Gene

KWMTBOMO00443

Pre Gene Modal

BGIBMGA000480

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_protein_scabrous_[Bombyx_mori]

Location

Bomo_Chr1(-):13010668-13042864      View in EpiBrowser

Full name

Protein scabrous      

Location in the cell

Nuclear   Reliability : 2.862

CDS

ATGTTGTGCCCGAAAATTTGTGGACTCTTGACTTTATTTCTTGTTTTCACCGTGATCAAGGCCGAGTTGAGGTTCAAGGAAGAGCTGCAGGCCGTCGCTGAACAAGTCGAGATCATGAAAACTTTGCACCTTACTGACATTACTCGTCTGAAAAGCGAGATTGAGGAGCTCAAACACAAACGTTCTACGCCAACCAACAATTACGAGAGAAATGAACAGGCAACACTCCAATGGGCCAAGACCTCCATGAAAGAGCTGAAGATGGAGATCAGGGAAATCGGTGAAAGCGTCAACAACTCAGCCCTCCTCCGTCAACTGCACATCATACGTAATGAGCTAAAGCAAGCCCTTACCGAGACCTCGGACTTAGCGCAACTTGCTCGCACTCAAGAAGCCAGGCTAGACAAGATGGACAATGAAGTTGGCAGGCTCAAATACGAAGGACAACAGATGAGGAGTACTGTGGCTGAATTACGAACCCACGTCAGCAAGCTGGTCAAAGAGATGAAAGCTAAACAAGTGGCGGAGATGAACGGTGACACCTACAATGATGTAATTGAGCCCCACGAGAACCGAGCCGGTGATCTTAAGCCCGAGCGCAACCATAAGTACCGCCACAACAAGATGGTGCACGCTCAGATTTCACGACTTGCACGCAGCCAGGAGCAGCTTGACGAATACCAACAGAGCCTACAGACCCAGATCCTTGATGTGCAGCGCCGGCTCGACCGCTTCGAAGAACCGAACTGGAACCTACTTTCAGCCAAGGTCGATTTCCTCGAAGTTGAATCGAAAATACTTCGGAACGAACTGCAGAACACCACACAGAGAGTGTCCGATTTCGATAAAGTGCACGCTTCCATTCTCGAGCTGCGTGAAGACATCGAAGGGCTCGAGAACAAAGTCGACAAAACTGTACCGGATTTCAGAAAGGAAATATCGAAATTGGACGTCAGCTTTGCCCAGCTGAATGCTCAGTCTTCGTACCTCAAGGAGGATCAGGAGAATATACGTCAATCAGTAAAAGCTATAGCAGTCAGTGTCAGCAACGCCATCGACCGCGCCGAGATGGACCGCCTGATGGTTAAGAAGATCAACGACTCCGTGTTCGACTTGGAAGCCCGGTCCAAGCAGCATTACTACAGACTCAACGATCACATTCTCAAGAGCGAGGCCAGTGTTCCAGACGCTAATTTGACTGAAACTATACCCCTTCCGGAGCTGATGGGCGAGGTCAAGGAACTGGAGCCGGTCCAACGTGAGTACGAGGATCTAGTCAACCAGCTACCTCGTGACTGCTCCAGCATCAAGGGGCCGGCCGGGACGTACCTTATCCACCCTGGGCACGCTCCCGTCGACACCTGGTGCGTCAACGGAAACACTCTATTGCAAAGACGCTATAATGGCTCGATCGAATTCAATCGTAAATTTAGCGAGTACGTTCATGGTTTCGGCGACCCCACTTCGGAATACTGGTTGGGCTTGGAATCAATGCACCAGATCACTTCCGATAACTGCTCTTCGATGAGGATCGATATGACCGATATATACGGCGGCAGCTGGTATGCCGAATACGATCACTTCTCGGTCAGCAACGCCGACACCGGATTCATTCTGAACGTGAGCGGATTTAGAGGAAATGCCAGCGATGCTTTTGAGTATCAAAATCATATGGAGTTCTCGACTATCGACCGCGACCGCGACATCTCTAACACTCACTGCGCCGGCAACTACGAGGGCGGTTGGTGGTTCTCTCACTGCCAGCATGTGAACATCAACGGCAAGTACACACTCGGCCTGACCTGGTTCGACTCCGCCAGGAACGAGTGGATCGCCGTAGCCACTAGCGAGATGCGCGTGTTCCGCAGAGCCGGCTGCTTCTAA

