Gene

KWMTBOMO00404

Annotation

PREDICTED:_tissue_factor_pathway_inhibitor-like_[Bombyx_mori]

Location

Bomo_Chr1(-):11879554-11882292      View in EpiBrowser

Full name

Tissue factor pathway inhibitor      

Alternative Name

Extrinsic pathway inhibitor
Lipoprotein-associated coagulation inhibitor

Location in the cell

Extracellular   Reliability : 2.216

CDS

ATGCGCGAGTCAAACGATTACGAGTATAATAACTTGGCTATATTATTGGACAAAATATTACTTTCCGACTATTCCACAGCTCGTCACAAAACATGTTTTCTACGGCCAGACTCCGGTCCGTGTCGAGCGGACATCGTTCAGTGGTACTTCGACGTGAAACAACACAGATGCTACAGATTCTTTTGGGGCGGTTGCCAAGGAAACGGTAACAAATTCGAAACTGAAAAGGAATGCCGAGACTACTGTTATCTTAATACCACAACTGCAATACTACAAATACCACACTTCTGTTCCTTGAGCTTCGACTATGGAACATGCTTCGGGTATTACCATCGATGGACTTGGGATAAATTTTTTAAGTAA

Protein

MRESNDYEYNNLAILLDKILLSDYSTARHKTCFLRPDSGPCRADIVQWYFDVKQHRCYRFFWGGCQGNGNKFETEKECRDYCYLNTTTAILQIPHFCSLSFDYGTCFGYYHRWTWDKFFK

Description

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity).

Similarity

Belongs to the peptidase S1 family.

Keywords

Blood coagulation   Complete proteome   Disulfide bond   Glycoprotein   Hemostasis   Protease inhibitor   Reference proteome   Repeat   Secreted   Serine protease inhibitor   Signal  

Feature

chain  Tissue factor pathway inhibitor

Uniprot

A0A194PF80   A0A2W1CP64   A0A2H1V448   A0A194QFN9   A0A2H1W4A7   A0A0N0PDX3   + More
A0A2W1BVA6   A0A087UDS1   A0A3P4MWC7   A0A151MQ62   A0A1I8M0Z7   K1PKN2   F6X3Z5   A0A340YD16   G9KT31   A0A0R3WQS2   A0A0R3TFN1   E1BVF2   F1KTP2   G3TI19   A0A0B2UXW5   A0A3Q0GS18   A0A0R3TAK2   A0A2K6P8A1   W5Q4W4   W5Q4W3   A0A0M3KEP4   M3YLF3   A0A085MYC6   A0A183U5B5   A0A2P4T5T1   A0A099Z4G5   A0A2K6P8B5   A0A085MYC9   Q2PFV4   A0A2K6CMM5   A0A2P8YTK1   A0A2Y9J753   Q5PQU8   A0A1I8M100   A0A2K5UGS2   A0A1I8M0Z3   A0A0N1INT2   A0A2K6CMM4   A0A3M7RVZ2   T1PLF5   A0A131YSD7   Q02445   A0A1I8M0Z6   H9EYM4   A0A131YTM6   T1PCP7   A0A1I8M0Z2   T1PCL6   A0A158RAC2   A0A2Y9RKH2   A0A0N5DEW7   A0A2K5ZK19   A0A2K5L9M9   A0A2I3NCR2   A0A2Y9RPQ6   A0A2Y9MLR0   A0A1W0XBH0   A0A218V109   F1KZ42   A0A0K8R9Z5   A0A1I8PZV8   A0A0D9RJ63   A0A3L8SZJ2   A0A2K5J0J7   D3PJG9   C1BT07   P19761   A0A384B960   A0A085LPN9   Q28874   A0A341BGB2   G1SUS9   F6X1B0   A0A085LPP2   A0A0B2VI74   A0A384BSA7   A0A085LMU4   A0A0B7C2A1   A0A3B4BR12   A0A2K5ZK23   A0A2K5L9L5   A0A2Y9N0V1   A0A384B937   A0A2U3VCX9   A0A096N566   A0A068XP45   A0A068WVY0   A0A226MQJ1   A0A2K5J141   A0A2U3X6C0   A0A2Y9I4L8  

Pubmed

26354079    28756777    22293439    25315136    22992520    19892987    + More
23236062    15592404    21685128    25362486    20809919    24929829    29403074    15489334    15057822    30375419    26830274    1639767    25319552    30282656    2136251    1630940    8503123    7980463    16341006    21993624    17431167    23485966   

