Gene

KWMTBOMO00488

Pre Gene Modal

BGIBMGA012294

Annotation

bombyxin_E-1_precursor_[Bombyx_mori]

Location

Bomo_Chr1(-):14010869-14011317      View in EpiBrowser

Full name

Bombyxin E-1       + More
Bombyxin A-7      
Bombyxin A      
Bombyxin A-6      
Bombyxin A-1      
Bombyxin A-4      
Bombyxin A-9      
Bombyxin A-3      
Bombyxin A-5      
Bombyxin B-12      
Bombyxin G-1      
Bombyxin A-8      
Bombyxin A-2      
Bombyxin D-1      
Bombyxin B-3      
Bombyxin B-7      
Bombyxin C-1      
Bombyxin B-2      
Bombyxin B      
Bombyxin B-1      
Bombyxin B-4      
Bombyxin B-10      
Bombyxin B-6      
Bombyxin F-1      
Bombyxin C-2      
Bombyxin B-9      
Bombyxin B-8      
Bombyxin B-5      
Bombyxin B-1 homolog      
Bombyxin B-11      
Insulin-related peptide 2      
Bombyxin B-2 homolog      
Bombyxin-related peptide A      
Bombyxin-related peptide B      
Bombyxin A-2 homolog      
Bombyxin A-3 homolog      
Insulin-related peptide 1      
Bombyxin A-1 homolog      

Alternative Name

4K-prothoracicotropic hormone IV
Bombyxin IV
4K-prothoracicotropic hormone
Bombyxin-II
ABRP

Location in the cell

Extracellular   Reliability : 4.381

CDS

ATGAATTGTCCAGTGTTTCTGGTGCTTCTGTTGACCGGCTTTCTTTGTATCGCGGCGCAAGAGGCAAACGTAGCACACCATTACTGTGGCAGGCATCTGGCGAATACTCTAGCAGATTTGTGTTGGGACACGAGTGCGGAGAAACGCAGCGAAAGTTCTTTGGCCAGCTACAGCAGCCGAGGCTGGCCTTGGTTGCCGACACCGAATTTCAACAAACGCGCCATCAAGAAACGCGGCGTCGTTGATGAGTGTTGCATCCAGCCCTGCACTTTAGACGTACTGGCGACTTATTGTTAA

Protein

MNCPVFLVLLLTGFLCIAAQEANVAHHYCGRHLANTLADLCWDTSAEKRSESSLASYSSRGWPWLPTPNFNKRAIKKRGVVDECCIQPCTLDVLATYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Direct protein sequencing   Disulfide bond   Hormone   Pyrrolidone carboxylic acid   Reference proteome   Secreted   Signal   3D-structure   Amidation   Neuropeptide  

Feature

peptide  Bombyxin E-1 B chain
propeptide  C peptide like
chain  Bombyxin A

Uniprot

H9JRY4   P21808   P26730   H9JQX3   P26729   Q17192   + More
P26727   P26732   P26726   P26728   P29519   H9JY76   O61271   P26731   P15411   P26736   P26737   P26741   P15410   P26734   H9JY78   H9JR12   P26733   H9JY77   P26738   Q17194   H9JQX2   H9JQX4   H9JRY3   P26740   B9A0V1   P91896   H9JR11   P26735   Q17193   P26743   P26742   A0A194RGH1   M4QC54   Q53X51   P26739   A0A0L7KP19   A0A2H1WZM1   P33721   Q4JJX8   A0A385H8W3   A0A385H8W6   A0A194RKP6   Q17196   C0HKS4   A0A194Q039   P33722   A0A194RFE4   A0A2H1WPS9   O09209   O09210   A0A194RGU3   A0A385H8X0   P33719   F6KMX2   A0A194RFD7   M4QEN0   A0A0L7L7G8   A0A194PZA6   A0A2H1WZT3   A0A2H1WLR7   A0A2H1WD29   A0A2H1WD32   A0A2H1WTS8   A0A212EPD8   A0A194Q0Y1   A0A194Q5I3   P33720   C0HKS3   A0A2A4JKR2   A0A385H8W9   M4QNU1   A0A2W1BXR4   A0A194RG26   H9ITT7   A0A194PZ95   A0A2H1WPT3   A0A212F2W7   A0A023EHB8   F8WTP8   P33718   A0A182GPE5   S4NYE8   A0A212EI08   A0A2A4JGH3   A0A385H8W5   A0A2H1X245   A0A2A4JKA0   A0EZS0   A0A2W1BUP0   F6KMX3   A0A1S4F823   Q17CI6   Q17CI7  

Pubmed

19121390    9253178    1515030    8683595    16593744    7473749    + More
2674935    9732555    2708384    9401466    26354079    26227816    1601275    30171635    29466015    8673077    17559850    22118469    28756777    24945155    26483478    23622113    16934367    17510324   

