Gene

KWMTBOMO00486  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012295

Annotation

Cdc42_[Spodoptera_litura]

Location

Bomo_Chr1(-):13926195-13930837      View in EpiBrowser

Full name

Cdc42 homolog      

Alternative Name

25 kDa GTP-binding protein

Location in the cell

Cytoplasmic   Reliability : 1.663 Extracellular   Reliability : 1.988

CDS

ATGCAGACAATAAAATGTGTTGTTGTGGGTGATGGTGCTGTTGGTAAAACATGTCTTCTGATCAGCTATACAACTAACAAATTTCCATCAGAGTATGTTCCAACTGTATTTGATAACTACGCAGTCACTGTCATGATTGGAGGTGAACCTTACACTCTAGGTCTTTTTGATACTGCAGGTCAGGAAGATTATGACAGGCTAAGACCACTGAGTTATCCTCAAACAGATGTTTTCCTTGTATGCTTCAGTGTTGTGAGCCCTAGTTCATTTGAAAATGTAAAGGAAAAGTGGGTCCCTGAAATAACTCATCATCAACAGAAGACACCGTTTTTGTTGGTTGGGACGCAAATAGACTTGCGCGATGATTCGGCTACAATGGAGAAACTTGCTAAAATAAAACAGAAGCCGGTTTCATTGGAACAAGGAGAGAAATTGGCAAAAGAGCTTAAGGCTGTCAAATATGTAGAATGCTCAGCGCTTACCCAGAAAGGTTTAAAGAACGTGTTCGACGAGGCTATACTTGCTGCACTGGAGCCTCCGGAACCAGCAAAGAAAAAGAAGTGTGTCCTTTTGTAA

Protein

MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHQQKTPFLLVGTQIDLRDDSATMEKLAKIKQKPVSLEQGEKLAKELKAVKYVECSALTQKGLKNVFDEAILAALEPPEPAKKKKCVLL

Description

Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).
Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions (PubMed:12490550). Together with mbt and Frl, regulates photoreceptor cell morphogenesis (PubMed:12490550, PubMed:26801180). Together with Frl, has a role in the neuronal development of mushroom bodies (PubMed:26801180).

Subunit

Interacts with Frl (via GBD/FH3 domain); the interaction is stronger with the GTP bound form of Cdc42 (PubMed:26801180). The GTP-bound but not the GDP-bound form interacts with mbt and gek (PubMed:9371783, PubMed:12490550).

Similarity

Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.

Keywords

Cell junction   Cell membrane   Complete proteome   Developmental protein   GTP-binding   Lipoprotein   Membrane   Methylation   Nucleotide-binding   Prenylation   Reference proteome  

Feature

chain  Cdc42 homolog
propeptide  Removed in mature form

Uniprot

H9JRY5   A0A2A4J3X5   A0A2H1WKE4   A0A059VBH0   A0A1E1W6W5   A0A194QU25   + More
A0A194PL43   A0A212EQJ9   E0VSX8   A0A0L7RAR9   R4WRF3   A0A067R1U4   A0A310SD05   A0A165VG29   A0A2A3E1I2   V5GKL4   N6TXA1   D6WN12   A0A2J7PTR6   A0A1B6GPR3   A0A1B6KK31   A0A1B6J2Q1   A0A1B6FTP5   A0A0K8VS38   A0A023GFP5   G3MKJ3   A0A1E1XJY3   A0A023FF98   L7M3T4   A0A023FUE4   A0A1E1WZ55   A0A224YT61   A0A131Z5G9   A0A131XMD5   W8AM21   A0A034WPG8   A0A0A1WMH4   A0A1W4W8W6   B7PHY7   A0A1B6LTH8   A0A154PP51   A0A0B4J2U1   A0A1S3CZK2   A0A195BRR0   A0A182XWZ5   A0A2M3ZGJ9   A0A2M4A9C9   A0A1Y1KT91   A0A182MGD6   A0A182QIQ5   A0A182VG73   W5JCL2   A0A182NFH5   A0A182K8T7   A0A182UJ57   A0A084VU61   A0A182J293   A0A182LF64   A0A182XI45   F5HK45   A0A182R9Y3   A0A182HT27   Q17031   A0A1A9YJ86   A0A1A9USV0   A0A1B0BCT9   A0A1A9WDQ6   D3TMK2   A0A1S3JM06   T1KKJ9   A0A1L8E4W7   A0A151IEJ7   A0A195EFX4   F4WQW1   A0A158NTJ8   A0A151X3C5   A0A1J1HH80   A0A0P6IHI2   A0A0K8TPP1   B4NQ65   B3MQD0   A0A1W4VTT8   B4R7S5   A0A3B0JXC3   A0A0R3P4F3   B4H4Q6   B4PZD5   B3NVS8   Q29HY3   A0A1Q3G3E7   T1DIT8   Q16YG0   M9NFF8   P40793   H9LJ43   K1PJ53   A0A2R5LJX9   A0A1Z5L6Q1   T1E8E5   A0A154P356  

