Gene

KWMTBOMO00389  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000721

Annotation

PREDICTED:_acetyl-coenzyme_A_synthetase_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr1(+):11459139-11476389      View in EpiBrowser

Full name

Acetyl-coenzyme A synthetase      

Alternative Name

Acetate--CoA ligase
Acetyl-CoA synthetase
Acyl-activating enzyme

Location in the cell

Cytoplasmic   Reliability : 2.018

CDS

ATGTCGTCGCGCATGTACAAGCCCACTGATCATGTCATCAAGAAATCGTATTTACCATCGATCCAAAAATACAAAGAAATGTATGAAAGATCACTCACTGAATCGGAACTGTTCTGGACCGAGGTCGCCCAAGAATTTCAGTGGCATGTAGCACCGAAGCCGGGTGGCTTCATGAAATACAACTTTGACATTACCAAAGGAAGGGTCTTTGTAAAATTTATGGAGGAAGCCGAGCTGAATGTGTGTTACAATTTGCTCGATCGCAATGTCAAGAATGGTTTCGGGGATAAAATTGCCTTTTTCTGGGAAGGGAACAGTCCGGATGATTATACGCGCATTACATACCGGAAACTGCTGGACTTGGTGTGCCAGTTTGCCAATGGTTTGCTGGCCAAAGGAATCCGTAAAGGAGATCGCGTTGCAGTCTACATGCCCATGATCTTGGAGGCAGTAATCTGCATGTTAGCCTGCGCTAGAATTGGTGCTGTACACACAGTCGTGTTCGCAGGATTTTCATCGGACGCTTTAGCGGAGCGCCTTTCCGACGCTAAAGCTAAACTTTTGGTCACCGCTGACGGTGCTTGGCGCGGCGAACGCATGTACGTGTACAAGAGAACCTGCGACGATGCCATAGAGAAGGCTAGAACATTCTTCAAGCACAGAGTGGATATGTGTATGGTCGTAAACCACCTCGATAGAGTTACACCTGGTGGTAGTTTGAAAAGCGAAATCAAAGATCTCTATAATTGGAATGAGGAGACAGATATCTGGTGGCACGAAGTGTTAGAGGGGGAATCTAACATTTGCCCTCCGGAATGGGTTGCCGCCGAGGATCCATTGTTCGTGCTCTACACAAGCGGTTCCACTGGTAAGCCGAAAGGGGTTGTGCACACTACCGCCGGGTACCTGATGTACGCAGCCGCCACGTTCCGATACGTGTTCGACTACCACAGGCGCGATGTGTATTGGTGCACCGCTGACGTCGGCTGGATCACCGGACACACATACGTTGTGTACGCGCCGCTGGCCAACGCTGCCACCTCGGTTATGTTCGAGGGGACTCCCTACTTTCCGAAGGTCGATCGTTACTGGAGTATTATCAACAAGTACAAAGTGACGCAATTTTATACTGCGCCCACTGCAATCCGGGCTCTCATGGCCCATTACAACGTGGAAGATGGCAATCTGACCATGCCGGATTTGTCGAGTCTCCGTGTGTTGGGAAGTGTGGGTGAGCCTATAAATCCGGCGGCTTGGCTGTGGTACTACACCAGGATTGGGAAAGAGCGCTGTTCTATCGTGGACACCTTCTGGCAGACAGAGACCGGGGGCCACGTGATTACCGGACTGCCTGGCGCCACTCCCATGAAGCCTGGTGCTGCAGGCTTCCCGTTCTTCGGTGTTGAACCGAAAATCTTGAATGAAGATGGTGTCGAAATAGAGGGACCCGGAGAAGGCTATCTAGTGTTCGCACGTCCATGGCCCGGCATGATGAGGACTCTGCTTGAGGACCAGGATCGCTTTGAAAGGGTCTATTTCAGCAAGTTTCCTGGTTACTACTGCACCGGAGATGGCGTGAGGCGCGACGAAGATGGATACTTGTGGATCACAGGCCGTATTGATGATATGCTTAACGTGTCTGGACATCTCATGTCTACTGCTGAAGTAGAGGGCGTTCTCGCCTCAGACCCCAGGGTCTCCGAAGCAGCAGTAGTGCCAAAACCCCACGAAGTTAAGGGCGAAGCACTGTATTGTTTCGTTGTACTCAAAGAGGGGTTGCAATTCGACGCTGATTTGGTTAAAACATTGACCTTGCTGGTGAGGCAGAAGATTGGAGCATTTGCCGCTCCTGACACTATCCAGAACGCTCCCGGCTTGCCTAAGACTCGTTCTGGAAAGATTATGCGCCGCATTTTAAGGAAGATCGCCGTGGGTGACCACGAGGTGGGCGACATTTCTACCCTGGCCGACCCCGGTGTCGTTGAAGAACTCTTCAACAACAGACCTGCCGAAGCGAAACCAAAAACTGGCTAG

