Gene

KWMTBOMO00437  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000743

Annotation

PREDICTED:_flotillin-1_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr1(+):12885895-12909348      View in EpiBrowser

Full name

Flotillin-1      

Location in the cell

Cytoplasmic   Reliability : 2.328

CDS

ATGACTTGGGGGTTCGTCACATGTGGCCCTAACGAAGCACTCGTGATTTCAGGATGCTGCTATTCCAAGCCACTCCTGGTCCCTGGTGGTCGAGCCTTTGTATGGCCAGCGATCCAGAGCGTACAACGGATATCTCTAAACACCATGACCCTTCAAGTGGAGTCACCAACTGTCTATACCAGTCAGGGTGTGCCCATTTCGGTTACTGGAATCGCTCAGGTCAAAATTCAAGGTCAGAATTCCGAGATGCTGCTCTCCGCGTGTGAGCAGTTTCTCGGTAAAACGGAGCAAGAGATTCAGCACATAGCCCTGGTGACGCTGGAGGGTCACCAACGTGCTATAATGGGATCTATGACGGTCGAGGAAATATACAAAGACAGAAAAATATTCTCGAAAAAGGTGTTCGAAGTTGCGTCGAGTGATCTAATCAACATGGGAATCACAGTTGTGTCGTATACTTTGAAGGACATCAGAGACGAGGAGGGCTACTTGAAAGCTCTAGGTATGGCTCGTACAGCCGAAGTGAAGCGCGACGCACGTATAGGCGAAGCTGAAGCTCAGGCCGAAGCCAAGATTAAGGAGGCGATGGCTGAGGAGCAACGCATGGCCGCCAGGTTCCTGAACGATACGGAGATCGCTAAGTCTCAGCGGGACTTTGAGCTAAAGAAGGCCGCTTACGACGTAGAAGTTCACACCAAAAAGGCCGAAGCCGAGATGGCCTACGAACTACAAGCTGCCAAGACGAAACAGCGTATCAAAGAGGAACAGATGCAGATAGCGGTCGTGGAGCGAACCCAGGAGATCGCCGTACAGAAGTGGGAAGTACAAAGACGCGAGAAGGAACTGGAAGCCACAATACGCAGACCCGCCGAAGCTGAGAAGTTCAGACTAGAGAAGATAGCGGAAGCGCACAGGCAGAAGACAGTGCTCGAAGCCGAAGCTGAGGCGGAAGCGGTTAAAGTACGAGGAGAGGCGGAAGCATACGCTATAAAAGCAAAGGCCGTTGCTGATGCCGAGCAGATGGCGAAAAAGGCAGAAGCGTGGAAGGAATATGGATCTGCCGCTATGGTGGACATGATGCTGGAAACTCTACCCAAGGTTGCAGCAGAAGTGGCTGCCCCCCTGTCCCAAGCCAGGAAGGTAACTATGGTGTCGTGCGGAGGCGGCGAGGTCGGTGCGGCCAAACTCACCGGTGAAGTATTGAGCATTGTACAGTGCTTACCTGAACTCGTGAAGGGAGTCACCGGAGTCGATATATCCAAGGGTGTTCGCGCACTGTAA

Protein

MTWGFVTCGPNEALVISGCCYSKPLLVPGGRAFVWPAIQSVQRISLNTMTLQVESPTVYTSQGVPISVTGIAQVKIQGQNSEMLLSACEQFLGKTEQEIQHIALVTLEGHQRAIMGSMTVEEIYKDRKIFSKKVFEVASSDLINMGITVVSYTLKDIRDEEGYLKALGMARTAEVKRDARIGEAEAQAEAKIKEAMAEEQRMAARFLNDTEIAKSQRDFELKKAAYDVEVHTKKAEAEMAYELQAAKTKQRIKEEQMQIAVVERTQEIAVQKWEVQRREKELEATIRRPAEAEKFRLEKIAEAHRQKTVLEAEAEAEAVKVRGEAEAYAIKAKAVADAEQMAKKAEAWKEYGSAAMVDMMLETLPKVAAEVAAPLSQARKVTMVSCGGGEVGAAKLTGEVLSIVQCLPELVKGVTGVDISKGVRAL

Description

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Subunit

Heterooligomeric complex of flotillins 1 and 2 and caveolins 1 and 2.