Pubmed

19121390    24866850    26354079    22118469    20566863    23691247    + More
24845553    23537049    18362917    19820115    22216098    29209593    25576852    28503490    28797301    26830274    28049606    24495485    25348373    25830018    20075255    25244985    28004739    20920257    23761445    24438588    20966253    12364791    14747013    17210077    8917545    20353571    21719571    21347285    26369729    17994087    18057021    15632085    17550304    24330624    17510324    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    7958857    10772800    12537569    9371783    12490550    26801180    22484279    22992520    28528879   

EMBL

BABH01016932    NWSH01003565    PCG66103.1    ODYU01009260    SOQ53553.1    KJ547700    + More
AHZ89304.1    GDQN01008341    GDQN01005206    JAT82713.1    JAT85848.1    KQ461108    KPJ09033.1    KQ459605    KPI91825.1    AGBW02013269    OWR43731.1    DS235758    EEB16484.1    KQ414617    KOC68017.1    AK417262    BAN20477.1    KK853090    KDR11574.1    KQ776822    OAD52173.1    KT984806    AMZ00358.1    KZ288496    PBC25182.1    GALX01003847    JAB64619.1    APGK01051402    KB741190    KB632094    ENN73011.1    ERL88706.1    KQ971343    EFA03253.1    NEVH01021221    PNF19725.1    GECZ01005343    JAS64426.1    GEBQ01028192    JAT11785.1    GECU01032386    GECU01014264    JAS75320.1    JAS93442.1    GECZ01016189    JAS53580.1    GDHF01027837    GDHF01010608    JAI24477.1    JAI41706.1    GBBM01002691    JAC32727.1    JO842394    AEO34011.1    GFAA01004113    JAT99321.1    GBBK01003861    JAC20621.1    GACK01006048    JAA58986.1    GBBL01002028    JAC25292.1    GFAC01006883    JAT92305.1    GFPF01006625    MAA17771.1    GEDV01001990    JAP86567.1    GEFH01000362    JAP68219.1    GAMC01019593    JAB86962.1    GAKP01003309    JAC55643.1    GBXI01014669    JAC99622.1    ABJB010057131    DS715571    EEC06209.1    GEBQ01013003    JAT26974.1    KQ434977    KZC12950.1    AAZX01008259    KQ976424    KYM88626.1    GGFM01006923    MBW27674.1    GGFK01004085    MBW37406.1    GEZM01074314    GEZM01074313    JAV64603.1    AXCM01006797    AXCN02000213    ADMH02001552    GGFL01004220    ETN62087.1    MBW68398.1    ATLV01016645    KE525099    KFB41505.1    AXCP01001391    AAAB01008859    EGK96886.1    EGK96887.1    APCN01000403    Z69980    JXJN01012114    CCAG010004713    EZ422654    ADD18930.1    CAEY01000176    GFDF01000311    JAV13773.1    KQ977870    KYM99231.1    KQ978983    KYN26794.1    GL888275    EGI63474.1    ADTU01025983    KQ982562    KYQ54891.1    CVRI01000002    CRK86914.1    GDIQ01004330    JAN90407.1    GDAI01001510    JAI16093.1    CH964291    EDW86290.1    CH902621    EDV44556.1    KPU81636.1    CM000366    EDX18408.1    OUUW01000011    SPP86715.1    CH379064    KRT06405.1    CH479209    EDW32668.1    CM000162    EDX02091.1    CH954180    EDV46743.1    EAL31624.1    GFDL01000720    JAV34325.1    GALA01000766    JAA94086.1    CH477516    EAT39696.1    AE014298    AFH07474.1    AFH07475.1    U11824    AF153423    AF153424    AF153425    AF153426    AF153427    AF153428    AF153429    AY119570    JF919360    AEF33422.1    JH818665    JH816127    EKC18954.1    EKC28126.1    GGLE01005727    MBY09853.1    GFJQ02003877    JAW03093.1    GAMD01002247    JAA99343.1    KQ434809    KZC06369.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000009046    + More
UP000053825    UP000027135    UP000242457    UP000019118    UP000030742    UP000007266    UP000235965    UP000192223    UP000001555    UP000076502    UP000002358    UP000079169    UP000078540    UP000076408    UP000075883    UP000075886    UP000075903    UP000000673    UP000075884    UP000075881    UP000075902    UP000030765    UP000075880    UP000075882    UP000076407    UP000007062    UP000075900    UP000075840    UP000092443    UP000078200    UP000092460    UP000091820    UP000092444    UP000085678    UP000015104    UP000078542    UP000078492    UP000007755    UP000005205    UP000075809    UP000183832    UP000007798    UP000007801    UP000192221    UP000000304    UP000268350    UP000001819    UP000008744    UP000002282    UP000008711    UP000008820    UP000000803    UP000005408   