Protein

MLCPKICGLLTLFLVFTVIKAELRFKEELQAVAEQVEIMKTLHLTDITRLKSEIEELKHKRSTPTNNYERNEQATLQWAKTSMKELKMEIREIGESVNNSALLRQLHIIRNELKQALTETSDLAQLARTQEARLDKMDNEVGRLKYEGQQMRSTVAELRTHVSKLVKEMKAKQVAEMNGDTYNDVIEPHENRAGDLKPERNHKYRHNKMVHAQISRLARSQEQLDEYQQSLQTQILDVQRRLDRFEEPNWNLLSAKVDFLEVESKILRNELQNTTQRVSDFDKVHASILELREDIEGLENKVDKTVPDFRKEISKLDVSFAQLNAQSSYLKEDQENIRQSVKAIAVSVSNAIDRAEMDRLMVKKINDSVFDLEARSKQHYYRLNDHILKSEASVPDANLTETIPLPELMGEVKELEPVQREYEDLVNQLPRDCSSIKGPAGTYLIHPGHAPVDTWCVNGNTLLQRRYNGSIEFNRKFSEYVHGFGDPTSEYWLGLESMHQITSDNCSSMRIDMTDIYGGSWYAEYDHFSVSNADTGFILNVSGFRGNASDAFEYQNHMEFSTIDRDRDISNTHCAGNYEGGWWFSHCQHVNINGKYTLGLTWFDSARNEWIAVATSEMRVFRRAGCF

Description

Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells.

Keywords

Complete proteome   Developmental protein   Differentiation   Disulfide bond   Endosome   Glycoprotein   Neurogenesis   Notch signaling pathway   Reference proteome   Signal  

Feature

chain  Protein scabrous

Uniprot

A0A2A4JSI9   A0A2W1C0K7   A0A212F9J7   A0A194PGS3   A0A194QLF3   A0A2H1WLZ3   + More
A0A2A4JRC5   A0A0L7KVL0   H9ITA0   A0A1W4XNJ2   A0A1Y1LMR7   D6WEF6   A0A2J7QQM2   N6TWG4   A0A1B6D1F2   A0A067RJR4   Q16TT3   A0A1S4FPK1   A0A182QUW6   A0A182Y288   A0A1Y9IUZ9   Q5TWN1   A0A1S4GTY1   B0X0D0   A0A182JAF2   A0A084WRL1   A0A3F2YXN1   A0A1B0CV60   W5JUA4   B4LK98   A0A336MJT6   B4J6U0   B3MD35   Q28XV4   B4GH40   B4MX41   A0A1B0FF50   A0A1A9Z5M0   A0A1A9UI60   A0A1B0BGC2   A0A1A9XG10   A0A3B0J2W6   A0A1I8PVJ1   A0A1W4VDB7   B4KNF8   P21520   A0A0J9U085   B4P4Y6   B3NRV2   B4QDH3   B4HPP5   A0A0M4EHV8   A0A0K8VMS8   A0A0L0BMC4   A0A146LY72   A0A2P8ZDB0   A0A2H8TGX7   A0A1J1JBR2   J9JKY9   A0A3Q0ILC5   A0A0C9RT39   A0A026WSH0   A0A3L8D9F8   A0A195CNV5   E2AZF8   T1HD12   E9IB88   A0A158NI54   A0A195B674   A0A195EGQ9   A0A151JXD2   A0A0J7LAG9   A0A0C9R307   F4WGB4   A0A0L7QSL1   A0A164YA83   A0A0P5LP28   A0A0P6AY65   A0A0M9A6Z2  

Pubmed

28756777    22118469    26354079    26227816    19121390    28004739    + More
18362917    19820115    23537049    24845553    17510324    25244985    12364791    24438588    20920257    23761445    17994087    15632085    2175046    10731132    12537572    12537569    12756167    22936249    17550304    26108605    26823975    29403074    24508170    30249741    20798317    21282665    21347285    21719571   