Similarity

Belongs to the band 7/mec-2 family. Flotillin subfamily.
Belongs to the mitochondrial carrier (TC 2.A.29) family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Developmental protein   Membrane   Reference proteome  

Feature

chain  Flotillin-1
splice variant  In isoform Long.

Uniprot

H9IU13   A0A2W1C063   A0A194PFV0   A0A212F9J2   A0A067R5R6   A0A2J7PGP4   + More
A0A1Q3FTX7   U5EWZ7   A0A182QEA8   A0A2M3Z2T6   A0A2M4A236   A0A182FF53   A0A2M4BNU2   A0A453Z3S4   A0A1Y9IVP9   A0A0K8TSA2   A0A1B6J7Q5   A0A2M3ZGR3   A0A1B6M950   A0A1B0CJH3   W5JNL9   A0A182HDX9   A0A1L8DVS9   A0A1B6G9M7   A0A1I8Q0W3   A0A1B6EG12   W8BIE9   A0A1I8MYU4   A0A1W4UGN5   A0A1Q3FVA1   A0A0P9BR37   A0A3B0JLX0   R4WPP3   Q7QJF7   A0A182RSP4   A0A0R3NMP5   A0A336LHD1   A0A336K0U0   A0A0K8VT48   A0A182K2I2   A0A0K8TY35   N6T011   A0A1I8Q0Y4   A0A1I8MYU0   E0VW73   A0A1W4UGJ6   W8BDL3   D6WVX3   A0A0J9REN1   A0A2R7W6F8   O61491   B3MUP6   A0A3B0J349   A0A0R1DSU8   B4MQW2   A0A0Q5VM84   A0A1Y1MT85   Q290U2   B4GB86   A0A0K8V3B8   A0A0K8W3P4   A0A0A1X4Q5   A0A0Q9XG90   A0A1J1IUH5   A0A0M3QUS5   A0A0P4VXL4   T1I757   A0A0L0BP94   O61491-2   A0A0Q9W2Y1   B4HS60   B4QGW6   B4P7B4   B3NQB1   A0A224XGW3   A0A0T6BAK5   A0A023FAK5   U4UH26   A0A232F1Y4   A0A069DUJ0   A0A0A9W8E3   B4KLK2   B4LM10   A0A2A3EM04   K7J6B6   A0A182KRD4   E2BW52   A0A026WEZ4   B4J5A5   A0A151J6F3   A0A088A9W3   A0A3L8E1A4   A0A151XI90   A0A151IFD8   A0A2M4BPI7   Q16EE7   A0A195FHI3   A0A0M8ZT24   A0A158ND57   A0A195BNR3  

Pubmed

19121390    28756777    26354079    22118469    24845553    26369729    + More
20920257    23761445    26483478    24495485    25315136    17994087    23691247    12364791    14747013    17210077    15632085    23537049    20566863    18362917    19820115    22936249    9573373    10731132    12537572    12537569    17550304    28004739    25830018    27129103    26108605    25474469    28648823    26334808    25401762    26823975    20075255    20966253    20798317    24508170    30249741    17510324    21347285   

