Gene

KWMTBOMO00397

Pre Gene Modal

BGIBMGA000725

Annotation

ATP-binding_cassette_sub-family_B_member_3_[Trichoplusia_ni]

Location

Bomo_Chr1(+):11700513-11724892      View in EpiBrowser

Full name

Multidrug resistance protein homolog 49      

Alternative Name

P-glycoprotein 49

Location in the cell

PlasmaMembrane   Reliability : 4.501

CDS

ATGGGGGTCAAAAAAGAAAAAAAAATAAAACTCGAAGAAAATATCGTTGAATCGTCACTTTCTTTCTTTCAAATATTTCGTTACGCCACGTGGTTGGAGCTTACGGCCACAATCTTGGGGACAGTATTCGGACTTCTCAGTGCTGGAGGTGTCACCTACAACCTGATGCAAGTTGGAGAAATGAGCACTGCCTTTGTTGAGAGAACTGTGCCGCCGGACAGATTGACCAGTAAAATGCCTATAATGTCTCTATTTGGAGGCGGTCGGAGATTATACAATGCCACGCACGAAGAAAATATGGCTGCTTTGATCGAAGATGCACAAGCTGTGGCTATAGGGGCATTTGTCAGTATAATCTTCTCGATATTATGCAACGTTCTATCGGTGGCTTTGGTAAGCTGGAGTGCACTCAAACAGATAACTACCATACGAAAGCTGTTTCTGACAGCAGTACTTCGTCAAGACATGACTTGGTTTGATACCGATTCTGATTTCAATTTAGCTTCGAAAATGTCTGAAAATCTAATGAAGCTTAAAGAAGGCATGGGTGAGAAATTGGCCGTGGTATCTAACTTAGTAGGCACCTCCATCATATGTTTATGCACTGCGTTTCCGCTGGGTTGGAAACTTGCGCTCGCTTGCATCACCGTTATGCCATTCTCAATAATGGCTTCTGTCGCTCTTACAAATTATCAAACCAAATCCTCTATTCGAGAAATGGAATCTTACAGTCAAGCTGGAAAGCAAGCCGAAGAAGTATTAAAATCTGTAAAGACGGTCGTGGCATTTGGTGGAGAAAATATTGAAGTTCAACGTTACAAATCATTGTTAGAGCCCGCTGAAATAAGTGGAAGCAGACGCGGCTTATTCACAGGACTGGGAAACGGTTTTAATTGGGTTCTCACGTATTCTCTAAACACAATTGGATTCATGTATGGCACTCGACTCATTATTGAAGATGCCAACAAACCAGACGACGAGAGAACTTACATTATTGGAATTGTATTAAGTATTACGTTTTCGGTGTACATGGCGACACAATCGATTACGCTCTGTGTGCCTCATATGGAAGTGTTCGCGACGGCCCGTGGTGCGGCCGCCAGTATTTTTAGCTTGTTGGACAAACACCCTAAAATTGACTGCCTAAGTGAGGCGGGTTCTTCTCCGCGAAGAGTCATAGGGGAAATTTCTTTAGAAGACGTACACTTTAGTTACCCATCTCGTTCGGATATTAAGATCTTGAAGGGATTTTCTCTTCACATAAAACCCGGAGAAAGCGTGGCGTTGGTTGGCTCATCTGGTTGTGGCAAATCAACTATACTCCAACTCCTGCAAAGGCTATACGATCCTAATCAAGGCTCCGTGAAACTAGACGGGAGAAATTTGAAAACTCTAAACATAGGATGGCTACGATCTTCGTTGGGTGTGGTAGGACAAGAGCCTGTCCTTTTTCGAGGAACGATTTACGATAATATAGCCATTGGGTATCCAGAAGCAACAAGTGAAGATGTTTACAGAGTAGCAGAAATGGCTTATGCACATGAATTCATCAAGAATTTACCAAACGGCTATGAAACAGTGATAGGTGAGCGTGGAGCCTCATTATCCGGCGGTCAGAAACAACGCATAGCCATAGCACGATCACTTCTACGTGAACCAGCTGTTCTGCTGTTAGATGAAGCTACTTCAGCATTAGATCCTCACTCCGAAAAACAAGTTCAAGCTGCATTGGACAGAGCAAGCGTTGGCAGAACCACACTAACAGTCTCACACAGATTGTCGACTATCGTGAATTGCCATCGAATTATTTGCATGGATCAAGGAACTATTATTGAGCAAGGGACTCATGTTGAACTGATGAAGGCCAAAGGTTTTTATCACAAACTAGTTACCAGCGGAAAAGAGACCAAAGAGCCAGAAGAAATTGGAACGGTGCTGGAAGAACAAGAAACAAAACAAAATGGCGAACTTCAGCCAGCGGTGCGACCCGAACCAGATGTCAAAAGACGATCTGTAAGGAAACTTCACAGGCGTCAGTCCGCCAAAGGAGCTCACGAATGGATGGCTACACCACGAGGGTCAATTTCCTCAATTATGTCAACAGCCTTACAAAGCCACGCTTACAGCGACACTTATGAAGTAGAAGAATTTGATGACGATGAGGACGTGACCCCGGTTAGTGATTGGCAGCTTCTGAAGCTTAATACACCCGAGTGGCTCTATCTTACAGTCGGATCCATTGCAGCTTTCATTCAAGGAGCCTGCTTTCCTGTTTTCGCTTTACTATTGGGCTACACAAGTGGTATTTTTATTTTGCCAGACGAGAACGAAGTTTTATATTTTGCGGACTTATATTCTGGACTGTTTCTCGTTGTGGCCGCAGTTGCTGGTATATCTATGTGCATCCAAAGCAGTACATTTACCACTGCAGGATTAAAAATGACGACACGTCTTCGTTACAAGTATTTTTCGGCTTTGTTAAGACAAGAAATTGGTTACTTTGATAGAGAATCGAATACAGTTGGTGCCGTATGTGCAAGACTTAGTGGCGATACAGCAGAAGTACAAGGCGCTACTGGATTACGAATCGGTCTTATTTTGCAAGGATTCAGTTCGGTTACGGTTGGATTCATCATGGCAATGAGCTACAACTGGAAACTAACCCTCGTGTCTACAACATTTTTGCCTTTGATGGTTGGAAGTATTTGGTTGGAAGGTATAATGTCTCAAAAATCACAGCAAGATGAACGAGAAGCAATGGAATCTGCTACAGCGATCGCAACAGAAGCAGTAGTTAGCATCAAAACCGTTCAGAGCTTAGGTATTGAATCTTTGTTTATTACAAGATTTCAAGACGCACTGATAGACGCTTGTGCAGCTGTCGTGAAGAAGAGTCGTTGGCGGGGCTTAGTCCTTGGTTTGTGTATTTACGTTCCACTGCTGTCTTACTGCAGCGCTGTCATTTATGGAGCAGTTCTAGTCGCCCACGGGGAAGTCGAATACGAAGTTGTTTTACTTGTTACTGAAGCAGTGATGTACGGAGCATACATGCTAGGTCAGTCATTAGTATACGCACCGAGCTTCAATTCGGCAAAAACTTGCGGTGCAAGGATCTTATCTATTATAAACCGAGAGCCGAGAATCAGAACAGTAGACGGTCTCAACGATAAACAGGATTGGTCCGCATCAGGAAATTTCAGCATCAACGATGTCGAATTTAGTTATCCTACTCGAGCACATCAGATGATTCTCAAAGGTATTGACTTGCACGTAGAAGCCGGCAAAACTGTTGCCCTTGTTGGTTCATCAGGCTGCGGAAAATCAACAGTGTTGCAACTTATACAGAGATTCTATGATCCCACAACTGGAAATATTGAATTGGACGGTGTGGATATAACGAAAAGCTTAACACTGAATCGCCTCCGAAAACAACTTGGGGTGGTGCAACAAGAACCCATTTTGTTCGATCGCACCCTCGCAGAGAACATCGCGTACGGTGACAACAGTCGCAAACCTACTATGGATGAAATCATTGCAGCAGCTAAAGCGGCCAATATACACAATTTCATCGTATCTTTACCAAAGGGCTACGAAACGAACTTAGGAGCAGGCGGTGCTCAATTATCCGGAGGACAAAAGCAGCGAGTGTGCATAGCGCGGGCCCTCATCAGATCACCACGCCTACTCCTCTTGGATGAGGCAACTTCGGCTTTGGATGCCAACAGTGAACGGGCTGTAACAGAGGCATTGGATCATGCAGCCAAAGGCCGAACTTGCATTACTATAGCTCATCGTCTAACTACAATCAAGGACGCTGATATCATTTGTGTTTTGGATAAAGGTAAAATAGTAGAAAAAGGCAACCACGCAGAGCTCATTGGCCTCAAGGGACATTACTGGCAACTAAGTAAACAGCAAAACGTCACGTGA

