Gene

KWMTBOMO00396  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000724

Annotation

ATP-binding_cassette_sub-family_B_member_3_[Trichoplusia_ni]

Location

Bomo_Chr1(+):11673733-11694334      View in EpiBrowser

Full name

Multidrug resistance protein 1B      

Alternative Name

ATP-binding cassette sub-family B member 1B
P-glycoprotein 1

Location in the cell

PlasmaMembrane   Reliability : 4.383

CDS

ATGGCAAATAAGAAAAAGAAATCGAAGAATGAAGAAAACATCACGACGCTGGTGTCCTTCTTTCAAATCTTTCGTTACGGAAATTGTTTGGAGCTGTTGGCAACCGCTCTCGGGGTAGTCTTCGGAATGATAAGTGGAGCCGGCGTGTGCTGCAACCTGCTCCAAATAGGAGAACTGAGCACGGCGTTCGTTGAGAGGACTAAGTATCATGACCGGCTTTCCAGCTACTTGCCGCTGACTGCGACTTTCGGAGGTGGCAAAAGATTGGTTAACGCTACGCACGAACAAAATATGGAGGCTCTTATCGATGACGCGAAAGCAATGGCCATCGGAATGTTCATCAGTATTGGAGTATCTCTTGTGTTCTGCGTGCTGTCCTTCAGCCTAATCAGTTGGAGCGCTTTACGCCAGATAACGAGAATAAGGACGTTGTTCCTGAGGTCTGTACTTCGTCAAGACATGTCTTGGTACGACACTGATTCAGAATTCAACTTAGCGTCGAAGATGTCCGAAAACTTGATGAGCATTAAGGAAGGTATGGGCGAGAAGTTGGCGGTTGTATCGAACTTGGTGGGGACTTCCGTGATTTGTCTGTGCACCGCATTCCCCCTCGGTTGGCAGTTGACTCTGGCCTGCGCAGCCGTGATGCCCTTCTCCGTGATCACTTCTATTGCCTTATCGAATTACCAAACAAAGTCTTCGATAAGAGAAATGGAATCATACAGTTTGGCCGGCAAGCAAGCTGAAGAGATTCTCAAGTCGGTCCGAACAATCGTCGCCTTCGGAGGGGAAAATAAGGAAGTAGAGCGGTACCGACGTCTGCTTGAGCCGGCTGAAGAATTTGGTCGAAAACGTGGTCTTTTCACGGGATTAGGCAACGGCTTCAACTGGGTCCTTACATATTCTCTGAATGCTATCGGCTTTTCGTACGGGACAAGGCTAGTTGTCAATGATTTCGATACTGATTCTAATTTGAGGCAATATCCCGTTGGCGCTGTGTATAGTATACTATTCTCTGTATATATGGCAACACAGTCTATTACATTCTGTGTCCCACATTTGGAGGGCTTCGCCGCGGCCCGTGGTGCGGCCGCAAGCATTTTCCACTTGATTGAAAGAGAACCAAAGATCGACAGTCTACAGCAAAAAGGTTTAACGCCTCGTCGAGTTGTTGGAGATATTTTACTTGAGGACGTTGAGTTCTGTTATCCGTCGCGACCCGAAGTCAAGGTTCTCAAAGGTTTTTCGATCCACGTAAAGCCGGGCGAATGCGTAGCTCTAGTGGGCTCCTCTGGTTGCGGTAAAAGTACTGTATTACAACTTTTACAAAGACTGTACGACCCACAAGCCGGCTCAGTTAAACTGGATGGTAAAAATTTGAAAAACCTCAATCTTAGCTGGCTGAGGTCATCTTTGGGTGTGGTAGGTCAAGAACCAGTACTGTTTCGAGGGACGATCTACGACAACATCGCCATCGGAAGTCCAGAGGCCACACGCGAAGAAATCCAAAGAGTCGCTGAGATTGCTTACGCCCATGACTTTATTAGTCTTCTACCAAATGGCTACGATACTGTGATAGGAGAACGAGGCGCTTCTCTTTCTGGTGGTCAGAAGCAACGAATTGCAATTGCCCGGTCTCTCTTACGTGAACCGGCGGTGCTACTGCTTGACGAGGCTACTTCAGCCCTTGACCCTCACTCTGAGAGACAAGTACAAGCAGCGCTCGATCGTGCCAGTGTCGGACGCACTACCATAACCGTGTCACATAGATTGTCGACCATAGTGAACGCCGATAGAATTATTTGCATGGACCAAGGAGTTATAGTCGAACAAGGAACGCACGAGGATCTCATGAAAGCCAAAGGGTTTTACCATAAACTGGTGACAACTGGTAACGAGAACAAAGAACCAGCAGATATAGAGCCCCTTATTGAGGAAGCTGACGGTGATGGAGACAACATAGAACCAACTGTACCTTCAAGATTAGACGTCAGACGACGATCAAGTAAGAAAGTGCTGAGACATCATTCTATTAAAAAAGATCACCCGGACTGGTTGACACCTCGCGGCTCGATTTCTTCAATGGTATCGATTGGACTGCAAAATTTCGTATTTAATAGTGATCTCGAATCTGAGGAAGATGAAGACGAAGAAGAGACTGTAAAAACTGTCAGTGATTGGCAGCTACTGAAATTGAATGCCCCTGAATGGCCATTGATAACAGTTGGCTCTATTGCTGCTTTCCTACAAGGAGCATGTTTCCCTGTCTTCGCCTTACTTTTTGGATTTTCCAGCGGGATCTTCATACTAGATAATCGCGATGATATCATTTATTTAGCAGATCTTTATTCTGTGTTATTCGTGGTGATAGCCGCGGTTGCTGGTATATCCATGTGTCTACAAAGTACAACCTTTACAAGCGCTGGCTTGAAAATGACAACTCGACTAAGACATCAATATTTTGCATCTTTGTTGAAACAGGAAATAGGGTTTTTCGATAAAGAAACGAATACGGTCGGCGCGATCTGTGCGAGATTGAGCGGTGACACTGCTGAGGTACAGGGTGCCACTGGACTCAGGATAGGCCTCATACTGCAGGGTATAAGCTCAGTGGTCGTCGGGTTTTTGTTAGCTATCAGCTACAACTGGAAACTTACCTTAGTTGCGACAGTTTTTCTTCCTTTGATGGTAGGTAGTATATGGTTGGAAGGTATTATATCTCAGAAGGCGCAAATAGATGAACGAAATGCAATGGAATCAGCCACTGCCATAGCTACTGAAGCCGTTGTCAGCATCAAGACAGTGCAGAGCTTAGGTGTGGAGACGGTTTTCCTCCAAAAATTTCAAGATGCACTCAAGACTGCCTGTGTAGCTGTGGCTTATAAAACGCGTTGGAGAGGATTAGTCTACGGTCTTGGAGTTTACATACCGTTCATGGCGTACTGTAGCGCTACTGTTTACGGCGCCGTGCTCGTCGCCTATGGAGAAATGGAATATAAACTAGTGTTGCTGGTAAACGAAGCTATAATGTACGGAGCCTACATGTTAGGCCAGTCGCTGGTGTATGCTCCCAGTTTGAATACGGCAAAGGCGTGTGGAGCAAGGATTCTGTCCATCATTCAAAGGCAACCTAAAATTCACAACGCAGTTGGAGTGAAAGACAAAAAAGATTGGGTGGCGTCCGGAAACTTCAGCATGCGTGATGTAGAATTCTGTTACCCTACAAGGCCAAGTCAACGTGTTTTGAAAGGAATCGATCTGAAAATGGAAGCTGGTAAAACCATCGCTCTCGTCGGGTCCTCCGGATGTGGCAAGTCTACAATCCTCCAGCTATTTCAACGTTTCTATGACCCTGATTCTGGTTTTATTGAATTAGACAATCGTGACATTAGATCTGCTCTGACTATACCACGGCTGCGTCGTCAGTTAGGAGTCGTGCAGCAAGAGCCGGTGCTCTTGGACAGAAGTCTGGCCGAGAATATCGCGTATGGAGATAACAATAGGAAGGTCACTATGCACGAAATCGTCGCCGCTGCCAAAGCAGCAAACATACACTCATTCATCGTGTCTTTACCCAAGGGTTATGAAACGAATTTGGGTGCGAACGGTGCTCAGCTGTCAGGAGGTCAAAAACAGCGGGTCTGTATAGCAAGGGCACTCATTAGGTCGCCACGCTTGTTACTGCTAGATGAAGCTACATCAGCATTGGATGCTAGCAGTGAACGGGCCGTGACAGAAGCTTTGGAGAAGGCTGCCAAGGGCCGCACTTGCATCACTATTGCTCACCGCCTCTCTACAGTTAAAGACGCTGACTTGATCTGCGTTATTGATAAAGGTAAAATCGTTGAGCGTGGAACTCATGCTGAATTGGTCAGCATGAAGGGACATTACTGGCGCATGTGTAGAGGCCAAAATATGGCTTAA

