Gene

KWMTBOMO00444

Pre Gene Modal

BGIBMGA000478

Annotation

PREDICTED:_intraflagellar_transport_protein_122_homolog_[Bombyx_mori]

Location

Bomo_Chr1(-):13077387-13101634      View in EpiBrowser

Full name

Intraflagellar transport protein 122 homolog      

Location in the cell

Cytoplasmic   Reliability : 1.148 PlasmaMembrane   Reliability : 1.418

CDS

ATGAGAACGTTACCAAAATGGGTAAATAAAATTCACGAAGCTGACAAAATTGAGTTTTCTAGTGTCCACACATTATGCTTCAGTCCAGATGGAAGCCAGCTGGTAGTTGGAGCTGGAGAGAAGGTTATGGTTTATGATCCTAGGGATGGATCTCTTCTACAACTGCTGCAGGCCCATAAAGGGGCAGTTCATGCTGTAGCTTATTGTGGAGATGGCAAGAAATTTGCAAGTGGTAGTGCTGACAGGAATGTTATTATTTGGACATCAAAAATGGAAGGCATATTGAAATATTCACACAGTGAAGCAATACAGTGTCTCGCCTACAACCCTGTAACATTTCATTTGGCCTCATGTGCCATTTCTGATTTTGCTTTCTGGTCAATGGACATAAAAGCTGTTCAGAAACATAAAGTTTCTGGGAGAATAACAAGTTGTGCTTGGTCACCAAATGGGCAATATCTGGTAATTGGTTTAGCAAGTGGTGCTGTAACTTTTAGGGATAAAGTAGGCAATGAAATACAACGAATTCTGAGAGAAGCTGCAGTTTGGGCGGTTGCCTTCTCAAAAATGACTTTACTTGTCACTGATTGGAATGAAACACTTTCTTTTTATACAATACAGGGTCAGCAAACACTAAAAGAAAGAAATATTGGAATGGCGGCTGTCTCTATTATGTTACTTGATTCTTTGATCCTCGTTGGTGGTGTGGGGGGATGGGCGATACTCACAGCAGAAGGAGTGCCTATAATTACAACTTCTCAAGATTGGGTTTGGGCAATAGCTCCTTCACCCTCCTTCAATAATATTGCTGTGGCATGTCAAGACGGGACGCTCTGGTGCTATCAAGTTGTGTTCAGTACTGTGCATGGTTTATACCGTGAGAGATACGCTTATAGAGAGAACATGACCGATGTTATAATACAACATCTCACCACCGGTAATAAAGTACGGATTAAATGTCACGACAGAGTACAGAAGATAGCAATTTATAAACATCGACTTGCCGTGCAATTACCAGAACGAGTGGTTGTGTACGAGCAGGGCGACGTTGAGGGAATGCTGTACAGAGTGAGAGAGAAACTTCCCCAAAAATCTGAATGTTCACTATTAGTGGCCACCAGTGACTCATTGCTATTATGTCAGGATACAAAACTTTCAATGATAGGACGTCAAATACCGAAATCCTGGTCGATGCCGGCCCCTATACGATACGTTAAAGTCACATCCTTACGTTTCGAGGAAGTATTACTTTTGGGTCTTATGAACGGAGAGATATGGCAAGTGGAACCGAACAGCGGTGTTTCTATGATGATACTTCAAACGCCCGCGAGCGTTCGTTGTTTAGACGTTAGCGCTTCACGAGGATGCCTTTCCGTAGTCGATGAAGCTTCCACTTGTCGAGTGTACAGTTTACCTAGTGGAGAACTACAGTACACTGAAGAAAATGTATCGTCGGTATCGTGGAATTCTTGGTGCGACGAGCTACTGAGCCTGTCCGGCGGTGGTACGCTGTCGATCAAAGCCGGACATTTTACTTCTGCGACACAACCTCTGATCGGATCAGTTGTAGGGTTTCAGGGTGGACGAGTGTTTTGTCTTCAAGCGAATTCGATGCAAACTATTAACGTACCTTTGTCACATGCTGTACACCAATACATTGAACATAAACTCTTCAATGAAGCGTATGCGGTCGCGTGTCTAGGTGTGACGTCATCGGACTGGGAGCGGCTCGGTGTTGCCGCCCTCGAAGAAATGTCATTCGAAGTTGCTAGAAAAGCATTCCAAAGAAGCGAAAATATTACATTCCTTTCGCTGATCGATAATTTGCAGGAGCGCTTCGATGCGGGCGAGAAACGTGACGTCATACATGGCGAGATACTGGCGTACCGCGGACGCTACACGGACGCCGCGCGGGCCTTCCACAGCGCGGACAGAGACGACCGAGCGCTCAATTTATACGTGGACTTGAGAATGTTCAACAAAGCTCAGGAATACGTCGGTGAGGGGGACGGTTTAGCGGCATTAACGAGACGCCGTGCTGAATGGGCCAGGCACGTGAACGAACCCCGGGCCGCCGCTGAGATGTACCTCGCTGCTGGCGACGTGAAGAGGGCAGCGCAGCTGATGGCCGAGACCGGACGACGTGACATGTTAATAGAATTGGCGCGAAAACTGGACAAGGGTTCGAGCGAGTCGTTGCGCTACGTGGCGGAAGCATTGGAGCAAGCGGGCGAGTTGGCAACCTCCGCTGATGTGTACCAGCGATTAGGAGATTACACAAAAGTTGCTCAGCTAGCGGTGGCCGCGGGCGAATGGTCGAGAGCTTTCTCTCTAGCCCGTGAACAATCTGAGTGCAAACGCGACGTGTACCTACCGTACGCACATAAGATGGCGCAGGAAAACAAATTCATCGAAGCGCAAAAAGCGTATCACATGGCCGGCGAGACCGCGACGGCGATGCGCGTGTTTACGATACTAGTTGGTAACGCCGTTACCGAGGAGCGGTTTAGCGACGCGGGCTACCTGCATCATTTACTGGCCTCGCAGTTTTTGGACACCGCATCTAGTTTAAGCGGCAAGGAACGTCAGAAGAGCCTCAACCAATACGAGTACAACGAGCGTCATGCACGTATATACCACGCGTACGATTCGGTGCATAAATGCGTTCACGAACCGTTCTCTCTGAGCCAGCCCGAGACGTTATTGAACGCAGCTCGCTACATCCTTGCCCTGCTGGACGGGGAAGCACCCCCCGGAGTATCTATGTTCTGTTTGTATCTATGTCTTGCTAAGCAAGCGAAAGCCCTGAGTGCTCACGGCCTAGCACGACAAATGCTAGACAAAATATTGGGACTTCAAATACCACAAAAATTTCAGGAGAGCGTCGAGTTACTTATATTGAAGACTCGTGCCAGTAGTGGCAGCGAGGCTCGAGATGACGAGGTGGCGCCACTGTGCTGGCGTTGTAGAAGACACGCGCCTCCCCTCTGTGCCGCTAGATGTCCGCACTGTCACCACAGCTTAGTACATTCCCTGGCAACACACGAAGTACTACCCCTCGTTCAGTTCAAGCCCGCTGAAGGAATAACACACGAGGAAGCCTTTGATTTGATAGAAAGGACTCCACTGCCTGAAGTTAAGGACGAACAAAATACTAGCGACGCCGAAATATTACGCATAGACCACGAAATCGATTCTAATGACCCCTTTCTCGATAAAGTCGAAGAGGAGGAAGACGAAGGCGTAGTTGTGTGCAGCAGAGGCAACCTCATGCAGTTAAGCCCGGCCAGTGTTGTCATAGTTAAAAGAAATCTCTTTCAACCGTTGTATTTCAGGAATATGCTACCCGAACTTCCGGCTACAGCATGCTCTAACTGTCAAAACCTGTTTTACTTGGAGGATTATGAAATACAGTTGGTAGTGAAAGGCCACTGTCCGTTCTGTCGTCACCCTGCCGAGCATTTGAAGAACGAAGACGACGACGCCGAGGACTCGATGTTAAATGATTCGACAGCATCAACGCCCGGCAGCCCAGGTGATCATCATTCTTGGCGATAG

Protein

MRTLPKWVNKIHEADKIEFSSVHTLCFSPDGSQLVVGAGEKVMVYDPRDGSLLQLLQAHKGAVHAVAYCGDGKKFASGSADRNVIIWTSKMEGILKYSHSEAIQCLAYNPVTFHLASCAISDFAFWSMDIKAVQKHKVSGRITSCAWSPNGQYLVIGLASGAVTFRDKVGNEIQRILREAAVWAVAFSKMTLLVTDWNETLSFYTIQGQQTLKERNIGMAAVSIMLLDSLILVGGVGGWAILTAEGVPIITTSQDWVWAIAPSPSFNNIAVACQDGTLWCYQVVFSTVHGLYRERYAYRENMTDVIIQHLTTGNKVRIKCHDRVQKIAIYKHRLAVQLPERVVVYEQGDVEGMLYRVREKLPQKSECSLLVATSDSLLLCQDTKLSMIGRQIPKSWSMPAPIRYVKVTSLRFEEVLLLGLMNGEIWQVEPNSGVSMMILQTPASVRCLDVSASRGCLSVVDEASTCRVYSLPSGELQYTEENVSSVSWNSWCDELLSLSGGGTLSIKAGHFTSATQPLIGSVVGFQGGRVFCLQANSMQTINVPLSHAVHQYIEHKLFNEAYAVACLGVTSSDWERLGVAALEEMSFEVARKAFQRSENITFLSLIDNLQERFDAGEKRDVIHGEILAYRGRYTDAARAFHSADRDDRALNLYVDLRMFNKAQEYVGEGDGLAALTRRRAEWARHVNEPRAAAEMYLAAGDVKRAAQLMAETGRRDMLIELARKLDKGSSESLRYVAEALEQAGELATSADVYQRLGDYTKVAQLAVAAGEWSRAFSLAREQSECKRDVYLPYAHKMAQENKFIEAQKAYHMAGETATAMRVFTILVGNAVTEERFSDAGYLHHLLASQFLDTASSLSGKERQKSLNQYEYNERHARIYHAYDSVHKCVHEPFSLSQPETLLNAARYILALLDGEAPPGVSMFCLYLCLAKQAKALSAHGLARQMLDKILGLQIPQKFQESVELLILKTRASSGSEARDDEVAPLCWRCRRHAPPLCAARCPHCHHSLVHSLATHEVLPLVQFKPAEGITHEEAFDLIERTPLPEVKDEQNTSDAEILRIDHEIDSNDPFLDKVEEEEDEGVVVCSRGNLMQLSPASVVIVKRNLFQPLYFRNMLPELPATACSNCQNLFYLEDYEIQLVVKGHCPFCRHPAEHLKNEDDDAEDSMLNDSTASTPGSPGDHHSWR

Description

Required for cilia formation during embryonal development. Acts as a negative regulator of Shh signaling.

Subunit

Component of the IFT complex A (IFT-A) complex.

Keywords

Cell projection   Cilium   Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   Reference proteome   Repeat   WD repeat  

Feature

chain  Intraflagellar transport protein 122 homolog

Uniprot

A0A194PFU5   A0A194QM04   A0A212ENY3   A0A2W1BKV7   A0A2A4JRP7   A0A1Y1NAG2   + More
A0A139WM23   A0A2J7QQD6   A0A1B6JCB8   E0VXI8   N6T065   A0A1B6CUB2   U4TUZ8   A0A1B6HU34   A0A210R4J6   A0A0K2TYY3   R7V7Z8   A0A1L8GPM1   A8WGF4   A0A2D0R1D4   A0A2D0R320   A0A1W5AXW4   W5N614   K1PT09   A0A023F232   A0A3B4BR72   A0A146KPJ0   V4C646   A0A3M6UCC7   T1IRE0   A0A3B3SPH2   Q16QM7   Q16I80   C3YV44   B0W847   A0A1J1I849   A7SB90   A0A182GFA9   A0A3P8YRH8   A0A2G8KR45   A0A1S3LH81   A0A182M6X2   A0A182FFE5   A0A182RU59   A0A182QQ17   A0A182WBV6   W5JVK3   A0A182Y7X8   A0A151MK40   A0A1S3EQ38   A0A182NIV7   A0A1S3ENS8   A0A1S3ERH3   A0A0P6K1T1   A0A182JZF7   A0A384CMK6   Q6NYH1   A0A1S3LH78   A0A369S8X9   A0A182TXC9   A0A084WMM3   F1P3M3   A0A182JEW0   A0A182I4C2   A0A1U7V5L8   A0A1U7UW64   A0A2J7QQE1   Q7PP89   U3I985   A0A1U7S1Z1   A0A182V3N7   A0A182LKK0   A0A3B4T7C9   A0A182PRY9   A0A182X4C6   H0V4E1   A0A1S3W3U4   A0A1S2ZC85   A0A2T7NT40   F7BN96   A0A3B4XLU3   F7BNA5   B3RUN6   U3KGW3   A0A2Y9HGY1   H3DKP0   A0A2I0LUB8   W5PYJ7   J9P0G8   G3TTP1   H2TLI6   A0A340XQJ2   K7FKW2   A0A1U7Q3M0   A0A091IH57   A0A091ME41   A0A1U7Q6V9   A0A2M4BAV7  

