Gene

KWMTBOMO00473  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012298

Annotation

6-phosphogluconate_dehydrogenase_[Bombyx_mori]

Location

Bomo_Chr1(-):13750104-13764940      View in EpiBrowser

Full name

6-phosphogluconate dehydrogenase, decarboxylating      

Location in the cell

Cytoplasmic   Reliability : 1.666 Mitochondrial   Reliability : 1.235

CDS

ATGCCTCAGAATGAAGCTGATATTGCACTCATAGGTTTGGCTGTTATGGGTCAAAATCTAATACTCAATATGAATGACAAGGGTTATGTTGTCTGCGCGTTTAATAGAACAGTGTCAAAGGTAGAGGAATTTCTAAAAAATGAAGCTAAGGGTACAAAAGTGATTGGGGCTACCTCCTTGGATGACATGGTATCTAAACTAAAAAGGCCAAGGAAAATTGTTCTTTTGGTAAAAGCTGGATTTGCTGTTGACGAGTTTGTGAAAAAGCTAATACCACTTTTAAGCAAAGGTGATATTATAATTGATGGTGGTAATTCACAATACTTAGACACACAGAAATGGTGTAAAGAGTTGTCAGGGACAGGAATACTTTATGTTGGAATGGGTGTAAGTGGAGGTGAAGATGGTGCACGATATGGACCATCTTTGATGCCTGGTGGGCATCCTGCTGCATGGCCGCATATAAAAGAAATTTTCCAAGCCATATGCGCTAAAGCTAATGATGAACCGTGCTGTGACTGGGTCGGTGAAGATGGAGCAGGCCATTTTGTCAAAATGGTGCACAATGGAATTGAATATGGTGATATGCAACTTATCTGCGAAGCTTATCATCTTATGAAAGATGTGATAGGTATTGAACAAGATGAAATGGCTAAAGTATTCGACGAGTGGAACAAAGGCGAACTAGATTCATTCTTGATCGAAATCACAAGGGATATTTTGAAATACAAAGACTCAGACGGTAAATATTTGCTACCCAAAATTCGAGATACGGCCGGACAGAAGGGTACCGGAAAATGGACGGGCATCAGCGCCCTGGAATACGGAGTACCTGTGACGCTAATCGGTGAAGCCGTTTTCTCACGTTGTCTCTCGGCTCTGAAAGATGAGCGCCTCGAAGCCAGCAAAGTGCTTCCGGGATCCGGTCACAAGTTCACGGGCGATAAAGTTGCCTTTCTGGAAGACCTGCGGCGAGCTCTGTACGCTAGCAAACTCATTTCTTATGCTCAAGGATTTATGTTGCTACGTGAAGCCGCCAAGGTGAACAAGTGGAATTTGAATTATGGTAGCATAGCTCTGATGTGGCGCGGCGGCTGTATAATACGCAGCGCGTTCCTCGGCAATATCAAGGATGCTTTCACGAAGAATCCTCAGCTGACCAACCTGCTATTGGATCCATTCTTCAGTGAGCGCATCAGTTCGGCTCAGTCCTCGTTGAGAACGGTCGTGGCCCAGGCGGCTCTTGTGGGAGTACCGGCTCCGGCGTTATCGGCGGCGCTCGCTTTCTACGACGGATACAGATCTGGAGTTCTGCCCGCTAATCTATTGCAGGCACAAAGGGATTATTTCGGGGCCCACACATACGAGCTTCTGCACAATCCCGGTCAGTTCATTCACACGAACTGGACCGGGCATGGCGGGAAAATTTCCGCATCGACATACAACAACTGA

