Gene

KWMTBOMO00427  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000484

Annotation

nonclathrin_coat_protein_gamma1-COP_[Danaus_plexippus]

Location

Bomo_Chr1(-):12551671-12558351      View in EpiBrowser

Full name

Coatomer subunit gamma       + More
Nipped-B protein      

Alternative Name

Gamma-coat protein

Location in the cell

Golgi   Reliability : 2.359

CDS

ATGAAGGCTCGCCGCGATGGAAAAGAAGAAGATAGCAATGTCTTCCAAAATCTTGATAAAACAACCCTTTTACAAGAGGCAAGATATTTCAACTCTACACCCGTGCATCCGAGAAAATGCATCCATATTTTGACGAAAATACTCTATTTACTAAACCAAGGCGAAGAATTAACCACGCAGGAGGCTACGGATATATTTTTTGCCACTACGAAACTGTTTCAGTCAAAGGACGTTGTGTTACGCCGCTTAGTTTACCTATGCATTAAAGAGTTGAGTCCTATGGCACAAGATGTGATCATTGTGACTTCTTCACTTACGAAGGACATGACGGGTAAAGACGATGAGTACCGACCTGCCGCCATTCGAGCTTTGTGTAGCATCACAGACAGTACAATGCTGCAAGCTATTGAGAGGTACATGAAACAAGCTATTGTTGATAAGAATCCTGCAGTAGGATCTGCCGCACTGGTCTCCGCTTTGCATCTGTCAGCCACCGTACCGGATTTAGTGCGTCGCTGGATAAATGAAGCACAGGAGGCCATGACTTCAGATCATGTGATGGTTTCTTACCATGCCTTGGCTGTTGTTGCTGGTGCAAGACGCAACGATAGATTATCAACTGTGAAACTCATTACAAAACTAGCTCGGACACCAGTTCGCTCGCCTTACACACTTTGCCTCCAAATACGCTTTGCTGCCAAGCTAGCAGAAGAGGATCCATCTGAAGCATCAGAACCTTACCTTGAATTCATTGAATCCTGTCTACGCAACAAGTCAGAAATGGTTGTTTATGAAGCAGCACATGCTATTGTCAATCTCAGAAAATCTGCTAAAGATCTTGCCCAAGCTGTGTCTGTGCTGCAAATTTTTTGTGGCTCTTCTAAAGCGACTTTGCGTTTAGCTGGAGCTCGCACCTTAGCCAGACTGACTGCGAAACACCCCAATGCAGTTGCAGCCTGTGCTGTGGATTTGGAAAATCTGATCTCTGATTCTAATCGATCAGTTGCAACTCTGGCTGTCACAACACTTCTTGCAACTGGTGCTGAAAGCTCCATTGACCGTCTGATGAAGCAAATATCTGAGTTTATGTCAGAAATATCGGATGAATTTAAAATTGTGGTGGTCCGTGCTATCCGACGTCTCTGCTCTAAGTATCCCCGCAAGCATCAGTCTTTGGCTGCGTTTTTGGCAGGAATGCTTCGTGACGAAGGAGGTCTGCAATATAAAACTGCAATTGCTGAGGCTTTAATAGCTCTCATTGAAGAAAATCCTGATGCTAAGGAAACAGGGCTGGCTCACCTGTGTGAATTTATTGAAGATTGTGAACATGTCACTTTAGCTGTGCGTATTTTGCATGTCCTGGGACGAGAAGGGCCAAAAGCACGCCAACCTTCTAGGTACATTAGATACATTTATAACAGAGTGATTTTGGAGTCAGGTCCAGTTCGGGCTGCTGCAGTATCTGCTGTTGCTCGTTTCGGAGCCTCCCGTCCTGAGTTGCTGCCAAATATAAGGGTTTTGTTGTCACGCTGCCAACTAGATGAAGACGACGAAGTTCGTGATCGCGCCGTATTCTACAGCGCTATTTTAGATTCTGGAAATCCTCAGTTGATCAACGATTACATCATTAACATTCAGGTACCGAATCCGGTACTATTAGAAAAGTCGTTGAGTGATTATCTTGCTTCAGGCGATCAAAGCGAGCCCTTCAACATCGCGGCGGTTCCCACAGCTGAAGAACCACAAGAGCCTAAAGAATCTCCCGTTGAGATTGAAACACGTAAAGCACCAGTAGTGTCTAGAGAAGAACAATATACTGAGCAGTTACAGGCTATTCCTGGAATAGAGAAACTGGGACCTTTATTCAAATCTTGCGAAGCCATTGACTTGACTGAACCTGAAACTGAATATCGTGTGAGATGCGTTAAACACATTTTCGCTCGTCATTTGATTCTACAGTTTGAATGCTTGAACACTTTAAGTGACCAACTTCTCGAGAAGGTTTACGTTCGTCTAGATTCCATACCAGGATACAAAATTTCTAACGTTGTGCCGTGTGATGAGCTACCATATGACAAACAAGGCAATATTTTTTGTCTTTTGGAATTTCCCGAAAATCCAATAGAGACTCTTGGAAATTTCGGAGCTACTTTGGAATTTGTCGTTCGTGACTGCGATCCCACCACGGGTCTCCCGGATTCTAATGAAGGTTATGCTGATACTTACCCTCTAGAGGAAATTGAGATTACTTGCGCTGATCAGTTCCGAACTCGTGCGGCGACTGACGATTGGGAACAGGCGTGGGAGCGGGCCGCTAATGCCGCTGAAGCTTGTGACACGTTCGGTTTGACCCAATCAGATGTGGGTGCGGCGGCCAGTGCTGTGTGTGAGCATTTGGGAATGCCAAAAGCGGCTATTTCTGGTGAGGCCGTGAAGGAAATCCGCGGCGGCGGCTTGTGGCGTGCCGGAGCACCTGTTCTTATGAGAGCAAGATTGGTAGCCGCCCAAGGAACTGTTACTATGCAACTGATTGCTCGTTCTCCGCGGGAAGACGTGGCGACACTGTTATTGGCTGCAGTTGGCTAA