Pubmed

26354079    22118469    28756777    28004739    18362917    19820115    + More
20566863    23537049    28812685    23254933    27762356    22992520    25474469    26823975    30382153    29240929    17510324    18563158    17615350    26483478    25069045    29023486    20920257    23761445    25244985    22293439    24813606    20493458    30042472    24438588    15592404    12364791    14747013    17210077    23749191    20966253    21993624    20431018    18719581    15496914    23371554    20809919    16341006    21551351    17381049   

EMBL

KQ459605    KPI91903.1    KQ461196    KPJ06394.1    AGBW02013565    OWR43215.1    + More
KZ150110    PZC73360.1    NWSH01000761    PCG74368.1    GEZM01012090    JAV93216.1    KQ971318    KYB28943.1    NEVH01012087    PNF30791.1    GECU01010881    JAS96825.1    DS235832    EEB18094.1    APGK01057395    APGK01057396    KB741280    ENN70898.1    GEDC01020222    JAS17076.1    KB631604    ERL84617.1    GECU01029518    JAS78188.1    NEDP02000459    OWF55875.1    HACA01013220    CDW30581.1    AMQN01005382    KB295903    ELU12491.1    CM004472    OCT85770.1    BC154689    AHAT01029338    JH818077    EKC21994.1    GBBI01003586    JAC15126.1    GDHC01020208    JAP98420.1    KB201338    ESO97099.1    RCHS01001805    RMX51343.1    JH431355    CH477744    EAT36690.1    CH478099    EAT33973.1    GG666556    EEN55760.1    DS231857    EDS38672.1    CVRI01000043    CRK96440.1    DS469614    EDO39045.1    JXUM01000815    MRZV01000419    PIK50410.1    AXCM01005529    AXCN02000477    ADMH02000354    ETN66859.1    AKHW03005996    KYO24892.1    GEBF01006383    JAN97249.1    BC066599    NOWV01000046    RDD42914.1    ATLV01024483    KE525352    KFB51467.1    AADN05000356    APCN01002301    PNF30792.1    AAAB01008960    EAA10847.3    ADON01022615    ADON01022616    AAKN02051849    PZQS01000009    PVD24347.1    AAMC01055389    AAMC01055390    AAMC01055391    AAMC01055392    AAMC01055393    AAMC01055394    DS985244    EDV25853.1    AGTO01000490    AKCR02000093    PKK21018.1    AMGL01045898    AMGL01045899    AMGL01045900    AMGL01045901    AMGL01045902    AAEX03012060    AGCU01151952    AGCU01151953    AGCU01151954    AGCU01151955    AGCU01151956    AGCU01151957    KL218571    KFP06695.1    KK825589    KFP72498.1    GGFJ01001001    MBW50142.1   

Proteomes

UP000053268    UP000053240    UP000007151    UP000218220    UP000007266    UP000235965    + More
UP000009046    UP000019118    UP000030742    UP000242188    UP000014760    UP000186698    UP000008143    UP000221080    UP000192224    UP000018468    UP000005408    UP000261440    UP000030746    UP000275408    UP000261540    UP000008820    UP000001554    UP000002320    UP000183832    UP000001593    UP000069940    UP000265140    UP000230750    UP000087266    UP000075883    UP000069272    UP000075900    UP000075886    UP000075920    UP000000673    UP000076408    UP000050525    UP000081671    UP000075884    UP000075881    UP000261680    UP000291021    UP000000437    UP000253843    UP000075902    UP000030765    UP000000539    UP000075880    UP000075840    UP000189704    UP000007062    UP000016666    UP000189705    UP000075903    UP000075882    UP000261420    UP000075885    UP000076407    UP000005447    UP000079721    UP000245119    UP000261360    UP000009022    UP000016665    UP000248481    UP000007303    UP000053872    UP000002356    UP000002254    UP000007646    UP000005226    UP000265300    UP000007267    UP000189706    UP000054308   