Protein

MGVKKEKKIKLEENIVESSLSFFQIFRYATWLELTATILGTVFGLLSAGGVTYNLMQVGEMSTAFVERTVPPDRLTSKMPIMSLFGGGRRLYNATHEENMAALIEDAQAVAIGAFVSIIFSILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGAHEWMATPRGSISSIMSTALQSHAYSDTYEVEEFDDDEDVTPVSDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALLLGYTSGIFILPDENEVLYFADLYSGLFLVVAAVAGISMCIQSSTFTTAGLKMTTRLRYKYFSALLRQEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGEVEYEVVLLVTEAVMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEIIAAAKAANIHNFIVSLPKGYETNLGAGGAQLSGGQKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQNVT

Catalytic Activity

ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Keywords

ATP-binding   Complete proteome   Glycoprotein   Membrane   Nucleotide-binding   Polymorphism   Reference proteome   Repeat   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Multidrug resistance protein homolog 49

Uniprot

H9ITZ5   E9LP52   E9LP53   A0A212EGJ7   A0A194PLG2   A0A194QS38   + More
A0A2A4J7A7   A0A2A4IW09   H9ITZ4   S4PS85   A0A2A4IWG8   A0A2H1W3L7   A0A2H1W7P0   A0A212EWQ3   A0A1J1IAJ6   A0A0N1I5L8   E2AWB0   A0A1A9X3Q1   A0A0L7R809   A0A1B0BVA0   A0A026W1C9   A0A3L8D5X6   A0A336LRH3   A0A336LJ59   A0A194PSR0   H9JNX4   A0A0N0PA82   B4P4W4   A0A0J9RBI5   A0A2W1BMH9   Q00449   H9JIV1   B4HPY9   A0A212ET05   A0A0P5KNX8   A0A0P5KP88   A0A0P5KL14   A0A0P5KY70   A0A0N8BFL4   A0A0P5L3X1   A0A0P5MN93   A0A0N8BT06   A0A0P5FGC1   A0A0N8D682   A0A0P5VVT8   A0A0P5PLT2   A0A0P5E484   A0A0P5XWL8   A0A0P4ZYS2   A0A0P5QN51   A0A0P5R1J7   A0A0P6EKP1   A0A0N8E416   A0A0P5NUA5   A0A0P5E0L6   A0A0P4Y5X8   A0A0P5I1J6   A0A0P5ECU1   A0A0P5SBT7   A0A0P5GRW8   A0A0P5J0U1   A0A0P5QWS5   A0A0P5GNX2   A0A0P6HHN0   A0A0P5GTW0   A0A0P5J2A6   A0A0P5SZX8   A0A0P5E4X0   A0A0P5BB79   A0A0P5J6M5   A0A0N8C9R6   B3MDC5   A0A0P6E7L3   A0A0P5M5G2   A0A0N8E1X9   A0A0P5E4G0   A0A0N8BLF7   A0A0P5E7Z2   A0A0N8EE90   A0A0P5E3P5   A0A0N8DCM7   A0A0P5CPM6   E9G5N8   A0A0P5FKW7   A0A087U4K8   A0A0P5DU88   A0A0P5E521   A0A1Y1LW74   A0A0P5EKF5   A0A0N8AA02   A0A0P5EG60   A0A0P5E7W6   A0A0N8AHH7   A0A0P5Y039   A0A0P5LZK8   A0A0N0PE45   A0A0P5XGQ2   A0A0A7AS38   A0A0P5XWT3   A0A0L0CPE3  

EC Number

7.6.2.2

Pubmed

19121390    23170973    22118469    26354079    23622113    20798317    + More
24508170    30249741    17994087    17550304    22936249    28756777    2072901    10731132    12537572    12537569    21292972    28004739    26108605   