Protein

MPQNEADIALIGLAVMGQNLILNMNDKGYVVCAFNRTVSKVEEFLKNEAKGTKVIGATSLDDMVSKLKRPRKIVLLVKAGFAVDEFVKKLIPLLSKGDIIIDGGNSQYLDTQKWCKELSGTGILYVGMGVSGGEDGARYGPSLMPGGHPAAWPHIKEIFQAICAKANDEPCCDWVGEDGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVIGIEQDEMAKVFDEWNKGELDSFLIEITRDILKYKDSDGKYLLPKIRDTAGQKGTGKWTGISALEYGVPVTLIGEAVFSRCLSALKDERLEASKVLPGSGHKFTGDKVAFLEDLRRALYASKLISYAQGFMLLREAAKVNKWNLNYGSIALMWRGGCIIRSAFLGNIKDAFTKNPQLTNLLLDPFFSERISSAQSSLRTVVAQAALVGVPAPALSAALAFYDGYRSGVLPANLLQAQRDYFGAHTYELLHNPGQFIHTNWTGHGGKISASTYNN

Description

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.

Catalytic Activity

6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH

Subunit

Homodimer.

Similarity

Belongs to the 6-phosphogluconate dehydrogenase family.

Feature

chain  6-phosphogluconate dehydrogenase, decarboxylating

Uniprot

Q1HPX8   A0A2H1X2E4   A0A2A4J5Z7   A0A2A4J542   A0A212EQI3   S4NIL1   + More
A0A194PL38   I6P139   A0A1B6F0W7   A0A1B6HIT5   A0A158NK91   F4W8J1   T1K9E7   A0A151X6V2   A0A195BAY0   A0A194QU92   W5MI18   Q6TNR8   Q803T9   A0A2P2I197   W5MI34   V9KQ70   A0A026WU10   A0A3B3SU84   F1Q883   A0A088AKI3   A0A2A3EKM5   A0A195FAL7   K1RH70   A0A0M8ZX98   R7TUN9   A0A151I7Q1   A0A195EIU9   A0A1I9WLK7   V4AME8   Q502S9   A0A2J7PJI5   A0A369RWD7   B3S0A8   A0A3P9A0E2   A0A093Q7T4   A0A3L8RZ58   G7MGT9   A0A091FU90   A0A0L7R089   A0A1S3H7B5   A0A1W4XIW3   H2ZK97   A0A3B1KDT6   A0A218UQ91   A0A1V4KNW5   A0A093QYB3   A0A087QL53   U3FWE2   A0A0Q3LZI4   A0A1W7RJS3   G1NSQ2   A0A091UV65   A0A094L8Z0   A0A2D4NKB9   A0A0K8RYJ6   A0A1S3AIN1   A0A091N4P4   A0A093NSZ2   A0A232FD60   A0A091R712   A0A210Q2Q9   A0A0K2UC83   K7J4Y2   A0A226PBW1   A0A3B4D0B3   J3S0H5   Q6PB25   A0A2R5LL78   A0A1W7RB71   A0A226MN94   A0A0A0ATS0   A0A093HJ89   A0A1S5R934   A0A3B4FFJ5   A0A099ZL80   A0A093GYU9   Q5ZIZ0   H2TZH2   A0A091VCK2   I3J231   A0A293N293   M7CKD0   Q4RVN6   A0A340XPE0   F7DHT9   A0A3P8RAC9   A0A3P9C746   A0A3B4AKB1   A0A2D0SKL7   G3NW14   A0A2U4AZR9   A0A3B4ZWB2   A0A091IM62   A0A093C8B3  

EC Number

1.1.1.44

Pubmed

22118469    23622113    26354079    23569222    21347285    21719571    + More
15520368    24402279    24508170    30249741    29240929    23594743    22992520    23254933    27538518    30042472    18719581    25069045    30282656    22002653    25329095    23915248    26358130    21993624    25727380    28648823    28812685    20075255    24621616    23025625    27762356    15592404    15642098    21551351    25186727    23624526    15496914    17495919    25463417   

