Gene

KWMTBOMO00410

Pre Gene Modal

BGIBMGA000732

Annotation

Cytochrome_b-c1_complex_subunit_Rieske?_mitochondrial_[Operophtera_brumata]

Location

Bomo_Chr1(+):11983403-11984434      View in EpiBrowser

Full name

Cytochrome b-c1 complex subunit Rieske, mitochondrial      

Alternative Name

Complex III subunit 5
Cytochrome b-c1 complex subunit 5
Rieske iron-sulfur protein
Rieske protein UQCRFS1
Ubiquinol-cytochrome c reductase iron-sulfur subunit

Location in the cell

Nuclear   Reliability : 0.963

CDS

ATGAATGTTCTAAATAATGCGCGTGCAATTTGTCCTAATCTTTGGACCGGGCTGTGCTGTCAGAATTTAACTTGTATAAAAACTGTACGGGAGGTGCGACGAAAACGAGCGTCTGTCAATAAAAGCGATGCACCTCTAACGAGATTTTGTAGAAACAATCTTGAGCAAATACCGAGTCTGAGTATGTGGGTACAAGTGCGATACCACAAAGAATGTCCTCGTCTTCACCGCGATATCGAATTCCCAAACTTTAATCCGTACAGGAAAGATCAATACAAGGATGTGAGAAAGACAAGATGGGGTGCGGGCGACGAGAAGTCCGGAGTGACCTACACGATTGGCTTCTTCGGATTGCTCTGTGGATCGTATGCTGTAAAATCCGAGCTAGTACATTTCATTTCTTACATGGCCGCAGCCGCTGACGTGTTAGCTATGGCATCGATAGAAGTAGATCTGACCAAAATCACACCCGGGGCTTGTGTCTCATACAAATGGCGTGGAAAACCGCTTTTCATTAAGCGTAGAACTCAAGCAGACATCGATATTGAGGCAAAGACTCCATTGTCGGTTCTACGCGATCCAGAGACCCCGGAACAACGTACTACGATCCCGGAGTGGCTAATAGTGATTGGAATTTGTACTCATTTGGGATGTGTGCCGATCGCAAATGCTGGTGACTATCCGGGAGGTTTTTACTGTCCCTGCCACGGTAGTCATTACGATAACGTCGGTAGAGCTCGCAAAGGACCCGCGCCTTTGAATTTAGAGGTTCCCCCTTATAAGTTTGTTAGTGACTCTCTAGTAATTGTAGGATAA

Protein

MNVLNNARAICPNLWTGLCCQNLTCIKTVREVRRKRASVNKSDAPLTRFCRNNLEQIPSLSMWVQVRYHKECPRLHRDIEFPNFNPYRKDQYKDVRKTRWGAGDEKSGVTYTIGFFGLLCGSYAVKSELVHFISYMAAAADVLAMASIEVDLTKITPGACVSYKWRGKPLFIKRRTQADIDIEAKTPLSVLRDPETPEQRTTIPEWLIVIGICTHLGCVPIANAGDYPGGFYCPCHGSHYDNVGRARKGPAPLNLEVPPYKFVSDSLVIVG

Description

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity).
Cytochrome b-c1 complex subunit 9: Possible component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer, including this fragment, called subunit 9, which corresponds to the transit peptide (By similarity). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (By similarity). It is therefore unsure whether the UQCRFS1 fragments, including this fragment, are structural subunits (By similarity).

Catalytic Activity

2 [Fe(III)cytochrome c](out) + a quinol = 2 [Fe(II)cytochrome c](out) + a quinone + 2 H(+)(out)

Cofactor

[2Fe-2S] cluster

Subunit

Binds to the mitochondrial respiratory complex III dimer. The monomeric module of the mitochondrial respiratory complex III contains 11 subunits: 3 respiratory subunits involved in its catalytic activity (cytochrome b, cytochrome c1 and Rieske protein UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1) (By similarity). Incorporation of the Rieske protein UQCRFS1 is the penultimate step in complex III assembly (By similarity). Interacts with TTC19, which is involved in the clearance of UQCRFS1 fragments (By similarity).

Miscellaneous

The Rieske protein is a high potential 2Fe-2S protein.

Keywords

2Fe-2S   Disulfide bond   Electron transport   Iron   Iron-sulfur   Membrane   Metal-binding   Mitochondrion   Mitochondrion inner membrane   Respiratory chain   Transit peptide   Translocase   Transmembrane   Transmembrane helix   Transport   3D-structure   Complete proteome   Reference proteome  