Protein

MSSRMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEELFNNRPAEAKPKTG

Description

Activates acetate so that it can be used for lipid synthesis or for energy generation.

Catalytic Activity

acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate

Similarity

Belongs to the ATP-dependent AMP-binding enzyme family.

Keywords

Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Ligase   Nucleotide-binding   Reference proteome  

Feature

chain  Acetyl-coenzyme A synthetase
splice variant  In isoform B.

Uniprot

H9ITZ1   A0A194QLA9   A0A194PFZ5   A0A212EGH6   A0A182YJ78   A0A0L0CQR3   + More
A0A182FFF8   A0A1W4VAF8   B4N528   A0A182RDH4   A0A182QW10   A0A2M4A143   A0A182VG71   A0A182U4P5   A0A182LKI0   A0A182X4E9   Q7Q597   A0A182I4E9   A0A2M4CTA6   A0A182WBT7   A0A2M4A164   A0A0J9RZB8   B3M6S1   B4LHB4   A0A2M4BGJ2   A0A2M3Z1B2   T1PCV0   A0A1I8M3R8   A0A182PDI2   A0A182NIT7   A0A182IJV6   B4IAL8   B3NIX6   Q2LYQ0   Q9VP61   B4KUM4   Q59E09   A0A084WMQ1   A0A3B0JW74   B4H5Z1   A0A0M4EPU7   B0XAY5   A0A1B0FBP1   Q16EU8   A0A023EUR3   A0A1J1IRT9   W8B5D4   B4J127   A0A023EVI9   A0A1I8NZX8   A0A0A1X8A8   A0A1Q3FHB3   A0A0K8WF19   A0A1Q3FHH9   D7EHZ9   A0A1B0CS69   A0A336LX57   U5EWV9   T1GC23   A0A2H8TJH2   A0A232EYE9   K7J8W1   A0A1L8DZ16   A0A2J7RP82   A0A2H1WQI7   A0A067RBD1   A0A0L7R9K8   A0A069DW55   A0A026WR02   T1H972   A0A023F5F3   E2BM27   A0A146LJE9   A0A151JAV0   A0A195FWR0   A0A151IDB0   F4X803   A0A151I1P4   A0A151XEM0   N6U507   B4PE55   A0A1Y1M9G5   B4QJQ3   E1ZXT4   A0A1W4WPW3   A0A1A8F8V5   A0A210PEM7   A0A1A8BIH5   A0A1A8J7N4   A0A0B6ZVD5   A0A1A8RMT5   A0A1D2NG40   V4BDJ7   A0A3P9NZQ6   A0A1A8UZK4   A0A131YNF0   A0A1A8LH76   A0A224YSJ9   L7MH44   A0A3B4AXC9  

EC Number

6.2.1.1

Pubmed

19121390    26354079    22118469    25244985    26108605    17994087    + More
20966253    12364791    14747013    17210077    22936249    25315136    15632085    10731132    12537572    12537569    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    24438588    17510324    24945155    24495485    25830018    18362917    19820115    28648823    20075255    24845553    26334808    24508170    30249741    25474469    20798317    26823975    21719571    23537049    17550304    28004739    28812685    27289101    23254933    26830274    28797301    25576852    25463417   