EMBL

BABH01007213    BABH01007214    HQ116793    ADV76538.1    HQ116794    ADV76539.1    + More
AGBW02015069    OWR40605.1    KQ459605    KPI91945.1    KQ461196    KPJ06356.1    NWSH01002654    PCG67759.1    NWSH01006407    PCG63464.1    BABH01007211    GAIX01014073    JAA78487.1    PCG63463.1    ODYU01006047    SOQ47556.1    ODYU01006552    SOQ48494.1    AGBW02011924    OWR45901.1    CVRI01000043    CRK95982.1    KQ458863    KPJ04743.1    GL443280    EFN62270.1    KQ414636    KOC67015.1    JXJN01021173    KK107488    EZA49880.1    QOIP01000012    RLU15877.1    UFQT01000131    SSX20626.1    UFQT01000028    SSX18184.1    KQ459593    KPI96347.1    BABH01009789    BABH01009790    KQ458751    KPJ05317.1    CM000158    EDW90685.1    CM002911    KMY93381.1    KZ149962    PZC76282.1    M59076    AE013599    AY058791    BT044206    BT081353    BABH01023141    BABH01023142    BABH01023143    BABH01023144    CH480816    EDW47652.1    AGBW02012702    OWR44581.1    GDIQ01182550    JAK69175.1    GDIQ01182548    JAK69177.1    GDIQ01182551    JAK69174.1    GDIQ01182552    JAK69173.1    GDIQ01182547    JAK69178.1    GDIQ01182549    JAK69176.1    GDIQ01154249    JAK97476.1    GDIQ01147811    JAL03915.1    GDIP01148275    JAJ75127.1    GDIP01064791    JAM38924.1    GDIP01109174    JAL94540.1    GDIQ01147810    JAL03916.1    GDIP01148276    JAJ75126.1    GDIP01066181    JAM37534.1    GDIP01219361    GDIP01219360    JAJ04042.1    GDIQ01111964    JAL39762.1    GDIQ01126919    JAL24807.1    GDIQ01147809    GDIQ01062282    GDIQ01051648    JAN32455.1    GDIQ01063940    JAN30797.1    GDIQ01147812    JAL03914.1    GDIP01148277    JAJ75125.1    GDIP01232016    JAI91385.1    GDIQ01219679    JAK32046.1    GDIP01148274    JAJ75128.1    GDIQ01098175    JAL53551.1    GDIQ01236626    JAK15099.1    GDIQ01206138    JAK45587.1    GDIQ01117914    JAL33812.1    GDIQ01237733    JAK13992.1    GDIQ01027999    JAN66738.1    GDIQ01237732    JAK13993.1    GDIQ01206136    JAK45589.1    GDIQ01098174    JAL53552.1    GDIP01146971    JAJ76431.1    GDIP01186914    JAJ36488.1    GDIQ01206137    JAK45588.1    GDIQ01100931    JAL50795.1    CH902619    EDV36373.1    GDIQ01081174    JAN13563.1    GDIQ01163316    JAK88409.1    GDIQ01069836    JAN24901.1    GDIP01146973    JAJ76429.1    GDIQ01166203    JAK85522.1    GDIP01146919    JAJ76483.1    GDIQ01035348    JAN59389.1    GDIP01146924    JAJ76478.1    GDIP01046831    JAM56884.1    GDIP01168463    JAJ54939.1    GL732532    EFX85237.1    GDIP01146922    JAJ76480.1    KK118129    KFM72297.1    GDIP01168462    JAJ54940.1    GDIP01146925    JAJ76477.1    GEZM01046271    JAV77371.1    GDIP01146972    JAJ76430.1    GDIP01167921    JAJ55481.1    GDIP01146920    JAJ76482.1    GDIP01146923    JAJ76479.1    GDIP01146921    JAJ76481.1    GDIP01064790    JAM38925.1    GDIQ01166204    JAK85521.1    KQ459986    KPJ18849.1    GDIP01073985    JAM29730.1    KF906269    AHK05634.1    GDIP01066179    JAM37536.1    JRES01000089    KNC34215.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000218220    UP000183832    + More
UP000000311    UP000091820    UP000053825    UP000092460    UP000053097    UP000279307    UP000002282    UP000000803    UP000001292    UP000007801    UP000000305    UP000054359    UP000037069   

PRIDE

H9ITZ5    H9ITZ4    H9JNX4    Q00449    H9JIV1   

Pfam

PF00005   ABC_tran        + More
PF00664   ABC_membrane

Interpro

IPR017871   ABC_transporter_CS        + More
IPR039421   Type_I_exporter       
IPR003439   ABC_transporter-like       
IPR027417   P-loop_NTPase       
IPR011527   ABC1_TM_dom       
IPR003593   AAA+_ATPase       
IPR036640   ABC1_TM_sf       
IPR030275   MDR3       
IPR030278   BSEP       