Feature

chain  Cytochrome b-c1 complex subunit 9

Uniprot

H9IU02   A0A0L7LQD2   A0A2A4JVB3   A0A2H1W0R7   A0A212F9N6   H9J0M9   + More
B4JA98   B4KIH8   B3VTV1   A0A0P4Y3M5   A0A0P5IC96   A0A0P5EYS5   A0A0P4Z1V4   A0A162SVR7   A0A0P5NNX5   A0A0P5CVN3   A0A0P5Y6D5   A0A0P5L3B9   B4MW60   A0A0P5EY59   A0A0P5IT71   A0A0K8TIR8   A0A3M0K799   A0A0P5TK94   A0A212F5M9   A0A0P6E5P7   A0A0P4WSE7   B4LT56   A0A0P5BMS7   A0A0A9VZF5   A0A0P4ZNC7   A0A0P4WVP1   A0A0P4WVT4   A0A0P4ZSY3   Q69BJ9   A0A2K5D649   A0A0P4WPJ4   A0A0P5LF84   Q69BJ1   A0A0P5BW38   Q69BJ3   A0A0P5JPW9   A0A0P5D019   A0A0P5Z0W9   A0A0P5DZ82   A0A1L1RWY0   A0A0P5EDR0   A0A0P5EK99   A0A0N8CDX4   A0A0P5KR86   A0A099YV87   A0A0P5USJ2   A0A0P6IKA8   F1RNZ1   Q1G0W2   A0A091F3N1   Q5ZLR5   A0A093QH65   A0A1I8MQH0   A0A0P5APU4   A8JJ26   A0A0P5BEY8   R0JL39   A0A2P4T7P8   A0A1I8MQG2   A0A1Y1M8C3   U3KID7   T1PKU2   B3MK87   T1PDX2   A0A2K6UHY8   A0A0P5AD28   A0A1Q3FM73   K7GAR0   A0A091J6B5   A0A091U5Q4   Q69BJ8   A0A194PNL4   A0A1Q3FM50   A0A0N8AJI9   Q69BK7   Q69BJ7   A0A226PVD0   I4DKU3   H3A400   A0A0P6DGL8   A0A1I8PF44   K4FY92   A0A2K5TT07   A0A1I8PF34   A0A0M4EDJ2   S4PDC4   A0A0P4WSH9   B0XCK7   A0A287ASX6   Q69BJ5   A0A0A0MXF2   A0A091HVH6  

EC Number

7.1.1.8

Pubmed

19121390    26227816    22118469    17994087    25401762    26823975    + More
15906147    27912063    30723633    15642098    9565029    25315136    17932292    28004739    17381049    26354079    24621616    22651552    9215903    23056606    23622113   

EMBL

BABH01007234    JTDY01000340    KOB77629.1    NWSH01000563    PCG75628.1    ODYU01005637    + More
SOQ46685.1    AGBW02009564    OWR50455.1    BABH01010178    CH916368    EDW03772.1    CH933807    EDW11321.1    EU815629    HM210791    ACF21937.1    ADN06277.1    GDIP01236749    JAI86652.1    GDIQ01216818    JAK34907.1    GDIQ01268111    JAJ83613.1    GDIP01220602    JAJ02800.1    LRGB01000024    KZS21668.1    GDIQ01142342    JAL09384.1    GDIP01181098    JAJ42304.1    GDIP01062268    JAM41447.1    GDIQ01184529    JAK67196.1    CH963857    EDW75930.1    GDIQ01268321    JAJ83403.1    GDIQ01234064    JAK17661.1    GBRD01000816    JAG65005.1    QRBI01000116    RMC09053.1    GDIP01142610    JAL61104.1    AGBW02010163    OWR49045.1    GDIQ01067326    JAN27411.1    GDIP01252888    JAI70513.1    CH940649    EDW63887.1    GDIP01182795    JAJ40607.1    GBHO01044046    GDHC01010200    GDHC01004532    JAF99557.1    JAQ08429.1    JAQ14097.1    GDIP01211194    JAJ12208.1    GDIP01254486    JAI68915.1    GDIP01254422    JAI68979.1    GDIP01212151    JAJ11251.1    AY387510    AY387509    GDIP01254421    JAI68980.1    GDIQ01181165    JAK70560.1    AY387521    AAR32722.1    GDIP01179151    JAJ44251.1    AY387519    AAR32720.1    GDIQ01221465    JAK30260.1    GDIP01179150    JAJ44252.1    GDIP01050571    JAM53144.1    GDIP01149659    JAJ73743.1    GDIP01149660    JAJ73742.1    GDIP01147054    JAJ76348.1    GDIP01141255    JAL62459.1    GDIQ01187775    JAK63950.1    KL885851    KGL73296.1    GDIP01112302    JAL91412.1    GDIQ01003539    JAN91198.1    AEMK02000041    DQIR01031907    HCZ87382.1    DQ521661    ABF60225.1    KK719362    KFO63164.1    AJ719669    KL671666    KFW83422.1    GDIP01200699    JAJ22703.1    DS496302    EDO96122.1    GDIP01200700    JAJ22702.1    KB743565    EOA98015.1    PPHD01005941    POI32389.1    GEZM01037770    JAV81943.1    AGTO01021029    KA649334    KA649498    AFP63963.1    CH902620    EDV32471.1    KA646340    AFP60969.1    GDIP01200698    JAJ22704.1    GFDL01006459    JAV28586.1    AGCU01072991    AGCU01072992    KK501485    KFP15265.1    KK417835    KFQ85771.1    AY387512    AY387511    KQ459598    KPI94573.1    GFDL01006443    JAV28602.1    GDIQ01269547    JAJ82177.1    AY387494    AAR26321.1    AY387514    AY387513    AWGT02000007    OXB83991.1    AK401911    BAM18533.1    AFYH01216797    AFYH01216798    GDIQ01077917    JAN16820.1    JX052859    AFK11087.1    AQIA01035236    CP012523    ALC37967.1    GAIX01003721    JAA88839.1    GDIP01252187    JAI71214.1    DS232704    EDS44903.1    AY387517    AAR32718.1    AHZZ02014081    KL217815    KFO99147.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000007151    UP000001070    UP000009192    + More
UP000076858    UP000007798    UP000269221    UP000008792    UP000233020    UP000053641    UP000008227    UP000052976    UP000000539    UP000053258    UP000095301    UP000016665    UP000007801    UP000233220    UP000007267    UP000053119    UP000053268    UP000198419    UP000008672    UP000095300    UP000233100    UP000092553    UP000002320    UP000028761    UP000054308   