EMBL

BABH01007198    KQ461196    KPJ06348.1    KQ459605    KPI91953.1    AGBW02015069    + More
OWR40596.1    JRES01000036    KNC34715.1    CH964101    EDW79467.1    AXCN02000480    GGFK01001182    MBW34503.1    AAAB01008960    EAA11289.2    APCN01002307    GGFL01004408    MBW68586.1    GGFK01001171    MBW34492.1    CM002912    KMZ00959.1    CH902618    EDV39757.1    CH940647    EDW70627.1    GGFJ01002962    MBW52103.1    GGFM01001566    MBW22317.1    KA645955    AFP60584.1    CH480826    EDW44331.1    CH954178    EDV52622.1    CH379069    EAL29811.1    Z46786    AE014296    AY089540    BT001456    AAL90278.1    CH933809    EDW18252.1    BT126330    AAX52767.2    AEB72010.1    ATLV01024499    KE525352    KFB51495.1    OUUW01000009    SPP85333.1    CH479212    EDW33208.1    CP012525    ALC44192.1    DS232603    EDS43955.1    CCAG010001560    CCAG010001561    CH478576    CH477191    EAT32761.1    EAT48627.1    GAPW01000429    GAPW01000428    JAC13170.1    CVRI01000058    CRL02935.1    GAMC01021596    JAB84959.1    CH916366    EDV96882.1    GAPW01000430    JAC13168.1    GBXI01007317    GBXI01003494    JAD06975.1    JAD10798.1    GFDL01008084    JAV26961.1    GDHF01029295    GDHF01002864    JAI23019.1    JAI49450.1    GFDL01008082    JAV26963.1    KQ972204    EFA12933.2    AJWK01025709    AJWK01025710    AJWK01025711    UFQT01000185    SSX21243.1    GANO01001244    JAB58627.1    CAQQ02067234    CAQQ02067235    CAQQ02067236    GFXV01002384    MBW14189.1    NNAY01001586    OXU23516.1    AAZX01000809    GFDF01002415    JAV11669.1    NEVH01002140    PNF42629.1    ODYU01009948    SOQ54704.1    KK852573    KDR21062.1    KQ414627    KOC67441.1    GBGD01000744    JAC88145.1    KK107128    QOIP01000006    EZA58398.1    RLU21429.1    ACPB03009098    ACPB03009099    ACPB03009100    ACPB03009101    ACPB03009102    ACPB03009103    ACPB03009104    ACPB03009105    GBBI01002344    JAC16368.1    GL449100    EFN83276.1    GDHC01011597    JAQ07032.1    KQ979254    KYN22082.1    KQ981193    KYN45095.1    KQ977979    KYM98360.1    GL888900    EGI57420.1    KQ976554    KYM80806.1    KQ982249    KYQ58832.1    APGK01049779    APGK01049780    APGK01049781    APGK01049782    KB741156    ENN73647.1    CM000159    EDW95068.1    GEZM01036911    JAV82344.1    CM000363    EDX11353.1    GL435089    EFN74005.1    HAEB01009268    HAEC01008589    SBQ55795.1    NEDP02076747    OWF34906.1    HADZ01003058    SBP66999.1    HAED01018253    SBR04698.1    HACG01025447    CEK72312.1    HAEH01017996    SBS07007.1    LJIJ01000052    ODN04192.1    KB203019    ESO86719.1    HADY01009976    HAEJ01011996    SBS52453.1    GEDV01009146    JAP79411.1    HAEF01006560    SBR43942.1    GFPF01005666    MAA16812.1    GACK01002466    JAA62568.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000076408    UP000037069    + More
UP000069272    UP000192221    UP000007798    UP000075900    UP000075886    UP000075903    UP000075902    UP000075882    UP000076407    UP000007062    UP000075840    UP000075920    UP000007801    UP000008792    UP000095301    UP000075885    UP000075884    UP000075880    UP000001292    UP000008711    UP000001819    UP000000803    UP000009192    UP000030765    UP000268350    UP000008744    UP000092553    UP000002320    UP000092444    UP000008820    UP000183832    UP000001070    UP000095300    UP000007266    UP000092461    UP000015102    UP000215335    UP000002358    UP000235965    UP000027135    UP000053825    UP000053097    UP000279307    UP000015103    UP000008237    UP000078492    UP000078541    UP000078542    UP000007755    UP000078540    UP000075809    UP000019118    UP000002282    UP000000304    UP000000311    UP000192223    UP000242188    UP000094527    UP000030746    UP000242638    UP000261520   