Protein

MKARRDGKEEDSNVFQNLDKTTLLQEARYFNSTPVHPRKCIHILTKILYLLNQGEELTTQEATDIFFATTKLFQSKDVVLRRLVYLCIKELSPMAQDVIIVTSSLTKDMTGKDDEYRPAAIRALCSITDSTMLQAIERYMKQAIVDKNPAVGSAALVSALHLSATVPDLVRRWINEAQEAMTSDHVMVSYHALAVVAGARRNDRLSTVKLITKLARTPVRSPYTLCLQIRFAAKLAEEDPSEASEPYLEFIESCLRNKSEMVVYEAAHAIVNLRKSAKDLAQAVSVLQIFCGSSKATLRLAGARTLARLTAKHPNAVAACAVDLENLISDSNRSVATLAVTTLLATGAESSIDRLMKQISEFMSEISDEFKIVVVRAIRRLCSKYPRKHQSLAAFLAGMLRDEGGLQYKTAIAEALIALIEENPDAKETGLAHLCEFIEDCEHVTLAVRILHVLGREGPKARQPSRYIRYIYNRVILESGPVRAAAVSAVARFGASRPELLPNIRVLLSRCQLDEDDEVRDRAVFYSAILDSGNPQLINDYIINIQVPNPVLLEKSLSDYLASGDQSEPFNIAAVPTAEEPQEPKESPVEIETRKAPVVSREEQYTEQLQAIPGIEKLGPLFKSCEAIDLTEPETEYRVRCVKHIFARHLILQFECLNTLSDQLLEKVYVRLDSIPGYKISNVVPCDELPYDKQGNIFCLLEFPENPIETLGNFGATLEFVVRDCDPTTGLPDSNEGYADTYPLEEIEITCADQFRTRAATDDWEQAWERAANAAEACDTFGLTQSDVGAAASAVCEHLGMPKAAISGEAVKEIRGGGLWRAGAPVLMRARLVAAQGTVTMQLIARSPREDVATLLLAAVG

Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development (By similarity).
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

Subunit

Oligomeric complex.
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Similarity

Belongs to the COPG family.
Belongs to the SCC2/Nipped-B family.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   Cytoplasmic vesicle   Endoplasmic reticulum   ER-Golgi transport   Golgi apparatus   Membrane   Protein transport   Reference proteome   Repeat   Transport  

Feature

chain  Coatomer subunit gamma
splice variant  In isoform A and isoform C.