EMBL

BABH01016939    D78138    D00772    D00773    BABH01028595    D00771    + More
D00340    D00769    D00776    M26069    D00770    D00789    BABH01042454    AB010380    AB010381    D00774    D00775    J04727    M26068    D00797    AB003905    D00778    D00782    D00783    D00790    D00791    J04728    BABH01042456    D00779    D00787    BABH01028597    BABH01028594    D00781    AB360450    AB360451    AB360452    AB360453    AB360454    BAH16557.1    AB001049    AB001050    D00792    D00777    BAA00673.1    D00785    D00784    KQ460211    KPJ16544.1    KC340940    AGH25572.1    D00786    BAA00682.1    D00780    JTDY01007633    JTDY01000351    KOB65058.1    KOB77585.1    ODYU01012310    SOQ58560.1    D13923    DQ080209    AAY84557.1    MH028095    AXY04264.1    MH028092    AXY04261.1    KPJ16546.1    D00788    KQ459583    KPI98658.1    D13924    KPJ16548.1    ODYU01010158    SOQ55081.1    D63147    D63146    D63148    BAA20092.1    KPJ16545.1    MH028093    AXY04262.1    HQ451072    AEE43936.1    KPJ16543.1    KC340942    AGH25574.1    JTDY01002420    KOB71447.1    KPI98656.1    SOQ58561.1    ODYU01009526    SOQ54023.1    ODYU01007848    SOQ50980.1    ODYU01007998    SOQ50979.1    SOQ51243.1    ODYU01011005    SOQ56475.1    AGBW02013503    OWR43321.1    KPI98654.1    KPI98655.1    D13925    NWSH01001233    PCG72023.1    MH028097    AXY04266.1    KC340941    AGH25573.1    KZ149928    PZC77476.1    KPJ16547.1    BABH01006963    KPI98657.1    SOQ55080.1    AGBW02013861    AGBW02010668    OWR42608.1    OWR48079.1    GAPW01005354    JAC08244.1    AB661462    BAK57501.1    JXUM01078336    JXUM01078337    JXUM01078338    KQ563059    KXJ74559.1    GAIX01011802    JAA80758.1    AGBW02014744    OWR41114.1    NWSH01001540    PCG70919.1    MH028098    AXY04267.1    ODYU01012871    SOQ59389.1    PCG72024.1    DQ845755    ABI64121.1    KZ149897    PZC78689.1    HQ451073    AEE43937.1    DQ845756    CH477308    ABI64122.1    EAT44035.1    EAT44034.1   

Proteomes

UP000005204    UP000053240    UP000037510    UP000053268    UP000007151    UP000218220    + More
UP000069940    UP000249989    UP000008820   

PRIDE

H9JRY4    P21808    P26730    H9JQX3    P26729    P26727    + More
P26732    P26726    P26728    P29519    H9JY76    O61271    P26731    P15411    P26736    P26737    P26741    P15410    P26734    H9JY78    H9JR12    P26733    H9JY77    P26738    Q17194    H9JQX2    H9JQX4    H9JRY3    P26740    B9A0V1    P91896    H9JR11    P26735    Q17193    P26743    P26742    P26739    Q17196    P33719    H9ITT7    F8WTP8   

Pfam

PF00049   Insulin

Interpro

IPR040228   Insulin-relat-peptide_inver        + More
IPR017097   Bombyxin       
IPR016179   Insulin-like       
IPR022353   Insulin_CS       
IPR022352   Insulin_family       
IPR036438   Insulin-like_sf       
IPR030680   Bombyxin_A       
IPR027285   Bombyxin_B       
IPR016724   Insulin-rel_pep       

SUPFAM

SSF56994   SSF56994       

ProteinModelPortal

H9JRY4   P21808   P26730   H9JQX3   P26729   Q17192   + More
P26727   P26732   P26726   P26728   P29519   H9JY76   O61271   P26731   P15411   P26736   P26737   P26741   P15410   P26734   H9JY78   H9JR12   P26733   H9JY77   P26738   Q17194   H9JQX2   H9JQX4   H9JRY3   P26740   B9A0V1   P91896   H9JR11   P26735   Q17193   P26743   P26742   A0A194RGH1   M4QC54   Q53X51   P26739   A0A0L7KP19   A0A2H1WZM1   P33721   Q4JJX8   A0A385H8W3   A0A385H8W6   A0A194RKP6   Q17196   C0HKS4   A0A194Q039   P33722   A0A194RFE4   A0A2H1WPS9   O09209   O09210   A0A194RGU3   A0A385H8X0   P33719   F6KMX2   A0A194RFD7   M4QEN0   A0A0L7L7G8   A0A194PZA6   A0A2H1WZT3   A0A2H1WLR7   A0A2H1WD29   A0A2H1WD32   A0A2H1WTS8   A0A212EPD8   A0A194Q0Y1   A0A194Q5I3   P33720   C0HKS3   A0A2A4JKR2   A0A385H8W9   M4QNU1   A0A2W1BXR4   A0A194RG26   H9ITT7   A0A194PZ95   A0A2H1WPT3   A0A212F2W7   A0A023EHB8   F8WTP8   P33718   A0A182GPE5   S4NYE8   A0A212EI08   A0A2A4JGH3   A0A385H8W5   A0A2H1X245   A0A2A4JKA0   A0EZS0   A0A2W1BUP0   F6KMX3   A0A1S4F823   Q17CI6   Q17CI7  

PDB

1BON     E-value=0.00399072,     Score=88

KEGG

100146109    K04526 insulin | (RefSeq) Bbx-e1, BBXE1; bombyxin E1

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0005179   GO:0008083   GO:0005615   GO:0005576   GO:0007218   GO:0016021   GO:0018445   GO:0030126   GO:0005488   GO:0003677   GO:0003707   GO:0007169  

PANTHER

PTHR13647  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.996576

 

 

Length:

98

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

10.53509

Exp number, first 60 AAs:

10.53445

Total prob of N-in:

0.30469

POSSIBLE N-term signal

sequence

outside

1  -  98

 

 

Pi

16.999101

Theta

20.938871

Tajima's D

-0.573265

CLR

0.013875

CSRT

0.224688765561722

Interpretation

Uncertain