PRIDE

H9JRY5    B7PHY7    Q17031    Q29HY3    Q16YG0    M9NFF8    + More
P40793   

Pfam

PF00071   Ras

Interpro

IPR003578   Small_GTPase_Rho        + More
IPR037874   Cdc42       
IPR005225   Small_GTP-bd_dom       
IPR001806   Small_GTPase       
IPR027417   P-loop_NTPase       

SUPFAM

SSF52540   SSF52540       

CDD

cd01874  Cdc42

ProteinModelPortal

H9JRY5   A0A2A4J3X5   A0A2H1WKE4   A0A059VBH0   A0A1E1W6W5   A0A194QU25   + More
A0A194PL43   A0A212EQJ9   E0VSX8   A0A0L7RAR9   R4WRF3   A0A067R1U4   A0A310SD05   A0A165VG29   A0A2A3E1I2   V5GKL4   N6TXA1   D6WN12   A0A2J7PTR6   A0A1B6GPR3   A0A1B6KK31   A0A1B6J2Q1   A0A1B6FTP5   A0A0K8VS38   A0A023GFP5   G3MKJ3   A0A1E1XJY3   A0A023FF98   L7M3T4   A0A023FUE4   A0A1E1WZ55   A0A224YT61   A0A131Z5G9   A0A131XMD5   W8AM21   A0A034WPG8   A0A0A1WMH4   A0A1W4W8W6   B7PHY7   A0A1B6LTH8   A0A154PP51   A0A0B4J2U1   A0A1S3CZK2   A0A195BRR0   A0A182XWZ5   A0A2M3ZGJ9   A0A2M4A9C9   A0A1Y1KT91   A0A182MGD6   A0A182QIQ5   A0A182VG73   W5JCL2   A0A182NFH5   A0A182K8T7   A0A182UJ57   A0A084VU61   A0A182J293   A0A182LF64   A0A182XI45   F5HK45   A0A182R9Y3   A0A182HT27   Q17031   A0A1A9YJ86   A0A1A9USV0   A0A1B0BCT9   A0A1A9WDQ6   D3TMK2   A0A1S3JM06   T1KKJ9   A0A1L8E4W7   A0A151IEJ7   A0A195EFX4   F4WQW1   A0A158NTJ8   A0A151X3C5   A0A1J1HH80   A0A0P6IHI2   A0A0K8TPP1   B4NQ65   B3MQD0   A0A1W4VTT8   B4R7S5   A0A3B0JXC3   A0A0R3P4F3   B4H4Q6   B4PZD5   B3NVS8   Q29HY3   A0A1Q3G3E7   T1DIT8   Q16YG0   M9NFF8   P40793   H9LJ43   K1PJ53   A0A2R5LJX9   A0A1Z5L6Q1   T1E8E5   A0A154P356  

PDB

5C2J     E-value=4.65441e-87,     Score=815

KEGG

101742319    K04393 cell division control protein 42 | (RefSeq) cdc42 homolog

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0005525   GO:0003924   GO:0007264   GO:0042995   GO:0008360   GO:0005886   GO:0007015   GO:0030031   GO:0005938   GO:0007163   GO:0032488   GO:0007266   GO:0006897   GO:0032956   GO:0005737   GO:0030036   GO:0019901   GO:0051301   GO:0004767   GO:0005912   GO:0007275   GO:0007286   GO:0030011   GO:0008045   GO:0030866   GO:0048813   GO:0051601   GO:0016318   GO:0007274   GO:0048675   GO:0045177   GO:0060446   GO:0046330   GO:0045200   GO:0005634   GO:0035099   GO:0050770   GO:0045185   GO:0030833   GO:0090303   GO:0010592   GO:0030041   GO:0030027   GO:0035011   GO:0007391   GO:0032794   GO:0097206   GO:0031532   GO:0050975   GO:0008582   GO:0042060   GO:0035318   GO:0046843   GO:0016028   GO:0006909   GO:0045860   GO:0030426   GO:0051491   GO:0048010   GO:0072659   GO:0007411   GO:0030707   GO:0048477   GO:0007349   GO:0007409   GO:0009611   GO:0030424   GO:0048812   GO:0007179   GO:0031175   GO:0016192   GO:0035010   GO:0005515   GO:0008270   GO:0030126   GO:0005488   GO:0003677   GO:0003707   GO:0007169   GO:0016021  

Subcellular location

Cell junction  
Adherens junction  
Cell membrane  

Length:

191

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.25725

Exp number, first 60 AAs:

0.25301

Total prob of N-in:

0.21798

outside

1  -  191

 

 

Pi

15.58678

Theta

16.965683

Tajima's D

-1.146934

CLR

0.417047

CSRT

0.107444627768612

Interpretation

Uncertain