EMBL

KQ459605    KPI91937.1    NHMN01024249    PZC87394.1    ODYU01000580    SOQ35607.1    + More
KQ459011    KPJ04358.1    ODYU01006255    SOQ47929.1    KQ460170    KPJ17225.1    KZ149893    PZC78909.1    KK119375    KFM75510.1    CYRY02014350    VCW84470.1    AKHW03005461    KYO26671.1    JH817706    EKC24597.1    JP019462    AES08060.1    UYWX01001921    VDM21945.1    UZAE01005573    VDO01728.1    AADN05000033    JI165692    ADY41246.1    JPKZ01003074    KHN73695.1    UZAE01002670    VDN99948.1    AMGL01052059    AMGL01052060    AMGL01052061    AMGL01052062    UYRR01036178    VDK66417.1    AEYP01057875    AEYP01057876    AEYP01057877    KL367600    KFD62222.1    UYWY01004991    VDM29402.1    PPHD01007783    POI31730.1    KL889280    KGL76592.1    KFD62225.1    AQIA01015273    AQIA01015274    AQIA01015275    AB220483    BAE73016.1    PYGN01000368    PSN47564.1    AC116089    BC087020    AAH87020.1    KQ460973    KPJ10062.1    REGN01002516    RNA27619.1    KA649534    AFP64163.1    GEDV01006393    JAP82164.1    D10926    JU323727    AFE67483.1    GEDV01006717    JAP81840.1    KA646454    AFP61083.1    KA646481    AFP61110.1    UYRS01018942    VDK41397.1    AHZZ02004241    AHZZ02004242    AHZZ02004243    MTYJ01000005    OQV24774.1    MUZQ01000073    OWK59697.1    JI168367    ADY43146.1    GADI01005843    JAA67965.1    AQIB01009430    AQIB01009431    AQIB01009432    QUSF01000003    RLW11630.1    BT121775    HACA01028906    ADD38705.1    CDW46267.1    BT077736    BT120802    ACO12160.1    ADD24442.1    X54708    S61902    KL363346    KFD46935.1    AAEX03017869    S75369    AAB32443.1    AAGW02003574    AAGW02003575    JSUE03009282    JSUE03009283    JSUE03009284    KFD46938.1    JPKZ01001680    KHN80725.1    KL363380    KFD46290.1    HACG01052451    CEK99322.1    LK028587    CDS22657.1    MCFN01000537    OXB57583.1   

Proteomes

UP000053268    UP000053240    UP000054359    UP000050525    UP000095301    UP000005408    + More
UP000002281    UP000265300    UP000046396    UP000274429    UP000046398    UP000278807    UP000000539    UP000007646    UP000031036    UP000189705    UP000233200    UP000002356    UP000036680    UP000000715    UP000050794    UP000267007    UP000053641    UP000233100    UP000233120    UP000245037    UP000248482    UP000002494    UP000276133    UP000046400    UP000282613    UP000248480    UP000046395    UP000233140    UP000233060    UP000028761    UP000248483    UP000197619    UP000095300    UP000029965    UP000276834    UP000233080    UP000001811    UP000261681    UP000002254    UP000252040    UP000006718    UP000261680    UP000261440    UP000245340    UP000198323    UP000245341    UP000248481   

PRIDE

Q02445    P19761   

Pfam

PF00014   Kunitz_BPTI        + More
PF00089   Trypsin
PF01826   TIL
PF08686   PLAC
PF07679   I-set
PF00090   TSP_1
PF05986   ADAM_spacer1
PF00095   WAP
PF00057   Ldl_recept_a
PF00041   fn3

Interpro

IPR036880   Kunitz_BPTI_sf        + More
IPR020901   Prtase_inh_Kunz-CS       
IPR002223   Kunitz_BPTI       
IPR033116   TRYPSIN_SER       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR009003   Peptidase_S1_PA       
IPR001314   Peptidase_S1A       
IPR002919   TIL_dom       
IPR036084   Ser_inhib-like_sf       
IPR008296   TFPI-like       
IPR000884   TSP1_rpt       
IPR036383   TSP1_rpt_sf       
IPR010294   ADAM_spacer1       
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       
IPR010909   PLAC       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013783   Ig-like_fold       
IPR036645   Elafin-like_sf       
IPR013273   ADAMTS/ADAMTS-like       
IPR008197   WAP_dom       
IPR013098   Ig_I-set       
IPR002557   Chitin-bd_dom       
IPR023415   LDLR_class-A_CS       
IPR003961   FN3_dom       
IPR036055   LDL_receptor-like_sf       
IPR002172   LDrepeatLR_classA_rpt       
IPR036116   FN3_sf       