EMBL

NWSH01000761    PCG74370.1    KZ149901    PZC78496.1    AGBW02009564    OWR50412.1    + More
KQ459605    KPI91904.1    KQ461196    KPJ06393.1    ODYU01009479    SOQ53952.1    PCG74369.1    JTDY01005153    KOB67312.1    BABH01007345    GEZM01053187    JAV74138.1    KQ971318    EFA01305.1    NEVH01012087    PNF30891.1    APGK01049655    APGK01049656    KB741156    ENN73590.1    GEDC01017790    JAS19508.1    KK852639    KDR19650.1    CH477640    EAT37938.1    AXCN02000438    AAAB01008807    EAL41889.3    DS232233    EDS38091.1    ATLV01026157    ATLV01026158    ATLV01026159    ATLV01026160    ATLV01026161    KE525407    KFB52855.1    AJWK01030133    AJWK01030134    AJWK01030135    AJWK01030136    ADMH02000472    ETN66339.1    CH940648    EDW61689.1    UFQT01001464    SSX30674.1    CH916367    EDW02021.1    CH902619    EDV36350.2    CM000071    EAL26212.2    CH479183    EDW35810.1    CH963857    EDW76680.1    CCAG010011452    JXJN01013822    OUUW01000001    SPP75607.1    CH933808    EDW08917.1    M60065    AE013599    AY129456    CM002911    KMY93340.1    CM000158    EDW90707.1    CH954179    EDV56254.1    CM000362    EDX06838.1    CH480816    EDW47629.1    CP012524    ALC40567.1    GDHF01012118    JAI40196.1    JRES01001648    KNC21196.1    GDHC01006116    JAQ12513.1    PYGN01000092    PSN54485.1    GFXV01001549    MBW13354.1    CVRI01000075    CRL08513.1    ABLF02029629    GBYB01010671    JAG80438.1    KK107111    EZA58995.1    QOIP01000011    RLU16782.1    KQ977481    KYN02418.1    GL444207    EFN61197.1    ACPB03009095    GL762111    EFZ22173.1    ADTU01016299    KQ976579    KYM80018.1    KQ978957    KYN27069.1    KQ981578    KYN39762.1    LBMM01000112    KMR04882.1    GBYB01002315    JAG72082.1    GL888128    EGI66881.1    KQ414758    KOC61456.1    LRGB01000930    KZS15043.1    GDIQ01170566    JAK81159.1    GDIP01029292    JAM74423.1    KQ435724    KOX78497.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000053240    UP000037510    UP000005204    + More
UP000192223    UP000007266    UP000235965    UP000019118    UP000027135    UP000008820    UP000075886    UP000076408    UP000075920    UP000007062    UP000002320    UP000075880    UP000030765    UP000075900    UP000092461    UP000000673    UP000008792    UP000001070    UP000007801    UP000001819    UP000008744    UP000007798    UP000092444    UP000092445    UP000078200    UP000092460    UP000092443    UP000268350    UP000095300    UP000192221    UP000009192    UP000000803    UP000002282    UP000008711    UP000000304    UP000001292    UP000092553    UP000037069    UP000245037    UP000183832    UP000007819    UP000079169    UP000053097    UP000279307    UP000078542    UP000000311    UP000015103    UP000005205    UP000078540    UP000078492    UP000078541    UP000036403    UP000007755    UP000053825    UP000076858    UP000053105   

PRIDE

H9ITA0    P21520   

Pfam

PF00147   Fibrinogen_C

Interpro

IPR036056   Fibrinogen-like_C        + More
IPR002181   Fibrinogen_a/b/g_C_dom       
IPR020837   Fibrinogen_CS       
IPR002078   Sigma_54_int       
IPR014715   Fibrinogen_a/b/g_C_2       
IPR014716   Fibrinogen_a/b/g_C_1       
IPR039034   INPP4       

SUPFAM

SSF56496   SSF56496       

Gene 3D

3.90.215.10     4.10.530.10    

CDD

cd00087  FReD

ProteinModelPortal

A0A2A4JSI9   A0A2W1C0K7   A0A212F9J7   A0A194PGS3   A0A194QLF3   A0A2H1WLZ3   + More
A0A2A4JRC5   A0A0L7KVL0   H9ITA0   A0A1W4XNJ2   A0A1Y1LMR7   D6WEF6   A0A2J7QQM2   N6TWG4   A0A1B6D1F2   A0A067RJR4   Q16TT3   A0A1S4FPK1   A0A182QUW6   A0A182Y288   A0A1Y9IUZ9   Q5TWN1   A0A1S4GTY1   B0X0D0   A0A182JAF2   A0A084WRL1   A0A3F2YXN1   A0A1B0CV60   W5JUA4   B4LK98   A0A336MJT6   B4J6U0   B3MD35   Q28XV4   B4GH40   B4MX41   A0A1B0FF50   A0A1A9Z5M0   A0A1A9UI60   A0A1B0BGC2   A0A1A9XG10   A0A3B0J2W6   A0A1I8PVJ1   A0A1W4VDB7   B4KNF8   P21520   A0A0J9U085   B4P4Y6   B3NRV2   B4QDH3   B4HPP5   A0A0M4EHV8   A0A0K8VMS8   A0A0L0BMC4   A0A146LY72   A0A2P8ZDB0   A0A2H8TGX7   A0A1J1JBR2   J9JKY9   A0A3Q0ILC5   A0A0C9RT39   A0A026WSH0   A0A3L8D9F8   A0A195CNV5   E2AZF8   T1HD12   E9IB88   A0A158NI54   A0A195B674   A0A195EGQ9   A0A151JXD2   A0A0J7LAG9   A0A0C9R307   F4WGB4   A0A0L7QSL1   A0A164YA83   A0A0P5LP28   A0A0P6AY65   A0A0M9A6Z2  

PDB

4M7H     E-value=1.59884e-28,     Score=316

KEGG

101738052    no KO assigned | (RefSeq) protein scabrous

GO

GO:0016021   GO:0008407   GO:0007399   GO:0097305   GO:0008587   GO:0016318   GO:0005524   GO:0008134   GO:0006355   GO:0048749   GO:0005770   GO:0007219   GO:0016321   GO:0030154   GO:0016316  

PANTHER

PTHR12187  

Subcellular location

Late endosome  

SignalP

Position:   1 - 21,         Likelihood:  0.909303

 

 

Length:

627

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.624249999999999

Exp number, first 60 AAs:

0.62406

Total prob of N-in:

0.03462

outside

1  -  627

 

 

Pi

22.305147

Theta

18.469359

Tajima's D

0.492565

CLR

0.12446

CSRT

0.522673866306685

Interpretation

Uncertain