Protein

MANKKKKSKNEENITTLVSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYLPLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFAAARGAAASIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVKLDGKNLKNLNLSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEADGDGDNIEPTVPSRLDVRRRSSKKVLRHHSIKKDHPDWLTPRGSISSMVSIGLQNFVFNSDLESEEDEDEEETVKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKGYETNLGANGAQLSGGQKQRVCIARALIRSPRLLLLDEATSALDASSERAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRGQNMA

Catalytic Activity

ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Subunit

Interacts with PSMB5.

Miscellaneous

In mouse the MDR gene family includes three or more related but distinct cellular genes.

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Keywords

ATP-binding   Cell membrane   Complete proteome   Glycoprotein   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Multidrug resistance protein 1B

Uniprot

H9ITZ4   E9LP52   E9LP53   A0A2A4J7A7   A0A212EGJ7   A0A194PLG2   + More
A0A194QS38   S4PS85   A0A2A4IW09   A0A2A4IWG8   A0A2H1W7P0   H9ITZ5   A0A2H1W3L7   H9JNX4   B4MJQ1   A0A212ET05   E9G2X2   A0A0L0CPE3   A0A1I8N682   A0A1B0G265   G3TGB8   B2RUR3   P06795   G3U8Q2   H0XA31   J9R1J6   A2VBC7   A0A1S3WN29   A0A2Y9RED6   Q9JK64   H0XJ01   O02793   Q6PSM0   G1T8H8   A0A0K2A212   B3RRZ8   A0A2U3WPH7   A0A384BPA4   A0A2Y9H1A3   A0A2U3XDU9   A0A2K6F8D6   Q6UUW3   M3Z3M9   G1N7X9   A0A3Q0HF50   M1FTP0   A0A091EHW6   A0A226NJG9   A0A1U7TSX7   W6RRJ8   A0A1L8FJP3   B5DP27   H0W664   A0A1U7U2H5   W6RT25   F1NKW0   A0A218V100   E1BS63   A0A151MQG6   R7T3N8   A0A3B5MXA8   A0A286Y4X3   O93437   A0A3Q0E6X1   U4USH3   G3X771   A0A3P9D7T4   H0VLE6   H2ZR93   A0A3B4FGC4   A0A3P8Q775   A0A2B4SKX2   A0A384BQ86   D7F607   A0A3G2BZA7   A0A3L8SY15   A0A093EZD3   A0A2K6F8D9   I3JQE9   A0A1L8G6K1   G1NDS9   A0A2I0UTT2   U3JDD3   V9K7H3   A0A091EQ32   A0A1U7TNX3   I3JQF0   A0A0A0A3M1   A0A2U3ZRF7   E1C757   F1QSX6   A0A1L8FW23   A0A3Q0E088   A0A286Y222   H2LEC5   A0A087YEQ8   A0A1W3JMB5   A0A3P9IED0   U3IQT2   F6NLY2  

EC Number

7.6.2.2

Pubmed

19121390    23170973    22118469    26354079    23622113    17994087    + More
21292972    26108605    25315136    12040188    15489334    19144319    3768958    2570420    2248681    15057822    15632090    22673903    10442984    16545584    21993624    18719581    20838655    24811006    27762356    15632085    15592404    22293439    23254933    10195430    23537049    19393038    25186727    24813606    30282656    24402279    23594743    17554307    23749191   