Uniprot

Q9NKX3   A0A2H1VY70   H9ITA4   A0A2A4JW01   A0A1E1WA37   A0A212F9T7   + More
A0A2W1BER4   A0A2A4JXQ0   A0A1E1W6K7   A0A2H1WIN6   H9JNS6   A0A0L7LE61   Q9NKX2   A0A194PZ47   A0A0L7KGN8   A0A0N1PIW6   A0A212FD53   S4PDR5   A0A194QLD5   A0A1Y1K3A8   D6WZN0   A0A067RRI8   A0A1W4XWS4   A0A194PEY4   A0A1L8DWC7   E0VLD3   U5EXW3   A0A0L0BKH8   A0A034V598   B4PNE7   A0A1W4VVW6   A0A1W4W7X2   A0A0K8VBR2   A0A1B0B319   A0A1A9YDP7   B3P533   B3MSZ6   B4JHF3   A0A0R1EB90   A0A1A9ZSS0   A0A2J7QYL1   A0A0A1WN12   A0A0P8XU24   T1PGC9   B4IJ02   Q8I0G5-3   A0A1I8MSK7   Q8I0G5-2   A0A0B4KHL2   G4LU37   A0A1I8P3V3   A0A0A1WTM0   Q8I0G5   A0A1A9UTH5   A0A182F4S4   W5JWS0   A0A2M4A194   A0A0K8TSF1   A0A2M3Z005   A0A2M3Z008   B4M106   B4K7Z2   A0A0M5IZI1   A0A2M3Z006   Q29AE5   W8B1R1   A0A1J1J0M5   B4NAH4   A0A2M4BD79   A0A3B0JJL6   A0A182VUJ0   A0A3B0JIH4   A0A1Q3G384   A0A182GMC1   A0A182RAX4   A0A0P6ISE4   A0A182MK06   A0A1S4H0Q2   A0A182L6H5   A0A1B0G192   A0A1S4EK05   A0A182J3G7   A0A232F7I9   A0A182UZ16   A0A182Q0C2   A0A1B6LJG1   A0A023EWA4   A0A182PVI2   Q7PVF6   A0A182SRR6   A0A084W6N0   A0A336LB12   A0A182MZ12   V5I8Q5   A0A336LFZ9   A0A087UHC8   T1IMS8   A0A0M9A3E6   A0A0P6AG54   A0A0A9ZC94  

Pubmed

11018518    19121390    22118469    28756777    26227816    26354079    + More
23622113    28004739    18362917    19820115    24845553    20566863    26108605    25348373    17994087    17550304    25830018    10731132    12537572    12537569    16169286    19067489    18398480    18802472    25315136    12537568    12537573    12537574    16110336    17569856    17569867    20920257    23761445    26369729    15632085    24495485    26483478    26999592    12364791    20966253    28648823    24945155    24438588    25401762   