PRIDE

H9IU02    H9J0M9    Q69BJ9    F1RNZ1    Q1G0W2    Q5ZLR5    + More
Q69BJ8    Q69BJ7   

Pfam

PF00355   Rieske        + More
PF02921   UCR_TM
PF09165   Ubiq-Cytc-red_N

Interpro

IPR014349   Rieske_Fe-S_prot        + More
IPR036922   Rieske_2Fe-2S_sf       
IPR004192   Rieske_TM       
IPR017941   Rieske_2Fe-2S       
IPR005805   Rieske_Fe-S_prot_C       
IPR006317   Ubiquinol_cyt_c_Rdtase_Fe-S-su       
IPR037008   bc1_Rieske_TM_sf       
IPR015248   Ubiqinol_cyt_c_Rdtase_N       
IPR011070   Globular_prot_asu/bsu       

SUPFAM

SSF50022   SSF50022        + More
SSF56568   SSF56568       

Gene 3D

1.20.5.270     2.102.10.10    

ProteinModelPortal

H9IU02   A0A0L7LQD2   A0A2A4JVB3   A0A2H1W0R7   A0A212F9N6   H9J0M9   + More
B4JA98   B4KIH8   B3VTV1   A0A0P4Y3M5   A0A0P5IC96   A0A0P5EYS5   A0A0P4Z1V4   A0A162SVR7   A0A0P5NNX5   A0A0P5CVN3   A0A0P5Y6D5   A0A0P5L3B9   B4MW60   A0A0P5EY59   A0A0P5IT71   A0A0K8TIR8   A0A3M0K799   A0A0P5TK94   A0A212F5M9   A0A0P6E5P7   A0A0P4WSE7   B4LT56   A0A0P5BMS7   A0A0A9VZF5   A0A0P4ZNC7   A0A0P4WVP1   A0A0P4WVT4   A0A0P4ZSY3   Q69BJ9   A0A2K5D649   A0A0P4WPJ4   A0A0P5LF84   Q69BJ1   A0A0P5BW38   Q69BJ3   A0A0P5JPW9   A0A0P5D019   A0A0P5Z0W9   A0A0P5DZ82   A0A1L1RWY0   A0A0P5EDR0   A0A0P5EK99   A0A0N8CDX4   A0A0P5KR86   A0A099YV87   A0A0P5USJ2   A0A0P6IKA8   F1RNZ1   Q1G0W2   A0A091F3N1   Q5ZLR5   A0A093QH65   A0A1I8MQH0   A0A0P5APU4   A8JJ26   A0A0P5BEY8   R0JL39   A0A2P4T7P8   A0A1I8MQG2   A0A1Y1M8C3   U3KID7   T1PKU2   B3MK87   T1PDX2   A0A2K6UHY8   A0A0P5AD28   A0A1Q3FM73   K7GAR0   A0A091J6B5   A0A091U5Q4   Q69BJ8   A0A194PNL4   A0A1Q3FM50   A0A0N8AJI9   Q69BK7   Q69BJ7   A0A226PVD0   I4DKU3   H3A400   A0A0P6DGL8   A0A1I8PF44   K4FY92   A0A2K5TT07   A0A1I8PF34   A0A0M4EDJ2   S4PDC4   A0A0P4WSH9   B0XCK7   A0A287ASX6   Q69BJ5   A0A0A0MXF2   A0A091HVH6  

PDB

5GUP     E-value=1.6579e-55,     Score=545

KEGG

101736488    K00411 ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8] | (RefSeq) cytochrome b-c1

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008121   GO:0051537   GO:0070469   GO:0005743   GO:0016020   GO:0016021   GO:0046872   GO:0006122   GO:0005750   GO:0005739   GO:0005751   GO:0016491   GO:0005667   GO:0005737   GO:0003677   GO:0003707   GO:0007169   GO:0055114  

PANTHER

PTHR10134  

Subcellular location

Mitochondrion inner membrane  

Length:

271

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

5.39942

Exp number, first 60 AAs:

0.03239

Total prob of N-in:

0.25874

outside

1  -  271

 

 

Pi

19.951501

Theta

18.466431

Tajima's D

0.124116

CLR

0

CSRT

0.415979201039948

Interpretation

Uncertain