PRIDE

A8WGF4    Q6NYH1   

Pfam

PF00400   WD40        + More
PF01778   Ribosomal_L28e

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR039857   Ift122       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR011990   TPR-like_helical_dom_sf       
IPR029004   L28e/Mak16       
IPR011044   Quino_amine_DH_bsu       

SUPFAM

SSF50978   SSF50978        + More
SSF48452   SSF48452       
SSF50969   SSF50969       

Gene 3D

2.130.10.10     1.25.40.10    

ProteinModelPortal

A0A194PFU5   A0A194QM04   A0A212ENY3   A0A2W1BKV7   A0A2A4JRP7   A0A1Y1NAG2   + More
A0A139WM23   A0A2J7QQD6   A0A1B6JCB8   E0VXI8   N6T065   A0A1B6CUB2   U4TUZ8   A0A1B6HU34   A0A210R4J6   A0A0K2TYY3   R7V7Z8   A0A1L8GPM1   A8WGF4   A0A2D0R1D4   A0A2D0R320   A0A1W5AXW4   W5N614   K1PT09   A0A023F232   A0A3B4BR72   A0A146KPJ0   V4C646   A0A3M6UCC7   T1IRE0   A0A3B3SPH2   Q16QM7   Q16I80   C3YV44   B0W847   A0A1J1I849   A7SB90   A0A182GFA9   A0A3P8YRH8   A0A2G8KR45   A0A1S3LH81   A0A182M6X2   A0A182FFE5   A0A182RU59   A0A182QQ17   A0A182WBV6   W5JVK3   A0A182Y7X8   A0A151MK40   A0A1S3EQ38   A0A182NIV7   A0A1S3ENS8   A0A1S3ERH3   A0A0P6K1T1   A0A182JZF7   A0A384CMK6   Q6NYH1   A0A1S3LH78   A0A369S8X9   A0A182TXC9   A0A084WMM3   F1P3M3   A0A182JEW0   A0A182I4C2   A0A1U7V5L8   A0A1U7UW64   A0A2J7QQE1   Q7PP89   U3I985   A0A1U7S1Z1   A0A182V3N7   A0A182LKK0   A0A3B4T7C9   A0A182PRY9   A0A182X4C6   H0V4E1   A0A1S3W3U4   A0A1S2ZC85   A0A2T7NT40   F7BN96   A0A3B4XLU3   F7BNA5   B3RUN6   U3KGW3   A0A2Y9HGY1   H3DKP0   A0A2I0LUB8   W5PYJ7   J9P0G8   G3TTP1   H2TLI6   A0A340XQJ2   K7FKW2   A0A1U7Q3M0   A0A091IH57   A0A091ME41   A0A1U7Q6V9   A0A2M4BAV7  

PDB

2YMU     E-value=4.23317e-14,     Score=194

KEGG

101738179    K19656 intraflagellar transport protein 122 | (RefSeq) intraflagellar transport protein 122 homolog

GO

GO:0060271   GO:0031514   GO:0016021   GO:1905515   GO:0035721   GO:0061512   GO:0030991   GO:0097730   GO:0042073   GO:0005737   GO:0007275   GO:0036064   GO:0045879   GO:0005929   GO:0048593   GO:0032402   GO:0008589   GO:0045494   GO:0008594   GO:0072001   GO:0010172   GO:0036372   GO:0007507   GO:0007227   GO:0035720   GO:0060831   GO:0097546   GO:0035115   GO:0072594   GO:0005829   GO:0005654   GO:0032391   GO:0050680   GO:0060830   GO:0021914   GO:0060971   GO:0042733   GO:0001843   GO:0005515   GO:0006508   GO:0016020   GO:0005198   GO:0030126   GO:0005488   GO:0003677   GO:0003707   GO:0007169  

PANTHER

PTHR12764  

Subcellular location

Cell projection  
Cilium  
Cytoplasm  
Cytoskeleton  
Cilium basal body  

Length:

1185

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.8330099999999

Exp number, first 60 AAs:

0.00189

Total prob of N-in:

0.79584

inside

1  -  219

TMhelix

220  -  242

outside

243  -  1185

 

 

Pi

2.38061

Theta

2.609877

Tajima's D

-1.054203

CLR

0.056894

CSRT

0.121993900304985

Interpretation

Uncertain