EMBL

BABH01007211    HQ116793    ADV76538.1    HQ116794    ADV76539.1    NWSH01002654    + More
PCG67759.1    AGBW02015069    OWR40605.1    KQ459605    KPI91945.1    KQ461196    KPJ06356.1    GAIX01014073    JAA78487.1    NWSH01006407    PCG63464.1    PCG63463.1    ODYU01006552    SOQ48494.1    BABH01007213    BABH01007214    ODYU01006047    SOQ47556.1    BABH01009789    BABH01009790    CH963846    EDW72340.2    AGBW02012702    OWR44581.1    GL732530    EFX86431.1    JRES01000089    KNC34215.1    CCAG010019770    BC141363    BC150811    CH466600    AAI41364.1    EDL14680.1    M14757    M60348    AAQR03012497    AAQR03012498    AAQR03012499    AAQR03012500    JX312084    AFR33964.1    AM491812    CAM33439.1    AABR07059500    AABR07059501    AABR07059502    AABR07059503    AABR07072972    AC133679    AF257746    CH474013    AAF69007.1    EDL84318.1    U78609    AAB58489.1    AY582535    AAS91649.1    AAGW02061966    AAGW02061967    AAGW02061968    KR905170    AKZ42358.1    DS985243    EDV26959.1    AY360144    AAQ63650.3    AEYP01005833    JQ696953    AFV15804.1    KK718434    KFO56227.1    MCFN01000033    OXB67674.1    HG917089    CDM63410.1    CM004478    OCT71794.1    CH379067    EDY73278.1    AAKN02015613    AAKN02015614    AAKN02015615    AAKN02015616    HG917090    CDM63411.1    AADN05000033    KP663379    AKN23386.1    MUZQ01000073    OWK59687.1    AKHW03005461    KYO26786.1    AMQN01003653    AMQN01003654    KB312379    ELT87338.1    AJ009799    CAA08835.1    KB632345    ERL93126.1    AAKN02016682    AAKN02016683    AAKN02016684    LSMT01000057    PFX30016.1    FJ938210    ACX30417.1    MH420553    AYM45157.1    QUSF01000003    RLW11219.1    KK378712    KFV47214.1    AERX01017567    CM004474    OCT79361.1    KZ505638    PKU49436.1    AGTO01011562    JW861206    AFO93723.1    KK718916    KFO59998.1    KL870333    KGL87620.1    AADN05000350    CR626882    CM004476    OCT75761.1    AYCK01002214    ADON01068769   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000007798    + More
UP000000305    UP000037069    UP000095301    UP000092444    UP000007646    UP000000589    UP000005225    UP000079721    UP000248480    UP000002494    UP000001811    UP000009022    UP000245340    UP000261680    UP000248481    UP000245341    UP000233160    UP000000715    UP000001645    UP000189705    UP000052976    UP000198323    UP000189704    UP000186698    UP000001819    UP000005447    UP000000539    UP000197619    UP000050525    UP000014760    UP000261380    UP000030742    UP000009136    UP000265160    UP000007875    UP000261460    UP000265100    UP000225706    UP000291021    UP000276834    UP000005207    UP000016665    UP000053858    UP000000437    UP000001038    UP000028760    UP000265200    UP000016666   

PRIDE

H9ITZ4    H9ITZ5    H9JNX4    P06795   

Pfam

PF00664   ABC_membrane        + More
PF00005   ABC_tran
PF17833   UPF0113_N
PF03657   UPF0113

Interpro

IPR036640   ABC1_TM_sf        + More
IPR011527   ABC1_TM_dom       
IPR027417   P-loop_NTPase       
IPR003439   ABC_transporter-like       
IPR017871   ABC_transporter_CS       
IPR039421   Type_I_exporter       
IPR003593   AAA+_ATPase       
IPR030258   MDR1       
IPR030275   MDR3       
IPR030278   BSEP       
IPR015947   PUA-like_sf       
IPR040598   UPF0113_N       
IPR036974   PUA_sf       
IPR002478   PUA       
IPR005155   UPF0113_PUA       