EMBL

BABH01007335    KZ149901    PZC78500.1    KQ459605    KPI91908.1    AGBW02009564    + More
OWR50416.1    KK852680    KDR18625.1    NEVH01025174    PNF15505.1    GFDL01004030    JAV31015.1    GANO01001196    JAB58675.1    AXCN02000377    GGFM01002080    MBW22831.1    GGFK01001491    MBW34812.1    GGFJ01005609    MBW54750.1    GDAI01000369    JAI17234.1    GECU01037022    GECU01030300    GECU01022134    GECU01012499    JAS70684.1    JAS77406.1    JAS85572.1    JAS95207.1    GGFM01006932    MBW27683.1    GEBQ01007522    JAT32455.1    AJWK01014645    AJWK01014646    ADMH02000549    ETN65967.1    JXUM01034908    JXUM01034909    JXUM01034910    KQ561040    KXJ79928.1    GFDF01003540    JAV10544.1    GECZ01010658    JAS59111.1    GEDC01000443    JAS36855.1    GAMC01009772    JAB96783.1    GFDL01003521    JAV31524.1    CH902624    KPU74210.1    OUUW01000001    SPP73641.1    AK417636    BAN20851.1    AAAB01008807    EAA04642.4    CM000071    KRT02028.1    UFQS01000047    UFQS01003939    UFQT01000047    UFQT01003939    SSW98527.1    SSX16045.1    SSX18913.1    SSW98526.1    SSX18912.1    GDHF01010286    JAI42028.1    GDHF01033319    JAI18995.1    APGK01050028    APGK01050029    APGK01050030    KB741165    KB632352    ENN73389.1    ERL93295.1    DS235817    EEB17629.1    GAMC01009773    JAB96782.1    KQ971358    EFA08627.2    CM002911    KMY94029.1    KK854254    PTY13795.1    AF044734    AE013599    AY058794    EDV32961.1    SPP73642.1    CM000158    KRK00294.1    CH963849    EDW74501.1    CH954179    KQS62535.1    GEZM01021631    JAV88893.1    EAL25270.2    CH479181    EDW32188.1    GDHF01018897    JAI33417.1    GDHF01006610    JAI45704.1    GBXI01008471    JAD05821.1    CH933808    KRG04212.1    CVRI01000059    CRL03354.1    CP012524    ALC41143.1    GDKW01001193    JAI55402.1    ACPB03000761    JRES01001578    KNC21841.1    CH940648    KRF79158.1    CH480816    EDW48007.1    CM000362    EDX07229.1    KMY94028.1    EDW92059.1    EDV55887.1    GFTR01006162    JAW10264.1    LJIG01002564    KRT84376.1    GBBI01000181    JAC18531.1    ERL93294.1    NNAY01001263    OXU24572.1    GBGD01001542    JAC87347.1    GBHO01039540    GBHO01039535    GDHC01021038    JAG04064.1    JAG04069.1    JAP97590.1    EDW08638.1    EDW59930.1    KZ288212    PBC32833.1    GL451091    EFN80084.1    KK107260    EZA54251.1    CH916367    EDW01747.1    KQ979878    KYN18692.1    QOIP01000001    RLU26243.1    KQ982116    KYQ59930.1    KQ977796    KYM99616.1    GGFJ01005855    MBW54996.1    CH478807    EAT32605.1    KQ981560    KYN39848.1    KQ435891    KOX69406.1    ADTU01012403    KQ976438    KYM86873.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000027135    UP000235965    UP000075886    + More
UP000069272    UP000076407    UP000075920    UP000092461    UP000000673    UP000069940    UP000249989    UP000095300    UP000095301    UP000192221    UP000007801    UP000268350    UP000007062    UP000075900    UP000001819    UP000075881    UP000019118    UP000030742    UP000009046    UP000007266    UP000000803    UP000002282    UP000007798    UP000008711    UP000008744    UP000009192    UP000183832    UP000092553    UP000015103    UP000037069    UP000008792    UP000001292    UP000000304    UP000215335    UP000242457    UP000002358    UP000075882    UP000008237    UP000053097    UP000001070    UP000078492    UP000005203    UP000279307    UP000075809    UP000078542    UP000008820    UP000078541    UP000053105    UP000005205    UP000078540   

PRIDE

H9IU13    O61491   

Pfam

PF15975   Flot        + More
PF01145   Band_7
PF07052   Hep_59
PF13649   Methyltransf_25
PF06859   Bin3
PF00153   Mito_carr

