A0A2H1WD29   A0A2H1WTS8   A0A2H1WLR7   H9JQX4   P91896   P26743   A0A2H1WD32   Q53X51   P26739   M4QC54   C0HKS5   B9A0V1   C0HKS4   A0A385H8W9   Q17196   O09209   H9JR11   A0A1B6MM39   Q4JJX8   A0A023EHB8   A0A385H8W6   A0A1B6FLK7   A0EZS0   A0A2H1WZT3   Q17CI7   A0A182GPE5   A0A1S4F886   A0A0L7KP19   Q17CI6   A0A1S4F823   A0A194RG26   A0A2H1WPT3   A0A212EPD8   A0A2H1WPS9   A0A1B6BZF9   A0A2H1WZM1   F6KMX2   A0A194RFE4   A0A385H8X0   A0A194Q5I3   C0HKS3   M4QEN0   A0A2P8YMI6   M4QNU1   A0A194RGH1   B0W8M1   P33720   A0A385H8W3   A0A2A4JKA0   A0A1Q3FG68   A0A1Q3FF89   A0A0L7KQ08   A0A2A4JKR2   A0A2W1BXR4   A0A1B6HNK2   A0A1Q3FG25   A0A1B6HP34   A0A1Q3FC17   A0A1Q3FBN3   A0A1Q3FEZ9   A0A2A4J1N6   M4QG01   A0A1Q3FCI0   A0A1B6HXG0   A0A2A4JGH3  

PDB

1BON     E-value=0.0223617,     Score=81

KEGG

NA   

GO

GO:0005179   GO:0005576   GO:0005615   GO:0008083   GO:0007218   GO:0018445   GO:0016021   GO:0030126   GO:0005488   GO:0003677   GO:0003707   GO:0007169  

PANTHER

PTHR13647  

Subcellular location

Secreted  

SignalP

Position:   1 - 17,         Likelihood:  0.996347

 

 

Length:

94

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.15272

Exp number, first 60 AAs:

0.15272

Total prob of N-in:

0.06454

outside

1  -  94

 

 

Pi

12.947227

Theta

11.049437

Tajima's D

0.507535

CLR

0

CSRT

0.527423628818559

Interpretation

Uncertain