SUPFAM

SSF52540   SSF52540        + More
SSF90123   SSF90123       
SSF88697   SSF88697       

Gene 3D

1.20.1560.10     2.30.130.10    

ProteinModelPortal

H9ITZ4   E9LP52   E9LP53   A0A2A4J7A7   A0A212EGJ7   A0A194PLG2   + More
A0A194QS38   S4PS85   A0A2A4IW09   A0A2A4IWG8   A0A2H1W7P0   H9ITZ5   A0A2H1W3L7   H9JNX4   B4MJQ1   A0A212ET05   E9G2X2   A0A0L0CPE3   A0A1I8N682   A0A1B0G265   G3TGB8   B2RUR3   P06795   G3U8Q2   H0XA31   J9R1J6   A2VBC7   A0A1S3WN29   A0A2Y9RED6   Q9JK64   H0XJ01   O02793   Q6PSM0   G1T8H8   A0A0K2A212   B3RRZ8   A0A2U3WPH7   A0A384BPA4   A0A2Y9H1A3   A0A2U3XDU9   A0A2K6F8D6   Q6UUW3   M3Z3M9   G1N7X9   A0A3Q0HF50   M1FTP0   A0A091EHW6   A0A226NJG9   A0A1U7TSX7   W6RRJ8   A0A1L8FJP3   B5DP27   H0W664   A0A1U7U2H5   W6RT25   F1NKW0   A0A218V100   E1BS63   A0A151MQG6   R7T3N8   A0A3B5MXA8   A0A286Y4X3   O93437   A0A3Q0E6X1   U4USH3   G3X771   A0A3P9D7T4   H0VLE6   H2ZR93   A0A3B4FGC4   A0A3P8Q775   A0A2B4SKX2   A0A384BQ86   D7F607   A0A3G2BZA7   A0A3L8SY15   A0A093EZD3   A0A2K6F8D9   I3JQE9   A0A1L8G6K1   G1NDS9   A0A2I0UTT2   U3JDD3   V9K7H3   A0A091EQ32   A0A1U7TNX3   I3JQF0   A0A0A0A3M1   A0A2U3ZRF7   E1C757   F1QSX6   A0A1L8FW23   A0A3Q0E088   A0A286Y222   H2LEC5   A0A087YEQ8   A0A1W3JMB5   A0A3P9IED0   U3IQT2   F6NLY2  

PDB

6QEX     E-value=0,     Score=2317

KEGG

101735430    K05658 ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] | (RefSeq) multidrug resis

GO

GO:0016021   GO:0005524   GO:0042626   GO:0015721   GO:0097254   GO:0017085   GO:0001666   GO:0008354   GO:0005886   GO:0099038   GO:0009986   GO:0072089   GO:1901529   GO:0000086   GO:0090555   GO:0047484   GO:0016324   GO:0090554   GO:2001225   GO:0014045   GO:0061843   GO:0042493   GO:0005739   GO:0005215   GO:0000139   GO:0046581   GO:0043278   GO:1902065   GO:1904478   GO:0006855   GO:1905233   GO:0071407   GO:0071312   GO:0071475   GO:0033762   GO:2001025   GO:1905231   GO:0016020   GO:0071549   GO:0071217   GO:0009914   GO:0001890   GO:0032355   GO:0036146   GO:0071548   GO:0014072   GO:0031526   GO:0010033   GO:0046618   GO:0071392   GO:0033189   GO:1990962   GO:0050892   GO:0046686   GO:0071236   GO:0060548   GO:1904446   GO:0007623   GO:0032496   GO:0045177   GO:1902396   GO:0033231   GO:0097068   GO:1905235   GO:0007420   GO:0007595   GO:1903416   GO:0060856   GO:1905232   GO:0010046   GO:1990963   GO:0043215   GO:0033280   GO:0035633   GO:0014070   GO:1905237   GO:0031667   GO:0097327   GO:0009636   GO:0005925   GO:0005654   GO:0005829   GO:0061092   GO:0055088   GO:0032376   GO:0015629   GO:1903413   GO:1901557   GO:0032782   GO:0006703   GO:0008584   GO:0048568   GO:0008585   GO:0003723   GO:0015462   GO:0019534   GO:0015562   GO:0015722   GO:0015126   GO:0006810   GO:0016887   GO:0043401   GO:0003677   GO:0003707   GO:0007169   GO:0055085  

PANTHER

PTHR24221   PTHR24221:SF251   PTHR24221:SF241   PTHR24221:SF165  

Subcellular location

Cell membrane  

Length:

1307

Number of predicted TMHs:

9

Exp number of AAs in TMHs:

241.205150000001

Exp number, first 60 AAs:

22.45419

Total prob of N-in:

0.99265

POSSIBLE N-term signal

sequence

inside

1  -  33

TMhelix

34  -  56

outside

57  -  109

TMhelix

110  -  132

inside

133  -  183

TMhelix

184  -  206

outside

207  -  747

TMhelix

748  -  770

inside

771  -  782

TMhelix

783  -  805

outside

806  -  855

TMhelix

856  -  878

inside

879  -  884

TMhelix

885  -  907

outside

908  -  971

TMhelix

972  -  994

inside

995  -  1000

TMhelix

1001  -  1023

outside

1024  -  1307

 

 

Pi

22.30863

Theta

22.667174

Tajima's D

-0.656838

CLR

0.008288

CSRT

0.209139543022849

Interpretation

Uncertain