Interpro

IPR001107   Band_7        + More
IPR031905   Flotillin_C       
IPR027705   Flotillin_fam       
IPR036013   Band_7/SPFH_dom_sf       
IPR010756   Tls1       
IPR010675   Bin3_C       
IPR029063   SAM-dependent_MTases       
IPR024160   BIN3_SAM-bd_dom       
IPR041698   Methyltransf_25       
IPR002113   Aden_trnslctor       
IPR002067   Mit_carrier       
IPR023395   Mt_carrier_dom_sf       
IPR018108   Mitochondrial_sb/sol_carrier       

SUPFAM

SSF117892   SSF117892        + More
SSF53335   SSF53335       
SSF103506   SSF103506       

Gene 3D

1.50.40.10    

ProteinModelPortal

H9IU13   A0A2W1C063   A0A194PFV0   A0A212F9J2   A0A067R5R6   A0A2J7PGP4   + More
A0A1Q3FTX7   U5EWZ7   A0A182QEA8   A0A2M3Z2T6   A0A2M4A236   A0A182FF53   A0A2M4BNU2   A0A453Z3S4   A0A1Y9IVP9   A0A0K8TSA2   A0A1B6J7Q5   A0A2M3ZGR3   A0A1B6M950   A0A1B0CJH3   W5JNL9   A0A182HDX9   A0A1L8DVS9   A0A1B6G9M7   A0A1I8Q0W3   A0A1B6EG12   W8BIE9   A0A1I8MYU4   A0A1W4UGN5   A0A1Q3FVA1   A0A0P9BR37   A0A3B0JLX0   R4WPP3   Q7QJF7   A0A182RSP4   A0A0R3NMP5   A0A336LHD1   A0A336K0U0   A0A0K8VT48   A0A182K2I2   A0A0K8TY35   N6T011   A0A1I8Q0Y4   A0A1I8MYU0   E0VW73   A0A1W4UGJ6   W8BDL3   D6WVX3   A0A0J9REN1   A0A2R7W6F8   O61491   B3MUP6   A0A3B0J349   A0A0R1DSU8   B4MQW2   A0A0Q5VM84   A0A1Y1MT85   Q290U2   B4GB86   A0A0K8V3B8   A0A0K8W3P4   A0A0A1X4Q5   A0A0Q9XG90   A0A1J1IUH5   A0A0M3QUS5   A0A0P4VXL4   T1I757   A0A0L0BP94   O61491-2   A0A0Q9W2Y1   B4HS60   B4QGW6   B4P7B4   B3NQB1   A0A224XGW3   A0A0T6BAK5   A0A023FAK5   U4UH26   A0A232F1Y4   A0A069DUJ0   A0A0A9W8E3   B4KLK2   B4LM10   A0A2A3EM04   K7J6B6   A0A182KRD4   E2BW52   A0A026WEZ4   B4J5A5   A0A151J6F3   A0A088A9W3   A0A3L8E1A4   A0A151XI90   A0A151IFD8   A0A2M4BPI7   Q16EE7   A0A195FHI3   A0A0M8ZT24   A0A158ND57   A0A195BNR3  

PDB

1WIN     E-value=3.36274e-29,     Score=320

KEGG

101737828    K07192 flotillin | (RefSeq) flotillin-1

GO

GO:0005198   GO:0005737   GO:0007275   GO:0016600   GO:0008168   GO:0022857   GO:0005743   GO:0016021  

PANTHER

PTHR13806  

Subcellular location

Cell membrane  
Membrane  
Caveola  

Length:

426

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.331340000000001

Exp number, first 60 AAs:

0.31649

Total prob of N-in:

0.01672

outside

1  -  426

 

 

Pi

0.920425

Theta

2.297353

Tajima's D

-2.224076

CLR

0.053056

CSRT

0.00129993500324984

Interpretation

Uncertain