SUPFAM

SSF90123   SSF90123        + More
SSF52540   SSF52540       

Gene 3D

1.20.1560.10    

ProteinModelPortal

H9ITZ5   E9LP52   E9LP53   A0A212EGJ7   A0A194PLG2   A0A194QS38   + More
A0A2A4J7A7   A0A2A4IW09   H9ITZ4   S4PS85   A0A2A4IWG8   A0A2H1W3L7   A0A2H1W7P0   A0A212EWQ3   A0A1J1IAJ6   A0A0N1I5L8   E2AWB0   A0A1A9X3Q1   A0A0L7R809   A0A1B0BVA0   A0A026W1C9   A0A3L8D5X6   A0A336LRH3   A0A336LJ59   A0A194PSR0   H9JNX4   A0A0N0PA82   B4P4W4   A0A0J9RBI5   A0A2W1BMH9   Q00449   H9JIV1   B4HPY9   A0A212ET05   A0A0P5KNX8   A0A0P5KP88   A0A0P5KL14   A0A0P5KY70   A0A0N8BFL4   A0A0P5L3X1   A0A0P5MN93   A0A0N8BT06   A0A0P5FGC1   A0A0N8D682   A0A0P5VVT8   A0A0P5PLT2   A0A0P5E484   A0A0P5XWL8   A0A0P4ZYS2   A0A0P5QN51   A0A0P5R1J7   A0A0P6EKP1   A0A0N8E416   A0A0P5NUA5   A0A0P5E0L6   A0A0P4Y5X8   A0A0P5I1J6   A0A0P5ECU1   A0A0P5SBT7   A0A0P5GRW8   A0A0P5J0U1   A0A0P5QWS5   A0A0P5GNX2   A0A0P6HHN0   A0A0P5GTW0   A0A0P5J2A6   A0A0P5SZX8   A0A0P5E4X0   A0A0P5BB79   A0A0P5J6M5   A0A0N8C9R6   B3MDC5   A0A0P6E7L3   A0A0P5M5G2   A0A0N8E1X9   A0A0P5E4G0   A0A0N8BLF7   A0A0P5E7Z2   A0A0N8EE90   A0A0P5E3P5   A0A0N8DCM7   A0A0P5CPM6   E9G5N8   A0A0P5FKW7   A0A087U4K8   A0A0P5DU88   A0A0P5E521   A0A1Y1LW74   A0A0P5EKF5   A0A0N8AA02   A0A0P5EG60   A0A0P5E7W6   A0A0N8AHH7   A0A0P5Y039   A0A0P5LZK8   A0A0N0PE45   A0A0P5XGQ2   A0A0A7AS38   A0A0P5XWT3   A0A0L0CPE3  

PDB

6QEX     E-value=0,     Score=2238

KEGG

101735703    K05658 ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] | (RefSeq) multidrug resis

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)

GO

GO:0042626   GO:0005524   GO:0016021   GO:0015721   GO:0008354   GO:0001666   GO:0017085   GO:0097254   GO:0015562   GO:0015238   GO:0008559   GO:0005887   GO:0042908   GO:0009636   GO:0006855   GO:0005886   GO:0043190   GO:0016887   GO:0006810   GO:0043401   GO:0003677   GO:0003707   GO:0007169   GO:0055085  

PANTHER

PTHR24221   PTHR24221:SF241   PTHR24221:SF165  

Subcellular location

Membrane  

Length:

1309

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

256.776850000001

Exp number, first 60 AAs:

22.52924

Total prob of N-in:

0.99508

POSSIBLE N-term signal

sequence

inside

1  -  30

TMhelix

31  -  53

outside

54  -  109

TMhelix

110  -  132

inside

133  -  185

TMhelix

186  -  208

outside

209  -  211

TMhelix

212  -  231

inside

232  -  295

TMhelix

296  -  318

outside

319  -  330

TMhelix

331  -  353

inside

354  -  738

TMhelix

739  -  761

outside

762  -  789

TMhelix

790  -  812

inside

813  -  860

TMhelix

861  -  883

outside

884  -  886

TMhelix

887  -  904

inside

905  -  970

TMhelix

971  -  993

outside

994  -  1002

TMhelix

1003  -  1025

inside

1026  -  1309

 

 

Pi

26.726457

Theta

26.575943

Tajima's D

-1.054731

CLR

0.07537

CSRT

0.127743612819359

Interpretation

Uncertain