EMBL

AB040669    BAA93047.2    ODYU01005182    SOQ45790.1    BABH01007296    NWSH01000574    + More
PCG75562.1    GDQN01007176    JAT83878.1    AGBW02009564    OWR50469.1    KZ150337    PZC71320.1    NWSH01000384    PCG76795.1    GDQN01008422    JAT82632.1    ODYU01008925    SOQ52929.1    BABH01010017    JTDY01001569    KOB73496.1    AB040670    BAA93048.2    KQ459593    KPI96430.1    JTDY01009845    KOB62497.1    KQ460036    KPJ18403.1    AGBW02009108    OWR51662.1    GAIX01004842    JAA87718.1    KQ461196    KPJ06373.1    GEZM01094084    JAV55944.1    KQ971372    EFA09678.1    KK852470    KDR23235.1    KQ459605    KPI91926.1    GFDF01003529    JAV10555.1    DS235271    EEB14189.1    GANO01000740    JAB59131.1    JRES01001712    KNC20586.1    GAKP01020481    GAKP01020480    JAC38471.1    CM000160    EDW99229.2    GDHF01016028    JAI36286.1    JXJN01007759    CH954182    EDV52947.1    CH902623    EDV30386.1    CH916369    EDV92780.1    KRK04737.1    NEVH01009087    PNF33659.1    GBXI01014417    JAC99874.1    KPU72823.1    KA647821    AFP62450.1    CH480846    EDW50955.1    AF191563    AE014297    AY113545    BT001628    AAF05719.1    AAN14275.1    AAN71383.1    AGB96524.1    BT132667    AEQ05569.1    GBXI01012296    JAD01996.1    ADMH02000176    ETN67504.1    GGFK01001201    MBW34522.1    GDAI01000316    JAI17287.1    GGFM01001080    MBW21831.1    GGFM01001094    MBW21845.1    CH940650    EDW67417.2    CH933806    EDW14326.1    CP012526    ALC45581.1    GGFM01001092    MBW21843.1    CM000070    EAL27405.1    GAMC01019354    GAMC01019353    JAB87201.1    CVRI01000066    CRL05888.1    CH964232    EDW80788.1    GGFJ01001859    MBW51000.1    OUUW01000005    SPP80522.1    SPP80523.1    GFDL01000768    JAV34277.1    JXUM01074479    JXUM01074480    KQ562832    KXJ75044.1    GDUN01001107    JAN94812.1    AXCM01001007    AAAB01008984    CCAG010001934    NNAY01000795    OXU26460.1    AXCN02000790    GEBQ01016135    JAT23842.1    GAPW01000182    JAC13416.1    EAA14827.2    ATLV01020880    KE525309    KFB45874.1    UFQS01002986    UFQT01002986    SSX15016.1    SSX34402.1    GALX01004275    JAB64191.1    UFQS01003479    UFQT01003479    SSX15677.1    SSX35036.1    KK119796    KFM76767.1    JH431094    KQ435759    KOX75646.1    GDIP01043181    LRGB01003216    JAM60534.1    KZS03726.1    GBHO01000717    GBRD01011071    JAG42887.1    JAG54753.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000037510    UP000053268    UP000053240    + More
UP000007266    UP000027135    UP000192223    UP000009046    UP000037069    UP000002282    UP000192221    UP000092460    UP000092443    UP000008711    UP000007801    UP000001070    UP000092445    UP000235965    UP000001292    UP000000803    UP000095301    UP000095300    UP000078200    UP000069272    UP000000673    UP000008792    UP000009192    UP000092553    UP000001819    UP000183832    UP000007798    UP000268350    UP000075920    UP000069940    UP000249989    UP000075900    UP000075883    UP000075882    UP000092444    UP000079169    UP000075880    UP000215335    UP000075903    UP000075886    UP000075885    UP000007062    UP000075901    UP000030765    UP000075884    UP000054359    UP000053105    UP000076858   

PRIDE

Q9NKX3    H9ITA4    H9JNS6    Q9NKX2    D6WZN0    E0VLD3    + More
Q8I0G5    G4LU37    Q29AE5    Q7PVF6   

Pfam

PF16381   Coatomer_g_Cpla        + More
PF08752   COP-gamma_platf
PF01602   Adaptin_N
PF12830   Nipped-B_C
PF12765   Cohesin_HEAT
PF00107   ADH_zinc_N
PF16884   ADH_N_2

Interpro

IPR012295   TBP_dom_sf        + More
IPR016024   ARM-type_fold       
IPR037067   Coatomer_gsu_app_sf       
IPR002553   Clathrin/coatomer_adapt-like_N       
IPR013041   Clathrin_app_Ig-like_sf       
IPR013040   Coatomer_gsu_app_Ig-like_dom       
IPR017106   Coatomer_gsu       
IPR011989   ARM-like       
IPR032154   Coatomer_g_Cpla       
IPR009028   Coatomer/calthrin_app_sub_C       
IPR026003   Cohesin_HEAT       
IPR024986   Nipped-B_C       
IPR033031   SCC2/Nipped-B       
IPR014190   PTGR1       
IPR036291   NAD(P)-bd_dom_sf       
IPR041694   ADH_N_2       
IPR011032   GroES-like_sf       
IPR013149   ADH_C       