EMBL

DQ443274    ABF51363.1    ODYU01012939    SOQ59489.1    NWSH01003022    PCG67098.1    + More
PCG67101.1    AGBW02013269    OWR43737.1    GAIX01014024    JAA78536.1    KQ459605    KPI91820.1    JQ771338    AFD93369.1    GECZ01026028    JAS43741.1    GECU01033231    JAS74475.1    ADTU01018741    GL887908    EGI69482.1    CAEY01001890    KQ982472    KYQ56117.1    KQ976537    KYM81349.1    KQ461108    KPJ09037.1    AHAT01009824    AHAT01009825    AY391449    AAQ91261.1    BC044196    BC165755    AAH44196.1    AAI65755.1    IACF01002154    LAB67817.1    JW867961    AFP00479.1    KK107105    QOIP01000011    EZA59468.1    RLU16678.1    BX957303    CR381616    KZ288217    PBC32373.1    KQ981693    KYN37665.1    JH818113    EKC40830.1    KQ435808    KOX72985.1    AMQN01010781    KB308507    ELT97633.1    KQ978406    KYM94161.1    KQ978881    KYN27789.1    KU932391    APA34027.1    KB201750    ESO94806.1    BC095571    AAH95571.1    NEVH01024949    PNF16478.1    NOWV01000158    RDD38850.1    DS985246    EDV23979.1    KL672239    KFW85033.1    QUSF01000135    RLV89920.1    CM001253    EHH14311.1    KK719670    KFO64785.1    KQ414672    KOC64216.1    MUZQ01000186    OWK55778.1    LSYS01002427    OPJ86146.1    KL439748    KFW93878.1    KL225737    KFM01957.1    GAEP01001130    JAB53691.1    LMAW01002900    KQK75896.1    GDAY02000015    JAV51398.1    AAPE02050831    KL410063    KFQ93815.1    KL279380    KFZ67220.1    IACN01004072    LAB46151.1    GBKC01000034    JAG46036.1    KL376705    KFP84376.1    KL225141    KFW67923.1    NNAY01000415    OXU28562.1    KK809760    KFQ34709.1    NEDP02005192    OWF42959.1    HACA01017960    CDW35321.1    AWGT02000102    OXB77234.1    JU175390    GBEX01002451    AFJ50914.1    JAI12109.1    BC059958    CM004478    AAH59958.1    OCT72210.1    GGLE01006158    MBY10284.1    GFAH01000003    JAV48386.1    MCFN01000615    OXB56774.1    KL872854    KGL96928.1    KL206171    KFV79495.1    KX066237    ANJ04914.1    KL894345    KGL81698.1    KL216962    KFV72290.1    AADN05000197    AJ720644    CAG32303.1    KK733826    KFR00153.1    AERX01012597    GFWV01021741    MAA46469.1    KB489737    EMP41532.1    CAAE01014991    CAG07546.1    KL218792    KFP08410.1    KL236597    KFV09274.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000005205    UP000007755    UP000015104    + More
UP000075809    UP000078540    UP000053240    UP000018468    UP000053097    UP000279307    UP000261540    UP000000437    UP000005203    UP000242457    UP000078541    UP000005408    UP000053105    UP000014760    UP000078542    UP000078492    UP000030746    UP000235965    UP000253843    UP000009022    UP000265140    UP000053258    UP000276834    UP000052976    UP000053825    UP000085678    UP000192223    UP000007875    UP000018467    UP000197619    UP000190648    UP000053286    UP000051836    UP000001074    UP000053283    UP000079721    UP000054081    UP000215335    UP000242188    UP000002358    UP000198419    UP000261440    UP000186698    UP000198323    UP000053858    UP000053584    UP000261460    UP000053641    UP000053875    UP000000539    UP000005226    UP000053605    UP000005207    UP000031443    UP000007303    UP000265300    UP000002280    UP000265100    UP000265160    UP000261520    UP000221080    UP000007635    UP000245320    UP000261400    UP000054308   