PRIDE

H9ITZ1    Q9VP61    Q59E09   

Pfam

PF00501   AMP-binding        + More
PF16177   ACAS_N
PF13193   AMP-binding_C

Interpro

IPR025110   AMP-bd_C        + More
IPR011904   Ac_CoA_lig       
IPR032387   ACAS_N       
IPR020845   AMP-binding_CS       
IPR000873   AMP-dep_Synth/Lig       
IPR042099   AMP-dep_Synthh-like_sf       

Gene 3D

3.40.50.12780    

CDD

cd05966  ACS

ProteinModelPortal

H9ITZ1   A0A194QLA9   A0A194PFZ5   A0A212EGH6   A0A182YJ78   A0A0L0CQR3   + More
A0A182FFF8   A0A1W4VAF8   B4N528   A0A182RDH4   A0A182QW10   A0A2M4A143   A0A182VG71   A0A182U4P5   A0A182LKI0   A0A182X4E9   Q7Q597   A0A182I4E9   A0A2M4CTA6   A0A182WBT7   A0A2M4A164   A0A0J9RZB8   B3M6S1   B4LHB4   A0A2M4BGJ2   A0A2M3Z1B2   T1PCV0   A0A1I8M3R8   A0A182PDI2   A0A182NIT7   A0A182IJV6   B4IAL8   B3NIX6   Q2LYQ0   Q9VP61   B4KUM4   Q59E09   A0A084WMQ1   A0A3B0JW74   B4H5Z1   A0A0M4EPU7   B0XAY5   A0A1B0FBP1   Q16EU8   A0A023EUR3   A0A1J1IRT9   W8B5D4   B4J127   A0A023EVI9   A0A1I8NZX8   A0A0A1X8A8   A0A1Q3FHB3   A0A0K8WF19   A0A1Q3FHH9   D7EHZ9   A0A1B0CS69   A0A336LX57   U5EWV9   T1GC23   A0A2H8TJH2   A0A232EYE9   K7J8W1   A0A1L8DZ16   A0A2J7RP82   A0A2H1WQI7   A0A067RBD1   A0A0L7R9K8   A0A069DW55   A0A026WR02   T1H972   A0A023F5F3   E2BM27   A0A146LJE9   A0A151JAV0   A0A195FWR0   A0A151IDB0   F4X803   A0A151I1P4   A0A151XEM0   N6U507   B4PE55   A0A1Y1M9G5   B4QJQ3   E1ZXT4   A0A1W4WPW3   A0A1A8F8V5   A0A210PEM7   A0A1A8BIH5   A0A1A8J7N4   A0A0B6ZVD5   A0A1A8RMT5   A0A1D2NG40   V4BDJ7   A0A3P9NZQ6   A0A1A8UZK4   A0A131YNF0   A0A1A8LH76   A0A224YSJ9   L7MH44   A0A3B4AXC9  

PDB

2P2F     E-value=0,     Score=1686

KEGG

101746722    K01895 acetyl-CoA synthetase [EC:6.2.1.1] | (RefSeq) acetyl-coenzyme A synthetase

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
00640    Propanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0019427   GO:0016208   GO:0016021   GO:0003987   GO:0005524   GO:0048149   GO:0005737   GO:0006633   GO:0031955   GO:0003824   GO:0008152   GO:0043401   GO:0003677   GO:0003707   GO:0007169  

Subcellular location

Cytoplasm  

Length:

677

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

32.4616100000001

Exp number, first 60 AAs:

0.00015

Total prob of N-in:

0.85303

inside

1  -  139

TMhelix

140  -  162

outside

163  -  677

 

 

Pi

21.143872

Theta

18.677043

Tajima's D

0.548423

CLR

0.116985

CSRT

0.534473276336183

Interpretation

Uncertain