SUPFAM

SSF57362   SSF57362        + More
SSF50494   SSF50494       
SSF57567   SSF57567       
SSF82895   SSF82895       
SSF57256   SSF57256       
SSF48726   SSF48726       
SSF57424   SSF57424       
SSF49265   SSF49265       

Gene 3D

4.10.410.10     2.20.100.10     2.60.40.10     4.10.400.10     4.10.75.10    

CDD

cd00109  KU
cd00063  FN3
cd00112  LDLa

ProteinModelPortal

A0A194PF80   A0A2W1CP64   A0A2H1V448   A0A194QFN9   A0A2H1W4A7   A0A0N0PDX3   + More
A0A2W1BVA6   A0A087UDS1   A0A3P4MWC7   A0A151MQ62   A0A1I8M0Z7   K1PKN2   F6X3Z5   A0A340YD16   G9KT31   A0A0R3WQS2   A0A0R3TFN1   E1BVF2   F1KTP2   G3TI19   A0A0B2UXW5   A0A3Q0GS18   A0A0R3TAK2   A0A2K6P8A1   W5Q4W4   W5Q4W3   A0A0M3KEP4   M3YLF3   A0A085MYC6   A0A183U5B5   A0A2P4T5T1   A0A099Z4G5   A0A2K6P8B5   A0A085MYC9   Q2PFV4   A0A2K6CMM5   A0A2P8YTK1   A0A2Y9J753   Q5PQU8   A0A1I8M100   A0A2K5UGS2   A0A1I8M0Z3   A0A0N1INT2   A0A2K6CMM4   A0A3M7RVZ2   T1PLF5   A0A131YSD7   Q02445   A0A1I8M0Z6   H9EYM4   A0A131YTM6   T1PCP7   A0A1I8M0Z2   T1PCL6   A0A158RAC2   A0A2Y9RKH2   A0A0N5DEW7   A0A2K5ZK19   A0A2K5L9M9   A0A2I3NCR2   A0A2Y9RPQ6   A0A2Y9MLR0   A0A1W0XBH0   A0A218V109   F1KZ42   A0A0K8R9Z5   A0A1I8PZV8   A0A0D9RJ63   A0A3L8SZJ2   A0A2K5J0J7   D3PJG9   C1BT07   P19761   A0A384B960   A0A085LPN9   Q28874   A0A341BGB2   G1SUS9   F6X1B0   A0A085LPP2   A0A0B2VI74   A0A384BSA7   A0A085LMU4   A0A0B7C2A1   A0A3B4BR12   A0A2K5ZK23   A0A2K5L9L5   A0A2Y9N0V1   A0A384B937   A0A2U3VCX9   A0A096N566   A0A068XP45   A0A068WVY0   A0A226MQJ1   A0A2K5J141   A0A2U3X6C0   A0A2Y9I4L8  

PDB

1BIK     E-value=1.70743e-11,     Score=160

KEGG

101736287    K03909 tissue factor pathway inhibitor | (RefSeq) tissue factor pathway inhibitor-like

GO

GO:0004867   GO:0004252   GO:0005576   GO:0007596   GO:0008233   GO:0008061   GO:0006030   GO:0005615   GO:0016021   GO:0009986   GO:0030195   GO:0005901   GO:0071383   GO:0071222   GO:0071347   GO:0032496   GO:0032355   GO:0007507   GO:1903706   GO:0007417   GO:0045214   GO:0006857   GO:0016020   GO:0006810   GO:0005667   GO:0005737   GO:0003677   GO:0003707   GO:0007169  

Subcellular location

Secreted  

Length:

120

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.52768

Exp number, first 60 AAs:

0.00884

Total prob of N-in:

0.59116

inside

1  -  120

 

 

Pi

7.306077

Theta

17.420905

Tajima's D

-1.67778

CLR

0.139843

CSRT

0.0381480925953702

Interpretation

Uncertain