SUPFAM

SSF49348   SSF49348        + More
SSF48371   SSF48371       
SSF55711   SSF55711       
SSF50129   SSF50129       
SSF51735   SSF51735       

Gene 3D

1.25.10.10     2.60.40.1480     3.30.310.10    

CDD

cd08294  leukotriene_B4_DH_like

ProteinModelPortal

Q9NKX3   A0A2H1VY70   H9ITA4   A0A2A4JW01   A0A1E1WA37   A0A212F9T7   + More
A0A2W1BER4   A0A2A4JXQ0   A0A1E1W6K7   A0A2H1WIN6   H9JNS6   A0A0L7LE61   Q9NKX2   A0A194PZ47   A0A0L7KGN8   A0A0N1PIW6   A0A212FD53   S4PDR5   A0A194QLD5   A0A1Y1K3A8   D6WZN0   A0A067RRI8   A0A1W4XWS4   A0A194PEY4   A0A1L8DWC7   E0VLD3   U5EXW3   A0A0L0BKH8   A0A034V598   B4PNE7   A0A1W4VVW6   A0A1W4W7X2   A0A0K8VBR2   A0A1B0B319   A0A1A9YDP7   B3P533   B3MSZ6   B4JHF3   A0A0R1EB90   A0A1A9ZSS0   A0A2J7QYL1   A0A0A1WN12   A0A0P8XU24   T1PGC9   B4IJ02   Q8I0G5-3   A0A1I8MSK7   Q8I0G5-2   A0A0B4KHL2   G4LU37   A0A1I8P3V3   A0A0A1WTM0   Q8I0G5   A0A1A9UTH5   A0A182F4S4   W5JWS0   A0A2M4A194   A0A0K8TSF1   A0A2M3Z005   A0A2M3Z008   B4M106   B4K7Z2   A0A0M5IZI1   A0A2M3Z006   Q29AE5   W8B1R1   A0A1J1J0M5   B4NAH4   A0A2M4BD79   A0A3B0JJL6   A0A182VUJ0   A0A3B0JIH4   A0A1Q3G384   A0A182GMC1   A0A182RAX4   A0A0P6ISE4   A0A182MK06   A0A1S4H0Q2   A0A182L6H5   A0A1B0G192   A0A1S4EK05   A0A182J3G7   A0A232F7I9   A0A182UZ16   A0A182Q0C2   A0A1B6LJG1   A0A023EWA4   A0A182PVI2   Q7PVF6   A0A182SRR6   A0A084W6N0   A0A336LB12   A0A182MZ12   V5I8Q5   A0A336LFZ9   A0A087UHC8   T1IMS8   A0A0M9A3E6   A0A0P6AG54   A0A0A9ZC94  

PDB

5NZV     E-value=0,     Score=1949

KEGG

692386    K17267 coatomer subunit gamma | (RefSeq) Copg1; nonclathrin coat protein gamma1-COP

GO

GO:0006886   GO:0000139   GO:0030126   GO:0016192   GO:0005198   GO:0009306   GO:0005794   GO:0006891   GO:0005783   GO:0072384   GO:0006888   GO:0016020   GO:0005793   GO:0035147   GO:0036063   GO:0005801   GO:0007436   GO:0010883   GO:0007424   GO:0030198   GO:0035149   GO:0007112   GO:0000281   GO:0035158   GO:0008362   GO:0003682   GO:0007049   GO:0010468   GO:0005634   GO:0032440   GO:0047522   GO:0030117   GO:0005488   GO:0003677   GO:0003707   GO:0007169   GO:0016021  

PANTHER

PTHR10261   PTHR21704  

Subcellular location

Cytoplasm  
Golgi apparatus membrane  
Cytoplasmic vesicle  
COPI-coated vesicle membrane  
Endoplasmic reticulum   The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.   With evidence from 1 publications.
Nucleus  

Length:

861

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.2101

Exp number, first 60 AAs:

0.00042

Total prob of N-in:

0.01037

outside

1  -  861

 

 

Pi

7.57597

Theta

20.301232

Tajima's D

-1.600218

CLR

0.161963

CSRT

0.0474976251187441

Interpretation

Uncertain