PRIDE

Q1HPX8    I3J231   

Pfam

PF03446   NAD_binding_2        + More
PF00393   6PGD
PF15630   CENP-S

Interpro

IPR006184   6PGdom_BS        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR008927   6-PGluconate_DH-like_C_sf       
IPR006115   6PGDH_NADP-bd       
IPR006113   6PGDH_Gnd/GntZ       
IPR006114   6PGDH_C       
IPR013328   6PGD_dom2       
IPR006183   Pgluconate_DH       
IPR009072   Histone-fold       
IPR029003   CENP-S/Mhf1       

SUPFAM

SSF51735   SSF51735        + More
SSF48179   SSF48179       
SSF47113   SSF47113       

Gene 3D

1.10.1040.10     1.10.20.10    

ProteinModelPortal

Q1HPX8   A0A2H1X2E4   A0A2A4J5Z7   A0A2A4J542   A0A212EQI3   S4NIL1   + More
A0A194PL38   I6P139   A0A1B6F0W7   A0A1B6HIT5   A0A158NK91   F4W8J1   T1K9E7   A0A151X6V2   A0A195BAY0   A0A194QU92   W5MI18   Q6TNR8   Q803T9   A0A2P2I197   W5MI34   V9KQ70   A0A026WU10   A0A3B3SU84   F1Q883   A0A088AKI3   A0A2A3EKM5   A0A195FAL7   K1RH70   A0A0M8ZX98   R7TUN9   A0A151I7Q1   A0A195EIU9   A0A1I9WLK7   V4AME8   Q502S9   A0A2J7PJI5   A0A369RWD7   B3S0A8   A0A3P9A0E2   A0A093Q7T4   A0A3L8RZ58   G7MGT9   A0A091FU90   A0A0L7R089   A0A1S3H7B5   A0A1W4XIW3   H2ZK97   A0A3B1KDT6   A0A218UQ91   A0A1V4KNW5   A0A093QYB3   A0A087QL53   U3FWE2   A0A0Q3LZI4   A0A1W7RJS3   G1NSQ2   A0A091UV65   A0A094L8Z0   A0A2D4NKB9   A0A0K8RYJ6   A0A1S3AIN1   A0A091N4P4   A0A093NSZ2   A0A232FD60   A0A091R712   A0A210Q2Q9   A0A0K2UC83   K7J4Y2   A0A226PBW1   A0A3B4D0B3   J3S0H5   Q6PB25   A0A2R5LL78   A0A1W7RB71   A0A226MN94   A0A0A0ATS0   A0A093HJ89   A0A1S5R934   A0A3B4FFJ5   A0A099ZL80   A0A093GYU9   Q5ZIZ0   H2TZH2   A0A091VCK2   I3J231   A0A293N293   M7CKD0   Q4RVN6   A0A340XPE0   F7DHT9   A0A3P8RAC9   A0A3P9C746   A0A3B4AKB1   A0A2D0SKL7   G3NW14   A0A2U4AZR9   A0A3B4ZWB2   A0A091IM62   A0A093C8B3  

PDB

4GWK     E-value=0,     Score=1898

KEGG

733113    K00033 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343] | (RefSeq) 6-phosphogluconate dehydr

PATHWAY

00030    Pentose phosphate pathway - Bombyx mori (domestic silkworm)
00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0006098   GO:0019521   GO:0004616   GO:0050661   GO:0009051   GO:0005829   GO:0046177   GO:0016021   GO:0019322   GO:0046982   GO:0071821   GO:0016491   GO:0003676   GO:0030126   GO:0005488   GO:0003677   GO:0003707   GO:0007169   GO:0055114  

PANTHER

PTHR11811  

Length:

483

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.69784

Exp number, first 60 AAs:

0.07405

Total prob of N-in:

0.00917

outside

1  -  483

 

 

Pi

23.569074

Theta

21.669252

Tajima's D

-0.818284

CLR

0.146422

CSRT

0.171741412929354

Interpretation

Uncertain